AU638747B2 - Improvements in or relating to organic compounds - Google Patents

Improvements in or relating to organic compounds

Info

Publication number
AU638747B2
AU638747B2 AU63268/90A AU6326890A AU638747B2 AU 638747 B2 AU638747 B2 AU 638747B2 AU 63268/90 A AU63268/90 A AU 63268/90A AU 6326890 A AU6326890 A AU 6326890A AU 638747 B2 AU638747 B2 AU 638747B2
Authority
AU
Australia
Prior art keywords
relating
organic compounds
compounds
aralkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU63268/90A
Other languages
English (en)
Other versions
AU6326890A (en
Inventor
Ingolf Macher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT2287/89A external-priority patent/AT392272B/de
Priority claimed from AT0228689A external-priority patent/AT394554B/de
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Publication of AU6326890A publication Critical patent/AU6326890A/en
Application granted granted Critical
Publication of AU638747B2 publication Critical patent/AU638747B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C325/00—Thioaldehydes; Thioketones; Thioquinones; Oxides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU63268/90A 1989-10-03 1990-10-01 Improvements in or relating to organic compounds Expired AU638747B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT2287/89A AT392272B (de) 1989-10-03 1989-10-03 Verfahren zur herstellung eines pleuromutilinderivats und seiner saeureadditionssalze
AT2287/89 1989-10-03
AT0228689A AT394554B (de) 1989-10-03 1989-10-03 Neues thiazolidin, verfahren zur herstellung von thiazolidinen und ihre verwendung
AT2286/89 1989-10-03

Publications (2)

Publication Number Publication Date
AU6326890A AU6326890A (en) 1991-04-11
AU638747B2 true AU638747B2 (en) 1993-07-08

Family

ID=25598123

Family Applications (1)

Application Number Title Priority Date Filing Date
AU63268/90A Expired AU638747B2 (en) 1989-10-03 1990-10-01 Improvements in or relating to organic compounds

Country Status (19)

Country Link
US (2) US5164526A (OSRAM)
EP (1) EP0421364B1 (OSRAM)
JP (2) JP2515427B2 (OSRAM)
KR (1) KR0185971B1 (OSRAM)
AT (1) ATE124037T1 (OSRAM)
AU (1) AU638747B2 (OSRAM)
CA (1) CA2026690C (OSRAM)
DE (1) DE69020287T2 (OSRAM)
DK (1) DK0421364T3 (OSRAM)
ES (1) ES2072952T3 (OSRAM)
FI (1) FI104894B (OSRAM)
HK (1) HK112296A (OSRAM)
HU (1) HU208115B (OSRAM)
IE (1) IE68412B1 (OSRAM)
IL (1) IL95856A (OSRAM)
NZ (1) NZ235525A (OSRAM)
PL (1) PL164132B1 (OSRAM)
RU (1) RU2038350C1 (OSRAM)
TW (1) TW217406B (OSRAM)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT397654B (de) * 1992-05-04 1994-06-27 Biochemie Gmbh Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US7141603B2 (en) 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
TWI228048B (en) * 1999-12-09 2005-02-21 Novartis Ag New formulation
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
JP4989648B2 (ja) 2005-08-03 2012-08-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗癌剤として有用なイルジン類似体
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN102838599A (zh) 2006-05-04 2012-12-26 贝林格尔.英格海姆国际有限公司 多晶型
EP1908750A1 (en) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
AU2008290582B2 (en) * 2007-08-17 2014-08-14 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
CN101318921B (zh) * 2008-07-04 2011-07-27 江苏赛奥生化有限公司 沃尼妙林的制备方法
KR20200118243A (ko) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
MX370599B (es) * 2008-08-15 2019-12-18 Boehringer Ingelheim Int Derivados de purina para su uso en el tratamiento de enfermedades relacionadas con fab.
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EA022310B1 (ru) 2008-12-23 2015-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Солевые формы органического соединения
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
CN101597248B (zh) * 2009-07-10 2012-08-22 河北远征药业有限公司 沃尼妙林及其盐酸盐的制备方法
CN101993400A (zh) * 2009-08-17 2011-03-30 北京中牧科技服务有限责任公司 一种沃尼妙林的合成方法
KR101124759B1 (ko) 2009-11-17 2012-03-23 삼성메디슨 주식회사 엔트로피 정보에 기초하여 초음파 영상의 화질을 개선시키는 초음파 시스템 및 방법
NZ599298A (en) 2009-11-27 2014-11-28 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
WO2011138421A1 (en) 2010-05-05 2011-11-10 Boehringer Ingelheim International Gmbh Combination therapy
NZ603319A (en) 2010-06-24 2015-04-24 Boehringer Ingelheim Int Diabetes therapy
CN102001980B (zh) * 2010-10-27 2012-11-14 齐鲁动物保健品有限公司 一种沃尼妙林盐酸盐的出料方法
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
CN102225906B (zh) * 2011-05-12 2014-07-30 浙江国邦药业有限公司 一种沃尼妙林盐酸盐的结晶方法
CA2841552C (en) 2011-07-15 2020-06-23 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
CN102344397B (zh) * 2011-08-23 2013-09-04 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的提纯方法
CN102432510B (zh) * 2011-11-11 2014-02-12 山东胜利股份有限公司 一种二甲基半胱胺盐酸盐的合成方法
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303554A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in sirs and/or sepsis
EP3685839A1 (en) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin for use in the treatment of albuminuria and kidney related diseases
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
CN103193692A (zh) * 2013-04-23 2013-07-10 河北科技大学 一种沃尼妙林及其盐酸盐的制备
ES2950384T3 (es) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Uso médico de un inhibidor de DPP-4
CN105367467B (zh) * 2015-12-01 2017-07-14 苏利制药科技江阴有限公司 一种二甲基半胱氨盐酸盐的合成方法
WO2017211979A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153277A2 (de) * 1984-02-17 1985-08-28 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1324510A (fr) * 1962-04-26 1963-04-19 Bayer Ag Nouveau procédé de préparation de peptides
US3919290A (en) * 1972-10-03 1975-11-11 Sandoz Ltd Substituted 14-desoxy-mutilins
US4086359A (en) * 1975-09-30 1978-04-25 E. R. Squibb & Sons, Inc. Derivatives of pleuromutilin and compositions
CH619450A5 (OSRAM) * 1976-01-15 1980-09-30 Sandoz Ag
GB2072012B (en) * 1980-03-14 1984-07-25 Squibb & Sons Inc Veterinary compositions containing pleuromutilin derivatives
EP0054409B1 (en) * 1980-12-12 1985-09-18 Fine Organics Limited Preparation of thiazolidine derivatives
FR2526019A1 (fr) * 1982-04-28 1983-11-04 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leur utilisation comme medicaments
DE3742265A1 (de) * 1987-12-12 1989-06-22 Basf Ag Verfahren zur herstellung von cysteamin-saeureadditionssalzen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153277A2 (de) * 1984-02-17 1985-08-28 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US4675330A (en) * 1984-02-17 1987-06-23 Sandoz Ltd. Pleuromutilin derivatives process for their preparation and their use
AU585209B2 (en) * 1984-02-17 1989-06-15 Novartis Ag Pleuromutilin derivatives, processes for their preparation and their uses

Also Published As

Publication number Publication date
EP0421364A3 (en) 1992-01-22
PL287150A1 (en) 1992-01-27
CA2026690A1 (en) 1991-04-04
DE69020287D1 (de) 1995-07-27
JP2515427B2 (ja) 1996-07-10
US5284967A (en) 1994-02-08
ATE124037T1 (de) 1995-07-15
FI104894B (fi) 2000-04-28
EP0421364B1 (en) 1995-06-21
HK112296A (en) 1996-07-05
DE69020287T2 (de) 1995-11-02
DK0421364T3 (da) 1995-08-14
ES2072952T3 (es) 1995-08-01
FI904853A0 (fi) 1990-10-02
US5164526A (en) 1992-11-17
IE68412B1 (en) 1996-06-12
KR0185971B1 (ko) 1999-05-15
PL164132B1 (pl) 1994-06-30
IE903523A1 (en) 1991-04-10
JPH08225519A (ja) 1996-09-03
CA2026690C (en) 2003-01-21
HU906029D0 (en) 1991-03-28
JP2742250B2 (ja) 1998-04-22
IL95856A0 (en) 1991-07-18
RU2038350C1 (ru) 1995-06-27
TW217406B (OSRAM) 1993-12-11
AU6326890A (en) 1991-04-11
NZ235525A (en) 1992-11-25
KR910007874A (ko) 1991-05-30
HU208115B (en) 1993-08-30
EP0421364A2 (en) 1991-04-10
IL95856A (en) 1994-05-30
JPH03151356A (ja) 1991-06-27

Similar Documents

Publication Publication Date Title
AU6326890A (en) Improvements in or relating to organic compounds
ES2066991T3 (es) Agentes hipoglucemiantes de oxazolidinadiona.
AU1120095A (en) Novel imidazole derivative and process for producing the same
TW255886B (OSRAM)
AU5247986A (en) Difluorophenyl 1,3-thiazole derivatives
AU628521B2 (en) Improvements in or relating to organic compounds
EP0530369A4 (en) Crystal comprising indolinospirobenzothiopyran derivative and ring-opening isomer thereof
DE59409595D1 (de) Anellierte dihydropyridine und deren verwendung für die herstellung von pharmazeutischen zubereitungen
AU8460791A (en) Compound, preparation and use
ATE148128T1 (de) Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
AU8452591A (en) 2-thio-1-aminocarbonyl cyclo alk-1-enes
GR3018629T3 (en) Piperidine compounds with glycosidase inhibition activity.
NZ332245A (en) Substituted benzo-oxazolol carboxylic acid derivatives, process for their production and medicaments containing them
AU594952B2 (en) Pineapple ketone 1'-alkoxyalkyl derivatives
EP0307041A3 (en) Sterically hindered amino compounds and processes for their preparation
ATE75747T1 (de) Verfahren zur herstellung von antibiotika.
AU8716391A (en) Tri(lower alkoxy)benzene derivative
EP0529100A4 (en) Indolinospirobenzopyran derivative
GR3006580T3 (OSRAM)