AU747993B2 - Process for obtaining l-dihydroorotic acid and use thereof - Google Patents

Process for obtaining l-dihydroorotic acid and use thereof Download PDF

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Publication number
AU747993B2
AU747993B2 AU18775/99A AU1877599A AU747993B2 AU 747993 B2 AU747993 B2 AU 747993B2 AU 18775/99 A AU18775/99 A AU 18775/99A AU 1877599 A AU1877599 A AU 1877599A AU 747993 B2 AU747993 B2 AU 747993B2
Authority
AU
Australia
Prior art keywords
dho
dihydroorotic acid
serum
cells
mpa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU18775/99A
Other languages
English (en)
Other versions
AU1877599A (en
Inventor
Robert Bartlett
Claude Fudali
Ulrike Milbert
Eric Ruuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Publication of AU1877599A publication Critical patent/AU1877599A/en
Application granted granted Critical
Publication of AU747993B2 publication Critical patent/AU747993B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
AU18775/99A 1997-12-11 1998-12-08 Process for obtaining l-dihydroorotic acid and use thereof Ceased AU747993B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97121848A EP0933633A1 (en) 1997-12-11 1997-12-11 Process for obtaining L-dihydroorotic acid and use thereof
EP97121848 1997-12-11
PCT/EP1998/007972 WO1999030146A1 (en) 1997-12-11 1998-12-08 Process for obtaining l-dihydroorotic acid and use thereof

Publications (2)

Publication Number Publication Date
AU1877599A AU1877599A (en) 1999-06-28
AU747993B2 true AU747993B2 (en) 2002-05-30

Family

ID=8227782

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18775/99A Ceased AU747993B2 (en) 1997-12-11 1998-12-08 Process for obtaining l-dihydroorotic acid and use thereof

Country Status (20)

Country Link
US (1) US6545006B1 (cs)
EP (2) EP0933633A1 (cs)
JP (1) JP4189124B2 (cs)
KR (1) KR100700906B1 (cs)
CN (1) CN1237345C (cs)
AR (1) AR016430A1 (cs)
AT (1) ATE305610T1 (cs)
AU (1) AU747993B2 (cs)
BR (1) BR9813559A (cs)
CA (1) CA2315326A1 (cs)
CZ (1) CZ299968B6 (cs)
DE (1) DE69831752T2 (cs)
DK (1) DK1036319T3 (cs)
ES (1) ES2248927T3 (cs)
HU (1) HUP0004510A3 (cs)
ID (1) ID24807A (cs)
PL (1) PL194068B1 (cs)
RU (1) RU2228932C2 (cs)
TR (1) TR200001671T2 (cs)
WO (1) WO1999030146A1 (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0204069A3 (en) * 1999-12-16 2005-01-28 Teva Pharma Novel processes for making- and a new crystalline form of- leflunomide and pharmaceutical composition containing it
EP2857010B1 (en) * 2012-05-29 2018-07-04 Institute of Mitochondria Science, Inc. Dihydroorotic acid dehydrogenase inhibitor
US10708575B2 (en) 2012-06-25 2020-07-07 Sharp Kabushiki Kaisha Display system with diffuse and specular reflective modes
US9679506B2 (en) 2012-06-25 2017-06-13 Sharp Kabushiki Kaisha Multiple function display system
CN102787147B (zh) * 2012-08-31 2014-10-08 南京工业大学 一种酶法制备l-二氢乳清酸的方法
US10699612B2 (en) 2014-10-27 2020-06-30 Sharp Kabushiki Kaisha Display system with specular reflective mode
CN112305097A (zh) * 2020-09-30 2021-02-02 辰欣药业股份有限公司 一种特立氟胺片有关物质的检测方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2773872A (en) * 1954-04-12 1956-12-11 Merck & Co Inc Dihydroorotic acid
EP0769296A1 (de) * 1995-10-25 1997-04-23 Hoechst Aktiengesellschaft Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Herstellung eines Arzneimittels zur Behandlung von Krebserkrankungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178201B (en) * 1977-08-05 1982-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted orto-acids and dihydro-orto-acids and derivatives thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2773872A (en) * 1954-04-12 1956-12-11 Merck & Co Inc Dihydroorotic acid
EP0769296A1 (de) * 1995-10-25 1997-04-23 Hoechst Aktiengesellschaft Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Herstellung eines Arzneimittels zur Behandlung von Krebserkrankungen

Also Published As

Publication number Publication date
CA2315326A1 (en) 1999-06-17
CN1237345C (zh) 2006-01-18
JP4189124B2 (ja) 2008-12-03
KR100700906B1 (ko) 2007-03-29
PL341205A1 (en) 2001-03-26
ES2248927T3 (es) 2006-03-16
AR016430A1 (es) 2001-07-04
ATE305610T1 (de) 2005-10-15
BR9813559A (pt) 2000-10-10
DK1036319T3 (da) 2006-01-16
DE69831752T2 (de) 2006-06-22
HUP0004510A3 (en) 2003-05-28
CZ299968B6 (cs) 2009-01-07
EP0933633A1 (en) 1999-08-04
EP1036319B1 (en) 2005-09-28
WO1999030146A1 (en) 1999-06-17
CZ20002134A3 (cs) 2000-10-11
KR20010032978A (ko) 2001-04-25
HK1033171A1 (en) 2001-08-17
DE69831752D1 (de) 2006-02-09
PL194068B1 (pl) 2007-04-30
US6545006B1 (en) 2003-04-08
CN1281550A (zh) 2001-01-24
AU1877599A (en) 1999-06-28
ID24807A (id) 2000-08-24
TR200001671T2 (tr) 2000-11-21
EP1036319A1 (en) 2000-09-20
RU2228932C2 (ru) 2004-05-20
JP2001526387A (ja) 2001-12-18
HUP0004510A1 (hu) 2001-04-28

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