AU743827B2 - Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof - Google Patents
Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof Download PDFInfo
- Publication number
- AU743827B2 AU743827B2 AU71034/98A AU7103498A AU743827B2 AU 743827 B2 AU743827 B2 AU 743827B2 AU 71034/98 A AU71034/98 A AU 71034/98A AU 7103498 A AU7103498 A AU 7103498A AU 743827 B2 AU743827 B2 AU 743827B2
- Authority
- AU
- Australia
- Prior art keywords
- amyloid
- peptide
- terminus
- specific
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4185097P | 1997-04-09 | 1997-04-09 | |
US60/041850 | 1997-04-09 | ||
PCT/US1998/006900 WO1998044955A1 (en) | 1997-04-09 | 1998-04-09 | Recombinant antibodies specific for beta-amyloid ends, dna encoding and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7103498A AU7103498A (en) | 1998-10-30 |
AU743827B2 true AU743827B2 (en) | 2002-02-07 |
Family
ID=21918670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU71034/98A Ceased AU743827B2 (en) | 1997-04-09 | 1998-04-09 | Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof |
Country Status (16)
Country | Link |
---|---|
US (2) | US20090069258A1 (pt-PT) |
EP (3) | EP0994728B1 (pt-PT) |
JP (3) | JP3816111B2 (pt-PT) |
CN (1) | CN1177616C (pt-PT) |
AT (1) | ATE402717T1 (pt-PT) |
AU (1) | AU743827B2 (pt-PT) |
CA (1) | CA2286305A1 (pt-PT) |
CY (1) | CY1110371T1 (pt-PT) |
DE (1) | DE69839808D1 (pt-PT) |
DK (1) | DK0994728T3 (pt-PT) |
ES (1) | ES2312185T3 (pt-PT) |
IL (1) | IL132262A (pt-PT) |
NZ (1) | NZ337765A (pt-PT) |
PT (1) | PT994728E (pt-PT) |
SI (1) | SI0994728T1 (pt-PT) |
WO (1) | WO1998044955A1 (pt-PT) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
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US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
AU2008203784B2 (en) * | 1999-05-28 | 2012-01-19 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
AUPQ180499A0 (en) | 1999-07-23 | 1999-08-19 | Biomolecular Research Institute Limited | Beta-amyloid peptide inhibitors |
EP1307219A4 (en) * | 1999-08-13 | 2005-04-06 | Univ Columbia | PROCESS FOR INHIBITING THE BINDING OF BETA FOLDED FIBRILLES TO RAGE (ADVANCED GLYCATION ENDPRODUCT RECEPTOR) |
EP1237930B1 (en) | 1999-12-08 | 2006-11-08 | Intellect Neurosciences, Inc. | Chimeric amyloid beta peptides |
PL218883B1 (pl) | 2000-02-24 | 2015-02-27 | Lilly Co Eli | Kompozycja farmaceutyczna zawierająca przeciwciało do zastosowania w leczeniu klinicznej lub przedklinicznej choroby Alzheimera |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US6815175B2 (en) | 2001-03-16 | 2004-11-09 | Cornell Research Foundation, Inc. | Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder |
AU2002258808A1 (en) | 2001-04-30 | 2002-11-11 | Eli Lilly And Company | Humanized antibodies |
WO2002088307A2 (en) | 2001-04-30 | 2002-11-07 | Eli Lilly And Company | Humanized antibodies |
PT1944040E (pt) | 2001-08-17 | 2012-10-31 | Univ Washington | Método de avaliação para a doença de alzheimer |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
EP1523499A2 (en) * | 2002-07-24 | 2005-04-20 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
WO2004029629A1 (en) * | 2002-09-27 | 2004-04-08 | Janssen Pharmaceutica N.V. | N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses |
BR0315157A (pt) * | 2002-10-09 | 2005-08-09 | Rinat Neuroscience Corp | Métodos de tratar doença de alzheimer empregando-se anticorpos direcionados contra peptìdeo beta amilóide e composições deste |
ATE468886T1 (de) | 2003-02-10 | 2010-06-15 | Applied Molecular Evolution | Abeta-bindende moleküle |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
EP1797182A2 (en) * | 2004-10-05 | 2007-06-20 | Wyeth a Corporation of the State of Delaware | Methods and compositions for improving recombinant protein production |
GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
CA2590337C (en) | 2004-12-15 | 2017-07-11 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
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RU2008120027A (ru) * | 2005-10-21 | 2009-11-27 | Мерк энд Ко., Инк. (US) | Анти-addl моноклональное антитело и его применение |
CN1329413C (zh) * | 2006-01-23 | 2007-08-01 | 南京医科大学 | 一种治疗或预防老年性痴呆的抗体及其表达载体和在制药中的应用 |
SI2177536T1 (sl) * | 2006-03-30 | 2014-09-30 | Glaxo Group Limited | Protitelesa proti amiloidnemu peptidu beta |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
EA029481B1 (ru) | 2007-01-05 | 2018-04-30 | Юнивэсэти Оф Цюрих | Способ получения человеческого рекомбинантного антитела, специфично связывающего вариант эндогенного белка, формирующий аномальные патологические белковые структуры путем агрегации, олигомеризации или образования фибрилл |
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EP1944315A1 (en) * | 2007-01-11 | 2008-07-16 | Philipps-Universität Marburg | Prophylaxis and therapy of alzheimer's disease and other neurodementing diseases |
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- 1998-04-09 EP EP98918035A patent/EP0994728B1/en not_active Revoked
- 1998-04-09 EP EP10011650A patent/EP2305709A1/en not_active Withdrawn
- 1998-04-09 AT AT98918035T patent/ATE402717T1/de active
- 1998-04-09 CA CA002286305A patent/CA2286305A1/en not_active Abandoned
- 1998-04-09 JP JP54304398A patent/JP3816111B2/ja not_active Expired - Fee Related
- 1998-04-09 PT PT98918035T patent/PT994728E/pt unknown
- 1998-04-09 AU AU71034/98A patent/AU743827B2/en not_active Ceased
- 1998-04-09 WO PCT/US1998/006900 patent/WO1998044955A1/en active IP Right Grant
- 1998-04-09 ES ES98918035T patent/ES2312185T3/es not_active Expired - Lifetime
- 1998-04-09 SI SI9830913T patent/SI0994728T1/sl unknown
- 1998-04-09 EP EP08011798A patent/EP2006303A1/en not_active Withdrawn
- 1998-04-09 NZ NZ337765A patent/NZ337765A/en not_active IP Right Cessation
- 1998-04-09 DK DK98918035T patent/DK0994728T3/da active
- 1998-04-09 CN CNB988035464A patent/CN1177616C/zh not_active Expired - Fee Related
- 1998-04-09 DE DE69839808T patent/DE69839808D1/de not_active Expired - Lifetime
-
1999
- 1999-10-07 IL IL132262A patent/IL132262A/en not_active IP Right Cessation
-
2005
- 2005-07-20 JP JP2005210196A patent/JP2005320349A/ja active Pending
-
2007
- 2007-05-08 US US11/745,759 patent/US20090069258A1/en not_active Abandoned
-
2008
- 2008-10-30 CY CY20081101230T patent/CY1110371T1/el unknown
-
2009
- 2009-05-07 JP JP2009113001A patent/JP2009173680A/ja active Pending
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2010
- 2010-01-21 US US12/691,046 patent/US20110027279A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0683234A1 (en) * | 1993-01-25 | 1995-11-22 | Takeda Chemical Industries, Ltd. | ANTIBODY AGAINST $g(b)-AMYLOID OR DERIVATIVE THEREOF AND USE THEREOF |
Non-Patent Citations (1)
Title |
---|
HANAN ET AL (1996) INT & EXP CLIN INVEST 3, 130-3 * |
Also Published As
Publication number | Publication date |
---|---|
CY1110371T1 (el) | 2015-04-29 |
PT994728E (pt) | 2008-11-11 |
JP2005320349A (ja) | 2005-11-17 |
IL132262A (en) | 2009-11-18 |
ES2312185T3 (es) | 2009-02-16 |
EP0994728B1 (en) | 2008-07-30 |
JP3816111B2 (ja) | 2006-08-30 |
SI0994728T1 (sl) | 2009-02-28 |
EP2006303A1 (en) | 2008-12-24 |
US20090069258A1 (en) | 2009-03-12 |
EP2305709A1 (en) | 2011-04-06 |
DK0994728T3 (da) | 2008-12-01 |
CN1254294A (zh) | 2000-05-24 |
CA2286305A1 (en) | 1998-10-15 |
EP0994728A1 (en) | 2000-04-26 |
AU7103498A (en) | 1998-10-30 |
WO1998044955A1 (en) | 1998-10-15 |
JP2009173680A (ja) | 2009-08-06 |
DE69839808D1 (de) | 2008-09-11 |
CN1177616C (zh) | 2004-12-01 |
JP2002503092A (ja) | 2002-01-29 |
NZ337765A (en) | 2001-09-28 |
EP0994728A4 (en) | 2001-11-28 |
US20110027279A1 (en) | 2011-02-03 |
ATE402717T1 (de) | 2008-08-15 |
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