BE1001630A4 - Adjuvants immunologiques pour vaccins polysaccharidiques. - Google Patents

Adjuvants immunologiques pour vaccins polysaccharidiques. Download PDF

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Publication number
BE1001630A4
BE1001630A4 BE8700410A BE8700410A BE1001630A4 BE 1001630 A4 BE1001630 A4 BE 1001630A4 BE 8700410 A BE8700410 A BE 8700410A BE 8700410 A BE8700410 A BE 8700410A BE 1001630 A4 BE1001630 A4 BE 1001630A4
Authority
BE
Belgium
Prior art keywords
oil
sep
weight
biodegradable
emulsion system
Prior art date
Application number
BE8700410A
Other languages
English (en)
French (fr)
Inventor
John L Cantrell
Jon Rudbach
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Application granted granted Critical
Publication of BE1001630A4 publication Critical patent/BE1001630A4/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BE8700410A 1986-04-15 1987-04-15 Adjuvants immunologiques pour vaccins polysaccharidiques. BE1001630A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/852,118 US4803070A (en) 1986-04-15 1986-04-15 Immunological emulsion adjuvants for polysaccharide vaccines

Publications (1)

Publication Number Publication Date
BE1001630A4 true BE1001630A4 (fr) 1989-12-27

Family

ID=25312539

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700410A BE1001630A4 (fr) 1986-04-15 1987-04-15 Adjuvants immunologiques pour vaccins polysaccharidiques.

Country Status (9)

Country Link
US (1) US4803070A (enExample)
JP (1) JP2648305B2 (enExample)
BE (1) BE1001630A4 (enExample)
CA (1) CA1322333C (enExample)
CH (1) CH675076A5 (enExample)
DE (1) DE3712768A1 (enExample)
GB (1) GB2189143B (enExample)
IT (1) IT1205820B (enExample)
NL (1) NL194603C (enExample)

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US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
SK100893A3 (en) 1991-03-19 1994-04-06 Cytrx Corp Polyoxypropylene-polyoxyethylene copolymers with improved biological activity
US6048531A (en) * 1991-04-15 2000-04-11 Albany Medical College Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies
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US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
US5462735A (en) * 1993-06-10 1995-10-31 The United States Of America As Represented By The Secretary Of Agriculture Pasteurella haemolytica subunit vaccine containing capsular polysaccharide and muramyl dipeptide
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
EP0686030B1 (de) * 1993-12-23 2001-02-28 Bruno Gander Mit Antigen beladene Mikropartikel und pharmazeutische Zubereitungen, die diese Mikropartikel enthalten.
US20070231402A1 (en) * 1994-08-02 2007-10-04 Immunopath Profile, Inc. Therapeutic stem cell composition and stimulant, facilitator, accelerator, and synergizer thereof, growth factor, anti-inflammatory composition and uses thereof
US5718904A (en) * 1995-06-02 1998-02-17 American Home Products Corporation Adjuvants for viral vaccines
WO1997014407A1 (en) 1995-10-17 1997-04-24 Research Triangle Pharmaceuticals Insoluble drug delivery
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
DE69908304T2 (de) * 1998-02-11 2004-02-19 Rtp Pharma Corp. Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
HK1039458B (zh) 1998-05-29 2006-09-01 Skyepharma Canada Inc. 熱保護微粒組合物及其最終蒸汽滅菌的方法
WO2000010531A1 (en) * 1998-08-19 2000-03-02 Rtp Pharma Inc. Injectable aqueous dispersions of propofol
WO2000030616A1 (en) * 1998-11-20 2000-06-02 Rtp Pharma Inc. Dispersible phospholipid stabilized microparticles
AU769539B2 (en) * 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
ES2242604T3 (es) 1999-02-26 2005-11-16 Chiron Corporation Microemulsiones con macroparticulas y microparticulas adsorbidas.
CA2383233C (en) * 1999-09-21 2010-06-08 Rtp Pharma Inc. Surface modified particulate compositions of biologically active substances
CA2407027C (en) 2000-04-20 2011-02-15 Rtp Pharma Inc. Improved water-insoluble drug particle process
ES2325057T3 (es) 2000-08-31 2009-08-25 Jagotec Ag Particulas molturadas.
ES2372746T3 (es) * 2000-09-20 2012-01-26 Jagotec Ag Micropartículas de fibrato estabilizadas.
US8586094B2 (en) * 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
GB0031430D0 (en) 2000-12-22 2001-02-07 Norsk Hydro As Polypeptides
TWI288000B (en) * 2001-02-22 2007-10-11 Rtp Pharma Inc Fibrate-statin combinations with reduced fed-fasted effects
PT1613346E (pt) * 2003-04-04 2013-01-29 Pah Usa 15 Llc Emulsões óleo-em-água microfluidificadas e composições de vacinas
FR2873386B1 (fr) 2004-07-22 2011-01-14 Agence Francaise De Securite Sanitaire Des Aliments Afssa Composition vaccinale contre le rhodococcus equi
US20060210590A1 (en) 2005-02-03 2006-09-21 Alk-Abello A/S Minor allergen control to increase safety of immunotherapy
WO2007035930A2 (en) * 2005-09-22 2007-03-29 Prosci Incorporated Glycosylated polypeptides produced in yeast mutants and methods of use thereof
CN101827613A (zh) 2007-09-27 2010-09-08 免疫疫苗技术有限公司 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
MX2010004271A (es) * 2007-10-19 2010-05-03 Novartis Ag Formulaciones de vacuna meningococica.
CN102056622B (zh) 2008-06-05 2016-04-06 免疫疫苗技术有限公司 包含脂质体、抗原、多核苷酸和含疏水物质的连续相的载体的组合物
ES2855474T3 (es) 2011-10-06 2021-09-23 Immunovaccine Technologies Inc Composiciones de liposomas que comprenden un adyuvante que activa o incrementa la actividad de TLR2 y usos del mismo
WO2014055825A1 (en) * 2012-10-04 2014-04-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services A formulation of mycobacterial components as an adjuvant for inducing th17 responses
WO2019036663A1 (en) * 2017-08-17 2019-02-21 University Of Delaware FURANE COMPOSITIONS AND METHODS OF MAKING THE SAME
US12064480B2 (en) 2018-04-13 2024-08-20 Glaxosmithkline Biologicals Sa Immunigenic alpha-branched trehalose-diesters

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2527443A1 (fr) * 1982-05-26 1983-12-02 Ribi Immunochem Research Inc Composition contenant de l'endotoxine raffinee et medicament la contenant
FR2550945A1 (fr) * 1983-08-26 1985-03-01 Ribi Immunochem Research Inc Compositions d'endotoxines purifiees et leur application pharmacologique
GB2189141A (en) * 1986-04-15 1987-10-21 Ribi Immunochem Research Inc Immunological adjuvant

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US4185090A (en) * 1972-02-02 1980-01-22 Abbott Laboratories Chemically modified endotoxin immunizing agent
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US4338334A (en) * 1977-12-29 1982-07-06 Merck & Co., Inc. 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases
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US4307229A (en) * 1979-11-07 1981-12-22 Avraham Liav 6,6'-Diesters of trehalose and process for the synthesis thereof
US4340588A (en) 1980-03-28 1982-07-20 Research Corporation Brucellosis vaccine for cattle containing mycolate esters of trehalose
US4505900A (en) * 1982-05-26 1985-03-19 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
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US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
JPS6292947A (ja) * 1985-10-19 1987-04-28 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2527443A1 (fr) * 1982-05-26 1983-12-02 Ribi Immunochem Research Inc Composition contenant de l'endotoxine raffinee et medicament la contenant
FR2550945A1 (fr) * 1983-08-26 1985-03-01 Ribi Immunochem Research Inc Compositions d'endotoxines purifiees et leur application pharmacologique
GB2189141A (en) * 1986-04-15 1987-10-21 Ribi Immunochem Research Inc Immunological adjuvant

Also Published As

Publication number Publication date
JP2648305B2 (ja) 1997-08-27
IT8747856A0 (it) 1987-04-15
NL194603B (nl) 2002-05-01
DE3712768A1 (de) 1987-10-22
GB8709124D0 (en) 1987-05-20
NL8700892A (nl) 1987-11-02
US4803070A (en) 1989-02-07
GB2189143A (en) 1987-10-21
CH675076A5 (enExample) 1990-08-31
IT1205820B (it) 1989-03-31
DE3712768C2 (enExample) 1992-01-16
NL194603C (nl) 2002-09-03
JPS6322029A (ja) 1988-01-29
GB2189143B (en) 1990-07-25
CA1322333C (en) 1993-09-21

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *RIBI IMMUNOCHEM RESEARCH INC.

Effective date: 20070415