GB9012316D0 - Pharmacologically active cns compounds - Google Patents

Pharmacologically active cns compounds

Info

Publication number
GB9012316D0
GB9012316D0 GB909012316A GB9012316A GB9012316D0 GB 9012316 D0 GB9012316 D0 GB 9012316D0 GB 909012316 A GB909012316 A GB 909012316A GB 9012316 A GB9012316 A GB 9012316A GB 9012316 D0 GB9012316 D0 GB 9012316D0
Authority
GB
United Kingdom
Prior art keywords
hydrogen
halo
alkyl
compounds
pharmacologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB909012316A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB909012316A priority Critical patent/GB9012316D0/en
Publication of GB9012316D0 publication Critical patent/GB9012316D0/en
Priority to ZA914165A priority patent/ZA914165B/xx
Priority to NZ238360A priority patent/NZ238360A/en
Priority to FI961410A priority patent/FI961410A0/fi
Priority to CA002043640A priority patent/CA2043640A1/en
Priority to AT91304935T priority patent/ATE141263T1/de
Priority to DK91304935.9T priority patent/DK0459819T3/da
Priority to SK1643-91A priority patent/SK278444B6/sk
Priority to MYPI95001459A priority patent/MY136248A/en
Priority to IL113599A priority patent/IL113599A/xx
Priority to EP95111314A priority patent/EP0679645A1/en
Priority to AU78097/91A priority patent/AU652753B2/en
Priority to PT97827A priority patent/PT97827B/pt
Priority to MYPI91000962A priority patent/MY109958A/en
Priority to PL91305331A priority patent/PL170373B1/pl
Priority to SU914895583A priority patent/RU2091374C1/ru
Priority to EP91304935A priority patent/EP0459819B1/en
Priority to NZ248501A priority patent/NZ248501A/en
Priority to KR1019910009010A priority patent/KR920000733A/ko
Priority to TW080104285A priority patent/TW224460B/zh
Priority to NZ272001A priority patent/NZ272001A/en
Priority to IE186191A priority patent/IE911861A1/en
Priority to DE69121317T priority patent/DE69121317T2/de
Priority to JP3235334A priority patent/JPH06340634A/ja
Priority to HU911826A priority patent/HUT58707A/hu
Priority to NO912100A priority patent/NO180375C/no
Priority to PL91290496A priority patent/PL166656B1/pl
Priority to FI912623A priority patent/FI912623A7/fi
Priority to CS911643A priority patent/CZ281070B6/cs
Priority to ES91304935T priority patent/ES2093078T3/es
Priority to IL9833091A priority patent/IL98330A/en
Priority to AU67455/94A priority patent/AU680252B2/en
Priority to HU95P/P00669P priority patent/HU211649A9/hu
Priority to NO954109A priority patent/NO954109D0/no
Priority to GR960402585T priority patent/GR3021237T3/el
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
GB909012316A 1990-06-01 1990-06-01 Pharmacologically active cns compounds Pending GB9012316D0 (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
GB909012316A GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds
ZA914165A ZA914165B (en) 1990-06-01 1991-05-30 Pharmacologically active CNS compounds.
IL9833091A IL98330A (en) 1990-06-01 1991-05-31 4-Amino-2-(4-n- propylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl) pyrimidine and acid addition salts thereof their preparation and pharmaceutical compositions containing them
EP91304935A EP0459819B1 (en) 1990-06-01 1991-05-31 Pharmacologically active CNS compound
TW080104285A TW224460B (enExample) 1990-06-01 1991-05-31
CA002043640A CA2043640A1 (en) 1990-06-01 1991-05-31 Pharmacologically active cns compounds
AT91304935T ATE141263T1 (de) 1990-06-01 1991-05-31 Pharmazeutisch wirksame zns-verbindung
DK91304935.9T DK0459819T3 (da) 1990-06-01 1991-05-31 Farmakologisk aktiv CNS-forbindelse
SK1643-91A SK278444B6 (en) 1990-06-01 1991-05-31 Substituted 5-arylpyrimidine, manufacturing process thereof and pharmaceutical composition containing its
MYPI95001459A MY136248A (en) 1990-06-01 1991-05-31 Pharmacologically active cns compounds
IL113599A IL113599A (en) 1990-06-01 1991-05-31 5-aryl pyrimidines, their preparation and pharmaceutical compositions containing them
EP95111314A EP0679645A1 (en) 1990-06-01 1991-05-31 Pharmacologically active CNS pyridmidin compounds
AU78097/91A AU652753B2 (en) 1990-06-01 1991-05-31 5-aryl pyrimidine, processes for its production and use as treatment for CNS disorders
PT97827A PT97827B (pt) 1990-06-01 1991-05-31 Processo para a preparacao de 5-aril-pirimidinas substituidas
MYPI91000962A MY109958A (en) 1990-06-01 1991-05-31 5-aryl pyrimidine processes for its production and use as treatment for cns disorders
PL91305331A PL170373B1 (pl) 1990-06-01 1991-05-31 Sposób wytwarzania nowych, podstawionych 5-arylopirymidyn PL PL PL
SU914895583A RU2091374C1 (ru) 1990-06-01 1991-05-31 Способ получения замещенных 5-арил-пиримидинов
NZ238360A NZ238360A (en) 1990-06-01 1991-05-31 2,4-diamino- and 4-amino-2-(n-morpholinyl)-5-(3,5-dichlorophenyl)-6- trifluoromethyl pyrimidine
NZ248501A NZ248501A (en) 1990-06-01 1991-05-31 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidine
KR1019910009010A KR920000733A (ko) 1990-06-01 1991-05-31 약학적활성 cns 화합물
FI961410A FI961410A0 (fi) 1990-06-01 1991-05-31 Farmakologisesti aktiivisia keskushermostoon vaikuttavia yhdisteitä
NZ272001A NZ272001A (en) 1990-06-01 1991-05-31 Substituted 5-(phenyl)-pyrimidine derivatives and medicaments
IE186191A IE911861A1 (en) 1990-06-01 1991-05-31 Pharmacologically active cns compounds
DE69121317T DE69121317T2 (de) 1990-06-01 1991-05-31 Pharmazeutisch wirksame ZNS-Verbindung
JP3235334A JPH06340634A (ja) 1990-06-01 1991-05-31 薬学的に活性なｃｎｓ化合物
HU911826A HUT58707A (en) 1990-06-01 1991-05-31 Process for producing diamino-pyrimidine derivatives and pharmaceutical compositions containing them
NO912100A NO180375C (no) 1990-06-01 1991-05-31 Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin
PL91290496A PL166656B1 (pl) 1990-06-01 1991-05-31 Sposób wytwarzania 4-amlno-2-(4-n-propylo-1-plperazynylo)-5-(2,3,5-trichlorofenylo)pirymidyny PL PL PL
FI912623A FI912623A7 (fi) 1990-06-01 1991-05-31 Farmakologiskt aktiva foereningar med verkan pao det centrala nervsystemet.
CS911643A CZ281070B6 (cs) 1990-06-01 1991-05-31 Slučenina farmakologicky účinné pro centrální nervový systém
ES91304935T ES2093078T3 (es) 1990-06-01 1991-05-31 Compuesto farmaceuticamente activo sobre el snc.
AU67455/94A AU680252B2 (en) 1990-06-01 1994-07-13 Pharmacologically active CNS compounds
HU95P/P00669P HU211649A9 (en) 1990-06-01 1995-06-30 5-aryl pyrimidines, process for their production and use as treatment for cns disorders
NO954109A NO954109D0 (no) 1990-06-01 1995-10-16 Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte 5-arylpyrimidiner
GR960402585T GR3021237T3 (en) 1990-06-01 1996-10-03 Pharmacologically active CNS compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909012316A GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds

Publications (1)

Publication Number Publication Date
GB9012316D0 true GB9012316D0 (en) 1990-07-18

Family

ID=10676964

Family Applications (1)

Application Number Title Priority Date Filing Date
GB909012316A Pending GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds

Country Status (25)

Country Link
EP (2) EP0459819B1 (enExample)
JP (1) JPH06340634A (enExample)
KR (1) KR920000733A (enExample)
AT (1) ATE141263T1 (enExample)
AU (2) AU652753B2 (enExample)
CA (1) CA2043640A1 (enExample)
CZ (1) CZ281070B6 (enExample)
DE (1) DE69121317T2 (enExample)
DK (1) DK0459819T3 (enExample)
ES (1) ES2093078T3 (enExample)
FI (1) FI912623A7 (enExample)
GB (1) GB9012316D0 (enExample)
GR (1) GR3021237T3 (enExample)
HU (2) HUT58707A (enExample)
IE (1) IE911861A1 (enExample)
IL (2) IL98330A (enExample)
MY (2) MY136248A (enExample)
NO (1) NO180375C (enExample)
NZ (3) NZ248501A (enExample)
PL (2) PL166656B1 (enExample)
PT (1) PT97827B (enExample)
RU (1) RU2091374C1 (enExample)
SK (1) SK278444B6 (enExample)
TW (1) TW224460B (enExample)
ZA (1) ZA914165B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
FI20021701L (fi) * 1991-01-30 2002-09-24 Wellcome Found Veteen dispergoituvia tabletteja
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
AU5704594A (en) * 1992-12-18 1994-07-19 Wellcome Foundation Limited, The Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
GB9226377D0 (en) * 1992-12-18 1993-02-10 Babbedge Rachel C Pharmaceutical compositions
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9319341D0 (en) * 1993-09-17 1993-11-03 Wellcome Found Novel process
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en) * 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
CA2383466C (en) 1999-09-16 2009-08-25 Tanabe Seiyaku Co., Ltd. Aromatic nitrogen-containing 6-membered cyclic compounds
CN1438890A (zh) * 2000-02-25 2003-08-27 弗·哈夫曼-拉罗切有限公司 腺苷受体调制剂
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
AU2001241142B2 (en) 2000-04-28 2005-09-22 Tanabe Seiyaku Co., Ltd. Cyclic compounds
JP5154728B2 (ja) * 2000-07-24 2013-02-27 クレニツキー・ファーマシューティカルズ，インコーポレイテッド 神経栄養活性を有する置換５−アルキニルピリミジン
CN1503797A (zh) 2001-02-26 2004-06-09 田边制药株式会社 吡啶并嘧啶或二氮杂萘衍生物
CN1628109A (zh) * 2002-02-05 2005-06-15 诺沃挪第克公司 新颖的芳基－与杂芳基－哌嗪
TW200637556A (en) * 2005-01-31 2006-11-01 Basf Ag Substituted 5-phenyl pyrimidines I in therapy
BRPI0613564A2 (pt) 2005-07-04 2011-01-18 Novo Nordisk As compostos, seus usos na preparação de composições farmacêuticas e composições farmacêuticas compreendendo os mesmos
US8318927B2 (en) 2006-05-23 2012-11-27 High Point Pharmaceuticals, Llc 6-(4-cyclopropylpiperazin-1-yl)-2′-methyl-[3, 4′]-bipyridine and its uses as a medicament
AU2007267197B2 (en) 2006-05-29 2011-12-01 High Point Pharmaceuticals, Llc 3- (1, 3-Benzodioxol-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
KR20180084153A (ko) 2011-06-10 2018-07-24 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법
CN105899491B (zh) 2014-01-17 2019-04-02 诺华股份有限公司 用于抑制shp2活性的1-哒嗪-/三嗪-3-基-哌(-嗪)/啶/吡咯烷衍生物及其组合物
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
WO2017216706A1 (en) 2016-06-14 2017-12-21 Novartis Ag Compounds and compositions for inhibiting the activity of shp2
KR102571130B1 (ko) 2017-01-10 2023-08-28 노파르티스 아게 Alk 저해제 및 shp2 저해제를 포함하는 약제학적 조합

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE518622A (enExample) *
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds

Also Published As

Publication number Publication date
MY109958A (en) 1997-10-31
PL166656B1 (pl) 1995-06-30
ES2093078T3 (es) 1996-12-16
IE911861A1 (en) 1991-12-04
IL98330A0 (en) 1992-06-21
KR920000733A (ko) 1992-01-29
NO912100D0 (no) 1991-05-31
NO912100L (no) 1991-12-02
CA2043640A1 (en) 1991-12-02
SK278444B6 (en) 1997-05-07
NO180375C (no) 1997-04-09
EP0679645A1 (en) 1995-11-02
HUT58707A (en) 1992-03-30
MY136248A (en) 2008-08-29
EP0459819A3 (en) 1992-03-11
DE69121317T2 (de) 1997-01-02
HU211649A9 (en) 1995-12-28
DK0459819T3 (da) 1996-09-02
PT97827B (pt) 1998-10-30
CS164391A3 (en) 1992-02-19
DE69121317D1 (de) 1996-09-19
FI912623A0 (fi) 1991-05-31
RU2091374C1 (ru) 1997-09-27
NZ272001A (en) 1997-03-24
AU680252B2 (en) 1997-07-24
CZ281070B6 (cs) 1996-06-12
NO180375B (no) 1996-12-30
AU6745594A (en) 1994-09-15
AU7809791A (en) 1991-12-05
ZA914165B (en) 1993-03-01
NZ248501A (en) 1997-03-24
EP0459819A2 (en) 1991-12-04
IL113599A (en) 1997-09-30
EP0459819B1 (en) 1996-08-14
PL170373B1 (pl) 1996-12-31
FI912623A7 (fi) 1991-12-02
ATE141263T1 (de) 1996-08-15
GR3021237T3 (en) 1997-01-31
AU652753B2 (en) 1994-09-08
TW224460B (enExample) 1994-06-01
NZ238360A (en) 1997-03-24
HU911826D0 (en) 1991-12-30
JPH06340634A (ja) 1994-12-13
PT97827A (pt) 1992-03-31
IL98330A (en) 1996-10-31
IL113599A0 (en) 1995-08-31

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