NZ510776A - Method for preparing a solution for nasal spray containing sex hormones and a cyclodextrin - Google Patents
Method for preparing a solution for nasal spray containing sex hormones and a cyclodextrinInfo
- Publication number
- NZ510776A NZ510776A NZ510776A NZ51077699A NZ510776A NZ 510776 A NZ510776 A NZ 510776A NZ 510776 A NZ510776 A NZ 510776A NZ 51077699 A NZ51077699 A NZ 51077699A NZ 510776 A NZ510776 A NZ 510776A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cyclodextrin
- solution
- nasal spray
- sex hormones
- preparing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Nanotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Reproductive Health (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Process for the preparation of a nasal spray solution comprising one or more sex hormones and cyclodextrin, wherein (a) the cyclodextrin is dissolved in purified water at a concentration of 100 - 1000 mg/ml; (b) the hormone(s) is/are added and the mixture heated to 40 - 90 °C; and (c) purified water is added to give the final, desired concentration of hormone(s), this addition taking place either immediately or after lyophilisation of the preceding solution.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9812836A FR2784584B1 (en) | 1998-10-14 | 1998-10-14 | PROCESS FOR THE PREPARATION OF A NASAL SPRAY SOLUTION CONTAINING ONE OR MORE SEXUAL HORMONES AND A CYCLODEXTRIN |
PCT/FR1999/002480 WO2000021503A1 (en) | 1998-10-14 | 1999-10-13 | Method for preparing a solution for nasal spray containing sex hormones and a cyclodextrin |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ510776A true NZ510776A (en) | 2002-10-25 |
Family
ID=9531516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ510776A NZ510776A (en) | 1998-10-14 | 1999-10-13 | Method for preparing a solution for nasal spray containing sex hormones and a cyclodextrin |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1121100B1 (en) |
JP (1) | JP3911125B2 (en) |
KR (1) | KR100462441B1 (en) |
CN (1) | CN1323198A (en) |
AT (1) | ATE237310T1 (en) |
AU (1) | AU756441B2 (en) |
BR (1) | BR9914532A (en) |
CA (1) | CA2346567C (en) |
DE (1) | DE69907005T2 (en) |
DK (1) | DK1121100T3 (en) |
EA (1) | EA003069B1 (en) |
ES (1) | ES2197672T3 (en) |
FR (1) | FR2784584B1 (en) |
HK (1) | HK1040201A1 (en) |
HU (1) | HUP0103968A3 (en) |
NO (1) | NO20011673L (en) |
NZ (1) | NZ510776A (en) |
PL (1) | PL347322A1 (en) |
PT (1) | PT1121100E (en) |
WO (1) | WO2000021503A1 (en) |
ZA (1) | ZA200102961B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2827516B1 (en) * | 2001-07-19 | 2003-09-19 | Servier Lab | PHARMACEUTICAL COMPOSITION FOR NASAL ADMINISTRATION OF ESTRADIOL AND NORETHISTERONE |
CA2536283A1 (en) * | 2003-08-20 | 2005-03-03 | Ajinomoto Co., Inc. | Pharmaceutical preparations having an improved solubility |
GB2482868A (en) | 2010-08-16 | 2012-02-22 | Franciscus Wilhelmus Henricus Maria Merkus | A testosterone liquid spray formulation for oromucosal administration |
CA2851424A1 (en) * | 2011-10-07 | 2013-04-11 | Florida State University Research Foundation | Prophylactic and post-acute use of progesterone to better outcomes associated with concussion |
ES2575676T3 (en) | 2012-01-20 | 2016-06-30 | Aratana Therapeutics Nv | Eye drops composition |
RU2753511C2 (en) * | 2017-05-31 | 2021-08-17 | Аратана Терапьютикс, Инк. | Composition of eye drops |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8801670A (en) * | 1988-07-01 | 1990-02-01 | Walter Adrianus Josephus Johan | PHARMACEUTICAL PREPARATION. |
US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
GB9012663D0 (en) * | 1990-06-07 | 1990-08-01 | Erba Carlo Spa | Galenic formulations containing cyclodextrins |
DE4207922A1 (en) * | 1992-03-13 | 1993-09-23 | Pharmatech Gmbh | New water-soluble inclusion complexes contg randomly substd. methyl-beta-cyclodextrin - for admin. of substances which are only sparingly soluble in water |
BE1007402A5 (en) * | 1993-03-26 | 1995-06-06 | Adir | NASAL PHARMACEUTICAL PREPARATIONS WITH progestagen SUBSTANCE. |
-
1998
- 1998-10-14 FR FR9812836A patent/FR2784584B1/en not_active Expired - Fee Related
-
1999
- 1999-10-13 EA EA200100316A patent/EA003069B1/en not_active IP Right Cessation
- 1999-10-13 PL PL99347322A patent/PL347322A1/en unknown
- 1999-10-13 CA CA002346567A patent/CA2346567C/en not_active Expired - Fee Related
- 1999-10-13 AT AT99947567T patent/ATE237310T1/en not_active IP Right Cessation
- 1999-10-13 ES ES99947567T patent/ES2197672T3/en not_active Expired - Lifetime
- 1999-10-13 DE DE69907005T patent/DE69907005T2/en not_active Expired - Fee Related
- 1999-10-13 EP EP99947567A patent/EP1121100B1/en not_active Expired - Lifetime
- 1999-10-13 AU AU60967/99A patent/AU756441B2/en not_active Ceased
- 1999-10-13 DK DK99947567T patent/DK1121100T3/en active
- 1999-10-13 BR BR9914532-4A patent/BR9914532A/en not_active Application Discontinuation
- 1999-10-13 JP JP2000575479A patent/JP3911125B2/en not_active Expired - Fee Related
- 1999-10-13 PT PT99947567T patent/PT1121100E/en unknown
- 1999-10-13 WO PCT/FR1999/002480 patent/WO2000021503A1/en active IP Right Grant
- 1999-10-13 KR KR10-2001-7004679A patent/KR100462441B1/en not_active IP Right Cessation
- 1999-10-13 CN CN99812123A patent/CN1323198A/en active Pending
- 1999-10-13 NZ NZ510776A patent/NZ510776A/en unknown
- 1999-10-13 HU HU0103968A patent/HUP0103968A3/en unknown
-
2001
- 2001-04-03 NO NO20011673A patent/NO20011673L/en not_active Application Discontinuation
- 2001-04-10 ZA ZA200102961A patent/ZA200102961B/en unknown
-
2002
- 2002-03-15 HK HK02102010.0A patent/HK1040201A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR100462441B1 (en) | 2004-12-17 |
ES2197672T3 (en) | 2004-01-01 |
PL347322A1 (en) | 2002-03-25 |
HUP0103968A3 (en) | 2002-06-28 |
NO20011673D0 (en) | 2001-04-03 |
KR20010073214A (en) | 2001-07-31 |
ATE237310T1 (en) | 2003-05-15 |
FR2784584B1 (en) | 2002-09-20 |
DE69907005D1 (en) | 2003-05-22 |
EA200100316A1 (en) | 2002-02-28 |
CN1323198A (en) | 2001-11-21 |
PT1121100E (en) | 2003-07-31 |
HUP0103968A2 (en) | 2002-04-29 |
WO2000021503A1 (en) | 2000-04-20 |
DE69907005T2 (en) | 2004-03-18 |
CA2346567C (en) | 2005-06-14 |
JP3911125B2 (en) | 2007-05-09 |
JP2002527374A (en) | 2002-08-27 |
CA2346567A1 (en) | 2000-04-20 |
FR2784584A1 (en) | 2000-04-21 |
NO20011673L (en) | 2001-04-03 |
AU756441B2 (en) | 2003-01-16 |
BR9914532A (en) | 2001-11-06 |
ZA200102961B (en) | 2001-11-20 |
EA003069B1 (en) | 2002-12-26 |
AU6096799A (en) | 2000-05-01 |
DK1121100T3 (en) | 2003-07-21 |
EP1121100B1 (en) | 2003-04-16 |
EP1121100A1 (en) | 2001-08-08 |
HK1040201A1 (en) | 2002-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ASS | Change of ownership |
Owner name: LES LABORATOIRES SERVIER, FR Free format text: OLD OWNER(S): ADIR ET COMPAGNIE |
|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) | ||
RENW | Renewal (renewal fees accepted) |