BG104786A - Дихидробензо (1,4) оксазини и тетрахидрохиноксалини - Google Patents

Дихидробензо (1,4) оксазини и тетрахидрохиноксалини

Info

Publication number
BG104786A
BG104786A BG104786A BG10478600A BG104786A BG 104786 A BG104786 A BG 104786A BG 104786 A BG104786 A BG 104786A BG 10478600 A BG10478600 A BG 10478600A BG 104786 A BG104786 A BG 104786A
Authority
BG
Bulgaria
Prior art keywords
linkage
ny4y5
alkyl
compounds
ny1y2
Prior art date
Application number
BG104786A
Other languages
English (en)
Inventor
Jean-Dominique Bourzat
Alain Commercon
Bruno Jacques Christophe FILOCHE
Neil Harris
Thomas Pallin
Keith Alfred James Stuttle
Original Assignee
Aventis Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9828417.7A external-priority patent/GB9828417D0/en
Application filed by Aventis Pharma Limited filed Critical Aventis Pharma Limited
Publication of BG104786A publication Critical patent/BG104786A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретението се отнася до физиологично активни съединения с формула@@в която R1 представлява R3-Z3-, R3-L2-R4-Z3-, R3-L3-Ar1-L4-Z3- или R3-L3-Ar1-L2-R4-Z3-; R2 означава водород, халоген, по-нисш алкил или по-нисш алкокси; А1 е правоверижна С2-3 алкиленова връзка, допълнително заместена с една или повече групи, избрани от алкил, арил, арилалкил, хетероарил, хетероарилалкил, имино, оксо, тиоксо или алкил, заместен с -ZR6, -NY1Y2, -CO2R6 или -С(=O)-NY1Y2; L1 представлява алкениленова, алкиленова,алкиниленова, циклоалкениленова, циклоалкиленова,хетероарилдиилова, хетероциклоалкиленова или ариленова връзка, всяка допълнително заместена с: (а) киселинна функционална група, циано, оксо, -S(O)mR9, R3, -C(=O)-R3, -C(=O)-OR3, -N(R8)-C(=O)-R9, -N(R8)-C(=O)-OR9, -N(R8)-SO2-R9, -NY4Y5 или -[C(=O)-N(R10)-C(R5)(R11)]p-C(=O)-NY4Y5, или (б) алкил, заместен с киселинна функционална група или -S(O)mR9,-C(=O)-NY4Y5 или -NY4Y5; -[C(=O)-N(R10)-C(R5)(R11)]p връзка; -Z2-R12-връзка; -С(=O)-CH2-C(=O)- връзка; -R12-Z2-R12- връзка; -С(R4)(R13)-[C(=O)-N(R10)-C(R5)(R11)]p- връзка или -L5-L6-L7- връзка; Z1 представлява NR17 или О; Y е карбоксигрупа (или кисел биоизостер). Изобретението се отнася и до съответните N-оксиди и техните пролекарствени средства, до фармацевтично приемливи соли и солвати на такива съединения и техните N-оксиди и пролекарствени средства. Посочените съединения имат ценни фармацевтични свойства, особено възможността да регулират взаимодействието на VCAM-1 и фибронектин с интегрина VLA-4 (алфа4 бе
BG104786A 1998-12-23 2000-09-20 Дихидробензо (1,4) оксазини и тетрахидрохиноксалини BG104786A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9828417.7A GB9828417D0 (en) 1998-12-23 1998-12-23 Chemical compounds
US12608499P 1999-03-25 1999-03-25
PCT/GB1999/004430 WO2000039103A1 (en) 1998-12-23 1999-12-23 Dihydro-benzo(1,4)oxazines and tetrahydroquinoxalines

Publications (1)

Publication Number Publication Date
BG104786A true BG104786A (bg) 2001-04-30

Family

ID=26314897

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104786A BG104786A (bg) 1998-12-23 2000-09-20 Дихидробензо (1,4) оксазини и тетрахидрохиноксалини

Country Status (10)

Country Link
US (1) US6632814B1 (bg)
EP (1) EP1056728B1 (bg)
AP (1) AP2000001924A0 (bg)
AU (1) AU1881900A (bg)
BG (1) BG104786A (bg)
DE (1) DE69937603T2 (bg)
ES (1) ES2297943T3 (bg)
HU (1) HUP0200481A3 (bg)
SK (1) SK14192000A3 (bg)
WO (1) WO2000039103A1 (bg)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4591800A (en) * 1999-05-05 2000-11-21 Aventis Pharma Limited Ureas as cell adhesion modulators
US6750215B2 (en) 2001-08-08 2004-06-15 Pharmacia & Upjohn, S.P.A. Substituted benzoxazines as integrin antagonists
US6794385B2 (en) 2001-08-08 2004-09-21 Pharmacia & Upjohn, S.P.A. Benzoxazine derivatives useful as integrin receptor antagonists
EP3241833A1 (en) 2010-10-18 2017-11-08 Cerenis Therapeutics Holding SA Compounds, compositions and methods useful for cholesterol mobilisation
JP5903499B2 (ja) 2011-12-22 2016-04-13 ノバルティス アーゲー ジヒドロ−ベンゾ−オキサジンおよびジヒドロ−ピリド−オキサジン誘導体
CN103275021B (zh) * 2013-05-24 2015-05-20 东北农业大学 N-二氯乙酰基-6,7-二氯-1,2,3,4-四氢喹喔啉及其制备方法
US9422281B2 (en) 2013-11-18 2016-08-23 Forma Therapeutics, Inc. Benzopiperazine compositions as BET bromodomain inhibitors
HUE053645T2 (hu) 2013-11-18 2021-07-28 Forma Therapeutics Inc Tetrahidrokinolin kompozíciók mint BET bromodomén inhibitorok

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US4582909A (en) 1984-02-02 1986-04-15 Warner-Lambert Company Benzobicyclic lactam acids and derivatives as cognition activators
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GB9320277D0 (en) 1993-10-01 1993-11-17 Nycomed Salutar Inc Chelants
ATE205837T1 (de) 1991-04-15 2001-10-15 Aventis Pharma Gmbh Chinoxaline, verfahren zu ihrer herstellung und ihre verwendung
AU1493092A (en) * 1991-04-18 1992-10-22 Ortho Pharmaceutical Corporation (+) and (-) enantiomers of 5-aliphatic-6-(benzoxazinyl- or benzothiazinyl)-2,3,4,5-tetrahydropyridazin-3-ones
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CA2307613A1 (en) 1997-10-22 1999-04-29 Eisai Co., Ltd. Retinoic acid agonist as a prophylactic and therapeutic agent for nephritis
CA2303848C (en) * 1997-10-31 2008-09-30 Rhone-Poulenc Rorer Limited Substituted anilides
CA2316235A1 (en) * 1997-12-23 1999-07-08 Aventis Pharma Limited Substituted .beta.-alanines
AU3716499A (en) * 1998-04-21 1999-11-08 Aventis Pharma Limited Substituted diamines and their use as cell adhesion inhibitors

Also Published As

Publication number Publication date
AP2000001924A0 (en) 2000-09-30
AU1881900A (en) 2000-07-31
SK14192000A3 (sk) 2001-07-10
US6632814B1 (en) 2003-10-14
DE69937603T2 (de) 2008-10-23
EP1056728B1 (en) 2007-11-21
EP1056728A1 (en) 2000-12-06
DE69937603D1 (de) 2008-01-03
ES2297943T3 (es) 2008-05-01
WO2000039103A1 (en) 2000-07-06
HUP0200481A2 (en) 2002-06-29
WO2000039103B1 (en) 2000-09-28
HUP0200481A3 (en) 2002-12-28

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