BE1003815A4 - Nucleosides dideoxydidehydrocarbocyliques et composition pharmaceutique les contenant. - Google Patents

Nucleosides dideoxydidehydrocarbocyliques et composition pharmaceutique les contenant. Download PDF

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Publication number
BE1003815A4
BE1003815A4 BE8900061A BE8900061A BE1003815A4 BE 1003815 A4 BE1003815 A4 BE 1003815A4 BE 8900061 A BE8900061 A BE 8900061A BE 8900061 A BE8900061 A BE 8900061A BE 1003815 A4 BE1003815 A4 BE 1003815A4
Authority
BE
Belgium
Prior art keywords
compound
formula
purine
compounds
pharmaceutically acceptable
Prior art date
Application number
BE8900061A
Other languages
English (en)
French (fr)
Inventor
Vince Robert
Hua Mei
Leslie Myers Peter
Storer Richard
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/146,252 external-priority patent/US4916224A/en
Priority claimed from GB888821011A external-priority patent/GB8821011D0/en
Priority claimed from US07/278,652 external-priority patent/US4931559A/en
Application filed by Univ Minnesota filed Critical Univ Minnesota
Application granted granted Critical
Publication of BE1003815A4 publication Critical patent/BE1003815A4/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
BE8900061A 1988-01-20 1989-01-19 Nucleosides dideoxydidehydrocarbocyliques et composition pharmaceutique les contenant. BE1003815A4 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14625288 1988-01-20
US07/146,252 US4916224A (en) 1988-01-20 1988-01-20 Dideoxycarbocyclic nucleosides
GB8821011 1988-09-07
GB888821011A GB8821011D0 (en) 1988-09-07 1988-09-07 Chemical compounds
US27865288 1988-12-05
US07/278,652 US4931559A (en) 1988-01-20 1988-12-05 Optically-active isomers of dideoxycarbocyclic nucleosides

Publications (1)

Publication Number Publication Date
BE1003815A4 true BE1003815A4 (fr) 1992-06-23

Family

ID=27264063

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900061A BE1003815A4 (fr) 1988-01-20 1989-01-19 Nucleosides dideoxydidehydrocarbocyliques et composition pharmaceutique les contenant.

Country Status (29)

Country Link
JP (1) JP2793825B2 (da)
KR (1) KR0127137B1 (da)
AT (1) AT397801B (da)
AU (2) AU626278B2 (da)
BE (1) BE1003815A4 (da)
CA (1) CA1339896C (da)
CH (1) CH679152A5 (da)
DE (1) DE3901502C2 (da)
DK (1) DK175131B1 (da)
ES (1) ES2010091A6 (da)
FI (1) FI93546C (da)
FR (1) FR2626002B1 (da)
GB (1) GB2217320B (da)
GR (1) GR890100033A (da)
HU (1) HU203755B (da)
IE (1) IE62275B1 (da)
IL (1) IL88999A (da)
IT (1) IT1229531B (da)
LU (1) LU87437A1 (da)
MY (1) MY103801A (da)
NL (1) NL8900122A (da)
NO (1) NO169123C (da)
NZ (1) NZ227663A (da)
OA (1) OA09031A (da)
PL (1) PL163814B1 (da)
PT (1) PT89482B (da)
RU (1) RU2114846C1 (da)
SE (1) SE505213C2 (da)
YU (1) YU47791B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1215339B (it) * 1987-01-14 1990-02-08 Co Pharma Corp Srl Procedimento per la preparazione di 9-(idrossialchil)-ipoxantine
US5631370A (en) 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir
DE69033252T2 (de) * 1989-06-27 1999-12-09 The Wellcome Foundation Ltd., Greenford Therapeutische nukleoside
GB8916477D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916478D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916479D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916480D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5144034A (en) * 1990-04-06 1992-09-01 Glaxo Inc. Process for the synthesis of cyclopentene derivatives of purines
US5057630A (en) * 1990-04-06 1991-10-15 Glaxo Inc. Synthesis of cyclopentene derivatives
US5126452A (en) * 1990-04-06 1992-06-30 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
US5241069A (en) * 1990-04-06 1993-08-31 Glaxo Inc. Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
HUT74989A (en) * 1993-11-12 1997-03-28 Merrell Pharma Inc 6-oxo-nucleosides useful as immunosuppressants
GB9721780D0 (en) 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
ATE240945T1 (de) * 1998-10-30 2003-06-15 Lonza Ag Verfahren zur herstellung von 4-((2',5'-diamino- 6'-halogenpyrimidin-4'-yl)amino)-cyclopent-2- enylmethanolen
KR100606625B1 (ko) 1998-10-30 2006-07-28 론자 아게 4-[(2',5'-디아미노-6'-할로피리미딘-4'-일)아미노]-시클로펜트-2-에닐메탄올의 제조 방법
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB9903091D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Therapeutic nucleoside compound
AR039540A1 (es) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
JP7104154B2 (ja) 2018-07-27 2022-07-20 富士フイルム株式会社 シクロペンテニルプリン誘導体またはその塩
JP2023519882A (ja) 2020-03-27 2023-05-15 ソム、イノベーション、バイオテック、ソシエダッド、アノニマ シヌクレイノパチーの治療に有用な化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
EP0215759A1 (en) * 1985-09-10 1987-03-25 The Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
EP0236935A2 (en) * 1986-03-06 1987-09-16 Takeda Chemical Industries, Ltd. Carboxylic purine nucleosides, their production and use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62177234A (ja) * 1986-01-30 1987-08-04 Mitsubishi Heavy Ind Ltd 遠心紡糸によるカ−ボン繊維の製造装置
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
EP0215759A1 (en) * 1985-09-10 1987-03-25 The Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
EP0236935A2 (en) * 1986-03-06 1987-09-16 Takeda Chemical Industries, Ltd. Carboxylic purine nucleosides, their production and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 156, no. 2, 31 octobre 1988, pages 1046 - 1053; R. VINCE et al.: "Potent and selective activity of a new carbocyclic nucleoside analog Äcarbovir: NSC 614846Ü against human immunodeficiency virus..." *
JOURNAL OF ORGANIC CHEMISTRY, vol. 52, 1987, pages 1344 - 1347; V. NAIR et al.: "2-Halogenated Purine Nucleosides: Synthesis and Reactivity" *

Also Published As

Publication number Publication date
HUT48887A (en) 1989-07-28
ES2010091A6 (es) 1989-10-16
DK175131B1 (da) 2004-06-14
GB2217320B (en) 1992-04-08
NO890253D0 (no) 1989-01-19
FI890286A0 (fi) 1989-01-19
GB2217320A (en) 1989-10-25
NZ227663A (en) 1990-09-26
JP2793825B2 (ja) 1998-09-03
GR890100033A (el) 1994-03-31
NO890253L (no) 1989-07-21
RU2114846C1 (ru) 1998-07-10
AU626278B2 (en) 1992-07-30
JPH02196788A (ja) 1990-08-03
AU2867189A (en) 1989-07-20
NO169123B (no) 1992-02-03
AT397801B (de) 1994-07-25
IE62275B1 (en) 1995-01-25
NO169123C (no) 1992-05-13
ATA10689A (de) 1993-11-15
AU637015B2 (en) 1993-05-13
MY103801A (en) 1993-09-30
IE890153L (en) 1989-07-20
IL88999A0 (en) 1989-08-15
SE505213C2 (sv) 1997-07-14
DE3901502A1 (de) 1989-07-27
FI93546C (fi) 1995-04-25
IT1229531B (it) 1991-09-04
AU1018092A (en) 1992-03-12
PL163814B1 (en) 1994-05-31
DK23489D0 (da) 1989-01-19
KR0127137B1 (ko) 1997-12-29
IL88999A (en) 1994-12-29
YU12389A (en) 1991-10-31
YU47791B (sr) 1996-01-09
KR890011902A (ko) 1989-08-23
FI93546B (fi) 1995-01-13
HU203755B (en) 1991-09-30
DK23489A (da) 1989-07-21
FR2626002A1 (fr) 1989-07-21
GB8901187D0 (en) 1989-03-15
OA09031A (en) 1991-03-31
FI890286A (fi) 1989-07-21
CH679152A5 (da) 1991-12-31
SE8900192D0 (sv) 1989-01-19
FR2626002B1 (fr) 1994-01-28
LU87437A1 (fr) 1989-08-30
IT8947546A0 (it) 1989-01-19
NL8900122A (nl) 1989-08-16
PL277261A1 (en) 1989-09-18
DE3901502C2 (de) 2002-06-13
PT89482A (pt) 1989-10-04
CA1339896C (en) 1998-06-02
PT89482B (pt) 1994-02-28
SE8900192L (sv) 1989-07-21

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