BE892503A - 2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives - Google Patents

2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives

Info

Publication number
BE892503A
BE892503A BE0/207574A BE207574A BE892503A BE 892503 A BE892503 A BE 892503A BE 0/207574 A BE0/207574 A BE 0/207574A BE 207574 A BE207574 A BE 207574A BE 892503 A BE892503 A BE 892503A
Authority
BE
Belgium
Prior art keywords
antidepressive
phenoxyalkyl
triazol
ones
ones antidepressive
Prior art date
Application number
BE0/207574A
Other languages
English (en)
French (fr)
Inventor
D L Temple Jr
W G Lobeck Jr
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22922879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE892503(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BE892503A publication Critical patent/BE892503A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE0/207574A 1981-03-16 1982-03-15 2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives BE892503A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/244,464 US4338317A (en) 1981-03-16 1981-03-16 Phenoxyethyl-1,2,4,-triazol-3-one antidepressants

Publications (1)

Publication Number Publication Date
BE892503A true BE892503A (fr) 1982-09-15

Family

ID=22922879

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/207574A BE892503A (fr) 1981-03-16 1982-03-15 2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives

Country Status (26)

Country Link
US (1) US4338317A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS57159774A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR880001374B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT384022B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE892503A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1198436A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH649539A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (1) CY1373A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3209557A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK158728C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES510449A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI73670C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2501690B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2096137B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR76076B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK4788A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE52788B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1148137B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KE (1) KE3711A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU84011A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9203176A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (2) NL190757C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE447256B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG30287G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU43256B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA821359B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US4386091A (en) * 1982-02-24 1983-05-31 Mead Johnson & Company 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants
US4575555A (en) * 1983-06-29 1986-03-11 Mead Johnson & Company 4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative
AT388555B (de) * 1983-06-29 1989-07-25 Bristol Myers Co Verfahren zur herstellung von neuen 1,2,4-triazol-3-on-derivaten
US4613600A (en) * 1983-09-30 1986-09-23 Mead Johnson & Company Antidepressant 1,2,4-triazolone compounds
YU44721B (en) * 1983-11-30 1990-12-31 Bristol Myers Co Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
US4784998A (en) * 1987-04-06 1988-11-15 Bristol-Myers Company 1,3,4-oxadiazole pyschotropic compounds
US5116852A (en) * 1990-12-03 1992-05-26 Bristol-Myers Squibb Co. Treatment of sleep disorders
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
US5256664A (en) * 1992-04-28 1993-10-26 Bristol-Myers Squibb Company Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
IT1256387B (it) * 1992-11-13 1995-12-04 Acraf Procedimento per preparare triazoloni
DE4425144A1 (de) * 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
CA2160423A1 (en) * 1994-11-02 1996-05-03 Hemant N. Joshi Salts of nefazodone having improved dissolution rates
CA2187989A1 (en) 1995-10-17 1997-04-18 Ronald N. Marcus Nefazodone: treatment of panic attack
CA2182241C (en) * 1996-07-29 2002-09-17 Bo Lei Methods for the manufacture of nefazodone
AU2452397A (en) * 1996-07-31 1998-02-20 Bristol-Myers Squibb Company Nefazodone: use in migraine prophylaxis
US5852020A (en) * 1996-11-22 1998-12-22 Bristol-Myers Squibb Company Nefazodone: use in treating post traumatic stress disorder
US5735873A (en) * 1996-12-19 1998-04-07 Maclean; David S. Surgical tool handle
US5917050A (en) * 1998-02-11 1999-06-29 Bayer Corporation Process for preparing alkoxytriazolinones
ES2152860B1 (es) * 1998-10-23 2001-08-16 Finaf 92 Sa Forma cristalina de la nefazodona y procedimiento para su preparacion.
US6706282B1 (en) 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
US6469008B2 (en) 1999-04-09 2002-10-22 Sepracor Inc. (R)-hydroxynefazodone antipsychotic therapy
US6586437B2 (en) 1999-04-09 2003-07-01 Sepracor Inc. (S)-hydroxynefazodone antipsychotic therapy
DE60028955T2 (de) * 1999-04-09 2007-07-05 Sepracor Inc., Marlborough R-hydroxynefazodon
WO2000061129A2 (en) * 1999-04-09 2000-10-19 Sepracor Inc. S-hydroxynefazodone
CA97021S (en) 2001-03-02 2003-06-25 Nokia Mobile Phones Ltd Handset
AU144902S (en) 2001-03-02 2001-08-15 Nokia Mobile Phones Ltd A handset
AU144901S (en) 2001-03-02 2001-08-15 Nokia Mobile Phones Ltd A handset
AU144906S (en) 2001-03-02 2001-08-15 Nokia Mobile Phones Ltd A handset
CA2356450C (en) 2001-09-10 2003-11-25 Brantford Chemicals Inc. An improved process for the preparation of nefazodone hydrochloride
US20050256131A1 (en) * 2002-05-24 2005-11-17 Carl-Fr Coester Pharmaceutical active substance combination and the use thereof
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
JP2006525335A (ja) * 2003-04-30 2006-11-09 エフ　エム　シー　コーポレーション 殺虫性（ジハロプロペニル）フェニルアルキル置換ジヒドロベンゾフラン及びジヒドロベンゾピラン誘導体
JP4864719B2 (ja) * 2003-11-26 2012-02-01 ファイザー・プロダクツ・インク Ｇｓｋ−３インヒビターとしてのアミノピラゾール誘導体
CA2567249A1 (en) * 2004-04-19 2006-10-05 Jds Pharmaceuticals, Llc Lithium combinations, and uses related thereto
TW200612961A (en) * 2004-05-18 2006-05-01 Fmc Corp Substituted cyclic urea derivatives
WO2007008758A2 (en) * 2005-07-08 2007-01-18 Braincells, Inc. Methods for identifying agents and conditions that modulate neurogenesis
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
BRPI0716604A2 (pt) 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008083204A2 (en) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation of neurogenesis by melatoninergic ligands
AU2008204800A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation of neurogenesis with use of modafinil
GB2454290B (en) * 2007-08-07 2009-09-30 Prosarix Ltd Novel serotonergic modulators
US9339500B2 (en) 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20110034565A1 (en) 2008-04-18 2011-02-10 University College Dublin, National University Of Ireland, Dublin Psycho-pharmaceuticals
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
TWI368512B (en) * 2009-04-30 2012-07-21 Univ Kaohsiung Medical Pharmaceutical compositions comprising chlorophenyl piperazine derived compounds and use of the compounds in producing medicaments
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
CN104402842A (zh) * 2014-11-19 2015-03-11 苏州乔纳森新材料科技有限公司 一种哌嗪类药物中间体的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
IT1052119B (it) * 1972-10-16 1981-06-20 Sigma Tau Ind Farmaceuti Derivati del triazolinone e procedimento per la loro preparazione

Also Published As

Publication number Publication date
FI820856L (fi) 1982-09-17
YU52582A (en) 1985-06-30
MX9203176A (es) 1992-07-01
GB2096137B (en) 1985-01-03
NL190757B (nl) 1994-03-01
FR2501690B1 (fr) 1985-07-05
DE3209557A1 (de) 1982-12-09
YU43256B (en) 1989-06-30
ZA821359B (en) 1983-01-26
NL970014I1 (nl) 1997-06-02
IE52788B1 (en) 1988-03-02
HK4788A (en) 1988-01-29
DK112582A (da) 1982-09-17
AT384022B (de) 1987-09-25
SG30287G (en) 1987-07-17
IT8247978A0 (it) 1982-03-12
DE3209557C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-07-15
NL190757C (nl) 1994-08-01
NL8201021A (nl) 1982-10-18
KE3711A (en) 1987-04-30
KR830009089A (ko) 1983-12-17
DK158728B (da) 1990-07-09
GR76076B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-08-03
DK158728C (da) 1990-12-03
SE8201631L (sv) 1982-09-17
IE820589L (en) 1982-09-16
ES8305756A1 (es) 1983-04-16
ATA104582A (de) 1987-02-15
NL970014I2 (nl) 1997-09-01
AU8117082A (en) 1982-09-23
ES510449A0 (es) 1983-04-16
CY1373A (en) 1987-08-07
JPS57159774A (en) 1982-10-01
CH649539A5 (de) 1985-05-31
IT1148137B (it) 1986-11-26
AU555888B2 (en) 1986-10-16
KR880001374B1 (ko) 1988-07-29
JPH0237353B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-08-23
FI73670B (fi) 1987-07-31
LU84011A1 (fr) 1983-02-22
FR2501690A1 (fr) 1982-09-17
SE447256B (sv) 1986-11-03
CA1198436A (en) 1985-12-24
FI73670C (fi) 1987-11-09
US4338317A (en) 1982-07-06
GB2096137A (en) 1982-10-13

Similar Documents

Publication Publication Date Title
BE892503A (fr) 2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives
DK165695C (da) 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol
DK537780A (da) 1,8-naphthyridin-derivater
FI821696A0 (fi) Hydrodynamiskt smoerjsystem foer kolvanordningar, saerskilt foer stirling-motorer
FR2477145B1 (fr) 25-hydroxy-26, 26, 26, 27, 27, 27-hexafluorocholecalciferol
DK3881A (da) Substituerede 9,10-anthracen-bishydrazoner
SE8008339L (sv) 24,24-difluoro-1alfa,25-dihydroxikolekalciferol
FI832065A0 (fi) Traog, saerskilt foer livsmedel
IT1151077B (it) 24,24-difluoro-25-idrossicolecalciferolo
FI803727L (fi) 2,3-indolidionderivat
DK155594C (da) 3,3-dimethyl-1-phenoxybutan-2-oler
FI811967L (fi) 2,3-bis-hydroxibenzylderivat
FI812210L (fi) Stabiliserade 1,1,1-trikloretansammansaettningar
FI801473A7 (fi) Framstaellningsfoerfarande foer 5-merkapto-1,2,3-triazoler
BE883295A (fr) 6,7-secoergolines
BE875273A (fr) 0-carbamoyloximes de 2,3-dihydro-4h-1-benzo-pyranne-4-ones
IT8223097A0 (it) 5-fenossifenil-tetraidro-1,3,5-tiadiazin-4-oni.
IT1189320B (it) 1-fenil-1,2,3-triazoli impiegabili come disappetenti
DE3175752D1 (de) 1,3-dihalopropan-2-ols
FI810242L (fi) 1,3-diformyloxi-2-brom-nitropropan
FI821159A0 (fi) 2,4-dioxacyclohexanonderivat
TR21560A (tr) Etilsulfonilmetil-i,3 ogzazolidin herbisid antidot
IT1189011B (it) 1,4;3,6-dinanidro-2,5-diazido-2,5-dideossi-esitoli
IT1156322B (it) Immidazo-e pirimido-1,3,5-tiadiazin-4-oni
DE3175756D1 (de) 3,5,12-trihydroxy-6,11-dioxonaphthacenes

Legal Events

Date Code Title Description
CCPV Grant of a supplementary protection certificate

Free format text: 2000C/007, EXPIRES: 20070315

RE20 Patent expired

Owner name: BRISTOL-MYERS CY

Effective date: 20020315

CCRE Expiry of a supplementary protection certificate

Spc suppl protection certif: 2000C/007

Extension date: 20070315

Effective date: 20070315