AU748750B2 - Novel isoxazolinone antibacterial agents - Google Patents
Novel isoxazolinone antibacterial agents Download PDFInfo
- Publication number
- AU748750B2 AU748750B2 AU57833/99A AU5783399A AU748750B2 AU 748750 B2 AU748750 B2 AU 748750B2 AU 57833/99 A AU57833/99 A AU 57833/99A AU 5783399 A AU5783399 A AU 5783399A AU 748750 B2 AU748750 B2 AU 748750B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- optionally substituted
- phenyl
- alkoxy
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9757498P | 1998-08-24 | 1998-08-24 | |
| US60/097574 | 1998-08-24 | ||
| PCT/US1999/019265 WO2000010566A1 (en) | 1998-08-24 | 1999-08-23 | Novel isoxazolinone antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5783399A AU5783399A (en) | 2000-03-14 |
| AU748750B2 true AU748750B2 (en) | 2002-06-13 |
Family
ID=22264103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU57833/99A Ceased AU748750B2 (en) | 1998-08-24 | 1999-08-23 | Novel isoxazolinone antibacterial agents |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1107756A4 (ja) |
| JP (1) | JP2002523369A (ja) |
| KR (1) | KR20010072945A (ja) |
| CN (1) | CN1314813A (ja) |
| AR (1) | AR020250A1 (ja) |
| AU (1) | AU748750B2 (ja) |
| BR (1) | BR9913225A (ja) |
| CA (1) | CA2341271A1 (ja) |
| CO (1) | CO5160266A1 (ja) |
| CZ (1) | CZ2001669A3 (ja) |
| HU (1) | HUP0103433A3 (ja) |
| ID (1) | ID27690A (ja) |
| IL (1) | IL141542A0 (ja) |
| NO (1) | NO20010916L (ja) |
| NZ (1) | NZ509867A (ja) |
| PE (1) | PE20001063A1 (ja) |
| PL (1) | PL346267A1 (ja) |
| TR (1) | TR200100672T2 (ja) |
| TW (1) | TW572757B (ja) |
| UY (1) | UY25677A1 (ja) |
| WO (1) | WO2000010566A1 (ja) |
| ZA (1) | ZA200101505B (ja) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465456B2 (en) | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| JP2002020366A (ja) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | アルキルチオフェニル酢酸類の製造方法 |
| PE20020689A1 (es) | 2000-11-17 | 2002-08-03 | Upjohn Co | Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno |
| PE20030044A1 (es) | 2000-11-17 | 2003-02-09 | Upjohn Co | Isoxazolinonas biciclicas de formula i |
| US6861433B2 (en) * | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
| JP2004518677A (ja) | 2000-12-21 | 2004-06-24 | ファルマシア・アンド・アップジョン・カンパニー | 抗菌性キノロン誘導体および細菌感染を治療するためのその使用 |
| ES2180456B1 (es) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| WO2003035073A1 (en) | 2001-10-25 | 2003-05-01 | Astrazeneca Ab | Isoxazoline derivatives useful as antimicrobials |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| WO2004033449A1 (en) * | 2002-10-10 | 2004-04-22 | Pharmacia & Upjohn Company Llc | Antimicrobial 1-aryl dihydropyridone compounds |
| JP2006516991A (ja) * | 2003-02-07 | 2006-07-13 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 抗菌剤 |
| DE602004014361D1 (de) | 2003-04-30 | 2008-07-24 | Morphochem Ag Komb Chemie | Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| WO2005070904A2 (en) * | 2003-06-03 | 2005-08-04 | Rib-X Pharmaceutical, Inc. | Sulfonamide compounds and methods of making and using the same |
| US6969726B2 (en) | 2003-06-03 | 2005-11-29 | Rib X Pharmaceuticals Inc | Biaryl heterocyclic compounds and methods of making and using the same |
| WO2005012270A2 (en) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same |
| DE10340485B4 (de) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| JP2007514782A (ja) | 2003-12-17 | 2007-06-07 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法 |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| ATE401326T1 (de) | 2003-12-18 | 2008-08-15 | Morphochem Ag Komb Chemie | Oxazolidinon-chinolon hybrid antibiotika |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| KR101394307B1 (ko) | 2005-06-08 | 2014-05-13 | 멜린타 테라퓨틱스, 인크. | 트리아졸의 합성 방법 |
| AT503354B1 (de) * | 2006-02-22 | 2008-07-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen |
| JP4518066B2 (ja) * | 2006-10-25 | 2010-08-04 | 宇部興産株式会社 | ジアルコキシニトリル誘導体及びその製法 |
| CN110423610B (zh) * | 2019-08-29 | 2023-05-12 | 浙江理工大学 | 一种检测双光子汞离子荧光探针及其制备方法与使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2045049A1 (de) * | 1970-09-11 | 1972-03-23 | Dr Karl Thomae GmbH, 7950 Biberach | Neue Nitrofurandenvate und Ver fahren zu ihrer Herstellung |
| US4000155A (en) * | 1975-12-11 | 1976-12-28 | Eli Lilly And Company | Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones] |
| ES2111188T3 (es) * | 1992-12-08 | 1998-03-01 | Upjohn Co | Agentes antibacterianos derivados de feniloxazolidinona sustituida con tropona. |
| AU6902096A (en) * | 1995-09-15 | 1997-04-01 | Pharmacia & Upjohn Company | 5-amidomethyl alpha, beta-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents |
| GB9521508D0 (en) * | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
| PT920421E (pt) * | 1996-08-21 | 2003-03-31 | Upjohn Co | Derivados de isoxazolina uteis como agentes antimicrobianos |
-
1999
- 1999-08-19 TW TW88114208A patent/TW572757B/zh active
- 1999-08-23 TR TR2001/00672T patent/TR200100672T2/xx unknown
- 1999-08-23 PL PL99346267A patent/PL346267A1/xx not_active Application Discontinuation
- 1999-08-23 WO PCT/US1999/019265 patent/WO2000010566A1/en not_active Application Discontinuation
- 1999-08-23 IL IL14154299A patent/IL141542A0/xx unknown
- 1999-08-23 CZ CZ2001669A patent/CZ2001669A3/cs unknown
- 1999-08-23 BR BR9913225-7A patent/BR9913225A/pt not_active IP Right Cessation
- 1999-08-23 ID IDW20010439A patent/ID27690A/id unknown
- 1999-08-23 CA CA002341271A patent/CA2341271A1/en not_active Abandoned
- 1999-08-23 CN CN99809894A patent/CN1314813A/zh active Pending
- 1999-08-23 HU HU0103433A patent/HUP0103433A3/hu unknown
- 1999-08-23 NZ NZ509867A patent/NZ509867A/en unknown
- 1999-08-23 KR KR1020017002377A patent/KR20010072945A/ko not_active Application Discontinuation
- 1999-08-23 JP JP2000565887A patent/JP2002523369A/ja active Pending
- 1999-08-23 CO CO99053191A patent/CO5160266A1/es unknown
- 1999-08-23 EP EP99945157A patent/EP1107756A4/en not_active Withdrawn
- 1999-08-23 AU AU57833/99A patent/AU748750B2/en not_active Ceased
- 1999-08-24 UY UY25677A patent/UY25677A1/es unknown
- 1999-08-24 PE PE1999000853A patent/PE20001063A1/es not_active Application Discontinuation
- 1999-08-24 AR ARP990104229A patent/AR020250A1/es not_active Application Discontinuation
-
2001
- 2001-02-22 ZA ZA200101505A patent/ZA200101505B/en unknown
- 2001-02-23 NO NO20010916A patent/NO20010916L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20010916D0 (no) | 2001-02-23 |
| CO5160266A1 (es) | 2002-05-30 |
| ID27690A (id) | 2001-04-19 |
| CN1314813A (zh) | 2001-09-26 |
| WO2000010566A1 (en) | 2000-03-02 |
| AU5783399A (en) | 2000-03-14 |
| ZA200101505B (en) | 2002-02-22 |
| PE20001063A1 (es) | 2000-12-24 |
| UY25677A1 (es) | 2001-08-27 |
| HUP0103433A2 (hu) | 2002-01-28 |
| CA2341271A1 (en) | 2000-03-02 |
| KR20010072945A (ko) | 2001-07-31 |
| NO20010916L (no) | 2001-04-10 |
| PL346267A1 (en) | 2002-01-28 |
| AR020250A1 (es) | 2002-05-02 |
| BR9913225A (pt) | 2001-05-22 |
| TR200100672T2 (tr) | 2001-07-23 |
| JP2002523369A (ja) | 2002-07-30 |
| IL141542A0 (en) | 2002-03-10 |
| EP1107756A4 (en) | 2003-02-26 |
| NZ509867A (en) | 2003-08-29 |
| CZ2001669A3 (cs) | 2001-08-15 |
| HUP0103433A3 (en) | 2002-08-28 |
| EP1107756A1 (en) | 2001-06-20 |
| TW572757B (en) | 2004-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| NB | Applications allowed - extensions of time section 223(2) |
Free format text: THE TIME IN WHICH TO PROVIDE SEARCH RESULTS UNDER S45(3) HAS BEEN EXTENDED TO 20040401 |