AU780711B2 - Novel branched substituted amino derivatives of 3-amino-1-phenyl-H(1,2,4)triazol, methods for producing them and pharmaceutical compositions containing them - Google Patents

Novel branched substituted amino derivatives of 3-amino-1-phenyl-H(1,2,4)triazol, methods for producing them and pharmaceutical compositions containing them Download PDF

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Publication number
AU780711B2
AU780711B2 AU25259/01A AU2525901A AU780711B2 AU 780711 B2 AU780711 B2 AU 780711B2 AU 25259/01 A AU25259/01 A AU 25259/01A AU 2525901 A AU2525901 A AU 2525901A AU 780711 B2 AU780711 B2 AU 780711B2
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AU
Australia
Prior art keywords
alkyl
triazol
cyclopropyl
propyl
methylphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU25259/01A
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English (en)
Other versions
AU2525901A (en
Inventor
Michel Geslin
Danielle Gully
Jean-Pierre Maffrand
Pierre Roger
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Sanofi Aventis France
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Sanofi Aventis France
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Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of AU2525901A publication Critical patent/AU2525901A/en
Assigned to SANOFI-AVENTIS reassignment SANOFI-AVENTIS Amend patent request/document other than specification (104) Assignors: SANOFI-SYNTHELABO
Application granted granted Critical
Publication of AU780711B2 publication Critical patent/AU780711B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU25259/01A 1999-12-17 2000-12-14 Novel branched substituted amino derivatives of 3-amino-1-phenyl-H(1,2,4)triazol, methods for producing them and pharmaceutical compositions containing them Ceased AU780711B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9915935A FR2802530B1 (fr) 1999-12-17 1999-12-17 Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant
FR99/15935 1999-12-17
PCT/FR2000/003536 WO2001044207A2 (fr) 1999-12-17 2000-12-14 Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2 4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
AU2525901A AU2525901A (en) 2001-06-25
AU780711B2 true AU780711B2 (en) 2005-04-14

Family

ID=9553380

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25259/01A Ceased AU780711B2 (en) 1999-12-17 2000-12-14 Novel branched substituted amino derivatives of 3-amino-1-phenyl-H(1,2,4)triazol, methods for producing them and pharmaceutical compositions containing them

Country Status (33)

Country Link
US (1) US6806282B2 (enExample)
EP (1) EP1242389B1 (enExample)
JP (1) JP4146641B2 (enExample)
KR (1) KR100705525B1 (enExample)
CN (1) CN1293061C (enExample)
AR (1) AR031837A1 (enExample)
AT (1) ATE264847T1 (enExample)
AU (1) AU780711B2 (enExample)
BR (1) BR0017023A (enExample)
CA (1) CA2398772C (enExample)
CO (1) CO5251379A1 (enExample)
CZ (1) CZ302460B6 (enExample)
DE (1) DE60010126T2 (enExample)
DK (1) DK1242389T3 (enExample)
EA (1) EA004957B1 (enExample)
EE (1) EE04778B1 (enExample)
ES (1) ES2219436T3 (enExample)
FR (1) FR2802530B1 (enExample)
HU (1) HUP0204080A3 (enExample)
IL (2) IL150037A0 (enExample)
IS (1) IS2315B (enExample)
ME (1) MEP12108A (enExample)
MX (1) MXPA02006033A (enExample)
NO (1) NO20022828L (enExample)
PL (1) PL203819B1 (enExample)
PT (1) PT1242389E (enExample)
RS (1) RS50289B (enExample)
SK (1) SK285994B6 (enExample)
TR (2) TR200401775T4 (enExample)
TW (1) TWI289554B (enExample)
UA (1) UA73333C2 (enExample)
WO (1) WO2001044207A2 (enExample)
ZA (1) ZA200204422B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7226920B2 (en) * 2003-08-06 2007-06-05 Vertex Pharmaceuticals Inc. Aminotriazole compounds useful as inhibitors of protein kinases
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
ES2424023T3 (es) 2007-10-18 2013-09-26 Janssen Pharmaceutica N.V. 1,2,4-triazoles trisustituidos
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
MY152486A (en) * 2008-03-19 2014-10-15 Janssen Pharmaceutica Nv Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators
US8779158B2 (en) 2008-05-09 2014-07-15 Janssen Pharmaceutica Nv Trisubstituted pyrazoles as acetylcholine receptor modulators
EP2629616A4 (en) * 2010-10-21 2014-03-26 Merck Sharp & Dohme SUBSTITUTED AMINO-TRIAZOLYL-PDE10-HEMMER
LT3096756T (lt) 2014-01-21 2024-08-26 Neurocrine Biosciences, Inc. Crf1 receptoriaus antagonistai, skirti įgimtos antinksčių hiperplazijos gydymui
CN104059027B (zh) * 2014-07-01 2015-10-28 河北大学 一类含1,2,4-三唑的(e)-甲氧基亚氨基苯乙酸甲酯类化合物及其制备方法和用途
FI3984523T3 (fi) 2018-12-07 2025-10-21 Neurocrine Biosciences Inc Crf1-reseptorin antagonisti, lääkeformulaatioita ja niiden kiinteitä muotoja synnynnäisen lisämunuaisten liikakasvun hoitoon
KR20220069008A (ko) * 2019-09-25 2022-05-26 온코아렌디 테라퓨틱스 에스.에이. 5-(4-((2s,5s)-5-(4-클로로벤질)-2-메틸모르폴리노)피페리딘-1-일)-1h-1,2,4-트리아졸-3-아민의 생성 방법
CA3152590A1 (en) 2019-09-27 2021-04-01 Evan Smith Crf receptor antagonists and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3869167D1 (de) * 1987-03-27 1992-04-23 Kumiai Chemical Industry Co Phenyltriazol-derivate und insectizid.
US5795905A (en) * 1995-06-06 1998-08-18 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
FR2763337B1 (fr) * 1997-05-13 1999-08-20 Sanofi Sa Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
EP1242389A2 (fr) 2002-09-25
AU2525901A (en) 2001-06-25
ATE264847T1 (de) 2004-05-15
EA200200523A1 (ru) 2002-12-26
WO2001044207B1 (fr) 2002-06-06
PL203819B1 (pl) 2009-11-30
AR031837A1 (es) 2003-10-08
SK285994B6 (sk) 2008-01-07
EE04778B1 (et) 2007-02-15
CZ20022099A3 (cs) 2002-09-11
IL150037A (en) 2007-02-11
FR2802530B1 (fr) 2002-02-22
PT1242389E (pt) 2004-08-31
DE60010126D1 (de) 2004-05-27
CZ302460B6 (cs) 2011-06-01
UA73333C2 (en) 2005-07-15
EP1242389B1 (fr) 2004-04-21
CA2398772A1 (fr) 2001-06-21
HUP0204080A2 (hu) 2003-04-28
TR200401775T4 (tr) 2004-09-21
IS2315B (is) 2007-11-15
PL355811A1 (en) 2004-05-17
CO5251379A1 (es) 2003-02-28
SK8502002A3 (en) 2003-02-04
KR20020061002A (ko) 2002-07-19
ES2219436T3 (es) 2004-12-01
NO20022828D0 (no) 2002-06-13
WO2001044207A3 (fr) 2001-12-20
RS50289B (sr) 2009-09-08
TWI289554B (en) 2007-11-11
CN1293061C (zh) 2007-01-03
IS6402A (is) 2002-05-28
IL150037A0 (en) 2002-12-01
BR0017023A (pt) 2002-12-03
MEP12108A (en) 2010-06-10
EA004957B1 (ru) 2004-10-28
TR200201600T2 (tr) 2002-10-21
DE60010126T2 (de) 2005-04-28
CN1434808A (zh) 2003-08-06
WO2001044207A2 (fr) 2001-06-21
US20030162771A1 (en) 2003-08-28
DK1242389T3 (da) 2004-08-09
ZA200204422B (en) 2003-11-26
YU43902A (sh) 2005-03-15
JP4146641B2 (ja) 2008-09-10
CA2398772C (fr) 2011-07-05
MXPA02006033A (es) 2003-01-28
US6806282B2 (en) 2004-10-19
FR2802530A1 (fr) 2001-06-22
JP2003516975A (ja) 2003-05-20
WO2001044207A8 (fr) 2001-07-12
EE200200331A (et) 2003-06-16
NO20022828L (no) 2002-08-19
KR100705525B1 (ko) 2007-04-10
HUP0204080A3 (en) 2005-01-28
HK1055947A1 (en) 2004-01-30

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