BG104413A - Метод за синтез на пироламиди - Google Patents

Метод за синтез на пироламиди

Info

Publication number
BG104413A
BG104413A BG104413A BG10441300A BG104413A BG 104413 A BG104413 A BG 104413A BG 104413 A BG104413 A BG 104413A BG 10441300 A BG10441300 A BG 10441300A BG 104413 A BG104413 A BG 104413A
Authority
BG
Bulgaria
Prior art keywords
synthesis
reaction
followed
pyrrole amides
pyrrole
Prior art date
Application number
BG104413A
Other languages
English (en)
Other versions
BG64530B1 (bg
Inventor
John A. Ragan
Teresa W. Makowski
David J. Am Ende
Pamela J. Clifford
Gregory R. Young
Alyson K. Conrad
Shane A. Eisenbeis
George J. Quallich
Douglas John Meldrum Allen
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of BG104413A publication Critical patent/BG104413A/bg
Publication of BG64530B1 publication Critical patent/BG64530B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Tea And Coffee (AREA)
  • Fats And Perfumes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
BG104413A 1997-11-13 2000-05-09 Метод за синтез на пироламиди BG64530B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6542297P 1997-11-13 1997-11-13
US7426698P 1998-02-10 1998-02-10

Publications (2)

Publication Number Publication Date
BG104413A true BG104413A (bg) 2001-02-28
BG64530B1 BG64530B1 (bg) 2005-06-30

Family

ID=26745584

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104413A BG64530B1 (bg) 1997-11-13 2000-05-09 Метод за синтез на пироламиди

Country Status (35)

Country Link
US (1) US6262272B1 (bg)
EP (1) EP1030838B1 (bg)
JP (1) JP3497469B2 (bg)
KR (1) KR100386722B1 (bg)
CN (2) CN1508129A (bg)
AT (1) ATE231492T1 (bg)
AU (1) AU745788B2 (bg)
BG (1) BG64530B1 (bg)
BR (1) BR9814161A (bg)
CA (1) CA2310095A1 (bg)
CZ (1) CZ20001769A3 (bg)
DE (1) DE69810959T2 (bg)
DK (1) DK1030838T3 (bg)
DZ (1) DZ2651A1 (bg)
EA (1) EA002243B1 (bg)
ES (1) ES2186232T3 (bg)
HR (1) HRP20000298A2 (bg)
HU (1) HUP0100235A3 (bg)
ID (1) ID24135A (bg)
IL (1) IL135710A0 (bg)
IS (1) IS5469A (bg)
MA (1) MA24697A1 (bg)
NO (1) NO20002214L (bg)
NZ (1) NZ503916A (bg)
OA (1) OA11378A (bg)
PA (1) PA8462901A1 (bg)
PL (1) PL340554A1 (bg)
PT (1) PT1030838E (bg)
SK (1) SK6872000A3 (bg)
TN (1) TNSN98204A1 (bg)
TR (1) TR200001343T2 (bg)
TW (1) TW509675B (bg)
UY (1) UY25249A1 (bg)
WO (1) WO1999025684A1 (bg)
YU (1) YU27300A (bg)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1372546A (zh) 1999-08-31 2002-10-02 神经原公司 稠合的吡咯甲酰胺:gaba脑受体的配体
BR0113697A (pt) * 2000-09-06 2003-07-22 Neurogen Corp Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou sal, embalagem e métodos para, para alterar a atividade transdutora de sinal dos receptores de gabaa, para tratar ansiedade, depressão, um distúrbio do sono, ou demência de alzheimer, para demonstrar a presença dos receptores de gabaa em células ou amostras de tecido e para preparar um composto
CA2430841A1 (en) * 2000-12-04 2002-06-13 Pfizer Products Inc. Synthesis of fused pyrrolecarboxamides
MXPA04007606A (es) 2002-02-07 2004-11-10 Neurogen Corp Arilamidas de acido pirazolcarboxilico fusionadas substituidas y compuestos relacionados.
US20080153629A1 (en) * 2004-05-07 2008-06-26 Sullivan Michael J Thick Outer Cover Layer Golf Ball
CN102786458B (zh) * 2012-06-04 2014-02-12 天津渤海职业技术学院 吡咯甲酰胺衍生物、其制备方法和用途
CA2937074A1 (en) * 2014-01-24 2015-07-30 Abbvie Inc. Furo-3-carboxamide derivatives and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750702A (en) 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
AU2218997A (en) 1996-03-22 1997-10-10 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands

Also Published As

Publication number Publication date
YU27300A (sh) 2002-10-18
EA002243B1 (ru) 2002-02-28
BR9814161A (pt) 2000-09-26
WO1999025684A1 (en) 1999-05-27
AU9363998A (en) 1999-06-07
KR100386722B1 (ko) 2003-06-09
DE69810959D1 (de) 2003-02-27
EA200000413A1 (ru) 2000-12-25
ATE231492T1 (de) 2003-02-15
IL135710A0 (en) 2001-05-20
DK1030838T3 (da) 2003-02-24
ID24135A (id) 2000-07-06
IS5469A (is) 2000-04-26
JP2001523660A (ja) 2001-11-27
US6262272B1 (en) 2001-07-17
CN1280566A (zh) 2001-01-17
DZ2651A1 (fr) 2003-03-15
TR200001343T2 (tr) 2001-02-21
CN1508129A (zh) 2004-06-30
HRP20000298A2 (en) 2001-02-28
ES2186232T3 (es) 2003-05-01
BG64530B1 (bg) 2005-06-30
NZ503916A (en) 2002-08-28
AU745788B2 (en) 2002-03-28
UY25249A1 (es) 1999-07-19
HUP0100235A3 (en) 2002-04-29
NO20002214D0 (no) 2000-04-28
TW509675B (en) 2002-11-11
CZ20001769A3 (cs) 2001-09-12
CA2310095A1 (en) 1999-05-27
NO20002214L (no) 2000-05-12
EP1030838B1 (en) 2003-01-22
OA11378A (en) 2004-01-27
TNSN98204A1 (fr) 2005-03-15
EP1030838A1 (en) 2000-08-30
PA8462901A1 (es) 2000-05-24
DE69810959T2 (de) 2003-06-05
KR20010032063A (ko) 2001-04-16
SK6872000A3 (en) 2002-02-05
HUP0100235A2 (hu) 2001-12-28
PT1030838E (pt) 2003-03-31
JP3497469B2 (ja) 2004-02-16
MA24697A1 (fr) 1999-07-01
PL340554A1 (en) 2001-02-12

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