BE901576A - Composes heterocycliques. - Google Patents

Composes heterocycliques.

Info

Publication number
BE901576A
BE901576A BE0/214394A BE214394A BE901576A BE 901576 A BE901576 A BE 901576A BE 0/214394 A BE0/214394 A BE 0/214394A BE 214394 A BE214394 A BE 214394A BE 901576 A BE901576 A BE 901576A
Authority
BE
Belgium
Prior art keywords
heterocyclic compounds
phenylalkyl
cycloalkyl
alkenyl
alkyl
Prior art date
Application number
BE0/214394A
Other languages
English (en)
French (fr)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE901576A publication Critical patent/BE901576A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE0/214394A 1984-01-25 1985-01-25 Composes heterocycliques. BE901576A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
BE901576A true BE901576A (fr) 1985-07-25

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214394A BE901576A (fr) 1984-01-25 1985-01-25 Composes heterocycliques.

Country Status (29)

Country Link
KR (1) KR920003064B1 (en, 2012)
AT (1) AT392276B (en, 2012)
AU (1) AU579132B2 (en, 2012)
BE (1) BE901576A (en, 2012)
CA (1) CA1252793A (en, 2012)
CH (1) CH664152A5 (en, 2012)
CY (1) CY1479A (en, 2012)
CZ (1) CZ404391A3 (en, 2012)
DE (2) DE19375046I2 (en, 2012)
DK (1) DK169521B1 (en, 2012)
ES (3) ES8609309A1 (en, 2012)
FI (1) FI84349C (en, 2012)
FR (1) FR2561244B1 (en, 2012)
GB (1) GB2153821B (en, 2012)
GR (1) GR850219B (en, 2012)
HK (1) HK33189A (en, 2012)
HU (1) HU193592B (en, 2012)
IE (1) IE57809B1 (en, 2012)
IL (1) IL74165A (en, 2012)
IT (1) IT1182150B (en, 2012)
LU (2) LU85743A1 (en, 2012)
NL (2) NL190373C (en, 2012)
NO (2) NO164025C (en, 2012)
NZ (1) NZ210940A (en, 2012)
PH (1) PH22672A (en, 2012)
PT (1) PT79890B (en, 2012)
SE (1) SE460359B (en, 2012)
SG (1) SG7089G (en, 2012)
SK (1) SK277923B6 (en, 2012)

Cited By (1)

* Cited by examiner, † Cited by third party
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US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances

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DE385517T1 (de) * 1985-03-14 1991-07-25 Beecham Group p.l.c., Brentford, Middlesex Arzneimittel zur behandlung von erbrechen.
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
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GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
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AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
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GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
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GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
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DK662687A (da) * 1986-12-17 1988-06-18 Glaxo Group Ltd Anvendelse af tricycliske carbazoloner
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
EP0278173B1 (en) * 1986-12-17 1993-11-03 Glaxo Group Limited Use of heterocyclic derivatives in the treatment of depressions
DE3876006T2 (de) * 1987-04-14 1993-03-25 Glaxo Group Ltd Keton-derivate.
DE3874229T2 (de) * 1987-06-16 1993-03-25 British Tech Group Verwendung von dioxopiperidin-derivaten zur herstellung eines topischen praeparates als analgetika.
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US4939144A (en) * 1987-10-22 1990-07-03 Glaxo Group Limited Tricyclic ketone derivatives as 5-HT antagonists
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (ja) * 1988-04-07 1990-02-20 Glaxo Group Ltd イミダゾール誘導体
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
ES2061024T3 (es) * 1989-04-21 1994-12-01 Sandoz Ag Uso terapeutico de antagonistas de receptores de 5-ht3.
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
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US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
EP1022025A3 (en) * 1991-06-26 2002-06-05 Sepracor, Inc. Method and compositions for treating emesis nausea and other disorders using optically pure R(+) ondansetron
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
ES2043535B1 (es) * 1992-03-13 1994-08-01 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
CN1118990A (zh) * 1993-03-08 1996-03-20 藤泽药品工业株式会社 治疗或预防脑血管疾病药物
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325408B (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Chewing gum formulation comprising ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
US6548082B1 (en) 1999-03-01 2003-04-15 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure R(+) ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
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ES2288606T3 (es) 2002-04-29 2008-01-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Procedimiento para preparar 1,2,3,9-tetrahidro-9-metil-3-((2-metil-1h-imidazol-1-il)metil)-4h-carbazol-4-ona.
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US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
AU583343B2 (en) * 1985-01-23 1989-04-27 Glaxo Group Limited Heterocyclic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances

Also Published As

Publication number Publication date
GR850219B (en, 2012) 1985-05-23
NL190373B (nl) 1993-09-01
AU579132B2 (en) 1988-11-17
SK404391A3 (en) 1995-08-09
NO1994022I1 (no) 1994-11-09
IT8547600A0 (it) 1985-01-25
PH22672A (en) 1988-11-14
LU88268I2 (en, 2012) 1994-02-03
NL940009I1 (nl) 1994-07-18
IE850187L (en) 1985-07-25
SE460359B (sv) 1989-10-02
CZ404391A3 (en) 1993-04-14
IL74165A (en) 1988-11-15
NL190373C (nl) 1994-02-01
NZ210940A (en) 1989-08-29
DK35785A (da) 1985-07-26
CA1252793A (en) 1989-04-18
SE8500368D0 (sv) 1985-01-25
NO164025B (no) 1990-05-14
SK277923B6 (en) 1995-08-09
HU193592B (en) 1987-11-30
FI84349C (fi) 1991-11-25
NO850300L (no) 1985-07-26
HK33189A (en) 1989-04-28
GB2153821B (en) 1988-01-20
NL940009I2 (nl) 1999-05-03
DE19375046I2 (de) 2002-10-10
ES8609309A1 (es) 1986-07-16
ES539852A0 (es) 1986-07-16
ES548430A0 (es) 1987-10-01
FI850323A0 (fi) 1985-01-25
FI84349B (fi) 1991-08-15
DE3502508A1 (de) 1985-08-14
CH664152A5 (fr) 1988-02-15
ES8708224A1 (es) 1987-10-01
DK35785D0 (da) 1985-01-25
KR920003064B1 (ko) 1992-04-13
ATA20485A (de) 1990-08-15
PT79890B (en) 1987-02-03
SG7089G (en) 1989-06-09
AT392276B (de) 1991-02-25
FI850323L (fi) 1985-07-26
CY1479A (en) 1989-07-21
FR2561244B1 (fr) 1988-03-04
GB2153821A (en) 1985-08-29
IE57809B1 (en) 1993-04-21
ES556101A0 (es) 1987-12-16
HUT37784A (en) 1986-02-28
ES8801247A1 (es) 1987-12-16
GB8501889D0 (en) 1985-02-27
AU3809785A (en) 1985-08-01
DK169521B1 (da) 1994-11-21
SE8500368L (sv) 1985-07-26
FR2561244A1 (fr) 1985-09-20
LU85743A1 (fr) 1986-08-04
IT1182150B (it) 1987-09-30
KR850005439A (ko) 1985-08-26
NO164025C (no) 1990-08-22
NL8500202A (nl) 1985-08-16
DE3502508C2 (en, 2012) 1990-05-03
PT79890A (en) 1985-02-01

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Owner name: *GLAXO GROUP LTD

Effective date: 20050125

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Free format text: PRODUCT NAME = ONDANSETRON HCI DIHYDRATE; REGISTRATION NO/DATE: 276 S 566 F 12 19900223

Spc suppl protection certif: 93C0045

Filing date: 19950328

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CCRE Expiry of a supplementary protection certificate

Free format text: PRODUCT NAME: ONDANSETRON HCL DIHYDRATE 5,0 MG (=BASE 4 MG); REG.: 276 S 566 F 12 19900223

Spc suppl protection certif: 93C0045

Filing date: 19930602

Expiry date: 20050125

Extension date: 20050223

RE20 Patent expired

Owner name: *GLAXO GROUP LTD

Effective date: 20050125