BG102286A - Пиперазинови производни и процес за тяхното производство - Google Patents

Пиперазинови производни и процес за тяхното производство

Info

Publication number
BG102286A
BG102286A BG102286A BG10228698A BG102286A BG 102286 A BG102286 A BG 102286A BG 102286 A BG102286 A BG 102286A BG 10228698 A BG10228698 A BG 10228698A BG 102286 A BG102286 A BG 102286A
Authority
BG
Bulgaria
Prior art keywords
substituted
unsubstituted
orunsubstituted
alkyl
alkoxygroup
Prior art date
Application number
BG102286A
Other languages
English (en)
Inventor
Eui- Hwan CHO
Sun - Gan CHUNG
Sun - Hwan LEE
Ho - Seok KWON
Jae - Eung LEE
Dong - Wook KANG
Jeong - Ho JOO
Young - Hee LEE
Original Assignee
Samjin Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019970022984A external-priority patent/KR100204320B1/ko
Priority claimed from KR1019970022985A external-priority patent/KR100204319B1/ko
Priority claimed from KR1019970023192A external-priority patent/KR100204318B1/ko
Priority claimed from KR1019970023193A external-priority patent/KR100197111B1/ko
Application filed by Samjin Pharmaceutical Co., Ltd. filed Critical Samjin Pharmaceutical Co., Ltd.
Publication of BG102286A publication Critical patent/BG102286A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Изобретението се отнася до нови съединения със силно изявено противотуморно въздействие с обща формула в която R1 и R2 са независими водород, заместен или незаместен C1-C8 алкил, заместен или незаместен C3-C6 циклоалкил, заместен или незаместен C2-C8 ненаситен алкил, кетон, заместен или незаместен арил, заместена или незаместена C1-C4 алкоксигрупа, заместена или незаместена арилхидроксигрупа, заместен или незаместен амин, C1-C4 нисш естер, C1-C4 нисш тиоестер, тиол, заместен или незаместен карбоксил, епоксигрупа, заместена или незаместена C1-C4 нисша тиоалкоксигрупа, или R1 и R2 се комбинират, зада образуват C3-C4 наситена или ненаситена верига, R3, R4, R5, R6 и R7 са независими водород, халоген, хидроксигрупа, нитрогрупа, C1-C4 нисш естер, C1-C4 нисш алкил, C1-C4 нисш тиоалкил, заместен илинезаместен C3-C6 циклоалкил, C1-C4 нисша алкоксигрупа, C1-C4 нисша тиоалкоксигрупа, заместен или незаместен арил, заместена или незаместена нисша арилалкоксигрупа, заместен или незаместен нисш алкиламин, или нисш алкил, заместен или незаместен карбамат, или между R3, R4, R5, R6 и R7 две съседни групи се свързват една с друга, за да образуват 1,2-фенилен или 2,3-нафтилен, Х е кислород, сяра или заместен или незаместен имин, Y е свързан на 3-та или 4-та позиция от ароматния пръстен, където Y е кислород или -NR8- (където R8 е еднакъв с посочения R3), Z е хидроксигрупа, C1-C4 нисша алкоксигрупа, C1-C4 нисша тиоалкоксигрупа, заместена или незаместена арилоксигрупа, C1-C4 нисш алк
BG102286A 1996-06-29 1998-02-27 Пиперазинови производни и процес за тяхното производство BG102286A (bg)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
KR19960025827 1996-06-29
KR19960025826 1996-06-29
KR19960025825 1996-06-29
KR19960040596 1996-09-18
KR1019970022984A KR100204320B1 (ko) 1996-06-29 1997-06-03 신규 피페라진 유도체 및 그 제조방법
KR1019970022985A KR100204319B1 (ko) 1996-06-29 1997-06-03 신규 피페라진 유도체 및 그 제조방법
KR1019970023192A KR100204318B1 (ko) 1996-06-29 1997-06-04 신규 피페라진 유도체 및 그 제조방법
KR1019970023193A KR100197111B1 (ko) 1996-09-18 1997-06-04 신규 피페라진 유도체 및 그 제조방법
PCT/KR1997/000128 WO1998000402A1 (en) 1996-06-29 1997-06-28 Piperazine derivatives and process for the preparation thereof

Publications (1)

Publication Number Publication Date
BG102286A true BG102286A (bg) 1999-08-31

Family

ID=27573799

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102286A BG102286A (bg) 1996-06-29 1998-02-27 Пиперазинови производни и процес за тяхното производство

Country Status (17)

Country Link
US (1) US6028195A (bg)
EP (1) EP0850222B1 (bg)
JP (1) JP3032303B2 (bg)
CN (1) CN1152015C (bg)
AT (1) ATE241600T1 (bg)
AU (1) AU713171B2 (bg)
BG (1) BG102286A (bg)
CA (1) CA2230960C (bg)
CZ (1) CZ59398A3 (bg)
DE (1) DE69722360T2 (bg)
NO (1) NO311616B1 (bg)
NZ (1) NZ329847A (bg)
PL (1) PL325341A1 (bg)
RU (1) RU2146254C1 (bg)
SK (1) SK27598A3 (bg)
TR (1) TR199800371T1 (bg)
WO (1) WO1998000402A1 (bg)

Families Citing this family (28)

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AU754529B2 (en) 1998-09-22 2002-11-21 Yamanouchi Pharmaceutical Co., Ltd. Cyanophenyl derivatives
SI1690853T1 (sl) 1999-01-13 2010-07-30 Bayer Healthcare Llc Uporaba omega-karboksiarilno substituiranih difenilsečnin kot inhibitorjev raf-kinaze
CA2359244C (en) 1999-01-13 2013-10-08 Bayer Corporation .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US20020065296A1 (en) 1999-01-13 2002-05-30 Bayer Corporation Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
CN100354271C (zh) * 1999-03-03 2007-12-12 三进制药株式会社 哌嗪衍生物及其制备方法
MXPA03000458A (es) * 2000-07-20 2004-06-02 Neurogen Corp Ligandos receptores de capsaicina.
DE10035928A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035927A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035908A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
US7183050B2 (en) 2001-04-18 2007-02-27 Krull Ulrich J Gradient resolved information platform
WO2003066595A2 (en) 2002-02-01 2003-08-14 Euro-Celtique S.A. 2 - piperazine - pyridines useful for treating pain
US7279493B2 (en) * 2002-06-28 2007-10-09 Euro-Celtique S.A. Therapeutic agents useful for treating pain
PL375527A1 (en) * 2002-06-29 2005-11-28 Zentaris Gmbh Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases
US7262194B2 (en) * 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7157462B2 (en) * 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US20050130989A1 (en) * 2003-01-28 2005-06-16 Aventis Pharma S. A. N-arylheteroaromatic products compositions containing them and use thereof
AU2004218260A1 (en) * 2003-01-28 2004-09-16 Aventis Pharma S.A. N-aryl heteroaromatic products, compositions containing same and use thereof
PT1626714E (pt) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
PL1819698T3 (pl) 2004-11-17 2011-08-31 Rexahn Pharmaceuticals Inc Pochodne 1-[(6-podstawione alkoksychinoksalinylo)aminokarbonylo]-4-(hetero)arylopiperazyny
US7812025B2 (en) 2005-08-12 2010-10-12 Takeda Pharmaceutical Company Limited Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder
JP2009513707A (ja) 2005-10-31 2009-04-02 バイエル ヘルスケア リミティド ライアビリティ カンパニー ジアリールウレア及び併用剤
EA201070451A1 (ru) * 2007-10-10 2010-10-29 Такеда Фармасьютикал Компани Лимитед Амидные соединения
US7946206B2 (en) * 2007-11-21 2011-05-24 Rocksmart, Llc Quick-release system
TWI434842B (zh) * 2008-07-14 2014-04-21 Astellas Pharma Inc Azole compounds
JP2016513112A (ja) * 2013-02-18 2016-05-12 ザ スクリプス リサーチ インスティテュート 治療的潜在能力を有するバソプレッシン受容体のモジュレーター
CN109071504B (zh) 2016-02-05 2022-03-08 戴纳立制药公司 受体相互作用蛋白激酶1的抑制剂
CN110383066B (zh) 2016-12-09 2023-03-31 戴纳立制药公司 化合物、组合物和方法
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Also Published As

Publication number Publication date
ATE241600T1 (de) 2003-06-15
NO980856L (no) 1998-04-27
NO980856D0 (no) 1998-02-27
EP0850222A1 (en) 1998-07-01
CN1152015C (zh) 2004-06-02
CN1196724A (zh) 1998-10-21
CA2230960C (en) 2007-08-28
CA2230960A1 (en) 1998-01-08
NZ329847A (en) 1999-01-28
AU3464297A (en) 1998-01-21
CZ59398A3 (cs) 1998-07-15
EP0850222B1 (en) 2003-05-28
JPH11501680A (ja) 1999-02-09
JP3032303B2 (ja) 2000-04-17
DE69722360T2 (de) 2003-11-27
PL325341A1 (en) 1998-07-20
DE69722360D1 (de) 2003-07-03
WO1998000402A1 (en) 1998-01-08
TR199800371T1 (xx) 1998-06-22
RU2146254C1 (ru) 2000-03-10
SK27598A3 (en) 1998-11-04
AU713171B2 (en) 1999-11-25
NO311616B1 (no) 2001-12-17
US6028195A (en) 2000-02-22

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