AU682026B2 - New 4-aminopyridines, process for preparing the same and medicaments containing the same - Google Patents
New 4-aminopyridines, process for preparing the same and medicaments containing the same Download PDFInfo
- Publication number
- AU682026B2 AU682026B2 AU62574/94A AU6257494A AU682026B2 AU 682026 B2 AU682026 B2 AU 682026B2 AU 62574/94 A AU62574/94 A AU 62574/94A AU 6257494 A AU6257494 A AU 6257494A AU 682026 B2 AU682026 B2 AU 682026B2
- Authority
- AU
- Australia
- Prior art keywords
- group
- denotes
- compound
- methyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4306506A DE4306506A1 (de) | 1993-03-03 | 1993-03-03 | Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| DE4306506 | 1993-03-03 | ||
| DE4312966 | 1993-04-21 | ||
| DE19934312966 DE4312966A1 (de) | 1993-04-21 | 1993-04-21 | Neue 4-Aminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| PCT/EP1994/000608 WO1994020467A1 (de) | 1993-03-03 | 1994-03-02 | Neue 4-aminopyridine, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6257494A AU6257494A (en) | 1994-09-26 |
| AU682026B2 true AU682026B2 (en) | 1997-09-18 |
Family
ID=25923593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU62574/94A Ceased AU682026B2 (en) | 1993-03-03 | 1994-03-02 | New 4-aminopyridines, process for preparing the same and medicaments containing the same |
Country Status (22)
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4430755A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5792769A (en) * | 1995-09-29 | 1998-08-11 | 3-Dimensional Pharmaceuticals, Inc. | Guanidino protease inhibitors |
| GB9525620D0 (en) * | 1995-12-15 | 1996-02-14 | Glaxo Group Ltd | Chemical compounds |
| DE69631692T2 (de) | 1995-12-29 | 2004-12-02 | 3-Dimensional Pharmaceuticals, Inc. | Amidino proteaseinhibitoren |
| WO1997028128A1 (en) | 1996-02-02 | 1997-08-07 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| KR20000029984A (ko) * | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | 치환된피리미딘유도체및이의약학적용도 |
| CA2264037A1 (en) * | 1996-09-13 | 1998-03-19 | Merck & Co., Inc. | Thrombin inhibitors |
| GB9821483D0 (en) | 1998-10-03 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| WO1998024760A1 (en) * | 1996-12-03 | 1998-06-11 | Graybill Todd L | Aminobenzenedicarboxylic acid-based combinatorial libraries |
| WO1998035956A1 (en) | 1997-02-13 | 1998-08-20 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| US6391880B1 (en) | 1997-02-13 | 2002-05-21 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
| KR20010085852A (ko) | 1998-10-06 | 2001-09-07 | 도모따께 다께시 | 2,3-이치환 피리딘 유도체, 그의 제조방법, 그를 함유하는의약 조성물, 및 그의 제조용 중간체 |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| CA2417914A1 (en) | 2000-08-04 | 2002-02-14 | 3-Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine protease inhibitors |
| CN100439329C (zh) * | 2000-10-04 | 2008-12-03 | 橘生药品工业株式会社 | 5-脒基-2-羟基苯磺酰胺衍生物,含有它的药用组合物以及制备它们用的中间体 |
| WO2002089740A2 (en) * | 2001-05-07 | 2002-11-14 | Smithkline Beecham Corporation | Sulfonamides |
| WO2002089785A1 (en) * | 2001-05-07 | 2002-11-14 | Smithkline Beecham Corporation | Sulfonamides |
| AU2003250197B2 (en) * | 2002-08-27 | 2009-11-12 | Merck Patent Gmbh | Glycinamide derivatives as raf-kinase inhibitors |
| BR0314126A (pt) * | 2002-09-20 | 2005-06-28 | Pfizer Prod Inc | Ligandos de amida acìclica e sulfonamida para o receptor de estrogênio |
| KR20080042188A (ko) | 2003-11-05 | 2008-05-14 | 에프. 호프만-라 로슈 아게 | Ｐｐａｒ 작용제로서 페닐 유도체 |
| CA2679185A1 (en) * | 2007-02-28 | 2008-09-04 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
| RU2354647C2 (ru) * | 2007-06-28 | 2009-05-10 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе |
| RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| US8265575B2 (en) * | 2009-06-16 | 2012-09-11 | Mediatek Inc. | Methods for handling a transmitting process and communication apparatuses utilizing the same |
| US8207639B2 (en) | 2009-10-23 | 2012-06-26 | Sunonwealth Electric Machine Industry Co., Ltd. | Motor and heating dissipating fan including motor having an annular balancing member |
| RU2685261C1 (ru) * | 2018-04-05 | 2019-04-17 | Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" | Вещество 4-амино-1-{ 2-[3-метил-5-(бензолсульфонилокси)фенокси] этил} -пиридиний хлорид, обладающее свойствами биологически активного агента, влияющими на естественно текущие процессы свертываемости крови млекопитающих, антикоагулянт на его основе и способ его получения путем химического синтеза |
| CN109172573B (zh) * | 2018-09-12 | 2021-01-26 | 黑龙江中桂制药有限公司 | 一种口服抗血栓药物及其用途 |
| CN110669337B (zh) * | 2019-07-08 | 2020-09-25 | 中国科学院长春应用化学研究所 | 一种芳香型二胺单体及其制备方法 |
| WO2024243343A2 (en) * | 2023-05-23 | 2024-11-28 | John Karanicolas | Compounds that re-activate mutant p53 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0359389A1 (en) * | 1988-08-13 | 1990-03-21 | Pfizer Limited | Antiarrhythmic agents |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1097620A1 (ru) * | 1983-02-16 | 1984-06-15 | Новокузнецкий научно-исследовательский химико-фармацевтический институт | Способ получени диэтил-N-(6-метилпиридил-2)-аминометиленмалоната |
| SU1318599A1 (ru) * | 1985-06-26 | 1987-06-23 | МГУ им.М.В.Ломоносова | Способ получени 1-алкил-2-хлор-2-алкоксиэтенилалкил(арил)хлорфосфинов |
| DE3529529A1 (de) * | 1985-08-17 | 1987-02-19 | Boehringer Mannheim Gmbh | Verfahren zur herstellung einer stabilen modifikation von torasemid |
| JPH0256465A (ja) * | 1988-08-22 | 1990-02-26 | Hamari Yakuhin Kogyo Kk | アセトアミド化合物 |
| US4885927A (en) * | 1988-09-12 | 1989-12-12 | General Motors Corporation | Method and apparatus for press forming intricate metallic shapes such as spool valve elements |
| WO1993009133A1 (en) * | 1991-10-31 | 1993-05-13 | Smithkline Beecham Corporation | C8-cyclic peptidomimetics as fibrinogen antagonists |
| EP0612313A1 (en) * | 1991-11-14 | 1994-08-31 | Glaxo Group Limited | Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| DE4212304A1 (de) * | 1992-04-13 | 1993-10-14 | Cassella Ag | Asparaginsäurederivate, ihre Herstellung und Verwendung |
-
1994
- 1994-02-22 TW TW083101504A patent/TW257757B/zh active
- 1994-02-28 IL IL10878694A patent/IL108786A/en not_active IP Right Cessation
- 1994-03-02 FI FI954105A patent/FI954105A7/fi unknown
- 1994-03-02 AU AU62574/94A patent/AU682026B2/en not_active Ceased
- 1994-03-02 CN CN94191554A patent/CN1046710C/zh not_active Expired - Fee Related
- 1994-03-02 CA CA002156729A patent/CA2156729A1/en not_active Abandoned
- 1994-03-02 NZ NZ262725A patent/NZ262725A/en unknown
- 1994-03-02 WO PCT/EP1994/000608 patent/WO1994020467A1/de not_active Application Discontinuation
- 1994-03-02 RU RU95122612A patent/RU2126388C1/ru active
- 1994-03-02 AT AT94909909T patent/ATE174590T1/de not_active IP Right Cessation
- 1994-03-02 HU HU9502568A patent/HUT72898A/hu unknown
- 1994-03-02 PL PL94310520A patent/PL176455B1/pl unknown
- 1994-03-02 SK SK1082-95A patent/SK108295A3/sk unknown
- 1994-03-02 DK DK94909909T patent/DK0687253T3/da active
- 1994-03-02 JP JP6519556A patent/JPH08507503A/ja active Pending
- 1994-03-02 DE DE59407494T patent/DE59407494D1/de not_active Expired - Fee Related
- 1994-03-02 ES ES94909909T patent/ES2127919T3/es not_active Expired - Lifetime
- 1994-03-02 CZ CZ952254A patent/CZ225495A3/cs unknown
- 1994-03-02 EP EP94909909A patent/EP0687253B1/de not_active Expired - Lifetime
- 1994-03-02 KR KR1019950703694A patent/KR100252551B1/ko not_active Expired - Fee Related
-
1995
- 1995-09-01 NO NO953447A patent/NO953447L/no unknown
-
1999
- 1999-03-16 GR GR990400775T patent/GR3029691T3/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0359389A1 (en) * | 1988-08-13 | 1990-03-21 | Pfizer Limited | Antiarrhythmic agents |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ262725A (en) | 1997-05-26 |
| PL176455B1 (pl) | 1999-05-31 |
| CZ225495A3 (en) | 1996-01-17 |
| IL108786A0 (en) | 1994-06-24 |
| FI954105A0 (fi) | 1995-09-01 |
| FI954105A7 (fi) | 1995-09-01 |
| PL310520A1 (en) | 1995-12-27 |
| NO953447D0 (no) | 1995-09-01 |
| SK108295A3 (en) | 1996-06-05 |
| TW257757B (enrdf_load_html_response) | 1995-09-21 |
| CN1119858A (zh) | 1996-04-03 |
| EP0687253B1 (de) | 1998-12-16 |
| AU6257494A (en) | 1994-09-26 |
| ATE174590T1 (de) | 1999-01-15 |
| RU2126388C1 (ru) | 1999-02-20 |
| GR3029691T3 (en) | 1999-06-30 |
| IL108786A (en) | 1999-04-11 |
| KR100252551B1 (ko) | 2000-05-01 |
| ES2127919T3 (es) | 1999-05-01 |
| WO1994020467A1 (de) | 1994-09-15 |
| CN1046710C (zh) | 1999-11-24 |
| CA2156729A1 (en) | 1994-09-15 |
| EP0687253A1 (de) | 1995-12-20 |
| NO953447L (no) | 1995-09-01 |
| HU9502568D0 (en) | 1995-11-28 |
| JPH08507503A (ja) | 1996-08-13 |
| DE59407494D1 (de) | 1999-01-28 |
| KR960701019A (ko) | 1996-02-24 |
| DK0687253T3 (da) | 1999-08-23 |
| HUT72898A (en) | 1996-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |