BG102810A - Неклетъчен заместител на червените кръвни клетки - Google Patents
Неклетъчен заместител на червените кръвни клеткиInfo
- Publication number
- BG102810A BG102810A BG102810A BG10281098A BG102810A BG 102810 A BG102810 A BG 102810A BG 102810 A BG102810 A BG 102810A BG 10281098 A BG10281098 A BG 10281098A BG 102810 A BG102810 A BG 102810A
- Authority
- BG
- Bulgaria
- Prior art keywords
- preparation
- substituent
- cellular
- blood cells
- red blood
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Изобретението се отнася до воден разтвор на полимеризиран хемоглобин, който се прилага в хуманната медицина за трансфузии. Разтворът включва следнитехемоглобинови полимери в %: от 10 до 24 хемоглобинов полимер с мол.т. около 128, от 18 до 30 - с мол.т. около 192 и от 45 до 70 - с мол.т. около 256.По-специално водният разтвор съдържа пиридоксилиран полимеризиран хемоглобин със следните компоненти: общ хемоглобин приблизително от 9,5 до 12,0 g/dl, общ метхемоглобин < 8% от общия хемоглобин, общкарбоксихемоглобин < 5% от общия хемоглобин, концентрация на натрий от 135 до 155 mmol/kg, концентрация на калий от 3,5 до 4,5 mmol/kg, концентрация на хлорид от 85 до 110 mmol/kg, свободно желязо < 2,0 ppm, тетрамер < 0,8%, ендотоксин < 0,03 EU/ml,фосфолипиди < 50 ng/Hb и гликолипиди < 2 ng/Hb.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1438996P | 1996-03-28 | 1996-03-28 | |
| PCT/US1997/005088 WO1997035883A1 (en) | 1996-03-28 | 1997-03-27 | Method and apparatus for preparing an acellular red blood cell substitute |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG102810A true BG102810A (bg) | 1999-09-30 |
| BG63919B1 BG63919B1 (bg) | 2003-06-30 |
Family
ID=21765191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102810A BG63919B1 (bg) | 1996-03-28 | 1998-10-01 | Неклетъчен заместител на червените кръвни клетки |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US6498141B2 (bg) |
| EP (1) | EP0928294B1 (bg) |
| JP (1) | JP2000507947A (bg) |
| CN (1) | CN1129608C (bg) |
| AP (1) | AP1028A (bg) |
| AT (1) | ATE241646T1 (bg) |
| AU (1) | AU740210B2 (bg) |
| BG (1) | BG63919B1 (bg) |
| BR (1) | BR9708388A (bg) |
| CA (1) | CA2250274C (bg) |
| CZ (1) | CZ299357B6 (bg) |
| DE (1) | DE69722422T2 (bg) |
| DK (1) | DK0928294T3 (bg) |
| ES (1) | ES2200177T3 (bg) |
| IL (1) | IL126376A (bg) |
| IS (1) | IS4854A (bg) |
| NO (1) | NO324121B1 (bg) |
| NZ (2) | NZ332067A (bg) |
| OA (1) | OA10884A (bg) |
| PL (1) | PL187923B1 (bg) |
| PT (1) | PT928294E (bg) |
| RO (1) | RO121089B1 (bg) |
| RU (1) | RU2203087C2 (bg) |
| SK (1) | SK134398A3 (bg) |
| UA (1) | UA64710C2 (bg) |
| WO (1) | WO1997035883A1 (bg) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000507947A (ja) * | 1996-03-28 | 2000-06-27 | ノースフイールド ラボラトリーズ インコーポレイテツド | 無細胞性赤血球代用物を製造する方法及び装置 |
| CA2444590C (en) | 2001-04-18 | 2009-12-01 | Robert L. Mcginnis | Stabilized hemoglobin solutions |
| DE10220992A1 (de) * | 2002-05-11 | 2003-12-04 | Sanguibiotech Ag | Verwendung eines oder mehrerer Sauerstoffträger, ausgewählt aus Hämoglobin, Myoglobin und Derivaten hiervon zur Behandlung einer Organfunktionsstörung infolge eines akuten Versorgungsmangels und zur Behandlung/Vermeidung einer Gewebeschädigung infolge einer solchen Störung |
| EP1553968A4 (en) * | 2002-10-03 | 2009-06-24 | Northfield Lab | METHOD FOR TREATING PATIENTS WITH MASSIVE BLOOD LOSS |
| EP1592437A4 (en) * | 2003-01-29 | 2007-12-26 | Northfield Lab | POLYMERIZED HEMOGLOBIN SOLUTIONS WITH REDUCED TETRAMER QUANTITY AND MANUFACTURING METHOD |
| SE0501462L (sv) * | 2005-06-23 | 2006-09-26 | Proliff Ab | Förfarande för framställning av blodplättslysat |
| US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
| US20070196810A1 (en) * | 2006-01-24 | 2007-08-23 | Northfield Laboratories Inc. | Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells |
| RU2340354C1 (ru) * | 2007-06-05 | 2008-12-10 | Общество с ограниченной ответственностью "Геленпол" | Кровезаменитель с функцией переноса кислорода |
| RU2361608C1 (ru) | 2008-03-18 | 2009-07-20 | Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" | Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты) |
| AU2018304174A1 (en) | 2017-07-18 | 2020-02-06 | VirTech Bio, Inc. | Blood substitutes comprising hemoglobin and methods of making |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826811A (en) * | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5194590A (en) * | 1986-06-20 | 1993-03-16 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5464814A (en) * | 1986-06-20 | 1995-11-07 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| IL87708A (en) * | 1988-09-08 | 1994-04-12 | Technion Inst For Research And | Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof |
| SE9001378D0 (sv) * | 1990-04-18 | 1990-04-18 | Kabivitrum Ab | A method for the preparation of pyridoxylated hemoglobin |
| TW381022B (en) * | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
| JP2000507947A (ja) * | 1996-03-28 | 2000-06-27 | ノースフイールド ラボラトリーズ インコーポレイテツド | 無細胞性赤血球代用物を製造する方法及び装置 |
| US5998361A (en) * | 1996-10-18 | 1999-12-07 | University Of Maryland At Baltimore | Polymerized hemoglobin |
-
1997
- 1997-03-27 JP JP9534650A patent/JP2000507947A/ja active Pending
- 1997-03-27 AU AU24253/97A patent/AU740210B2/en not_active Ceased
- 1997-03-27 NZ NZ332067A patent/NZ332067A/en unknown
- 1997-03-27 BR BR9708388-7A patent/BR9708388A/pt not_active Application Discontinuation
- 1997-03-27 PT PT97919943T patent/PT928294E/pt unknown
- 1997-03-27 WO PCT/US1997/005088 patent/WO1997035883A1/en active IP Right Grant
- 1997-03-27 IL IL126376A patent/IL126376A/en not_active IP Right Cessation
- 1997-03-27 ES ES97919943T patent/ES2200177T3/es not_active Expired - Lifetime
- 1997-03-27 DE DE69722422T patent/DE69722422T2/de not_active Expired - Fee Related
- 1997-03-27 CN CN97194998A patent/CN1129608C/zh not_active Expired - Fee Related
- 1997-03-27 AT AT97919943T patent/ATE241646T1/de not_active IP Right Cessation
- 1997-03-27 CA CA002250274A patent/CA2250274C/en not_active Expired - Fee Related
- 1997-03-27 NZ NZ538045A patent/NZ538045A/en unknown
- 1997-03-27 EP EP97919943A patent/EP0928294B1/en not_active Expired - Lifetime
- 1997-03-27 RU RU98119535/14A patent/RU2203087C2/ru active
- 1997-03-27 CZ CZ0310098A patent/CZ299357B6/cs not_active IP Right Cessation
- 1997-03-27 DK DK97919943T patent/DK0928294T3/da active
- 1997-03-27 US US09/155,419 patent/US6498141B2/en not_active Expired - Fee Related
- 1997-03-27 SK SK1343-98A patent/SK134398A3/sk unknown
- 1997-03-27 RO RO98-01433A patent/RO121089B1/ro unknown
- 1997-03-27 PL PL32910897A patent/PL187923B1/pl not_active IP Right Cessation
- 1997-03-27 AP APAP/P/1998/001353A patent/AP1028A/en active
- 1997-03-27 UA UA98095067A patent/UA64710C2/uk unknown
-
1998
- 1998-09-25 NO NO19984473A patent/NO324121B1/no not_active IP Right Cessation
- 1998-09-25 OA OA9800177A patent/OA10884A/en unknown
- 1998-09-28 IS IS4854A patent/IS4854A/is unknown
- 1998-10-01 BG BG102810A patent/BG63919B1/bg unknown
-
2002
- 2002-10-17 US US10/274,099 patent/US20030191050A1/en not_active Abandoned
-
2004
- 2004-11-19 US US10/993,228 patent/US20050065067A1/en not_active Abandoned
-
2008
- 2008-01-10 US US11/972,322 patent/US7521417B2/en not_active Expired - Fee Related
-
2009
- 2009-04-20 US US12/426,566 patent/US20100197566A1/en not_active Abandoned
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