AU580746B2 - 5-pyrimidinecarboxamides and thiocarboxamides and treatment of leukemia and tumors therewith - Google Patents

5-pyrimidinecarboxamides and thiocarboxamides and treatment of leukemia and tumors therewith

Info

Publication number
AU580746B2
AU580746B2 AU36908/84A AU3690884A AU580746B2 AU 580746 B2 AU580746 B2 AU 580746B2 AU 36908/84 A AU36908/84 A AU 36908/84A AU 3690884 A AU3690884 A AU 3690884A AU 580746 B2 AU580746 B2 AU 580746B2
Authority
AU
Australia
Prior art keywords
tetrahydro
oxo
phenyl
hydroxy
pyrimidinecarboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU36908/84A
Other languages
English (en)
Other versions
AU3690884A (en
Inventor
Arthur D. Brewer
John A. Minatelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lanxess Canada Co
Uniroyal Chemical Co Inc
Original Assignee
Uniroyal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniroyal Inc filed Critical Uniroyal Inc
Publication of AU3690884A publication Critical patent/AU3690884A/en
Application granted granted Critical
Publication of AU580746B2 publication Critical patent/AU580746B2/en
Assigned to UNIROYAL CHEMICAL LTEE, UNIROYAL LTD. reassignment UNIROYAL CHEMICAL LTEE Request to Amend Deed and Register Assignors: UNIROYAL INC., UNIROYAL LTD.
Assigned to UNIROYAL CHEMICAL COMPANY, INC., UNIROYAL CHEMICAL LTD./ UNIROYAL CHEMICAL LTEE reassignment UNIROYAL CHEMICAL COMPANY, INC. Alteration of Name(s) in Register under S187 Assignors: UNIROYAL CHEMICAL LTD./ UNIROYAL CHEMICAL LTEE, UNIROYAL INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU36908/84A 1983-12-19 1984-12-19 5-pyrimidinecarboxamides and thiocarboxamides and treatment of leukemia and tumors therewith Ceased AU580746B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US56269383A 1983-12-19 1983-12-19
US562693 1983-12-19
US66526784A 1984-10-26 1984-10-26
US66520184A 1984-10-26 1984-10-26
US665267 1984-10-26
US665201 1984-10-26

Publications (2)

Publication Number Publication Date
AU3690884A AU3690884A (en) 1985-07-04
AU580746B2 true AU580746B2 (en) 1989-02-02

Family

ID=27415896

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36908/84A Ceased AU580746B2 (en) 1983-12-19 1984-12-19 5-pyrimidinecarboxamides and thiocarboxamides and treatment of leukemia and tumors therewith

Country Status (19)

Country Link
US (1) US4634707A (enExample)
JP (1) JPH0660164B2 (enExample)
AT (1) AT394194B (enExample)
AU (1) AU580746B2 (enExample)
BE (1) BE901301A (enExample)
CH (1) CH671225A5 (enExample)
DE (1) DE3446371A1 (enExample)
DK (1) DK164055C (enExample)
ES (1) ES8606296A1 (enExample)
FR (1) FR2557108B1 (enExample)
GB (1) GB2152047B (enExample)
GR (1) GR82494B (enExample)
IE (1) IE57675B1 (enExample)
IL (1) IL73840A (enExample)
IT (1) IT1213257B (enExample)
LU (1) LU85696A1 (enExample)
NL (1) NL8403856A (enExample)
NZ (2) NZ210599A (enExample)
SE (1) SE469171B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2145087B (en) * 1983-08-19 1987-02-04 Ciba Geigy Ag Barbituric acid derivatives
EP0167491A3 (de) * 1984-07-06 1986-12-30 Ciba-Geigy Ag Thiobarbitursäurederivate
GB2171099B (en) * 1985-02-15 1988-10-19 Ciba Geigy Ag 5-(azolyloxphenylcarbamoyl)barbituric acid derivatives as anthelmintics
US4636508A (en) * 1985-04-22 1987-01-13 Uniroyal Chemical Company, Inc. 5-pyrimidinecarboxyamides and treatment of leukemia therewith
EP0202823A3 (en) * 1985-05-17 1987-11-19 Uniroyal Limited Purification of 5-pyrimidinecarboxamides
US4845217A (en) * 1985-05-17 1989-07-04 Uniroyal Chemical Ltd./Ltee Purification of 5-pyrimidinecarboxamides
US4880811A (en) * 1987-06-24 1989-11-14 Memorial Hospital For Cancer And Allied Diseases Use of C-5 mono-substituted barbiturates to treat disorders of uric acid metabolism
US4920126A (en) * 1988-05-10 1990-04-24 Uniroyal Chemical Ltd/Uniroyal Chemical Ltee Barbituric acid derivative and treatment of leukemia and tumors therewith
WO1991013623A1 (en) * 1990-03-09 1991-09-19 Memorial Hospital For Cancer And Allied Diseases C-5 mono-substituted barbiturates in combination with therapeutic agents and uses thereof
EP1276728A2 (en) 2000-04-24 2003-01-22 ARYx Therapeutics Ultrashort acting hypnotic barbiturates
US10093631B2 (en) * 2014-02-14 2018-10-09 Acquist Llc Bifunctional compounds and use for reducing uric acid levels
CN107108526A (zh) * 2015-01-22 2017-08-29 R·P·小沃勒尔 双功能化合物及用于降低尿酸水平的用途
TWI771303B (zh) 2016-06-30 2022-07-21 美商艾克奎斯特有限責任公司 化合物及其於降低尿酸位準之用途(一)
EP3481819B1 (en) 2016-07-06 2022-06-01 Acquist LLC Compounds and their use for reducing uric acid levels
IT201700028709A1 (it) 2017-03-15 2018-09-15 Fondazione St Italiano Tecnologia Acidi-5-carbossamide-2-tiobarbiturici e loro uso come medicamenti

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3961061A (en) * 1974-02-07 1976-06-01 Bayer Aktiengesellschaft Pesticidal 2-amidocarbonylthiobarbituric acids
US4283444A (en) * 1978-09-12 1981-08-11 Ciba-Geigy Corporation Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds
AU4461985A (en) * 1984-07-06 1986-01-09 Ciba-Geigy Ag Thiobarbituric acid derivatives

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602664A5 (en) * 1973-06-14 1978-07-31 Sandoz Ag 2-Tert. amino-alkylamino-pyrimidine derivs.
DE2405732A1 (de) * 1974-02-07 1975-08-21 Bayer Ag Ekto- und endoparasitenmittel
CH614944A5 (en) * 1974-04-16 1979-12-28 Sandoz Ag Process for the preparation of novel pyrimidine derivatives
PL103086B1 (pl) * 1976-05-06 1979-05-31 Ciba Geigy Ag Srodek owadobojczy
CH616563A5 (en) * 1976-05-06 1980-04-15 Ciba Geigy Ag Pesticide containing a 5-phenylcarbamoylbarbituric acid as active ingredient
DE2624856A1 (de) * 1976-06-03 1977-12-22 Hoechst Ag 2-thiohexahydropyrimidin-4,6-dion-derivate und verfahren zu ihrer herstellung
EP0010941B1 (en) * 1978-10-30 1982-05-12 Fujisawa Pharmaceutical Co., Ltd. 5-fluorouracil derivatives, preparation thereof and their pharmaceutical compositions
US4349552A (en) * 1978-10-30 1982-09-14 Fujisawa Pharmaceutical Company, Ltd. 5-Fluorouracil derivatives, and their pharmaceutical compositions
CH654720A5 (de) * 1981-09-03 1986-03-14 Ciba Geigy Ag Lagerstabile mottenschutzformulierungen.
US4410524A (en) * 1982-06-01 1983-10-18 American Cyanamid Company Novel 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
GB2126582B (en) * 1982-08-26 1986-03-05 Ciba Geigy Ag Phenyl carbamoyl barbituric acid anthelmintics
CH658770A5 (de) * 1982-08-26 1986-12-15 Ciba Geigy Ag Motten- und kaeferschutzmittel.
ZA849819B (en) * 1983-12-19 1985-07-31 Uniroyal Inc 5-pyrimidinecarboxamides and thiocarboxamides and treatment of leukemia and tumors therewith

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3961061A (en) * 1974-02-07 1976-06-01 Bayer Aktiengesellschaft Pesticidal 2-amidocarbonylthiobarbituric acids
US4283444A (en) * 1978-09-12 1981-08-11 Ciba-Geigy Corporation Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds
AU4461985A (en) * 1984-07-06 1986-01-09 Ciba-Geigy Ag Thiobarbituric acid derivatives

Also Published As

Publication number Publication date
SE8406450L (sv) 1985-06-20
US4634707A (en) 1987-01-06
DE3446371C2 (enExample) 1990-08-16
NL8403856A (nl) 1985-07-16
DK609184A (da) 1985-06-20
DE3446371A1 (de) 1985-06-27
GB2152047B (en) 1988-04-27
ES8606296A1 (es) 1986-04-16
IE57675B1 (en) 1993-02-24
IL73840A (en) 1988-11-15
GB8432112D0 (en) 1985-01-30
JPS62174058A (ja) 1987-07-30
IT8424104A0 (it) 1984-12-18
AT394194B (de) 1992-02-10
JPH0660164B2 (ja) 1994-08-10
IL73840A0 (en) 1985-03-31
SE8406450D0 (sv) 1984-12-18
FR2557108A1 (fr) 1985-06-28
LU85696A1 (fr) 1985-09-12
NZ220399A (en) 1987-09-30
GB2152047A (en) 1985-07-31
DK164055C (da) 1992-09-28
CH671225A5 (enExample) 1989-08-15
GR82494B (en) 1985-04-19
AU3690884A (en) 1985-07-04
NZ210599A (en) 1987-09-30
DK609184D0 (da) 1984-12-18
ATA402684A (de) 1991-08-15
BE901301A (fr) 1985-06-18
IE843237L (en) 1985-06-19
ES538829A0 (es) 1986-04-16
FR2557108B1 (fr) 1988-11-18
DK164055B (da) 1992-05-04
IT1213257B (it) 1989-12-14
SE469171B (sv) 1993-05-24

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