BE903484A - Compositions therapeutiques contenant des anthracyclines-glycosides - Google Patents

Compositions therapeutiques contenant des anthracyclines-glycosides

Info

Publication number
BE903484A
BE903484A BE0/215752A BE215752A BE903484A BE 903484 A BE903484 A BE 903484A BE 0/215752 A BE0/215752 A BE 0/215752A BE 215752 A BE215752 A BE 215752A BE 903484 A BE903484 A BE 903484A
Authority
BE
Belgium
Prior art keywords
acid
glycosides
compositions containing
therapeutic compositions
solubilizing agent
Prior art date
Application number
BE0/215752A
Other languages
English (en)
French (fr)
Inventor
G Gatti
D Oldani
C Confalonieri
L Gambini
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE903484A publication Critical patent/BE903484A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BE0/215752A 1984-10-22 1985-10-21 Compositions therapeutiques contenant des anthracyclines-glycosides BE903484A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
BE903484A true BE903484A (fr) 1986-04-21

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215752A BE903484A (fr) 1984-10-22 1985-10-21 Compositions therapeutiques contenant des anthracyclines-glycosides

Country Status (35)

Country Link
US (4) US4675311A (en:Method)
JP (1) JPH0611700B2 (en:Method)
KR (1) KR920005813B1 (en:Method)
CN (1) CN85107562B (en:Method)
AT (1) AT401345B (en:Method)
AU (1) AU572003B2 (en:Method)
BE (1) BE903484A (en:Method)
BG (1) BG60934B2 (en:Method)
CA (1) CA1248453A (en:Method)
CH (1) CH667594A5 (en:Method)
CS (1) CS270421B2 (en:Method)
DE (1) DE3536896C2 (en:Method)
DK (1) DK165620C (en:Method)
ES (1) ES8605374A1 (en:Method)
FI (2) FI853913A7 (en:Method)
FR (1) FR2571966B1 (en:Method)
GB (2) GB8426672D0 (en:Method)
GR (1) GR852549B (en:Method)
HK (1) HK94390A (en:Method)
HU (1) HU197988B (en:Method)
IE (1) IE56992B1 (en:Method)
IL (1) IL76732A (en:Method)
IT (1) IT1186779B (en:Method)
MY (1) MY103956A (en:Method)
NL (1) NL191308C (en:Method)
NO (1) NO170616C (en:Method)
NZ (1) NZ213885A (en:Method)
PH (1) PH23982A (en:Method)
PT (1) PT81347B (en:Method)
RU (2) RU1836088C (en:Method)
SE (1) SE467520B (en:Method)
SG (1) SG80290G (en:Method)
UA (2) UA19169A (en:Method)
YU (1) YU46160B (en:Method)
ZA (1) ZA858033B (en:Method)

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US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
DE3777365D1 (de) * 1986-12-05 1992-04-16 Erba Carlo Spa Einspritzbare fertig brauchbare loesungen, die ein antracyclineglykosid als mittel gegen krebs enthalten.
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
EP0954283B1 (en) 1996-12-30 2007-03-21 Battelle Memorial Institute Use of a non-encapsulated anticancer drug for the preparation of a formulation for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
DE60321450D1 (de) 2002-02-22 2008-07-17 Schering Corp Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung
DK1474995T3 (da) * 2003-05-06 2013-02-18 Gumlink As Fremgangsmåde til fremstilling af tyggegummigranulater, et gummisammensætningsekstruder- og granuleringssystem og et tyggegummiprodukt
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
ATE471740T1 (de) * 2003-09-25 2010-07-15 Astellas Pharma Inc Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
BRPI0605832A2 (pt) * 2005-05-11 2009-05-26 Sicor Inc glicosìdeos de antraciclina liofilizados estáveis
JP4778053B2 (ja) 2005-07-14 2011-09-21 リセラ，インコーポレイテッド 局所的脂肪組織処置のための徐放性増強脂肪分解処方物
RU2450013C2 (ru) * 2005-12-13 2012-05-10 Солюкс Корпорейшен Способ получения 4-деметилдаунорубицина
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
CA2687291A1 (en) * 2007-05-16 2008-11-20 Ktb Tumorforschungsgesellschaft Mbh Low-viscous anthracycline formulation
ES2439497T3 (es) * 2007-09-04 2014-01-23 Meiji Seika Pharma Co., Ltd. Preparación de una inyección, de una solución para inyección y de un kit de inyección
CN101835474A (zh) * 2007-10-26 2010-09-15 辉瑞产品公司 用于在狗中治疗淋巴瘤的伊达比星
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
BR112012017556A2 (pt) * 2010-01-15 2016-08-16 Lithera Inc formulações de torta liofilizada
EP2646012A4 (en) 2010-11-24 2014-12-10 Neothetics Inc MONOTHERAPEUTIC FORMULATIONS OF SELECTIVE, LIPOPHILIC AND PROLONGED BETA AGONISTS AND METHODS OF COSMETIC TREATMENT OF SILHOUETTE ADPOSITY AND REINFORCEMENT
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
JP6433913B2 (ja) 2012-12-13 2018-12-05 サイトレックス コーポレイション アントラサイクリン製剤
KR20210059035A (ko) 2013-06-05 2021-05-24 싸이트알엑스 코포레이션 암 치료용 세포독성제

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US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
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US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
DE3317702A1 (de) * 1982-05-24 1983-11-24 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglykoside, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
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GR79729B (en:Method) * 1982-12-20 1984-10-31 Univ Ohio State Res Found
JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same

Also Published As

Publication number Publication date
SE8504945D0 (sv) 1985-10-21
IT8522507A0 (it) 1985-10-16
SG80290G (en) 1990-11-23
ZA858033B (en) 1986-06-25
UA34419C2 (uk) 2001-03-15
NO170616C (no) 1992-11-11
AU572003B2 (en) 1988-04-28
IL76732A0 (en) 1986-02-28
JPH0611700B2 (ja) 1994-02-16
ES8605374A1 (es) 1986-03-16
NL191308C (nl) 1995-05-16
YU46160B (sh) 1993-05-28
UA19169A (uk) 1997-12-25
DK165620C (da) 1993-06-01
KR860003014A (ko) 1986-05-19
US4675311A (en) 1987-06-23
US5091372A (en) 1992-02-25
FR2571966B1 (fr) 1988-04-15
GB8525709D0 (en) 1985-11-20
SE8504945L (sv) 1986-04-23
KR920005813B1 (ko) 1992-07-20
ATA303285A (de) 1996-01-15
PT81347B (pt) 1987-11-11
IE852593L (en) 1986-04-22
CH667594A5 (de) 1988-10-31
RU1836088C (ru) 1993-08-23
CA1248453A (en) 1989-01-10
GR852549B (en:Method) 1986-02-24
PH23982A (en) 1990-02-09
GB2165751B (en) 1988-08-17
FI853913A7 (fi) 1986-04-23
AT401345B (de) 1996-08-26
DK481585A (da) 1986-04-23
IL76732A (en) 1989-07-31
FR2571966A1 (fr) 1986-04-25
FI854035L (fi) 1986-04-23
YU164485A (en) 1987-10-31
JPS61246129A (ja) 1986-11-01
NZ213885A (en) 1988-05-30
NO170616B (no) 1992-08-03
BG60934B2 (bg) 1996-06-28
DE3536896A1 (de) 1986-04-24
CS756585A2 (en) 1989-11-14
NO854194L (no) 1986-04-23
CN85107562A (zh) 1986-07-23
PT81347A (en) 1985-11-01
NL191308B (nl) 1994-12-16
FI853913A0 (fi) 1985-10-08
DK165620B (da) 1992-12-28
GB2165751A (en) 1986-04-23
CS270421B2 (en) 1990-06-13
US4840938A (en) 1989-06-20
IT1186779B (it) 1987-12-16
IE56992B1 (en) 1992-02-26
HK94390A (en) 1990-11-23
NL8502869A (nl) 1986-05-16
DK481585D0 (da) 1985-10-21
ES547578A0 (es) 1986-03-16
SE467520B (sv) 1992-08-03
CN85107562B (zh) 1988-06-01
FI854035A0 (fi) 1985-10-16
MY103956A (en) 1993-10-30
DE3536896C2 (de) 1996-11-14
FI86252B (fi) 1992-04-30
FI86252C (fi) 1992-08-10
GB8426672D0 (en) 1984-11-28
HUT40759A (en) 1987-02-27
US5091373A (en) 1992-02-25
RU2101018C1 (ru) 1998-01-10
AU4880585A (en) 1986-05-01
HU197988B (en) 1989-07-28

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *PHARMACIA ITALIA S.P.A.

Effective date: 20051021

RE20 Patent expired

Owner name: *PHARMACIA ITALIA S.P.A.

Effective date: 20051021