BE1001630A4 - Adjuvants immunologiques pour vaccins polysaccharidiques. - Google Patents

Adjuvants immunologiques pour vaccins polysaccharidiques. Download PDF

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Publication number
BE1001630A4
BE1001630A4 BE8700410A BE8700410A BE1001630A4 BE 1001630 A4 BE1001630 A4 BE 1001630A4 BE 8700410 A BE8700410 A BE 8700410A BE 8700410 A BE8700410 A BE 8700410A BE 1001630 A4 BE1001630 A4 BE 1001630A4
Authority
BE
Belgium
Prior art keywords
oil
sep
weight
biodegradable
emulsion system
Prior art date
Application number
BE8700410A
Other languages
English (en)
French (fr)
Inventor
John L Cantrell
Jon Rudbach
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Application granted granted Critical
Publication of BE1001630A4 publication Critical patent/BE1001630A4/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BE8700410A 1986-04-15 1987-04-15 Adjuvants immunologiques pour vaccins polysaccharidiques. BE1001630A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/852,118 US4803070A (en) 1986-04-15 1986-04-15 Immunological emulsion adjuvants for polysaccharide vaccines

Publications (1)

Publication Number Publication Date
BE1001630A4 true BE1001630A4 (fr) 1989-12-27

Family

ID=25312539

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700410A BE1001630A4 (fr) 1986-04-15 1987-04-15 Adjuvants immunologiques pour vaccins polysaccharidiques.

Country Status (9)

Country Link
US (1) US4803070A (enExample)
JP (1) JP2648305B2 (enExample)
BE (1) BE1001630A4 (enExample)
CA (1) CA1322333C (enExample)
CH (1) CH675076A5 (enExample)
DE (1) DE3712768A1 (enExample)
GB (1) GB2189143B (enExample)
IT (1) IT1205820B (enExample)
NL (1) NL194603C (enExample)

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FR2649013B1 (fr) * 1989-07-03 1991-10-25 Seppic Sa Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable
FR2649012B1 (fr) * 1989-07-03 1991-10-25 Seppic Sa Emulsions multiphasiques injectables
US5268454A (en) * 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
DE4007315A1 (de) * 1990-03-08 1991-09-12 Behringwerke Ag Verwendung von zink-calciumhydroxid, lecithin und pao zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
DE69230372T2 (de) 1991-03-19 2000-06-15 Cytrx Corp., Norcross Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität
US6048531A (en) * 1991-04-15 2000-04-11 Albany Medical College Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies
DE69229779T2 (de) * 1991-04-19 1999-12-23 Lds Technologies, Inc. Konvertierbare mikroemulsionsverbindungen
US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
US5462735A (en) * 1993-06-10 1995-10-31 The United States Of America As Represented By The Secretary Of Agriculture Pasteurella haemolytica subunit vaccine containing capsular polysaccharide and muramyl dipeptide
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
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US20070231402A1 (en) 1994-08-02 2007-10-04 Immunopath Profile, Inc. Therapeutic stem cell composition and stimulant, facilitator, accelerator, and synergizer thereof, growth factor, anti-inflammatory composition and uses thereof
US5718904A (en) * 1995-06-02 1998-02-17 American Home Products Corporation Adjuvants for viral vaccines
AU709262B2 (en) * 1995-10-17 1999-08-26 Board Of Regents, The University Of Texas System Insoluble drug delivery
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
ATE241363T1 (de) * 1998-02-11 2003-06-15 Rtp Pharma Corp Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
CA2333648C (en) 1998-05-29 2008-10-21 Rtp Pharma Inc. Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
JP4198318B2 (ja) 1998-08-19 2008-12-17 ヤーゴテック アクチェンゲゼルシャフト プロポフォールの注射可能水性分散物
HUP0105089A3 (en) * 1998-11-20 2002-09-30 Skyepharma Canada Inc Compositions containing the active ingredient in form dispersible phospholipid stabilized microparticles
AU769539B2 (en) * 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
ATE297190T1 (de) * 1999-02-26 2005-06-15 Chiron Corp Mikroemulsionen mit adsorbierten makromolekülen und mikropartikeln
DE60020382T2 (de) * 1999-09-21 2006-01-26 Skyepharma Canada Inc., Verdun Oberflächenmodifizierte teilchenförmige zusammensetzungen biologisch aktiver stoffe
ES2469642T3 (es) 2000-04-20 2014-06-18 Jagotec Ag Procedimiento mejorado para partículas de fármaco insoluble en agua
US6634576B2 (en) 2000-08-31 2003-10-21 Rtp Pharma Inc. Milled particles
US8586094B2 (en) * 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
TWI354568B (en) * 2000-09-20 2011-12-21 Jagotec Ag Insoluble drug particle compositions with improved
GB0031430D0 (en) 2000-12-22 2001-02-07 Norsk Hydro As Polypeptides
CA2440355C (en) * 2001-02-22 2011-03-08 Skyepharma Canada Inc. Fibrate-statin combinations with reduced fed-fasted effects
JP2006522090A (ja) * 2003-04-04 2006-09-28 ファイザー・プロダクツ・インク マイクロ流動化された水中油形エマルジョン及びワクチン組成物
FR2873386B1 (fr) 2004-07-22 2011-01-14 Agence Francaise De Securite Sanitaire Des Aliments Afssa Composition vaccinale contre le rhodococcus equi
US20060210590A1 (en) 2005-02-03 2006-09-21 Alk-Abello A/S Minor allergen control to increase safety of immunotherapy
EP1934605B1 (en) * 2005-09-22 2014-03-26 Prosci Incorporated Glycosylated polypeptides produced in yeast mutants and methods of use thereof
US9498493B2 (en) * 2007-09-27 2016-11-22 Immunovaccine Technologies Inc. Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
PT2200642E (pt) * 2007-10-19 2012-05-30 Novartis Ag Formulações de vacinas meningocócicas
ES2524699T3 (es) * 2008-06-05 2014-12-11 Immunovaccine Technologies Inc. Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba
SG11201401177WA (en) 2011-10-06 2014-04-28 Immunovaccine Technologies Inc Liposome compositions comprising an adjuvant that activates or increases the activity of tlr2 and uses thereof
WO2014055825A1 (en) * 2012-10-04 2014-04-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services A formulation of mycobacterial components as an adjuvant for inducing th17 responses
US20210040055A1 (en) * 2017-08-17 2021-02-11 University Of Delaware Furan based compositions and methods of making thereof
US12064480B2 (en) 2018-04-13 2024-08-20 Glaxosmithkline Biologicals Sa Immunigenic alpha-branched trehalose-diesters

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2527443A1 (fr) * 1982-05-26 1983-12-02 Ribi Immunochem Research Inc Composition contenant de l'endotoxine raffinee et medicament la contenant
FR2550945A1 (fr) * 1983-08-26 1985-03-01 Ribi Immunochem Research Inc Compositions d'endotoxines purifiees et leur application pharmacologique
GB2189141A (en) * 1986-04-15 1987-10-21 Ribi Immunochem Research Inc Immunological adjuvant

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FR2160326B1 (enExample) * 1971-11-19 1975-02-07 Anvar
US4185090A (en) * 1972-02-02 1980-01-22 Abbott Laboratories Chemically modified endotoxin immunizing agent
GB1506563A (en) * 1974-04-25 1978-04-05 Williams J Immunosuppressive agents
US4338334A (en) * 1977-12-29 1982-07-06 Merck & Co., Inc. 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases
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US4307229A (en) * 1979-11-07 1981-12-22 Avraham Liav 6,6'-Diesters of trehalose and process for the synthesis thereof
US4340588A (en) 1980-03-28 1982-07-20 Research Corporation Brucellosis vaccine for cattle containing mycolate esters of trehalose
US4505900A (en) * 1982-05-26 1985-03-19 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
CA1206416A (en) * 1982-06-30 1986-06-24 John L. Cantrell Pyridine soluble extract of a microorganism
NL8301996A (nl) * 1983-06-06 1985-01-02 Duphar Int Res Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins.
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
JPS6292947A (ja) * 1985-10-19 1987-04-28 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2527443A1 (fr) * 1982-05-26 1983-12-02 Ribi Immunochem Research Inc Composition contenant de l'endotoxine raffinee et medicament la contenant
FR2550945A1 (fr) * 1983-08-26 1985-03-01 Ribi Immunochem Research Inc Compositions d'endotoxines purifiees et leur application pharmacologique
GB2189141A (en) * 1986-04-15 1987-10-21 Ribi Immunochem Research Inc Immunological adjuvant

Also Published As

Publication number Publication date
CH675076A5 (enExample) 1990-08-31
NL194603C (nl) 2002-09-03
CA1322333C (en) 1993-09-21
GB2189143A (en) 1987-10-21
DE3712768A1 (de) 1987-10-22
JP2648305B2 (ja) 1997-08-27
US4803070A (en) 1989-02-07
GB2189143B (en) 1990-07-25
NL194603B (nl) 2002-05-01
GB8709124D0 (en) 1987-05-20
DE3712768C2 (enExample) 1992-01-16
IT8747856A0 (it) 1987-04-15
IT1205820B (it) 1989-03-31
NL8700892A (nl) 1987-11-02
JPS6322029A (ja) 1988-01-29

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *RIBI IMMUNOCHEM RESEARCH INC.

Effective date: 20070415