BE1001630A4 - Adjuvants immunologiques pour vaccins polysaccharidiques. - Google Patents

Adjuvants immunologiques pour vaccins polysaccharidiques. Download PDF

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Publication number
BE1001630A4
BE1001630A4 BE8700410A BE8700410A BE1001630A4 BE 1001630 A4 BE1001630 A4 BE 1001630A4 BE 8700410 A BE8700410 A BE 8700410A BE 8700410 A BE8700410 A BE 8700410A BE 1001630 A4 BE1001630 A4 BE 1001630A4
Authority
BE
Belgium
Prior art keywords
oil
sep
weight
biodegradable
emulsion system
Prior art date
Application number
BE8700410A
Other languages
English (en)
French (fr)
Inventor
John L Cantrell
Jon Rudbach
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Application granted granted Critical
Publication of BE1001630A4 publication Critical patent/BE1001630A4/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BE8700410A 1986-04-15 1987-04-15 Adjuvants immunologiques pour vaccins polysaccharidiques. BE1001630A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/852,118 US4803070A (en) 1986-04-15 1986-04-15 Immunological emulsion adjuvants for polysaccharide vaccines

Publications (1)

Publication Number Publication Date
BE1001630A4 true BE1001630A4 (fr) 1989-12-27

Family

ID=25312539

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700410A BE1001630A4 (fr) 1986-04-15 1987-04-15 Adjuvants immunologiques pour vaccins polysaccharidiques.

Country Status (9)

Country Link
US (1) US4803070A (enExample)
JP (1) JP2648305B2 (enExample)
BE (1) BE1001630A4 (enExample)
CA (1) CA1322333C (enExample)
CH (1) CH675076A5 (enExample)
DE (1) DE3712768A1 (enExample)
GB (1) GB2189143B (enExample)
IT (1) IT1205820B (enExample)
NL (1) NL194603C (enExample)

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US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
EP0324455A3 (en) * 1988-01-15 1991-03-27 Hans O. Ribi Novel polymeric immunological adjuvants
WO1990014837A1 (en) * 1989-05-25 1990-12-13 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
FR2649013B1 (fr) * 1989-07-03 1991-10-25 Seppic Sa Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable
FR2649012B1 (fr) * 1989-07-03 1991-10-25 Seppic Sa Emulsions multiphasiques injectables
US5268454A (en) * 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
DE4007315A1 (de) * 1990-03-08 1991-09-12 Behringwerke Ag Verwendung von zink-calciumhydroxid, lecithin und pao zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
EP0576612B1 (en) 1991-03-19 1999-12-01 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US6048531A (en) * 1991-04-15 2000-04-11 Albany Medical College Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies
US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
DE69229779T2 (de) * 1991-04-19 1999-12-23 Lds Technologies, Inc. Konvertierbare mikroemulsionsverbindungen
US5462735A (en) * 1993-06-10 1995-10-31 The United States Of America As Represented By The Secretary Of Agriculture Pasteurella haemolytica subunit vaccine containing capsular polysaccharide and muramyl dipeptide
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
CA2156718A1 (en) 1993-12-23 1995-06-29 Bruno Gander Immunological response potentiation process
US20070231402A1 (en) 1994-08-02 2007-10-04 Immunopath Profile, Inc. Therapeutic stem cell composition and stimulant, facilitator, accelerator, and synergizer thereof, growth factor, anti-inflammatory composition and uses thereof
US5718904A (en) * 1995-06-02 1998-02-17 American Home Products Corporation Adjuvants for viral vaccines
ES2306452T3 (es) * 1995-10-17 2008-11-01 Jagotec Ag Aporte de farmacos insolubles.
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
WO1999040906A2 (en) * 1998-02-11 1999-08-19 Research Triangle Pharmaceuticals Method and composition for treatment of inflammatory conditions
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
AU764001B2 (en) 1998-05-29 2003-08-07 Skyepharma Canada Inc. Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
CN1221249C (zh) * 1998-08-19 2005-10-05 斯凯伊药品加拿大公司 普鲁泊福的可注射水分散体
SK288117B6 (sk) 1998-11-20 2013-09-03 Skyepharma Canada Inc. Rapidly dispersing solid dry therapeutic dosage form
AU769539B2 (en) * 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
WO2000050006A2 (en) 1999-02-26 2000-08-31 Chiron Corporation Microemulsions with adsorbed macromoelecules and microparticles
WO2001021154A2 (en) * 1999-09-21 2001-03-29 Rtp Pharma Inc. Surface modified particulate compositions of biologically active substances
AU2001257115B2 (en) 2000-04-20 2005-01-27 Rtp Pharma Inc. Improved water-insoluble drug particle process
CA2420597C (en) 2000-08-31 2011-05-17 Rtp Pharma Inc. Milled particles
TWI354568B (en) * 2000-09-20 2011-12-21 Jagotec Ag Insoluble drug particle compositions with improved
US8586094B2 (en) * 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
GB0031430D0 (en) 2000-12-22 2001-02-07 Norsk Hydro As Polypeptides
NZ527408A (en) * 2001-02-22 2005-04-29 Skyepharma Canada Inc Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia
RU2541809C2 (ru) * 2003-04-04 2015-02-20 Зоетис Пи ЛЛК Микрофлюидизированные эмульсии "масло в воде" и композиции вакцины
FR2873386B1 (fr) 2004-07-22 2011-01-14 Agence Francaise De Securite Sanitaire Des Aliments Afssa Composition vaccinale contre le rhodococcus equi
US20060210590A1 (en) 2005-02-03 2006-09-21 Alk-Abello A/S Minor allergen control to increase safety of immunotherapy
US8202523B2 (en) * 2005-09-22 2012-06-19 ProSci, Inc. Glycosylated polypeptides produced in yeast mutants and methods of use thereof
ES2588705T3 (es) * 2007-09-27 2016-11-04 Immunovaccine Technologies Inc. Uso de liposomas en un vehículo que comprende una fase hidrófoba continua para la entrega de polinucleótidos in vivo
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
HRP20120433T1 (en) * 2007-10-19 2012-07-31 Novartis@Ag Meningococcal vaccine formulations
CA2723918C (en) 2008-06-05 2018-01-09 Immunovaccine Technologies Inc. Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance
IN2014CN02581A (enExample) 2011-10-06 2015-08-07 Immunovaccine Technologies Inc
WO2014055825A1 (en) * 2012-10-04 2014-04-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services A formulation of mycobacterial components as an adjuvant for inducing th17 responses
US12703689B2 (en) 2017-08-17 2026-08-11 University Of Delaware Furan based compositions and methods of making thereof
EP3774829A2 (en) 2018-04-13 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunigenic alpha-branched trehalose-diesters

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2527443A1 (fr) * 1982-05-26 1983-12-02 Ribi Immunochem Research Inc Composition contenant de l'endotoxine raffinee et medicament la contenant
FR2550945A1 (fr) * 1983-08-26 1985-03-01 Ribi Immunochem Research Inc Compositions d'endotoxines purifiees et leur application pharmacologique
GB2189141A (en) * 1986-04-15 1987-10-21 Ribi Immunochem Research Inc Immunological adjuvant

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FR2160326B1 (enExample) * 1971-11-19 1975-02-07 Anvar
US4185090A (en) * 1972-02-02 1980-01-22 Abbott Laboratories Chemically modified endotoxin immunizing agent
GB1506563A (en) * 1974-04-25 1978-04-05 Williams J Immunosuppressive agents
US4338334A (en) * 1977-12-29 1982-07-06 Merck & Co., Inc. 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases
ES483541A1 (es) * 1979-08-21 1980-03-01 Benlloch Llorach Alfredo Perfeccionamientos en los colectores de aparatos captadores de la energia solar.
US4307229A (en) * 1979-11-07 1981-12-22 Avraham Liav 6,6'-Diesters of trehalose and process for the synthesis thereof
US4340588A (en) 1980-03-28 1982-07-20 Research Corporation Brucellosis vaccine for cattle containing mycolate esters of trehalose
US4505900A (en) * 1982-05-26 1985-03-19 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
CA1206416A (en) * 1982-06-30 1986-06-24 John L. Cantrell Pyridine soluble extract of a microorganism
NL8301996A (nl) * 1983-06-06 1985-01-02 Duphar Int Res Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins.
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
JPS6292947A (ja) * 1985-10-19 1987-04-28 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2527443A1 (fr) * 1982-05-26 1983-12-02 Ribi Immunochem Research Inc Composition contenant de l'endotoxine raffinee et medicament la contenant
FR2550945A1 (fr) * 1983-08-26 1985-03-01 Ribi Immunochem Research Inc Compositions d'endotoxines purifiees et leur application pharmacologique
GB2189141A (en) * 1986-04-15 1987-10-21 Ribi Immunochem Research Inc Immunological adjuvant

Also Published As

Publication number Publication date
NL194603C (nl) 2002-09-03
US4803070A (en) 1989-02-07
JP2648305B2 (ja) 1997-08-27
DE3712768C2 (enExample) 1992-01-16
GB2189143A (en) 1987-10-21
JPS6322029A (ja) 1988-01-29
GB8709124D0 (en) 1987-05-20
NL194603B (nl) 2002-05-01
CA1322333C (en) 1993-09-21
DE3712768A1 (de) 1987-10-22
CH675076A5 (enExample) 1990-08-31
IT1205820B (it) 1989-03-31
GB2189143B (en) 1990-07-25
NL8700892A (nl) 1987-11-02
IT8747856A0 (it) 1987-04-15

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *RIBI IMMUNOCHEM RESEARCH INC.

Effective date: 20070415