AU773698B2 - Intermediates for the production of quinolone carboxylic acid derivatives - Google Patents

Intermediates for the production of quinolone carboxylic acid derivatives Download PDF

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Publication number
AU773698B2
AU773698B2 AU68573/00A AU6857300A AU773698B2 AU 773698 B2 AU773698 B2 AU 773698B2 AU 68573/00 A AU68573/00 A AU 68573/00A AU 6857300 A AU6857300 A AU 6857300A AU 773698 B2 AU773698 B2 AU 773698B2
Authority
AU
Australia
Prior art keywords
formula
compound
process according
reaction
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU68573/00A
Other languages
English (en)
Other versions
AU6857300A (en
Inventor
Trevor John Grinter
Simon Howie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG Chem Ltd
Original Assignee
LG Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LG Life Sciences Ltd filed Critical LG Life Sciences Ltd
Publication of AU6857300A publication Critical patent/AU6857300A/en
Assigned to LG LIFE SCIENCES LIMITED reassignment LG LIFE SCIENCES LIMITED Alteration of Name(s) of Applicant(s) under S113 Assignors: SB PHARMCO PUERTO RICO INC
Application granted granted Critical
Publication of AU773698B2 publication Critical patent/AU773698B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU68573/00A 1999-09-03 2000-09-01 Intermediates for the production of quinolone carboxylic acid derivatives Ceased AU773698B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9920919.9A GB9920919D0 (en) 1999-09-03 1999-09-03 Novel compound
GB9920919 1999-09-03
PCT/GB2000/003358 WO2001017961A2 (en) 1999-09-03 2000-09-01 Intermediates for the production of naphthyridine-3-carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
AU6857300A AU6857300A (en) 2001-04-10
AU773698B2 true AU773698B2 (en) 2004-06-03

Family

ID=10860355

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68573/00A Ceased AU773698B2 (en) 1999-09-03 2000-09-01 Intermediates for the production of quinolone carboxylic acid derivatives

Country Status (30)

Country Link
US (3) US6703512B1 (enExample)
EP (1) EP1212321B1 (enExample)
JP (1) JP4208463B2 (enExample)
KR (1) KR100705363B1 (enExample)
CN (1) CN1255402C (enExample)
AR (1) AR029452A1 (enExample)
AT (1) ATE270671T1 (enExample)
AU (1) AU773698B2 (enExample)
BR (1) BRPI0013750B8 (enExample)
CA (1) CA2383751C (enExample)
CO (1) CO5180620A1 (enExample)
CZ (1) CZ2002759A3 (enExample)
DE (1) DE60012028T2 (enExample)
DK (1) DK1212321T3 (enExample)
ES (1) ES2223570T3 (enExample)
GB (1) GB9920919D0 (enExample)
HK (1) HK1046908B (enExample)
HU (1) HU229391B1 (enExample)
IL (2) IL148441A0 (enExample)
MX (1) MXPA02002356A (enExample)
MY (1) MY126789A (enExample)
NO (1) NO322501B1 (enExample)
NZ (1) NZ517601A (enExample)
PL (1) PL206491B1 (enExample)
PT (1) PT1212321E (enExample)
SI (1) SI1212321T1 (enExample)
TR (1) TR200200548T2 (enExample)
TW (1) TWI264435B (enExample)
WO (1) WO2001017961A2 (enExample)
ZA (1) ZA200201779B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2281817C (en) * 1999-06-29 2008-07-29 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against maxillary sinus pathogenic bacteria
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
ATE410225T1 (de) 2001-08-02 2008-10-15 Lg Life Sciences Ltd Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
JP4563804B2 (ja) * 2002-07-17 2010-10-13 チバ ホールディング インコーポレーテッド キナクリドン顔料を製造するための酸化法
KR100653334B1 (ko) * 2003-03-07 2006-12-04 주식회사 엘지생명과학 4-아미노메틸-3-알콕시이미노피롤리딘 메탄설폰산염의 신규한 제조 방법
US8822934B2 (en) * 2006-11-03 2014-09-02 Accuray Incorporated Collimator changer
CN104693088B (zh) * 2013-12-06 2018-01-05 常州市勇毅生物药业有限公司 一种吉米沙星侧链的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0688772A1 (en) * 1994-06-16 1995-12-27 LG Chemical Limited Novel quinoline carboxylic acid derivatives having 7-(4-amino-methyl-3-oxime) pyrrolidine substituents and processes for their preparation
WO1998042705A1 (en) * 1997-03-21 1998-10-01 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
AU7019700A (en) * 1999-09-03 2001-04-10 Lg Life Sciences Limited Process for production of naphthyridine-3-carboxylic acid derivatives

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57134482A (en) 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
IN162769B (enExample) 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja) 1987-10-13 1989-04-18 Shionogi & Co Ltd オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
JPH0356479A (ja) 1989-07-24 1991-03-12 Takeshi Yokota 水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩
HU219403B (hu) 1989-08-16 2001-04-28 Pfizer Inc. Azabiciklo-csoporttal helyettesített kinolon- és naftiridon-karbonsavak és eljárás ezek előállítására
US5137892A (en) 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
US5276041A (en) 1991-11-08 1994-01-04 Kaken Pharmaceutical Co., Ltd. Oxime derivatives
JPH0673056A (ja) 1992-08-26 1994-03-15 Kaken Pharmaceut Co Ltd キノリンカルボン酸誘導体およびその塩
US5776944A (en) 1994-06-16 1998-07-07 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
JP3449658B2 (ja) 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
CA2223404C (en) 1995-06-06 2001-01-16 Thomas A. Morris Novel crystal form of anhydrous 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt
EP0843661B1 (en) 1995-08-11 2002-03-27 Pfizer Inc. (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate
JP4316013B2 (ja) 1996-03-29 2009-08-19 スミスクライン・ビーチャム・コーポレイション エプロサルタン二水和物ならびにその製法および処方
KR100286874B1 (ko) 1998-03-04 2001-04-16 성재갑 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
ATE249432T1 (de) 1998-05-29 2003-09-15 Upjohn Co 3-((1'-n-methylamino)ethyl-n-benzyl)pyrrolidin- monomethanesulfonat
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
WO2001000209A1 (en) 1999-06-29 2001-01-04 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
WO2001015695A1 (en) 1999-09-01 2001-03-08 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
GB9920919D0 (en) * 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
EP1242079A4 (en) 1999-09-22 2003-01-22 Smithkline Beecham Methods of anti-bacterial use of fluoroquinolonic compounds
KR20010091379A (ko) 2000-03-15 2001-10-23 성재갑 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
KR20020018560A (ko) 2000-09-01 2002-03-08 성재갑 3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0688772A1 (en) * 1994-06-16 1995-12-27 LG Chemical Limited Novel quinoline carboxylic acid derivatives having 7-(4-amino-methyl-3-oxime) pyrrolidine substituents and processes for their preparation
WO1998042705A1 (en) * 1997-03-21 1998-10-01 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
AU7019700A (en) * 1999-09-03 2001-04-10 Lg Life Sciences Limited Process for production of naphthyridine-3-carboxylic acid derivatives

Also Published As

Publication number Publication date
ZA200201779B (en) 2003-08-27
BRPI0013750B8 (pt) 2021-05-25
PT1212321E (pt) 2004-10-29
MY126789A (en) 2006-10-31
WO2001017961A2 (en) 2001-03-15
JP2003508517A (ja) 2003-03-04
CA2383751A1 (en) 2001-03-15
HK1046908B (en) 2005-05-27
HU229391B1 (hu) 2013-11-28
AU6857300A (en) 2001-04-10
US20050033064A1 (en) 2005-02-10
NO322501B1 (no) 2006-10-16
CA2383751C (en) 2010-06-29
IL148441A (en) 2007-03-08
DE60012028T2 (de) 2005-08-18
AR029452A1 (es) 2003-07-02
SI1212321T1 (en) 2004-12-31
PL354725A1 (en) 2004-02-09
CO5180620A1 (es) 2002-07-30
WO2001017961A3 (en) 2001-09-20
CN1372558A (zh) 2002-10-02
JP4208463B2 (ja) 2009-01-14
IL148441A0 (en) 2002-09-12
DK1212321T3 (da) 2004-10-25
TR200200548T2 (tr) 2002-09-23
CN1255402C (zh) 2006-05-10
KR100705363B1 (ko) 2007-04-10
DE60012028D1 (de) 2004-08-12
CZ2002759A3 (cs) 2002-06-12
MXPA02002356A (es) 2002-07-30
PL206491B1 (pl) 2010-08-31
HUP0202733A3 (en) 2005-12-28
NZ517601A (en) 2003-08-29
US6703512B1 (en) 2004-03-09
EP1212321B1 (en) 2004-07-07
EP1212321A2 (en) 2002-06-12
KR20020041423A (ko) 2002-06-01
HK1046908A1 (en) 2003-01-30
GB9920919D0 (en) 1999-11-10
ES2223570T3 (es) 2005-03-01
BR0013750B1 (pt) 2014-06-17
NO20021043D0 (no) 2002-03-01
US20040138292A1 (en) 2004-07-15
BR0013750A (pt) 2002-05-21
US6803467B2 (en) 2004-10-12
HUP0202733A2 (hu) 2003-01-28
NO20021043L (no) 2002-03-01
TWI264435B (en) 2006-10-21
ATE270671T1 (de) 2004-07-15

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: LG LIFE SCIENCES LIMITED

Free format text: THE FORMER OWNER WAS: SB PHARMCO PUERTO RICO INC

FGA Letters patent sealed or granted (standard patent)