BR9708388A - Solução aquosa de hemoglobina polimerizada piridoxilada e processo de sua preparação. - Google Patents

Solução aquosa de hemoglobina polimerizada piridoxilada e processo de sua preparação.

Info

Publication number
BR9708388A
BR9708388A BR9708388-7A BR9708388A BR9708388A BR 9708388 A BR9708388 A BR 9708388A BR 9708388 A BR9708388 A BR 9708388A BR 9708388 A BR9708388 A BR 9708388A
Authority
BR
Brazil
Prior art keywords
preparation
pyridoxylated
aqueous solution
hemoglobin
polymerized hemoglobin
Prior art date
Application number
BR9708388-7A
Other languages
English (en)
Inventor
Richard E Dewoskin
Marc D Doubleday
Original Assignee
Northfield Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northfield Lab filed Critical Northfield Lab
Publication of BR9708388A publication Critical patent/BR9708388A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"SOLUçãO AQUOSA DE HEMOGLOBINA POLIMERIZADA PIRIDOXILADA E PROCESSO DE SUA PREPARAçãO". Um processo é apresentado para a preparação de uma hemoglobina essencialmente livre de tetrâmero, substancialmente livre de estroma, polimerizada, piridoxilada. Também é exposto um produto de hemoglobina essencialmente livre de tetrâmero, substancialmente livre de estroma, polimerizado, piridoxilado suscetível de ser ministrado por infusão a pacientes humanos em uma quantidade de até cerca de 5 litros.
BR9708388-7A 1996-03-28 1997-03-27 Solução aquosa de hemoglobina polimerizada piridoxilada e processo de sua preparação. BR9708388A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1438996P 1996-03-28 1996-03-28
PCT/US1997/005088 WO1997035883A1 (en) 1996-03-28 1997-03-27 Method and apparatus for preparing an acellular red blood cell substitute

Publications (1)

Publication Number Publication Date
BR9708388A true BR9708388A (pt) 2000-01-04

Family

ID=21765191

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9708388-7A BR9708388A (pt) 1996-03-28 1997-03-27 Solução aquosa de hemoglobina polimerizada piridoxilada e processo de sua preparação.

Country Status (26)

Country Link
US (5) US6498141B2 (pt)
EP (1) EP0928294B1 (pt)
JP (1) JP2000507947A (pt)
CN (1) CN1129608C (pt)
AP (1) AP1028A (pt)
AT (1) ATE241646T1 (pt)
AU (1) AU740210B2 (pt)
BG (1) BG63919B1 (pt)
BR (1) BR9708388A (pt)
CA (1) CA2250274C (pt)
CZ (1) CZ299357B6 (pt)
DE (1) DE69722422T2 (pt)
DK (1) DK0928294T3 (pt)
ES (1) ES2200177T3 (pt)
IL (1) IL126376A (pt)
IS (1) IS4854A (pt)
NO (1) NO324121B1 (pt)
NZ (2) NZ332067A (pt)
OA (1) OA10884A (pt)
PL (1) PL187923B1 (pt)
PT (1) PT928294E (pt)
RO (1) RO121089B1 (pt)
RU (1) RU2203087C2 (pt)
SK (1) SK134398A3 (pt)
UA (1) UA64710C2 (pt)
WO (1) WO1997035883A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ299357B6 (cs) * 1996-03-28 2008-07-02 Northfield Laboratories, Inc. Vodný roztok pyridoxylovaného zpolymerovaného hemoglobinu a zpusoby jeho prípravy
JP2004538264A (ja) 2001-04-18 2004-12-24 ノースフィールド ラボラトリーズ 安定化ヘモグロビン溶液の保管のための可撓性容器システム
DE10220992A1 (de) * 2002-05-11 2003-12-04 Sanguibiotech Ag Verwendung eines oder mehrerer Sauerstoffträger, ausgewählt aus Hämoglobin, Myoglobin und Derivaten hiervon zur Behandlung einer Organfunktionsstörung infolge eines akuten Versorgungsmangels und zur Behandlung/Vermeidung einer Gewebeschädigung infolge einer solchen Störung
EP1553968A4 (en) * 2002-10-03 2009-06-24 Northfield Lab METHOD FOR TREATING PATIENTS WITH MASSIVE BLOOD LOSS
BRPI0407106A (pt) * 2003-01-29 2006-01-24 Northfield Lab Soluções de hemoglobina polimerizadas com quantidade reduzida de tetrâmero e método para preparação
SE528214C2 (sv) * 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
EP1978802A2 (en) * 2006-01-24 2008-10-15 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
RU2340354C1 (ru) * 2007-06-05 2008-12-10 Общество с ограниченной ответственностью "Геленпол" Кровезаменитель с функцией переноса кислорода
RU2361608C1 (ru) 2008-03-18 2009-07-20 Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)
WO2019018403A1 (en) * 2017-07-18 2019-01-24 Virtech Bio, Llc BLOOD SUBSTITUTES COMPRISING HEMOGLOBIN AND METHODS OF MAKING

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194590A (en) * 1986-06-20 1993-03-16 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
IL87708A (en) * 1988-09-08 1994-04-12 Technion Inst For Research And Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof
SE9001378D0 (sv) * 1990-04-18 1990-04-18 Kabivitrum Ab A method for the preparation of pyridoxylated hemoglobin
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
CZ299357B6 (cs) * 1996-03-28 2008-07-02 Northfield Laboratories, Inc. Vodný roztok pyridoxylovaného zpolymerovaného hemoglobinu a zpusoby jeho prípravy
US5998361A (en) * 1996-10-18 1999-12-07 University Of Maryland At Baltimore Polymerized hemoglobin

Also Published As

Publication number Publication date
AU2425397A (en) 1997-10-17
DE69722422T2 (de) 2004-05-06
CN1129608C (zh) 2003-12-03
WO1997035883A1 (en) 1997-10-02
US7521417B2 (en) 2009-04-21
AU740210B2 (en) 2001-11-01
JP2000507947A (ja) 2000-06-27
NO984473D0 (no) 1998-09-25
ES2200177T3 (es) 2004-03-01
US20080108555A1 (en) 2008-05-08
US20050065067A1 (en) 2005-03-24
CN1219939A (zh) 1999-06-16
IL126376A (en) 2009-09-22
IS4854A (is) 1998-09-28
CZ310098A3 (cs) 1999-09-15
RU2203087C2 (ru) 2003-04-27
NO984473L (no) 1998-11-25
SK134398A3 (en) 2001-01-18
CZ299357B6 (cs) 2008-07-02
RO121089B1 (ro) 2006-12-29
US20020025343A1 (en) 2002-02-28
IL126376A0 (en) 1999-05-09
US6498141B2 (en) 2002-12-24
CA2250274C (en) 2003-09-16
EP0928294A1 (en) 1999-07-14
US20030191050A1 (en) 2003-10-09
NO324121B1 (no) 2007-08-27
BG63919B1 (bg) 2003-06-30
DK0928294T3 (da) 2003-09-22
OA10884A (en) 2001-10-11
UA64710C2 (en) 2004-03-15
PT928294E (pt) 2003-10-31
NZ332067A (en) 2001-03-30
EP0928294B1 (en) 2003-05-28
PL187923B1 (pl) 2004-11-30
AP9801353A0 (en) 1998-09-30
ATE241646T1 (de) 2003-06-15
DE69722422D1 (de) 2003-07-03
AP1028A (en) 2001-11-30
CA2250274A1 (en) 1997-10-02
US20100197566A1 (en) 2010-08-05
NZ538045A (en) 2006-11-30
BG102810A (en) 1999-09-30
PL329108A1 (en) 1999-03-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: UMA VEZ QUE NAO FICOU COMPROVADA ATIVIDADE INVENTIVA QUE MERECA PRIVILEGIO DE INVENCAO, SUGERIMOS O INDEFERIMENTO DO PRESENTE PEDIDO COM BASE NOS ARTIGOS 8 E 13 DA LPI 9279 DE 14 DE MAIO DE 1996.

B12B Appeal against refusal [chapter 12.2 patent gazette]