IL132262A - Recombinant antibodies specific for beta amyloid ends, dna encoding and method of use thereof - Google Patents
Recombinant antibodies specific for beta amyloid ends, dna encoding and method of use thereofInfo
- Publication number
- IL132262A IL132262A IL132262A IL13226299A IL132262A IL 132262 A IL132262 A IL 132262A IL 132262 A IL132262 A IL 132262A IL 13226299 A IL13226299 A IL 13226299A IL 132262 A IL132262 A IL 132262A
- Authority
- IL
- Israel
- Prior art keywords
- antibody
- amyloid
- peptide
- gene
- terminus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4185097P | 1997-04-09 | 1997-04-09 | |
PCT/US1998/006900 WO1998044955A1 (en) | 1997-04-09 | 1998-04-09 | Recombinant antibodies specific for beta-amyloid ends, dna encoding and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IL132262A true IL132262A (en) | 2009-11-18 |
Family
ID=21918670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL132262A IL132262A (en) | 1997-04-09 | 1999-10-07 | Recombinant antibodies specific for beta amyloid ends, dna encoding and method of use thereof |
Country Status (16)
Country | Link |
---|---|
US (2) | US20090069258A1 (pt-PT) |
EP (3) | EP2305709A1 (pt-PT) |
JP (3) | JP3816111B2 (pt-PT) |
CN (1) | CN1177616C (pt-PT) |
AT (1) | ATE402717T1 (pt-PT) |
AU (1) | AU743827B2 (pt-PT) |
CA (1) | CA2286305A1 (pt-PT) |
CY (1) | CY1110371T1 (pt-PT) |
DE (1) | DE69839808D1 (pt-PT) |
DK (1) | DK0994728T3 (pt-PT) |
ES (1) | ES2312185T3 (pt-PT) |
IL (1) | IL132262A (pt-PT) |
NZ (1) | NZ337765A (pt-PT) |
PT (1) | PT994728E (pt-PT) |
SI (1) | SI0994728T1 (pt-PT) |
WO (1) | WO1998044955A1 (pt-PT) |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
AU2008203784B2 (en) * | 1999-05-28 | 2012-01-19 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
AUPQ180499A0 (en) | 1999-07-23 | 1999-08-19 | Biomolecular Research Institute Limited | Beta-amyloid peptide inhibitors |
EP1307219A4 (en) * | 1999-08-13 | 2005-04-06 | Univ Columbia | PROCESS FOR INHIBITING THE BINDING OF BETA FOLDED FIBRILLES TO RAGE (ADVANCED GLYCATION ENDPRODUCT RECEPTOR) |
IL149976A0 (en) | 1999-12-08 | 2002-12-01 | Mindset Biopharmaceuticals Usa | Chimeric peptides as immunogens, antibodies thereto, and methods for immunization using chimeric peptides or antibodies |
PL210157B1 (pl) | 2000-02-24 | 2011-12-30 | Lilly Co Eli | Humanizowane przeciwciało lub jego fragment, kwas polinukleinowy, wektor ekspresyjny do ekspresji przeciwciała lub jego fragmentu, komórka transfekowana wektorem ekspresyjnym, kompozycja farmaceutyczna i zastosowanie humanizowanego przeciwciała lub jego fragmentu do leczenia choroby Alzheimera |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US6815175B2 (en) | 2001-03-16 | 2004-11-09 | Cornell Research Foundation, Inc. | Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder |
US7320790B2 (en) | 2001-04-30 | 2008-01-22 | Eli Lilly And Company | Humanized antibodies |
ES2318006T3 (es) | 2001-04-30 | 2009-05-01 | Eli Lilly And Company | Anticuerpos humanizados que reconocen el peptido beta-amiloide. |
DK1944040T3 (da) | 2001-08-17 | 2012-10-29 | Univ Washington | Analysefremgangsmåde for Alzheimers sygdom |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
EP1523499A2 (en) * | 2002-07-24 | 2005-04-20 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
WO2004029629A1 (en) * | 2002-09-27 | 2004-04-08 | Janssen Pharmaceutica N.V. | N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses |
BR0315157A (pt) * | 2002-10-09 | 2005-08-09 | Rinat Neuroscience Corp | Métodos de tratar doença de alzheimer empregando-se anticorpos direcionados contra peptìdeo beta amilóide e composições deste |
EP1596809B1 (en) | 2003-02-10 | 2010-05-26 | Applied Molecular Evolution, Inc. | Abeta binding molecules |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
TWI374893B (en) | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
EP1797182A2 (en) * | 2004-10-05 | 2007-06-20 | Wyeth a Corporation of the State of Delaware | Methods and compositions for improving recombinant protein production |
WO2007050359A2 (en) * | 2005-10-21 | 2007-05-03 | Merck & Co., Inc. | Anti-addl monoclonal antibody and use thereof |
GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
WO2006066089A1 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
EP1841455A1 (en) | 2005-01-24 | 2007-10-10 | Amgen Inc. | Humanized anti-amyloid antibody |
CN1329413C (zh) * | 2006-01-23 | 2007-08-01 | 南京医科大学 | 一种治疗或预防老年性痴呆的抗体及其表达载体和在制药中的应用 |
ES2338179T3 (es) * | 2006-03-30 | 2010-05-04 | Glaxo Group Limited | Anticuerpos contra el peptido beta-amiloide. |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
CN101622275B (zh) | 2007-01-05 | 2013-11-06 | 苏黎世大学 | 提供疾患特异性结合分子和靶的方法 |
ES2610474T3 (es) | 2007-01-11 | 2017-04-27 | Michael Bacher | Diagnóstico y tratamiento de la enfermedad de Alzheimer y otras enfermedades neurodegenerativas causantes de demencia |
EP1944315A1 (en) * | 2007-01-11 | 2008-07-16 | Philipps-Universität Marburg | Prophylaxis and therapy of alzheimer's disease and other neurodementing diseases |
LT2842967T (lt) | 2007-01-18 | 2017-02-27 | Eli Lilly And Company | Beta amiloido pegilintas fab |
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JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
BRPI0923157B1 (pt) | 2008-12-19 | 2021-12-28 | University Of Zürich | Anticorpos anti-alfa-sinucleína e seus fragmentos, seus usos e método de preparação, composição compreendendo-os, bem como kit e métodos para o diagnóstico e monitoramento de uma doença sinucleinopática |
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EP2598236A2 (en) * | 2010-07-30 | 2013-06-05 | Technische Universität Dortmund | Polymeric complements to b-amyloid peptides |
CN103189507A (zh) * | 2010-10-27 | 2013-07-03 | 学校法人自治医科大学 | 用于向神经系统细胞导入基因的腺相关病毒粒子 |
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KR20180078347A (ko) | 2014-04-10 | 2018-07-09 | 화이자 인코포레이티드 | 2-아미노-6-메틸-4,4a,5,6-테트라히드로피라노[3,4-d][1,3]티아진-8a(8H)-일-1,3-티아졸-4-일 아미드 |
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MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
ES2818806T3 (es) | 2015-02-03 | 2021-04-14 | Pfizer | Novedosas ciclopropabenzofuranil piridopirazindionas |
KR102426986B1 (ko) | 2015-06-17 | 2022-07-28 | 화이자 인코포레이티드 | 삼환형 화합물 및 포스포다이에스터라제 억제제로서 이의 용도 |
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-
1998
- 1998-04-09 EP EP10011650A patent/EP2305709A1/en not_active Withdrawn
- 1998-04-09 ES ES98918035T patent/ES2312185T3/es not_active Expired - Lifetime
- 1998-04-09 AT AT98918035T patent/ATE402717T1/de active
- 1998-04-09 CA CA002286305A patent/CA2286305A1/en not_active Abandoned
- 1998-04-09 EP EP98918035A patent/EP0994728B1/en not_active Revoked
- 1998-04-09 PT PT98918035T patent/PT994728E/pt unknown
- 1998-04-09 SI SI9830913T patent/SI0994728T1/sl unknown
- 1998-04-09 EP EP08011798A patent/EP2006303A1/en not_active Withdrawn
- 1998-04-09 JP JP54304398A patent/JP3816111B2/ja not_active Expired - Fee Related
- 1998-04-09 WO PCT/US1998/006900 patent/WO1998044955A1/en active IP Right Grant
- 1998-04-09 CN CNB988035464A patent/CN1177616C/zh not_active Expired - Fee Related
- 1998-04-09 DK DK98918035T patent/DK0994728T3/da active
- 1998-04-09 DE DE69839808T patent/DE69839808D1/de not_active Expired - Lifetime
- 1998-04-09 AU AU71034/98A patent/AU743827B2/en not_active Ceased
- 1998-04-09 NZ NZ337765A patent/NZ337765A/en not_active IP Right Cessation
-
1999
- 1999-10-07 IL IL132262A patent/IL132262A/en not_active IP Right Cessation
-
2005
- 2005-07-20 JP JP2005210196A patent/JP2005320349A/ja active Pending
-
2007
- 2007-05-08 US US11/745,759 patent/US20090069258A1/en not_active Abandoned
-
2008
- 2008-10-30 CY CY20081101230T patent/CY1110371T1/el unknown
-
2009
- 2009-05-07 JP JP2009113001A patent/JP2009173680A/ja active Pending
-
2010
- 2010-01-21 US US12/691,046 patent/US20110027279A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2005320349A (ja) | 2005-11-17 |
JP2009173680A (ja) | 2009-08-06 |
AU7103498A (en) | 1998-10-30 |
EP0994728B1 (en) | 2008-07-30 |
DK0994728T3 (da) | 2008-12-01 |
CN1254294A (zh) | 2000-05-24 |
EP0994728A4 (en) | 2001-11-28 |
US20110027279A1 (en) | 2011-02-03 |
EP2305709A1 (en) | 2011-04-06 |
ATE402717T1 (de) | 2008-08-15 |
CA2286305A1 (en) | 1998-10-15 |
ES2312185T3 (es) | 2009-02-16 |
JP2002503092A (ja) | 2002-01-29 |
EP0994728A1 (en) | 2000-04-26 |
CN1177616C (zh) | 2004-12-01 |
EP2006303A1 (en) | 2008-12-24 |
PT994728E (pt) | 2008-11-11 |
NZ337765A (en) | 2001-09-28 |
JP3816111B2 (ja) | 2006-08-30 |
WO1998044955A1 (en) | 1998-10-15 |
SI0994728T1 (sl) | 2009-02-28 |
US20090069258A1 (en) | 2009-03-12 |
DE69839808D1 (de) | 2008-09-11 |
CY1110371T1 (el) | 2015-04-29 |
AU743827B2 (en) | 2002-02-07 |
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