AU650315B2 - Substituted 1,2,3,4-tetrahydrocyclopent(B)indoles, 1,2,3,3a,4,8a-hexahydrocyclopent(B)indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments - Google Patents

Substituted 1,2,3,4-tetrahydrocyclopent(B)indoles, 1,2,3,3a,4,8a-hexahydrocyclopent(B)indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments Download PDF

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Publication number
AU650315B2
AU650315B2 AU10279/92A AU1027992A AU650315B2 AU 650315 B2 AU650315 B2 AU 650315B2 AU 10279/92 A AU10279/92 A AU 10279/92A AU 1027992 A AU1027992 A AU 1027992A AU 650315 B2 AU650315 B2 AU 650315B2
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AU
Australia
Prior art keywords
compound
hydrogen
formula
loweralkyl
arylloweralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU10279/92A
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English (en)
Other versions
AU1027992A (en
Inventor
Michael Clayton Merriman
Gerard Joseph O'malley
Helen Hu Ong
Mark Gabriel Palermo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of AU1027992A publication Critical patent/AU1027992A/en
Application granted granted Critical
Publication of AU650315B2 publication Critical patent/AU650315B2/en
Assigned to HOECHST MARION ROUSSEL, INC. reassignment HOECHST MARION ROUSSEL, INC. Alteration of Name(s) in Register under S187 Assignors: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU10279/92A 1991-01-18 1992-01-17 Substituted 1,2,3,4-tetrahydrocyclopent(B)indoles, 1,2,3,3a,4,8a-hexahydrocyclopent(B)indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments Ceased AU650315B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US642952 1991-01-18
US07/642,952 US5100891A (en) 1991-01-18 1991-01-18 Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds

Publications (2)

Publication Number Publication Date
AU1027992A AU1027992A (en) 1992-07-23
AU650315B2 true AU650315B2 (en) 1994-06-16

Family

ID=24578739

Family Applications (1)

Application Number Title Priority Date Filing Date
AU10279/92A Ceased AU650315B2 (en) 1991-01-18 1992-01-17 Substituted 1,2,3,4-tetrahydrocyclopent(B)indoles, 1,2,3,3a,4,8a-hexahydrocyclopent(B)indoles and related compounds, intermediates and a process for the preparation thereof and their use as medicaments

Country Status (26)

Country Link
US (1) US5100891A (show.php)
EP (1) EP0496314B1 (show.php)
JP (1) JP2665422B2 (show.php)
KR (1) KR100230881B1 (show.php)
AT (1) ATE158790T1 (show.php)
AU (1) AU650315B2 (show.php)
BR (1) BR9200171A (show.php)
CA (1) CA2059610C (show.php)
CZ (1) CZ282732B6 (show.php)
DE (1) DE69222444T2 (show.php)
DK (1) DK0496314T3 (show.php)
ES (1) ES2109953T3 (show.php)
FI (2) FI102174B (show.php)
GR (1) GR3025318T3 (show.php)
HU (1) HUT67027A (show.php)
IE (1) IE920149A1 (show.php)
IL (1) IL100693A0 (show.php)
MX (1) MX9200206A (show.php)
NO (1) NO178397C (show.php)
NZ (1) NZ241305A (show.php)
PH (1) PH31429A (show.php)
PL (2) PL167465B1 (show.php)
RO (1) RO112505B1 (show.php)
RU (1) RU2077530C1 (show.php)
TW (1) TW198024B (show.php)
ZA (1) ZA92341B (show.php)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298626A (en) * 1991-01-18 1994-03-29 Hoechst-Roussel Pharmaceuticals Incorporated Select cyclopent[b]indoles
US5350762A (en) * 1993-03-08 1994-09-27 Hoechst-Roussel Pharmaceuticals Incorporated Tetrahydrocyclopent[B]indole methanamines and related compounds
AU735249B2 (en) * 1997-07-03 2001-07-05 Asahi Kasei Kabushiki Kaisha Novel tricyclic compounds having saturated rings and medicinal compositions containing the same
TWI220143B (en) * 1998-05-13 2004-08-11 Solvay Pharm Gmbh Method for stereochemically controlled production of isomerically pure highly substituted azacyclic compounds and novel cyclic compounds, and intermediate products
UA69420C2 (uk) * 1998-10-06 2004-09-15 Янссен Фармацевтика Н.В. ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ
UA70334C2 (en) * 1998-10-06 2004-10-15 Janssen Pharmaceutica N V Jans BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
ATE269337T1 (de) * 1998-10-06 2004-07-15 Janssen Pharmaceutica Nv Trizyclische delta3-pyridine als arzneimittel
IT1317926B1 (it) * 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Derivati triciclici dell'indolo ad attivita' antiangiogenica.
EP1654228B1 (en) 2003-06-10 2008-10-22 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives and their pharmaceutical use
ES2327416T3 (es) 2003-06-12 2009-10-29 Smithkline Beecham Corporation Derivados de tetraidrocarbazol y su uso farmaceutico.
EP1817025A2 (en) * 2004-11-23 2007-08-15 PTC Therapeutics, Inc. Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control
GB2422828A (en) * 2005-02-03 2006-08-09 Hunter Fleming Ltd Tricyclic cytoprotective compounds comprising an indole residue
WO2013139929A1 (en) * 2012-03-22 2013-09-26 Ludwig-Maximilians-Universität München Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging
KR20140013471A (ko) 2012-07-24 2014-02-05 주식회사 쎄코 진공증착용 발열조립체 및 이를 구비하는 진공증착장치
US10882821B1 (en) 2017-09-26 2021-01-05 The Board Of Trustees Of The Leland Stanford Junior University Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1187299A (en) * 1966-10-21 1970-04-08 Upjohn Co Improvements in or relating to Heterocyclic Compounds and the manufacture thereof
US3595874A (en) * 1969-02-28 1971-07-27 Upjohn Co 3,4,5,10-tetrahydroazepino(2,3-b)indol-5a (2h)-ols

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
SU482086A1 (ru) * 1973-11-30 1976-03-15 Всесоюзный Научно-Исследовательски% Химико-Фармацевтический Институт Им.С.Орджоникидзе Способ получени производных 1- -амино1,2,3,4-тетрагидрокарбазола
JPS5111760A (show.php) * 1974-06-18 1976-01-30 Ayerst Mckenna & Harrison
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1187299A (en) * 1966-10-21 1970-04-08 Upjohn Co Improvements in or relating to Heterocyclic Compounds and the manufacture thereof
US3595874A (en) * 1969-02-28 1971-07-27 Upjohn Co 3,4,5,10-tetrahydroazepino(2,3-b)indol-5a (2h)-ols

Also Published As

Publication number Publication date
FI20001775L (fi) 2000-08-10
KR100230881B1 (ko) 1999-11-15
MX9200206A (es) 1992-08-01
DK0496314T3 (da) 1998-05-18
KR920014777A (ko) 1992-08-25
FI920192L (fi) 1992-07-19
PH31429A (en) 1998-11-03
RU2077530C1 (ru) 1997-04-20
JPH04334367A (ja) 1992-11-20
DE69222444T2 (de) 1998-06-04
CZ282732B6 (cs) 1997-09-17
FI102174B1 (fi) 1998-10-30
AU1027992A (en) 1992-07-23
HUT67027A (en) 1995-01-30
IL100693A0 (en) 1992-09-06
TW198024B (show.php) 1993-01-11
ZA92341B (en) 1992-09-30
DE69222444D1 (de) 1997-11-06
IE920149A1 (en) 1992-07-29
PL169417B1 (pl) 1996-07-31
BR9200171A (pt) 1992-10-06
FI107919B (fi) 2001-10-31
NO178397C (no) 1996-03-20
US5100891A (en) 1992-03-31
NO920235D0 (no) 1992-01-17
RO112505B1 (ro) 1997-10-30
NO178397B (no) 1995-12-11
CA2059610A1 (en) 1992-07-19
NO920235L (no) 1992-07-20
JP2665422B2 (ja) 1997-10-22
CS12992A3 (en) 1992-08-12
EP0496314B1 (en) 1997-10-01
ATE158790T1 (de) 1997-10-15
FI102174B (fi) 1998-10-30
HU9200172D0 (en) 1992-04-28
PL167465B1 (pl) 1995-09-30
EP0496314A1 (en) 1992-07-29
PL296651A1 (en) 1993-07-26
GR3025318T3 (en) 1998-02-27
FI920192A0 (fi) 1992-01-16
CA2059610C (en) 2002-04-02
ES2109953T3 (es) 1998-02-01
PL293209A1 (en) 1993-04-05
NZ241305A (en) 1994-10-26

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