AU652753B2 - 5-aryl pyrimidine, processes for its production and use as treatment for CNS disorders - Google Patents

5-aryl pyrimidine, processes for its production and use as treatment for CNS disorders Download PDF

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Publication number
AU652753B2
AU652753B2 AU78097/91A AU7809791A AU652753B2 AU 652753 B2 AU652753 B2 AU 652753B2 AU 78097/91 A AU78097/91 A AU 78097/91A AU 7809791 A AU7809791 A AU 7809791A AU 652753 B2 AU652753 B2 AU 652753B2
Authority
AU
Australia
Prior art keywords
pyrimidine
propylpiperazin
amino
acid addition
trichlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU78097/91A
Other languages
English (en)
Other versions
AU7809791A (en
Inventor
Ramachandran Iyer
Michael John Leach
Malcolm Stuart Nobbs
Philip Alan Skone
Clive Leonard Yeates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of AU7809791A publication Critical patent/AU7809791A/en
Application granted granted Critical
Publication of AU652753B2 publication Critical patent/AU652753B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU78097/91A 1990-06-01 1991-05-31 5-aryl pyrimidine, processes for its production and use as treatment for CNS disorders Ceased AU652753B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9012316 1990-06-01
GB909012316A GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU67455/94A Division AU680252B2 (en) 1990-06-01 1994-07-13 Pharmacologically active CNS compounds

Publications (2)

Publication Number Publication Date
AU7809791A AU7809791A (en) 1991-12-05
AU652753B2 true AU652753B2 (en) 1994-09-08

Family

ID=10676964

Family Applications (2)

Application Number Title Priority Date Filing Date
AU78097/91A Ceased AU652753B2 (en) 1990-06-01 1991-05-31 5-aryl pyrimidine, processes for its production and use as treatment for CNS disorders
AU67455/94A Expired - Fee Related AU680252B2 (en) 1990-06-01 1994-07-13 Pharmacologically active CNS compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU67455/94A Expired - Fee Related AU680252B2 (en) 1990-06-01 1994-07-13 Pharmacologically active CNS compounds

Country Status (25)

Country Link
EP (2) EP0679645A1 (enExample)
JP (1) JPH06340634A (enExample)
KR (1) KR920000733A (enExample)
AT (1) ATE141263T1 (enExample)
AU (2) AU652753B2 (enExample)
CA (1) CA2043640A1 (enExample)
CZ (1) CZ281070B6 (enExample)
DE (1) DE69121317T2 (enExample)
DK (1) DK0459819T3 (enExample)
ES (1) ES2093078T3 (enExample)
FI (1) FI912623A7 (enExample)
GB (1) GB9012316D0 (enExample)
GR (1) GR3021237T3 (enExample)
HU (2) HUT58707A (enExample)
IE (1) IE911861A1 (enExample)
IL (2) IL113599A (enExample)
MY (2) MY136248A (enExample)
NO (1) NO180375C (enExample)
NZ (3) NZ248501A (enExample)
PL (2) PL166656B1 (enExample)
PT (1) PT97827B (enExample)
RU (1) RU2091374C1 (enExample)
SK (1) SK278444B6 (enExample)
TW (1) TW224460B (enExample)
ZA (1) ZA914165B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
UA37214C2 (uk) * 1991-01-30 2001-05-15 Дзе Веллкам Фаундейшн Лімітед Таблетки, що диспергуються у воді, та спосіб їх виготовлення
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
GB9226377D0 (en) * 1992-12-18 1993-02-10 Babbedge Rachel C Pharmaceutical compositions
EP0674627A1 (en) * 1992-12-18 1995-10-04 The Wellcome Foundation Limited Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9319341D0 (en) * 1993-09-17 1993-11-03 Wellcome Found Novel process
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
DE19918325A1 (de) * 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
CA2383466C (en) 1999-09-16 2009-08-25 Tanabe Seiyaku Co., Ltd. Aromatic nitrogen-containing 6-membered cyclic compounds
YU63802A (sh) * 2000-02-25 2005-06-10 F. Hoffmann-La Roche Ag. Modulatori adenozinskih receptora
KR100711042B1 (ko) 2000-04-28 2007-04-24 다나베 세이야꾸 가부시키가이샤 환상 화합물
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
JP5154728B2 (ja) * 2000-07-24 2013-02-27 クレニツキー・ファーマシューティカルズ，インコーポレイテッド 神経栄養活性を有する置換５−アルキニルピリミジン
EP1364950A4 (en) 2001-02-26 2005-03-09 Tanabe Seiyaku Co Pyridopyrimidine and naphthyridine derivatives
PL372390A1 (en) * 2002-02-05 2005-07-25 Novo Nordisk A/S Novel aryl- and heteroarylpiperazines
TW200637556A (en) * 2005-01-31 2006-11-01 Basf Ag Substituted 5-phenyl pyrimidines I in therapy
CN103110635A (zh) 2005-07-04 2013-05-22 海波因特制药有限责任公司 组胺h3受体拮抗剂
CA2653062A1 (en) 2006-05-23 2007-11-29 Transtech Pharma, Inc. 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ' ] -bipyridine and its use as a medicament
ATE538116T1 (de) 2006-05-29 2012-01-15 High Point Pharmaceuticals Llc 3-(1,3-benyodioxol-5-yl)-6- (4- cyclopropylpiperazin-1-yl)-pyridazin, dessen salze und solvate und dessen verwendung als histamin-h3-rezeptorantagonist
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
US9073947B2 (en) 2011-06-10 2015-07-07 Merck Patent Gmbh Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
ES2699351T3 (es) 2014-01-17 2019-02-08 Novartis Ag Derivados de 1-piridazin/triazin-3-il-piper(-azina)/idina/pirolidina y composiciones de las mismas para inhibir la actividad de SHP2
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
PT3468972T (pt) 2016-06-14 2020-08-21 Novartis Ag Compostos e composições para inibir a atividade da shp2
CN110730678B (zh) 2017-01-10 2022-07-15 诺华股份有限公司 包含alk抑制剂和shp2抑制剂的药物组合

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4596489A (en) * 1988-12-07 1990-06-14 Wellcome Foundation Limited, The Pharmaceutically active CNS compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE518622A (enExample) *
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4596489A (en) * 1988-12-07 1990-06-14 Wellcome Foundation Limited, The Pharmaceutically active CNS compounds

Also Published As

Publication number Publication date
FI912623A7 (fi) 1991-12-02
PT97827B (pt) 1998-10-30
IE911861A1 (en) 1991-12-04
FI912623A0 (fi) 1991-05-31
PT97827A (pt) 1992-03-31
ATE141263T1 (de) 1996-08-15
IL113599A0 (en) 1995-08-31
NZ272001A (en) 1997-03-24
CA2043640A1 (en) 1991-12-02
IL113599A (en) 1997-09-30
HU211649A9 (en) 1995-12-28
MY136248A (en) 2008-08-29
NO180375C (no) 1997-04-09
DK0459819T3 (da) 1996-09-02
IL98330A (en) 1996-10-31
DE69121317T2 (de) 1997-01-02
NO180375B (no) 1996-12-30
KR920000733A (ko) 1992-01-29
IL98330A0 (en) 1992-06-21
EP0459819A3 (en) 1992-03-11
EP0679645A1 (en) 1995-11-02
TW224460B (enExample) 1994-06-01
NO912100L (no) 1991-12-02
NZ238360A (en) 1997-03-24
NZ248501A (en) 1997-03-24
ZA914165B (en) 1993-03-01
ES2093078T3 (es) 1996-12-16
GB9012316D0 (en) 1990-07-18
GR3021237T3 (en) 1997-01-31
SK278444B6 (en) 1997-05-07
EP0459819A2 (en) 1991-12-04
MY109958A (en) 1997-10-31
AU680252B2 (en) 1997-07-24
EP0459819B1 (en) 1996-08-14
AU7809791A (en) 1991-12-05
PL166656B1 (pl) 1995-06-30
PL170373B1 (pl) 1996-12-31
HU911826D0 (en) 1991-12-30
DE69121317D1 (de) 1996-09-19
CZ281070B6 (cs) 1996-06-12
HUT58707A (en) 1992-03-30
CS164391A3 (en) 1992-02-19
RU2091374C1 (ru) 1997-09-27
NO912100D0 (no) 1991-05-31
JPH06340634A (ja) 1994-12-13
AU6745594A (en) 1994-09-15

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