AU756441B2 - Method for preparing a solution for nasal spray containing sex hormones and a cyclodextrin - Google Patents

Method for preparing a solution for nasal spray containing sex hormones and a cyclodextrin Download PDF

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Publication number
AU756441B2
AU756441B2 AU60967/99A AU6096799A AU756441B2 AU 756441 B2 AU756441 B2 AU 756441B2 AU 60967/99 A AU60967/99 A AU 60967/99A AU 6096799 A AU6096799 A AU 6096799A AU 756441 B2 AU756441 B2 AU 756441B2
Authority
AU
Australia
Prior art keywords
solution
cyclodextrin
oestradiol
preparation
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU60967/99A
Other languages
English (en)
Other versions
AU6096799A (en
Inventor
Gilles Fonknechten
Patrick Wuthrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of AU6096799A publication Critical patent/AU6096799A/en
Assigned to LES LABORATOIRES SERVIER reassignment LES LABORATOIRES SERVIER Alteration of Name(s) of Applicant(s) under S113 Assignors: ADIR ET COMPAGNIE
Application granted granted Critical
Publication of AU756441B2 publication Critical patent/AU756441B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU60967/99A 1998-10-14 1999-10-13 Method for preparing a solution for nasal spray containing sex hormones and a cyclodextrin Ceased AU756441B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR98/12836 1998-10-14
FR9812836A FR2784584B1 (fr) 1998-10-14 1998-10-14 Procede de preparation d'une solution pour pulverisation nasale contenant une ou plusieurs hormones sexuelles et une cyclodextrine
PCT/FR1999/002480 WO2000021503A1 (fr) 1998-10-14 1999-10-13 Procede de preparation d'une solution pour pulverisation nasale contenant une ou plusieurs hormones sexuelles et une cyclodextrine

Publications (2)

Publication Number Publication Date
AU6096799A AU6096799A (en) 2000-05-01
AU756441B2 true AU756441B2 (en) 2003-01-16

Family

ID=9531516

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60967/99A Ceased AU756441B2 (en) 1998-10-14 1999-10-13 Method for preparing a solution for nasal spray containing sex hormones and a cyclodextrin

Country Status (21)

Country Link
EP (1) EP1121100B1 (enExample)
JP (1) JP3911125B2 (enExample)
KR (1) KR100462441B1 (enExample)
CN (1) CN1323198A (enExample)
AT (1) ATE237310T1 (enExample)
AU (1) AU756441B2 (enExample)
BR (1) BR9914532A (enExample)
CA (1) CA2346567C (enExample)
DE (1) DE69907005T2 (enExample)
DK (1) DK1121100T3 (enExample)
EA (1) EA003069B1 (enExample)
ES (1) ES2197672T3 (enExample)
FR (1) FR2784584B1 (enExample)
HK (1) HK1040201A1 (enExample)
HU (1) HUP0103968A3 (enExample)
NO (1) NO20011673L (enExample)
NZ (1) NZ510776A (enExample)
PL (1) PL347322A1 (enExample)
PT (1) PT1121100E (enExample)
WO (1) WO2000021503A1 (enExample)
ZA (1) ZA200102961B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827516B1 (fr) * 2001-07-19 2003-09-19 Servier Lab Composition pharmaceutique pour l'administration par voie nasale d'estradiol et de norethisterone
JPWO2005018607A1 (ja) * 2003-08-20 2007-11-01 味の素株式会社 溶解性を改善した医薬品製剤
GB2482868A (en) * 2010-08-16 2012-02-22 Franciscus Wilhelmus Henricus Maria Merkus A testosterone liquid spray formulation for oromucosal administration
MX2014004202A (es) * 2011-10-07 2015-03-05 Univ Florida State Res Found Uso post-agudo y profiláctico de progesterona para mejores resultados asociados con concusión.
RU2623066C2 (ru) 2012-01-20 2017-06-21 Аратана Терапьютикс Нв Композиция глазных капель
RU2753511C2 (ru) * 2017-05-31 2021-08-17 Аратана Терапьютикс, Инк. Композиция глазных капель

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8801670A (nl) * 1988-07-01 1990-02-01 Walter Adrianus Josephus Johan Farmaceutisch preparaat.
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9012663D0 (en) * 1990-06-07 1990-08-01 Erba Carlo Spa Galenic formulations containing cyclodextrins
DE4207922A1 (de) * 1992-03-13 1993-09-23 Pharmatech Gmbh Wasserloesliche einschlussverbindungen und verfahren zu deren herstellung
BE1007402A5 (nl) * 1993-03-26 1995-06-06 Adir Nasale farmaceutische preparaten met progestagene stof.

Also Published As

Publication number Publication date
DE69907005T2 (de) 2004-03-18
CA2346567C (fr) 2005-06-14
AU6096799A (en) 2000-05-01
CN1323198A (zh) 2001-11-21
EP1121100B1 (fr) 2003-04-16
NO20011673D0 (no) 2001-04-03
CA2346567A1 (fr) 2000-04-20
ZA200102961B (en) 2001-11-20
EA003069B1 (ru) 2002-12-26
DE69907005D1 (de) 2003-05-22
JP3911125B2 (ja) 2007-05-09
DK1121100T3 (da) 2003-07-21
HK1040201A1 (zh) 2002-05-31
WO2000021503A1 (fr) 2000-04-20
FR2784584A1 (fr) 2000-04-21
ES2197672T3 (es) 2004-01-01
HUP0103968A2 (hu) 2002-04-29
PT1121100E (pt) 2003-07-31
FR2784584B1 (fr) 2002-09-20
NO20011673L (no) 2001-04-03
EP1121100A1 (fr) 2001-08-08
NZ510776A (en) 2002-10-25
KR100462441B1 (ko) 2004-12-17
ATE237310T1 (de) 2003-05-15
JP2002527374A (ja) 2002-08-27
PL347322A1 (en) 2002-03-25
EA200100316A1 (ru) 2002-02-28
HUP0103968A3 (en) 2002-06-28
BR9914532A (pt) 2001-11-06
KR20010073214A (ko) 2001-07-31

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: LES LABORATOIRES SERVIER

Free format text: THE FORMER OWNER WAS: ADIR ET COMPAGNIE

FGA Letters patent sealed or granted (standard patent)