BG101117A - Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим - Google Patents

Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим

Info

Publication number
BG101117A
BG101117A BG101117A BG10111797A BG101117A BG 101117 A BG101117 A BG 101117A BG 101117 A BG101117 A BG 101117A BG 10111797 A BG10111797 A BG 10111797A BG 101117 A BG101117 A BG 101117A
Authority
BG
Bulgaria
Prior art keywords
cyclosporin
oral application
preparation
new
medicamentous
Prior art date
Application number
BG101117A
Other languages
English (en)
Other versions
BG62955B1 (bg
Inventor
Matthias Olbrich
Heinrich Poetter
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BG101117A publication Critical patent/BG101117A/bg
Publication of BG62955B1 publication Critical patent/BG62955B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Лекарствените форми на циклоспорин със състав, който не е сложен, и с висока биоактивност за оралноприлагане съдържат 0,5-2 тегл. части от един или повече циклоспорини, за предпочитане циклоспорин Аи/или циклоспорин G, 6-9 тегл. части от един или повече полиетиленгликолови естери на наситени С10-С22 хидроксимаслени киселини, по-специално SOLUTOLRHS 15, и 1-3 тегл. части един или повече моновалентни или поливалентни алкохоли, за предпочитане етанол и пропиленгликол. Лекарствената форма се получава първоначално чрез разтваряне на аморфния циклоспорин в етанол и прибавяне при разбъркване на пропиленгликол и SOLUTOLR дополучаване на прозрачен вискозен разтвор, който се опакова в капсули или се използва във вид на разтвор за орално приложение.
BG101117A 1994-11-03 1997-01-06 Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим BG62955B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4438861 1994-11-03
PCT/DE1995/000951 WO1996014079A1 (de) 1994-11-03 1995-07-19 Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
BG101117A true BG101117A (bg) 1997-08-29
BG62955B1 BG62955B1 (bg) 2000-12-29

Family

ID=6532126

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101117A BG62955B1 (bg) 1994-11-03 1997-01-06 Лекарствени форми на циклоспорин за орално прилагане с висока биоактивност и метод за получаванетоим

Country Status (27)

Country Link
US (1) US6486124B2 (bg)
EP (1) EP0789580B1 (bg)
JP (1) JP3833248B2 (bg)
KR (1) KR970704464A (bg)
CN (1) CN1121238C (bg)
AT (1) ATE218359T1 (bg)
AU (1) AU715165B2 (bg)
BG (1) BG62955B1 (bg)
BR (1) BR9509550A (bg)
CA (1) CA2231404C (bg)
CZ (1) CZ287806B6 (bg)
DE (2) DE59510233D1 (bg)
DK (1) DK0789580T3 (bg)
EE (1) EE03425B1 (bg)
ES (1) ES2177652T3 (bg)
FI (1) FI118722B (bg)
HU (1) HUT77283A (bg)
LT (1) LT4306B (bg)
LV (1) LV11884B (bg)
NO (1) NO970741L (bg)
PL (1) PL183579B1 (bg)
PT (1) PT789580E (bg)
RU (1) RU2158601C2 (bg)
SK (1) SK164796A3 (bg)
TR (1) TR199501361A2 (bg)
TW (1) TW492876B (bg)
WO (1) WO1996014079A1 (bg)

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Also Published As

Publication number Publication date
AU715165B2 (en) 2000-01-20
EE03425B1 (et) 2001-06-15
KR970704464A (ko) 1997-09-06
CZ361696A3 (en) 1997-07-16
PT789580E (pt) 2002-09-30
CN1121238C (zh) 2003-09-17
JPH10508306A (ja) 1998-08-18
EP0789580B1 (de) 2002-06-05
CA2231404C (en) 2009-02-17
LV11884B (lv) 1998-03-20
RU2158601C2 (ru) 2000-11-10
NO970741D0 (no) 1997-02-18
CZ287806B6 (en) 2001-02-14
LT97002A (en) 1997-11-25
EE9700112A (et) 1997-12-15
DK0789580T3 (da) 2002-09-09
HUT77283A (hu) 1998-03-30
CA2231404A1 (en) 1996-05-17
JP3833248B2 (ja) 2006-10-11
PL183579B1 (pl) 2002-06-28
PL318560A1 (en) 1997-06-23
US20020025927A1 (en) 2002-02-28
NO970741L (no) 1997-02-18
WO1996014079A1 (de) 1996-05-17
BR9509550A (pt) 1997-09-16
DE59510233D1 (de) 2002-07-11
ATE218359T1 (de) 2002-06-15
LT4306B (lt) 1998-03-25
DE19539860A1 (de) 1996-05-09
SK164796A3 (en) 1997-06-04
FI970634A (fi) 1997-02-14
FI118722B (fi) 2008-02-29
EP0789580A1 (de) 1997-08-20
LV11884A (lv) 1997-12-20
TW492876B (en) 2002-07-01
TR199501361A2 (tr) 1996-06-21
ES2177652T3 (es) 2002-12-16
FI970634A0 (fi) 1997-02-14
BG62955B1 (bg) 2000-12-29
AU2975195A (en) 1996-05-31
US6486124B2 (en) 2002-11-26
CN1162265A (zh) 1997-10-15

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