AU7101698A - Methods for fabricating enclosed microchannel structures - Google Patents

Methods for fabricating enclosed microchannel structures

Info

Publication number
AU7101698A
AU7101698A AU71016/98A AU7101698A AU7101698A AU 7101698 A AU7101698 A AU 7101698A AU 71016/98 A AU71016/98 A AU 71016/98A AU 7101698 A AU7101698 A AU 7101698A AU 7101698 A AU7101698 A AU 7101698A
Authority
AU
Australia
Prior art keywords
methods
microchannel structures
enclosed microchannel
fabricating
fabricating enclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU71016/98A
Other languages
English (en)
Inventor
M. Goretty Alonso Amigo
Herbert H. Hooper
David S. Soane
Zoya M Soane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Soane Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/853,661 external-priority patent/US6054034A/en
Application filed by Soane Biosciences Inc filed Critical Soane Biosciences Inc
Publication of AU7101698A publication Critical patent/AU7101698A/en
Abandoned legal-status Critical Current

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    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
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    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C66/731—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the intensive physical properties of the material of the parts to be joined
    • B29C66/7311—Thermal properties
    • B29C66/73117—Tg, i.e. glass transition temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/757—Moulds, cores, dies

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AU71016/98A 1997-04-04 1998-04-03 Methods for fabricating enclosed microchannel structures Abandoned AU7101698A (en)

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US83279097A 1997-04-04 1997-04-04
US08832790 1997-04-04
US08853661 1997-05-09
US08/853,661 US6054034A (en) 1990-02-28 1997-05-09 Acrylic microchannels and their use in electrophoretic applications
US08/878,437 US6176962B1 (en) 1990-02-28 1997-06-18 Methods for fabricating enclosed microchannel structures
US08878437 1997-06-18
PCT/US1998/006689 WO1998045693A1 (en) 1997-04-04 1998-04-03 Methods for fabricating enclosed microchannel structures

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Families Citing this family (348)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485625B1 (en) * 1995-05-09 2002-11-26 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
DE19815632C2 (de) * 1998-04-07 2001-02-15 Max Planck Gesellschaft Klebstoff-freie Verbindungen von Polymerbauteilen zur Erzeugung von geschlossenen Mikro- und Nanokanalstrukturen
US6123798A (en) * 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
EP1046032A4 (en) 1998-05-18 2002-05-29 Univ Washington LIQUID ANALYSIS CARTRIDGE
JP2002523741A (ja) * 1998-08-19 2002-07-30 イェーノプティク アクチエンゲゼルシャフト 極少量の液体を搬送する装置およびその製造方法
JP4178653B2 (ja) * 1999-02-26 2008-11-12 日立化成工業株式会社 電気泳動用チップとその製造方法、該電気泳動用チップを用いた電気泳動装置及び荷電性物質の分離方法
JP4178654B2 (ja) * 1999-02-26 2008-11-12 日立化成工業株式会社 電気泳動用チップとその製造方法、該電気泳動用チップを用いた電気泳動装置及び荷電性物質の分離方法
JP2000310615A (ja) * 1999-02-26 2000-11-07 Hitachi Chem Co Ltd 電気泳動用チップとその製造方法、該電気泳動用チップを用いた電気泳動装置及び荷電性物質の分離方法
US6503359B2 (en) 1999-03-05 2003-01-07 Burstein Technologies, Inc. Monomolecular adhesion methods for manufacturing microfabricated multilaminate devices
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
DE19927533B4 (de) * 1999-06-16 2004-03-04 Merck Patent Gmbh Miniaturisiertes Analysensystem
GB2385014B (en) * 1999-06-21 2003-10-15 Micro Chemical Systems Ltd Method of preparing a working solution
US7517442B1 (en) 1999-08-09 2009-04-14 Life Technologies Corporation Facile method and apparatus for the analysis of biological macromolecules in two dimensions using common and familiar electrophoresis formats
AU7101000A (en) * 1999-09-10 2001-04-10 Caliper Technologies Corporation Microfabrication methods and devices
DE19947496C2 (de) * 1999-10-01 2003-05-22 Agilent Technologies Inc Mikrofluidischer Mikrochip
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2394438A1 (en) * 1999-12-17 2001-06-21 Motorola, Inc. Devices and methods for making bioarrays
SE0000300D0 (sv) * 2000-01-30 2000-01-30 Amersham Pharm Biotech Ab Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly
DE10004853C1 (de) * 2000-02-03 2001-04-26 Fraunhofer Ges Forschung Verfahren zum dauerhaften Verbinden von Polymerbauteilen mit Bauteilen aus gleichartigem oder andersartigem Material
AU2001245549A1 (en) * 2000-03-10 2001-09-24 Dna Sciences, Inc. Cross channel device for serial sample injection
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
DE10029946A1 (de) * 2000-06-17 2001-12-20 Merck Patent Gmbh Integrierte optische Wellenleiter für mikrofluidische Analysensysteme
EP1309404A2 (en) 2000-08-07 2003-05-14 Nanostream, Inc. Fluidic mixer in microfluidic system
US6890093B2 (en) 2000-08-07 2005-05-10 Nanostream, Inc. Multi-stream microfludic mixers
EP1320741A4 (en) 2000-09-18 2006-09-06 Univ Washington MICROFLUIDIC EQUIPMENT FOR TORQUE MANIPULATION OF THE FLUIDIC INTERFACE BETWEEN SEVERAL FLOWS
US6939451B2 (en) 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
DE10153663B4 (de) * 2000-11-03 2005-05-25 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Mikroanalytische Vorrichtung zum Erfassen von Nahe-Infrarot-Strahlung emittierenden Molekülen
US20020079220A1 (en) * 2000-11-09 2002-06-27 Pawliszyn Janusz B. Micromachining using printing technology
WO2002060582A2 (en) * 2000-11-16 2002-08-08 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
WO2002041004A2 (en) 2000-11-16 2002-05-23 Burstein Technologies, Inc. Optical biodiscs with reflective layers
US7087203B2 (en) * 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US6942778B1 (en) 2000-11-28 2005-09-13 Nanogen, Inc. Microstructure apparatus and method for separating differently charged molecules using an applied electric field
US6649078B2 (en) * 2000-12-06 2003-11-18 The Regents Of The University Of California Thin film capillary process and apparatus
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
US7079468B2 (en) 2000-12-08 2006-07-18 Burstein Technologies, Inc. Optical discs for measuring analytes
US7091034B2 (en) 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
US20020129664A1 (en) * 2001-01-16 2002-09-19 Jorgenson James W. Non-invasive real-time flow meter and related flow measuring method
US7070681B2 (en) * 2001-01-24 2006-07-04 The Board Of Trustees Of The Leland Stanford Junior University Electrokinetic instability micromixer
US20020100714A1 (en) * 2001-01-31 2002-08-01 Sau Lan Tang Staats Microfluidic devices
US7601286B2 (en) 2001-03-26 2009-10-13 Lawrence Livermore National Security, Llc Polymer-based platform for microfluidic systems
US20040058437A1 (en) * 2001-04-10 2004-03-25 Rodgers Seth T. Materials and reactor systems having humidity and gas control
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
US20050032204A1 (en) * 2001-04-10 2005-02-10 Bioprocessors Corp. Microreactor architecture and methods
US7601251B2 (en) 2001-05-10 2009-10-13 Life Technologies Corporation Methods and apparatus for low resistance electrophoresis of prior-cast, hydratable separation media
DE10130428B4 (de) * 2001-06-23 2005-12-22 Boehringer Ingelheim Microparts Gmbh Verfahren zum flächenartigen Verbinden von Körpern
US6835293B2 (en) 2001-07-09 2004-12-28 Greiner Bio-One Gmbh Analysis system
AT500433B1 (de) * 2001-07-09 2008-09-15 Greiner Bio One Gmbh Analysevorrichtung
US6969489B2 (en) 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
US6803568B2 (en) * 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
EP1296133A1 (fr) * 2001-09-21 2003-03-26 Jean Brunner Dispositif miniaturisé destiné au transport et à l'analyse d'un échantillon liquide et son procédé de fabrication
US6942018B2 (en) 2001-09-28 2005-09-13 The Board Of Trustees Of The Leland Stanford Junior University Electroosmotic microchannel cooling system
US7134486B2 (en) * 2001-09-28 2006-11-14 The Board Of Trustees Of The Leeland Stanford Junior University Control of electrolysis gases in electroosmotic pump systems
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
CN1604810A (zh) * 2001-10-19 2005-04-06 创新建筑及建材有限责任公司 对于传染性气载微生物具有防护能力的抗致病性空气过滤介质和空气处理装置
WO2003055660A2 (en) * 2001-10-26 2003-07-10 Aclara Biosciences Inc. System and method for injection molded micro-replication of micro-fluidic substrates
DE10156767A1 (de) * 2001-11-19 2003-05-28 Rkt Rodinger Kunststoff Techni Verfahren zum Herstellen von Mikro-Fluidikkomponenten, Mikro-Fluidikkomponenten und Werkzeug zum Herstellen von Mikro-Fluidikkomponenten
US20030098661A1 (en) * 2001-11-29 2003-05-29 Ken Stewart-Smith Control system for vehicle seats
DE10159091A1 (de) * 2001-12-01 2003-06-12 Evotec Ag Trägersysteme und Verfahren zu ihrer Herstellung
AU2002351291A1 (en) 2001-12-06 2003-06-23 Nanostream, Inc. Adhesiveless microfluidic device fabrication
US7105810B2 (en) 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
US7238255B2 (en) * 2001-12-31 2007-07-03 Gyros Patent Ab Microfluidic device and its manufacture
US20030133222A1 (en) * 2002-01-11 2003-07-17 Ong Boon Seng Method and apparatus for sealing disc drives
US6877892B2 (en) 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers
US20040241381A1 (en) * 2002-01-31 2004-12-02 Chen Yihfar Microfluidic structures with circumferential grooves for bonding adhesives and related optical analysis discs
US6606251B1 (en) * 2002-02-07 2003-08-12 Cooligy Inc. Power conditioning module
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
WO2004048929A2 (en) * 2002-11-22 2004-06-10 Solus Biosystems, Inc. High throughput screening with parallel vibrational spectroscopy
US20050211555A1 (en) * 2002-02-14 2005-09-29 Solus Biosystems, Inc. Method for multiple sample screening using IR spectroscopy
US7033542B2 (en) * 2002-02-14 2006-04-25 Archibald William B High throughput screening with parallel vibrational spectroscopy
EP2100617A1 (en) 2002-03-15 2009-09-16 Schering Corporation Methods of modulating CD200 receptors
EP1352688A1 (fr) 2002-04-09 2003-10-15 Jean Brunner Porte échantillon miniaturisé
US7112444B2 (en) * 2002-04-24 2006-09-26 Wisconsin Alumni Research Foundation Method of performing gradient-based assays in a microfluidic device
CN1650171B (zh) * 2002-04-30 2012-10-03 爱科来株式会社 分析用具
US6808644B2 (en) * 2002-05-02 2004-10-26 Institute Of Microelectronics Capillary with glass internal surface
US6878523B2 (en) 2002-05-08 2005-04-12 Gentel Bio Surfaces, Inc. Molecular interaction assays on a solid surface
US20030211478A1 (en) * 2002-05-08 2003-11-13 Gentel Corporation Transcription factor profiling on a solid surface
US20040009516A1 (en) * 2002-05-08 2004-01-15 Nelson Bryce P. Arrayed SPR prism
EP1504248A1 (en) 2002-05-10 2005-02-09 Applera Corporation Imaging system for reduction of interstitial image regions and its related method
US7122093B1 (en) * 2002-05-14 2006-10-17 The Ohio State University Gas-assisted resin injection technique for bonding and surface modification in micro-fluidic devices
WO2003099073A1 (en) * 2002-05-23 2003-12-04 Rubbermaid Incorporated Slip-resistant step stool and a method of manufacturing the same
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
US20030232450A1 (en) * 2002-06-13 2003-12-18 Yoshikazu Yoshida Microfluidic device and method for producing the same
US7235164B2 (en) * 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7517440B2 (en) 2002-07-17 2009-04-14 Eksigent Technologies Llc Electrokinetic delivery systems, devices and methods
US7364647B2 (en) * 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
CA2498362C (en) * 2002-09-11 2012-11-06 Temple University - Of The Commonwealth System Of Higher Education Automated system for high-throughput electrophoretic separations
JP3725109B2 (ja) * 2002-09-19 2005-12-07 財団法人生産技術研究奨励会 マイクロ流体デバイス
AU2003270882A1 (en) 2002-09-23 2004-05-04 Cooligy, Inc. Micro-fabricated electrokinetic pump with on-frit electrode
US6881039B2 (en) 2002-09-23 2005-04-19 Cooligy, Inc. Micro-fabricated electrokinetic pump
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
EP1569510B1 (en) * 2002-09-27 2011-11-02 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US6994151B2 (en) * 2002-10-22 2006-02-07 Cooligy, Inc. Vapor escape microchannel heat exchanger
US20040076408A1 (en) * 2002-10-22 2004-04-22 Cooligy Inc. Method and apparatus for removeably coupling a heat rejection device with a heat producing device
US20040147045A1 (en) * 2002-10-29 2004-07-29 Gentel Biosurfaces, Inc. Signal molecule arrays
US6936167B2 (en) 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
AU2003287449A1 (en) 2002-10-31 2004-05-25 Nanostream, Inc. Parallel detection chromatography systems
US7010964B2 (en) 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
US7836597B2 (en) 2002-11-01 2010-11-23 Cooligy Inc. Method of fabricating high surface to volume ratio structures and their integration in microheat exchangers for liquid cooling system
US7104312B2 (en) 2002-11-01 2006-09-12 Cooligy, Inc. Method and apparatus for achieving temperature uniformity and hot spot cooling in a heat producing device
US7806168B2 (en) * 2002-11-01 2010-10-05 Cooligy Inc Optimal spreader system, device and method for fluid cooled micro-scaled heat exchange
US20050211417A1 (en) * 2002-11-01 2005-09-29 Cooligy,Inc. Interwoven manifolds for pressure drop reduction in microchannel heat exchangers
US6986382B2 (en) 2002-11-01 2006-01-17 Cooligy Inc. Interwoven manifolds for pressure drop reduction in microchannel heat exchangers
US20050211427A1 (en) * 2002-11-01 2005-09-29 Cooligy, Inc. Method and apparatus for flexible fluid delivery for cooling desired hot spots in a heat producing device
US7156159B2 (en) 2003-03-17 2007-01-02 Cooligy, Inc. Multi-level microchannel heat exchangers
US7000684B2 (en) 2002-11-01 2006-02-21 Cooligy, Inc. Method and apparatus for efficient vertical fluid delivery for cooling a heat producing device
EP1587834B1 (en) 2002-12-23 2011-07-06 Schering Corporation Uses of il-23 mammalian cytokine; related reagents
EP1594694A4 (en) 2002-12-30 2010-01-20 Univ California METHOD AND DEVICE FOR DETECTING AND ANALYZING DISEASES OF DISEASE
WO2004067444A1 (en) * 2003-01-30 2004-08-12 Gyros Ab Inner walls of microfluidic devices
US20090044928A1 (en) * 2003-01-31 2009-02-19 Girish Upadhya Method and apparatus for preventing cracking in a liquid cooling system
US7044196B2 (en) 2003-01-31 2006-05-16 Cooligy,Inc Decoupled spring-loaded mounting apparatus and method of manufacturing thereof
US7293423B2 (en) * 2004-06-04 2007-11-13 Cooligy Inc. Method and apparatus for controlling freezing nucleation and propagation
US7090001B2 (en) 2003-01-31 2006-08-15 Cooligy, Inc. Optimized multiple heat pipe blocks for electronics cooling
US7201012B2 (en) 2003-01-31 2007-04-10 Cooligy, Inc. Remedies to prevent cracking in a liquid system
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
EP1602623B1 (en) * 2003-03-07 2011-08-17 Tosoh Corporation Method of moulding a microfluidic structure and mould
BRPI0408247A (pt) 2003-03-10 2006-03-01 Schering Corp usos de antagonistas e agonistas de il-23 e reagentes relacionados
US7017654B2 (en) 2003-03-17 2006-03-28 Cooligy, Inc. Apparatus and method of forming channels in a heat-exchanging device
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US20050026273A1 (en) * 2003-06-05 2005-02-03 Zarur Andrey J. Reactor with memory component
CA2529285A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
FR2856047B1 (fr) * 2003-06-16 2005-07-15 Commissariat Energie Atomique Procede de collage de substrats micro-structures
US7309467B2 (en) * 2003-06-24 2007-12-18 Hewlett-Packard Development Company, L.P. Fluidic MEMS device
US7021369B2 (en) * 2003-07-23 2006-04-04 Cooligy, Inc. Hermetic closed loop fluid system
US7591302B1 (en) 2003-07-23 2009-09-22 Cooligy Inc. Pump and fan control concepts in a cooling system
DE10338967B4 (de) 2003-08-25 2007-02-22 Technische Universität Braunschweig Carolo-Wilhelmina Verfahren zum Kleben von Mikrobauteilen auf ein Substrat
WO2005028019A1 (en) * 2003-09-15 2005-03-31 The Regents Of The University Of Michigan Technology Management Office Shatter-resistant microprobes
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US20050100712A1 (en) * 2003-11-12 2005-05-12 Simmons Blake A. Polymerization welding and application to microfluidics
GB0327094D0 (en) * 2003-11-21 2003-12-24 Inverness Medical Switzerland Laminated device
KR100572207B1 (ko) 2003-12-18 2006-04-19 주식회사 디지탈바이오테크놀러지 플라스틱 마이크로 칩의 접합 방법
KR100535817B1 (ko) * 2003-12-26 2005-12-12 한국전자통신연구원 바이오 칩을 위한 플라스틱 구조체, 그를 이용한 미소가열기, 미소 반응기, 미소 반응기 어레이 및 마이크로어레이
WO2005066372A2 (en) * 2003-12-31 2005-07-21 Applera Corporation Quantitative amplification and detection of small numbers of target polynucleotides
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
ES2439225T3 (es) 2004-01-26 2014-01-22 President And Fellows Of Harvard College Sistema y método para el suministro de fluidos
NZ549040A (en) 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
JP4189424B2 (ja) * 2004-03-01 2008-12-03 パナソニック株式会社 バイオセンサチップおよびバイオセンサ装置
CA2557819A1 (en) * 2004-03-03 2005-09-15 The General Hospital Corporation Magnetic device for isolation of cells and biomolecules in a microfluidic environment
CN1957254B (zh) 2004-04-07 2012-01-25 沃德劳有限合伙公司 用于分析生物流体的可置换腔
JP2006030160A (ja) * 2004-04-14 2006-02-02 Hitachi Maxell Ltd 反応容器
US7559356B2 (en) * 2004-04-19 2009-07-14 Eksident Technologies, Inc. Electrokinetic pump driven heat transfer system
US7419639B2 (en) * 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
JP3952036B2 (ja) * 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 マイクロ流体デバイス並びに試液の試験方法および試験システム
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US7616444B2 (en) 2004-06-04 2009-11-10 Cooligy Inc. Gimballed attachment for multiple heat exchangers
US7188662B2 (en) 2004-06-04 2007-03-13 Cooligy, Inc. Apparatus and method of efficient fluid delivery for cooling a heat producing device
JP2008501365A (ja) * 2004-06-07 2008-01-24 バイオプロセッサーズ コーポレイション 反応器における剪断力の生成
EP1761331A2 (en) * 2004-06-07 2007-03-14 Bioprocessors Corporation Control of reactor environmental conditions
US20070036690A1 (en) * 2004-06-07 2007-02-15 Bioprocessors Corp. Inlet channel volume in a reactor
EP1765487A1 (en) * 2004-06-07 2007-03-28 Bioprocessors Corporation Reactor mixing
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US7211184B2 (en) * 2004-08-04 2007-05-01 Ast Management Inc. Capillary electrophoresis devices
US20060042785A1 (en) * 2004-08-27 2006-03-02 Cooligy, Inc. Pumped fluid cooling system and method
CN102759466A (zh) * 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
US7745207B2 (en) 2006-02-03 2010-06-29 IntegenX, Inc. Microfluidic devices
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7591883B2 (en) * 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
GB0421529D0 (en) * 2004-09-28 2004-10-27 Landegren Gene Technology Ab Microfluidic structure
US20060065361A1 (en) * 2004-09-30 2006-03-30 Matthias Stiene Process for manufacturing an analysis module with accessible electrically conductive contact pads for a microfluidic analytical system
US7402616B2 (en) * 2004-09-30 2008-07-22 Lifescan, Inc. Fusible conductive ink for use in manufacturing microfluidic analytical systems
US20060065532A1 (en) * 2004-09-30 2006-03-30 Matthias Stiene Microfluidic analytical system with accessible electrically conductive contact pads
US7608160B2 (en) * 2004-10-13 2009-10-27 Rheonix, Inc. Laminated microfluidic structures and method for making
US7837821B2 (en) 2004-10-13 2010-11-23 Rheonix, Inc. Laminated microfluidic structures and method for making
US7820168B2 (en) 2004-12-20 2010-10-26 Schering Corporation Treatment of diabetes using antibodies to IL-23, IL-23 receptor and IL-17
JP2006187685A (ja) * 2004-12-28 2006-07-20 Fuji Xerox Co Ltd 微小構造体、マイクロリアクタ、熱交換器、および微小構造体の製造方法
JP2006187684A (ja) * 2004-12-28 2006-07-20 Fuji Xerox Co Ltd マイクロ流体素子
JP2008527375A (ja) * 2005-01-18 2008-07-24 ソルス バイオシステムズ インコーポレイテッド 赤外線透過基板、半導体基板、珪素基板、流体サンプル分析装置、流体サンプル分析方法、及び計算機読み取り可能な記録媒体
US20060226117A1 (en) * 2005-03-29 2006-10-12 Bertram Ronald T Phase change based heating element system and method
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
NZ620811A (en) 2005-05-09 2015-09-25 Theranos Inc Point-of-care fluidic systems and uses thereof
US20070117873A1 (en) * 2005-05-13 2007-05-24 The Ohio State University Research Foundation Carbon nanofiber reinforced thermoplastic nanocomposite foams
WO2006123578A1 (ja) * 2005-05-19 2006-11-23 Konica Minolta Medical & Graphic, Inc. 検体中の標的物質を分析するための検査チップおよびマイクロ総合分析システム
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7390377B1 (en) 2005-09-22 2008-06-24 Sandia Corporation Bonding thermoplastic polymers
US8143337B1 (en) 2005-10-18 2012-03-27 The Ohio State University Method of preparing a composite with disperse long fibers and nanoparticles
US7731901B2 (en) 2005-10-19 2010-06-08 Abbott Laboratories Apparatus and method for performing counts within a biologic fluid sample
EP1941537A4 (en) * 2005-10-20 2010-03-31 Univ Ohio State MEDICAMENT AND GENERIC RELEASE OF A POLYMER NANODIUM AND A NANOSTOP CELL PLASTER
JP2007136292A (ja) * 2005-11-15 2007-06-07 National Institute Of Advanced Industrial & Technology マイクロチャネル構造体の製造方法、マイクロチャネル構造体、およびマイクロリアクタ
US8794929B2 (en) * 2005-11-23 2014-08-05 Eksigent Technologies Llc Electrokinetic pump designs and drug delivery systems
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US8741230B2 (en) * 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US20070244258A1 (en) * 2006-03-29 2007-10-18 Shanti Swarup Clear coating compositions with improved scratch resistance
TW200813695A (en) * 2006-03-30 2008-03-16 Cooligy Inc Integrated liquid to air conduction module
US7715194B2 (en) * 2006-04-11 2010-05-11 Cooligy Inc. Methodology of cooling multiple heat sources in a personal computer through the use of multiple fluid-based heat exchanging loops coupled via modular bus-type heat exchangers
HUE028594T2 (en) 2006-05-01 2016-12-28 Critical Care Diagnostics Inc Diagnosis of cardiovascular disease
US20100055683A1 (en) 2006-05-02 2010-03-04 Critical Care Diagnostics, Inc. Diagnosis of pulmonary and/or cardiovascular disease
US20070256825A1 (en) * 2006-05-04 2007-11-08 Conway Bruce R Methodology for the liquid cooling of heat generating components mounted on a daughter card/expansion card in a personal computer through the use of a remote drive bay heat exchanger with a flexible fluid interconnect
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US20080006396A1 (en) * 2006-06-30 2008-01-10 Girish Upadhya Multi-stage staggered radiator for high performance liquid cooling applications
KR100791363B1 (ko) * 2006-07-12 2008-01-03 한국과학기술원 미세유로 형성물 및 미세유체소자 제조방법
WO2008052138A2 (en) * 2006-10-25 2008-05-02 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated dna analysis system using same
MY158019A (en) 2006-10-25 2016-08-30 Proteus Digital Health Inc Controlled activation ingestible identifier
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
JP2008175795A (ja) * 2006-12-21 2008-07-31 Sumitomo Bakelite Co Ltd プラスチック製マイクロチップ、及びその製造方法、並びにそれを利用したバイオチップ又はマイクロ分析チップ
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
EP2109666A4 (en) * 2007-02-05 2011-09-14 Integenx Inc MICROFLUIDIC AND NANOFLUIDIC DEVICES, SYSTEMS, AND APPLICATIONS
US20080221805A1 (en) * 2007-03-09 2008-09-11 David Richard Andrews Multi-channel lock-in amplifier system and method
US8506908B2 (en) * 2007-03-09 2013-08-13 Vantix Holdings Limited Electrochemical detection system
ES2687620T3 (es) 2007-05-04 2018-10-26 Opko Diagnostics, Llc Dispositivo y método para análisis en sistemas microfluídicos
US20080296158A1 (en) 2007-05-31 2008-12-04 Sharp Kabushiki Kaisha Device for electrophoresis, device for transfer, device for electrophoresis and transfer, chip for electrophoresis and transfer, and method for electrophoresis, method for transfer, and method for electrophoresis and transfer
WO2009015296A1 (en) * 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
TW200924625A (en) * 2007-08-07 2009-06-01 Cooligy Inc Deformable duct guides that accommodate electronic connection lines
EP2205958B1 (en) * 2007-10-29 2019-04-24 Koninklijke Philips N.V. Frustrated total internal reflection system
WO2009076134A1 (en) * 2007-12-11 2009-06-18 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
CN101990516B (zh) 2008-01-22 2015-09-09 英特基因有限公司 多用试样准备系统及其在集成分析系统中的使用
US20090225514A1 (en) * 2008-03-10 2009-09-10 Adrian Correa Device and methodology for the removal of heat from an equipment rack by means of heat exchangers mounted to a door
US9297571B1 (en) 2008-03-10 2016-03-29 Liebert Corporation Device and methodology for the removal of heat from an equipment rack by means of heat exchangers mounted to a door
JP2011515236A (ja) * 2008-03-28 2011-05-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 制御された濡れ特性を有するマイクロ流体チャネルを含む表面
WO2009131677A1 (en) 2008-04-25 2009-10-29 Claros Diagnostics, Inc. Flow control in microfluidic systems
JP2011523383A (ja) * 2008-05-23 2011-08-11 富士フイルム株式会社 基板を接合する方法及び装置
US8277112B2 (en) 2008-05-27 2012-10-02 The Research Foundation Of State University Of New York Devices and fluid flow methods for improving mixing
US8507568B2 (en) * 2008-05-28 2013-08-13 The Ohio State University Suspension polymerization and foaming of water containing activated carbon-nano/microparticulate polymer composites
CN102171378A (zh) * 2008-08-05 2011-08-31 固利吉股份有限公司 用于光学和电子器件的热管理的键合金属和陶瓷板
ES2620012T3 (es) 2008-09-20 2017-06-27 The Board Of Trustees Of The Leland Stanford Junior University Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
EP3964821B1 (en) 2008-09-23 2024-11-06 Bio-Rad Laboratories, Inc. Droplet-based assay system
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
EP2376226B1 (en) 2008-12-18 2018-09-12 Opko Diagnostics, LLC Improved reagent storage in microfluidic systems and related articles and methods
EP2384429A1 (en) 2008-12-31 2011-11-09 Integenx Inc. Instrument with microfluidic chip
DK2391451T3 (en) 2009-02-02 2018-10-15 Opko Diagnostics Llc STRUCTURES FOR MANAGING LIGHT INTERACTION WITH MICROFLUIDIC DEVICES
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
EP2438016B1 (en) 2009-06-05 2021-06-02 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
US20110073292A1 (en) * 2009-09-30 2011-03-31 Madhav Datta Fabrication of high surface area, high aspect ratio mini-channels and their application in liquid cooling systems
MY165876A (en) 2009-10-19 2018-05-18 Theranos Inc Integrated health data capture and analysis system
ES2859481T3 (es) 2009-11-24 2021-10-04 Opko Diagnostics Llc Mezcla y suministro de fluidos en sistemas microfluídicos
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US20120248103A1 (en) 2009-12-15 2012-10-04 Olivetti I-Jet S.P.A. Process for assembling elements containing biological substances
EP2512647A2 (en) * 2009-12-18 2012-10-24 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
CA2795215C (en) 2010-04-16 2018-11-06 Opko Diagnostics, Llc Systems and devices for analysis of samples
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
EP2606242A4 (en) 2010-08-20 2016-07-20 Integenx Inc MICROFLUIDIC DEVICES WITH MECHANICALLY SEALED MEMBRANE VALVES
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
JP5616309B2 (ja) 2010-12-01 2014-10-29 アークレイ株式会社 デバイス及びその製造方法
EP2658653B1 (en) 2010-12-30 2015-03-04 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
US9844779B2 (en) * 2011-01-14 2017-12-19 The Charles Stark Draper Laboratory, Inc. Membrane-integrated microfluidic device for imaging cells
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
JP6215713B2 (ja) 2011-03-17 2017-10-18 クリティカル ケア ダイアグノスティクス インコーポレイテッド 有害臨床転帰のリスクを予測する方法
CN103813814A (zh) 2011-05-05 2014-05-21 艾克西根特技术有限公司 用于电动输送系统的凝胶联接
WO2013028980A1 (en) 2011-08-24 2013-02-28 Abbott Point Of Care, Inc. Biologic fluid sample analysis cartridge
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
SG11201406213WA (en) * 2012-03-05 2014-11-27 Arctic Partners Ab Oy Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume
DE102012103628B4 (de) * 2012-04-25 2020-12-31 Avl Emission Test Systems Gmbh Vorrichtung zur Bestimmung der Konzentration zumindest eines Gases in einem Probengasstrom
US20150239217A1 (en) * 2012-07-09 2015-08-27 Sony Corporation Microchip and method for manufacturing the same
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN111748607B (zh) 2012-08-14 2024-04-30 10X基因组学有限公司 微胶囊组合物及方法
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP2719460B1 (en) * 2012-10-12 2016-12-14 Sony DADC Austria AG Microfluidic devices
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014124338A1 (en) 2013-02-08 2014-08-14 10X Technologies, Inc. Polynucleotide barcode generation
DE102013002667B4 (de) 2013-02-15 2022-02-10 Microfluidic Chipshop Gmbh Mikrofluidiksystem mit nach außen verschlossenen Kavitäten
CA2900708C (en) 2013-03-13 2021-06-15 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
EP3071333A4 (en) 2013-11-18 2017-11-15 IntegenX Inc. Cartridges and instruments for sample analysis
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
DE102014001203A1 (de) * 2014-01-29 2015-07-30 Thermo Electron Led Gmbh Verbindungsleitungssystem für ein Laborgerät und/oder Medizinprodukt sowie Herstellungsverfahren dafür und Verwendung
HUE065029T2 (hu) 2014-03-28 2024-04-28 Opko Diagnostics Llc A prosztatarák diagnosztikával kapcsolatos készítmények és eljárások
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
CN106536756A (zh) 2014-06-26 2017-03-22 10X基因组学有限公司 核酸序列的分析
CN113249435B (zh) 2014-06-26 2024-09-03 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
KR102587637B1 (ko) 2014-12-12 2023-10-10 옵코 다이어그노스틱스, 엘엘씨 성형에 의해 제조되는 유체 시스템을 비롯한, 항온 처리 채널을 포함하는 유체 시스템
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
EP3253800B1 (en) 2015-03-27 2021-03-03 Opko Diagnostics, LLC Prostate antigen standards and uses thereof
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
WO2017100457A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation samples and/or reagents
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
USD812766S1 (en) * 2016-07-12 2018-03-13 EMULATE, Inc. Microfluidic chip for use with a fluid perfusion module
USD842493S1 (en) * 2016-09-07 2019-03-05 EMULATE, Inc. Microfluidic chip without pressure features for use with a fluid perfusion module
USD838864S1 (en) * 2016-09-07 2019-01-22 EMULATE, Inc. Opaque microfluidic chip without pressure features for use with a fluid perfusion module
USD816861S1 (en) * 2016-09-07 2018-05-01 EMULATE, Inc. Transparent microfluidic chip without pressure features for use with a fluid perfusion module
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
EP3545089B1 (en) 2017-01-30 2022-03-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
WO2018213643A1 (en) 2017-05-18 2018-11-22 10X Genomics, Inc. Methods and systems for sorting droplets and beads
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
EP3669178B1 (en) 2017-08-17 2023-07-19 Abbott Point Of Care Inc Systems for performing optical and electrochemical assays
US11067526B2 (en) 2017-08-17 2021-07-20 Abbott Point Of Care Inc. Devices, systems, and methods for performing optical and electrochemical assays
US10610865B2 (en) 2017-08-22 2020-04-07 10X Genomics, Inc. Droplet forming devices and system with differential surface properties
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
JP6939415B2 (ja) * 2017-10-27 2021-09-22 ウシオ電機株式会社 マイクロチップ
CN114525273B (zh) 2017-10-27 2025-01-28 10X基因组学有限公司 用于样品制备和分析的方法和系统
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
EP3724658A1 (en) 2017-12-12 2020-10-21 10X Genomics, Inc. Systems and methods for single cell processing
CN118547046A (zh) 2017-12-22 2024-08-27 10X基因组学有限公司 用于处理来自一个或多个细胞的核酸分子的系统和方法
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
WO2019169028A1 (en) 2018-02-28 2019-09-06 10X Genomics, Inc. Transcriptome sequencing through random ligation
JP7063682B2 (ja) * 2018-03-30 2022-05-09 住友理工株式会社 流体デバイス用複合部材およびその製造方法
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US12188014B1 (en) 2018-07-25 2025-01-07 10X Genomics, Inc. Compositions and methods for nucleic acid processing using blocking agents
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
CN112703252B (zh) 2018-08-03 2024-09-10 10X基因组学有限公司 用于最小化条形码交换的方法和系统
WO2020041148A1 (en) 2018-08-20 2020-02-27 10X Genomics, Inc. Methods and systems for detection of protein-dna interactions using proximity ligation
US12065688B2 (en) 2018-08-20 2024-08-20 10X Genomics, Inc. Compositions and methods for cellular processing
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US12169198B2 (en) 2019-01-08 2024-12-17 10X Genomics, Inc. Systems and methods for sample analysis
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
US12275993B2 (en) 2019-02-12 2025-04-15 10X Genomics, Inc. Analysis of nucleic acid sequences
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
WO2020167866A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transposon loading
CN118979095A (zh) 2019-02-12 2024-11-19 10X基因组学有限公司 用于加工核酸分子的方法
WO2020167862A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transfer of reagents between droplets
US12305239B2 (en) 2019-02-12 2025-05-20 10X Genomics, Inc. Analysis of nucleic acid sequences
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
CN113767178A (zh) 2019-03-11 2021-12-07 10X基因组学有限公司 用于处理光学标签化珠粒的系统和方法
CN114302808B (zh) 2019-06-28 2024-05-03 舒万诺知识产权公司 具有共形层的制品及其制造方法
US12235262B1 (en) 2019-09-09 2025-02-25 10X Genomics, Inc. Methods and systems for single cell protein analysis
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
US12084715B1 (en) 2020-11-05 2024-09-10 10X Genomics, Inc. Methods and systems for reducing artifactual antisense products
US12480158B1 (en) 2020-11-05 2025-11-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US12398262B1 (en) 2021-01-22 2025-08-26 10X Genomics, Inc. Triblock copolymer-based cell stabilization and fixation system and methods of use thereof
WO2022182682A1 (en) 2021-02-23 2022-09-01 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
JP2024539583A (ja) 2021-09-30 2024-10-29 ソルベンタム インテレクチュアル プロパティズ カンパニー 小容量流体装置

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50151971A (enExample) * 1974-05-31 1975-12-06
US4756884A (en) 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4680201A (en) 1985-10-30 1987-07-14 Stellan Hjerten Coating for electrophoresis tube
GB2191110B (en) 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US4999069A (en) 1987-10-06 1991-03-12 Integrated Fluidics, Inc. Method of bonding plastics
US4875956A (en) 1987-10-06 1989-10-24 Integrated Fluidics, Inc. Method of bonding plastics
US5114768A (en) 1988-06-02 1992-05-19 Hewlett-Packard Company Surfaces with reduced protein interactions
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5858188A (en) * 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
SE470347B (sv) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5061381A (en) 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids
EP0484278B1 (de) 1990-11-01 1995-04-12 Ciba-Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse
US5433898A (en) 1992-09-11 1995-07-18 Pilkington Barnes Hind, Inc. Method of manufacturing a contact lens
EP0620432B1 (en) 1993-04-15 2004-08-25 Zeptosens AG Method for controlling sample introduction in microcolumn separation techniques and sampling device
SE501380C2 (sv) 1993-06-15 1995-01-30 Pharmacia Lkb Biotech Sätt att tillverka mikrokanal/mikrokavitetsstrukturer
EP0665430B1 (en) 1994-01-28 1998-04-15 Hewlett-Packard GmbH Capillary made of plastics material for use in capillary electrophoresis and process for its production
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
EP0812434B1 (en) 1995-03-01 2013-09-18 President and Fellows of Harvard College Microcontact printing on surfaces and derivative articles
EP0784542B1 (en) 1995-08-04 2001-11-28 International Business Machines Corporation Stamp for a lithographic process
WO1997006013A1 (en) 1995-08-04 1997-02-20 International Business Machines Corporation Lithographic surface or thin layer modification

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