ES8105720A1 - Procedimiento para la preparacion de nuevos derivados de en-cafalina - Google Patents

Procedimiento para la preparacion de nuevos derivados de en-cafalina

Info

Publication number
ES8105720A1
ES8105720A1 ES492566A ES492566A ES8105720A1 ES 8105720 A1 ES8105720 A1 ES 8105720A1 ES 492566 A ES492566 A ES 492566A ES 492566 A ES492566 A ES 492566A ES 8105720 A1 ES8105720 A1 ES 8105720A1
Authority
ES
Spain
Prior art keywords
hydrogen
image
hydroxy
carbon atoms
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492566A
Other languages
English (en)
Other versions
ES492566A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ES8105720A1 publication Critical patent/ES8105720A1/es
Publication of ES492566A0 publication Critical patent/ES492566A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ENCEFALINA DE FORMULA (I) DIASTEREOMEROS, ENANTIOMEROS Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES, EN LA QUE R5 ES HIDROGENO Y R2 Y Q PUEDEN SER VARIOS TIPOS DE RADICALES. EL PROCEDIMIENTO SE BASA EN EL ACOPLAMIENTO DE UN COMPUESTO DE FORMULA (II) O (III) CON UN COMPUESTO DE FORMULA (IV), EN LA QUE R1, R2, R3, R4, R6 Y X'' PUEDEN SER VARIOS TIPOS DE RADICALES Y Z ES HIDROGENO O RADICAL ALQUILO C1-4; HIDROLIZAR O AMINIZAR EL COMPUESTO FORMADO. LOS COMPUESTOS INTERMEDIOS SE PUEDEN OBTENER "IN SITU" POR DIVERSOS PROCEDIMIENTOS, QUE DEPENDEN DE LOS RADICALES CARACTERISTICOS QUE CONTIENEN. ESTOS COMPUESTOS TIENEN APLICACION FARMACOLOGICA COMO ANALGESICOS. *FORMULA* E
ES492566A 1979-06-21 1980-06-18 Procedimiento para la preparacion de nuevos derivados de en-cafalina Granted ES492566A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5095079A 1979-06-21 1979-06-21
US06/130,431 US4341698A (en) 1979-06-21 1980-03-14 Enkaphalin derivatives
AU91877/82A AU559278B2 (en) 1979-06-21 1982-12-24 Piperazines

Publications (2)

Publication Number Publication Date
ES8105720A1 true ES8105720A1 (es) 1981-06-16
ES492566A0 ES492566A0 (es) 1981-06-16

Family

ID=36764304

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492566A Granted ES492566A0 (es) 1979-06-21 1980-06-18 Procedimiento para la preparacion de nuevos derivados de en-cafalina

Country Status (17)

Country Link
US (1) US4341698A (es)
AU (1) AU559278B2 (es)
CA (1) CA1161838A (es)
CH (2) CH645363A5 (es)
DE (1) DE3022401A1 (es)
DK (1) DK265780A (es)
ES (1) ES492566A0 (es)
FR (2) FR2459236A1 (es)
GB (3) GB2051821B (es)
IE (1) IE49834B1 (es)
IL (1) IL60245A (es)
IT (1) IT1148277B (es)
NL (1) NL8003580A (es)
NO (1) NO801855L (es)
NZ (1) NZ193934A (es)
PH (1) PH19222A (es)
SE (3) SE447250B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
AU6896298A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6133256A (en) * 1997-04-14 2000-10-17 Cor Therapeutics Inc Selective factor Xa inhibitors
AU6896398A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
JP2008534504A (ja) 2005-03-22 2008-08-28 アゼヴァン ファーマスーティカルズ，インコーポレイテッド 月経前障害を治療するためのβラクタミルアルカン酸
SI1910346T1 (sl) 2005-07-19 2019-08-30 Azevan Pharmaceuticals, Inc. Antagonist beta-laktamil fenilalalina, cisteina in serin vasopresina
EA200802060A1 (ru) * 2006-03-30 2009-10-30 Палатин Текнолоджиз, Инк. Суррогаты аминокислот для пептидных конструктов
US8580746B2 (en) 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
WO2007115175A2 (en) * 2006-03-30 2007-10-11 Palatin Technologies, Inc. Cyclic natriuretic peptide constructs
US8114844B2 (en) * 2006-03-30 2012-02-14 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptidomimetics
US7964181B2 (en) * 2006-03-30 2011-06-21 Palatin Technologies, Inc. Amino acid surrogates for peptidic constructs
US7795221B2 (en) * 2006-03-30 2010-09-14 Palatin Technologies, Inc. Linear natriuretic peptide constructs
NZ577114A (en) * 2006-12-19 2011-12-22 Hoffmann La Roche Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives
CA2728373A1 (en) * 2008-06-18 2009-12-23 F.Hoffmann-La Roche Ag Aryl ketone as mri
US9376424B2 (en) 2010-07-01 2016-06-28 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
US9802925B2 (en) 2014-03-28 2017-10-31 Azevan Pharmaceuticals, Inc. Compositions and methods for treating neurodegenerative diseases
AU2018333051B2 (en) 2017-09-15 2024-03-21 Azevan Pharmaceuticals, Inc. Compositions and methods for treating brain injury

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2604845A1 (de) * 1976-02-07 1977-08-18 Knoll Ag Neue piperazinderivate
US4254107A (en) * 1979-11-27 1981-03-03 Merck & Co., Inc. Long-lasting agonists of enkephalin

Also Published As

Publication number Publication date
CH648835A5 (de) 1985-04-15
SE447250B (sv) 1986-11-03
NZ193934A (en) 1983-02-15
CA1161838A (en) 1984-02-07
GB2132605A (en) 1984-07-11
GB2132605B (en) 1985-01-03
AU559278B2 (en) 1987-03-05
IT1148277B (it) 1986-11-26
FR2459236B1 (es) 1984-01-06
IE801152L (en) 1980-12-21
FR2473042A1 (fr) 1981-07-10
FR2459236A1 (fr) 1981-01-09
SE460540B (sv) 1989-10-23
IT8049032A0 (it) 1980-06-20
FR2473042B1 (es) 1983-07-01
NL8003580A (nl) 1980-12-23
GB2106515B (en) 1983-11-23
SE460541B (sv) 1989-10-23
ES492566A0 (es) 1981-06-16
US4341698A (en) 1982-07-27
GB2051821A (en) 1981-01-21
CH645363A5 (de) 1984-09-28
DE3022401A1 (de) 1981-01-08
SE8500877D0 (sv) 1985-02-22
GB2106515A (en) 1983-04-13
AU9187782A (en) 1983-04-21
GB2051821B (en) 1983-04-27
NO801855L (no) 1980-12-22
SE8500878D0 (sv) 1985-02-22
PH19222A (en) 1986-02-12
IL60245A (en) 1985-08-30
SE8500877L (sv) 1985-02-22
IE49834B1 (en) 1985-12-25
DK265780A (da) 1980-12-22
SE8004254L (sv) 1980-12-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401