AU5763296A - Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence - Google Patents

Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence

Info

Publication number
AU5763296A
AU5763296A AU57632/96A AU5763296A AU5763296A AU 5763296 A AU5763296 A AU 5763296A AU 57632/96 A AU57632/96 A AU 57632/96A AU 5763296 A AU5763296 A AU 5763296A AU 5763296 A AU5763296 A AU 5763296A
Authority
AU
Australia
Prior art keywords
sensor platform
analytes
luminescence
parallel detection
excited luminescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU57632/96A
Other languages
English (en)
Inventor
Wolfgang Budach
Gert Ludwig Duveneck
Dieter Neuschafer
Michael Pawlak
Uwe Pieles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU5763296A publication Critical patent/AU5763296A/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7793—Sensor comprising plural indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU57632/96A 1995-05-12 1996-05-02 Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence Abandoned AU5763296A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH139695 1995-05-12
CH1396/95 1995-05-12
PCT/EP1996/001817 WO1996035940A1 (en) 1995-05-12 1996-05-02 Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence

Publications (1)

Publication Number Publication Date
AU5763296A true AU5763296A (en) 1996-11-29

Family

ID=4209454

Family Applications (1)

Application Number Title Priority Date Filing Date
AU57632/96A Abandoned AU5763296A (en) 1995-05-12 1996-05-02 Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence

Country Status (15)

Country Link
US (2) US6078705A (https=)
EP (2) EP1890130A3 (https=)
JP (2) JPH11505610A (https=)
KR (1) KR19990014709A (https=)
AT (1) ATE377751T1 (https=)
AU (1) AU5763296A (https=)
BR (1) BR9608503A (https=)
CA (1) CA2219769A1 (https=)
DE (1) DE69637315T2 (https=)
IL (1) IL118217A0 (https=)
MX (1) MX9708698A (https=)
PL (1) PL323257A1 (https=)
TW (1) TW302435B (https=)
WO (1) WO1996035940A1 (https=)
ZA (1) ZA963731B (https=)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6327031B1 (en) 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
WO1998001533A1 (en) * 1996-07-08 1998-01-15 Burstein Laboratories, Inc. Cleavable signal element device and method
US6331275B1 (en) 1996-07-08 2001-12-18 Burstein Technologies, Inc. Spatially addressable, cleavable reflective signal elements, assay device and method
AU4207897A (en) * 1996-08-29 1998-03-19 Novartis Ag Optical chemical / biochemical sensor
WO1998022799A2 (de) * 1996-11-18 1998-05-28 Novartis Ag Messvorrichtung und deren verwendung
EP0843172A1 (de) * 1996-11-18 1998-05-20 Novartis AG Flusszelle sowie Vorrichtung zur Erzeugung evaneszent angeregter Strahlung
ID22965A (id) * 1997-02-28 1999-12-23 Burstein Lab Inc Laboratorium dalam suatu disk
EP0887645A1 (en) * 1997-06-23 1998-12-30 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Procedure and instrumentation for the ultrasensitive detection of prions, prion binding biomolecules and other biomolecules
EP0886141A1 (en) * 1997-06-23 1998-12-23 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
US6200814B1 (en) * 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
EP2112501A1 (de) 1998-02-05 2009-10-28 Novartis Ag Verfahren und Vorrichtung zur Lumineszenzmessung
AU2924399A (en) 1998-02-05 1999-08-23 Novartis Ag Method and device for measuring luminescence
GB9805935D0 (en) * 1998-03-19 1998-05-13 Ciba Geigy Ag Organic compounds
DE19815109A1 (de) 1998-04-03 1999-10-07 Bodenseewerk Perkin Elmer Co Vorrichtung zum Nachweis eines Fluoreszenzfarbstoffs
WO1999052633A1 (en) * 1998-04-14 1999-10-21 Ivd Systems Test cartridge with a single inlet port
FR2778986B1 (fr) 1998-05-22 2000-07-21 Suisse Electronique Microtech Capteur optique utilisant une reaction immunologique et un marqueur fluorescent
US6346376B1 (en) * 1998-06-03 2002-02-12 Centre Suisse D'electronique Et De Mictotechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
FR2783179B1 (fr) * 1998-09-16 2000-10-06 Commissariat Energie Atomique Dispositif d'analyse chimique ou biologique comprenant une pluralite de sites d'analyse sur un support, et son procede de fabrication
US7014815B1 (en) 1998-10-30 2006-03-21 Burstein Technologies, Inc. Trackable optical discs with concurrently readable nonoperational features
DE19964220C2 (de) 1998-11-23 2003-07-03 Friz Biochem Gmbh Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche
DE19856041A1 (de) * 1998-12-04 2000-07-13 Inst Chemo Biosensorik Verfahren und Vorrichtung zur Durchführung von quantitativen Fluoreszenz markierten Affinitätstests
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
CA2358566A1 (en) 1999-01-08 2000-07-13 Charles S. Vann Fiber array for contacting chemical species and methods for using and making same
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
DE19901761A1 (de) * 1999-01-18 1999-07-01 Gerhard Dr Hartwich Verfahren zur elektrochemischen Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen
DE69933193T2 (de) 1999-02-25 2007-08-02 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique S.A. Integrierter optischer Sensor und Verfahren zum integrierten optischen Nachweis einer Substanz
US6192168B1 (en) * 1999-04-09 2001-02-20 The United States Of America As Represented By The Secretary Of The Navy Reflectively coated optical waveguide and fluidics cell integration
SE9901306D0 (sv) * 1999-04-09 1999-04-09 Amersham Pharm Biotech Ab Improved TIRF chamber
WO2000075644A1 (de) * 1999-06-05 2000-12-14 Zeptosens Ag Sensorplatform und verfahren zur multianalytbestimmung
US6771376B2 (en) 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
KR100883079B1 (ko) 1999-07-05 2009-02-10 노파르티스 아게 플랫폼, 플랫폼을 가지는 장치, 및 플랫폼을 사용하는 방법
ATE516492T1 (de) 1999-08-13 2011-07-15 Bayer Technology Services Gmbh Vorrichtung und verfahren zur multianalytbestimmung
DK1204856T3 (da) † 1999-08-20 2005-08-08 Diagnostische Forsch Stiftung Fremgangsmåde til bestemmelse af stoffer ved evanescensfelt-metoden
DE19947616C2 (de) * 1999-10-01 2003-05-28 Fraunhofer Ges Forschung Verfahren zur Bestimmung von Substanzen, wie z.B. DNA-Sequenzen, in einer Probe und Vorrichtung zur Durchführung des Verfahrens
EP1218727A1 (de) * 1999-10-01 2002-07-03 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Verfahren und einrichtung zur bestimmung von substanzen, wie z.b. dna-sequenzen, in einer probe
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
AU2009401A (en) 1999-12-17 2001-06-25 Zeptosens Ag Flow cell array and the utilization thereof for multianalyte determination
DE19962668C1 (de) * 1999-12-23 2000-12-07 Siemens Ag Optische Meßeinrichtung für ein elektrisches Gerät mit einem in eine Nut gepreßten Leiter
DE10002566A1 (de) * 2000-01-21 2001-08-02 Fraunhofer Ges Forschung Verfahren und Einrichtung zur Bestimmung des Schmelzpunktes und/oder der Bindungskonstante von Substanzen, wie z. B. DNA-Sequenzen, in einer Probe
DE10012793C2 (de) * 2000-03-13 2002-01-24 Fraunhofer Ges Forschung Sensorelement zur optischen Detektion von chemischen oder biochemischen Analyten
US6368558B1 (en) * 2000-03-21 2002-04-09 The Board Of Trustees Of The University Of Illinois Colorimetric artificial nose having an array of dyes and method for artificial olfaction
AU2001247660A1 (en) * 2000-03-21 2001-10-03 The Board Of Trustees Of The University Of Illinois Colorimetric artificial nose having an array of dyes and method for artificial olfaction
US7058245B2 (en) * 2000-04-04 2006-06-06 Waveguide Solutions, Inc. Integrated optical circuits
WO2001092870A2 (de) 2000-06-02 2001-12-06 Zeptosens Ag Kit und verfahren zur multianalytbestimmung
US7555333B2 (en) * 2000-06-19 2009-06-30 University Of Washington Integrated optical scanning image acquisition and display
US7158224B2 (en) * 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
DE10036457A1 (de) * 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
FR2812942B1 (fr) * 2000-08-08 2002-10-31 Commissariat Energie Atomique Dispositif d'imagerie de fluorescence en lumiere polarisee
US6785433B2 (en) 2000-08-09 2004-08-31 Artificial Sensing Instruments Asi Ag Waveguide grid array and optical measurement arrangement
US7879598B2 (en) * 2000-09-04 2011-02-01 Bayer Technology Services Gmbh Multianalyte determination system and methods
WO2002020873A2 (de) 2000-09-05 2002-03-14 Zeptosens Ag Verfahren zur abscheidung von mono- und mehrfachschichten von organophosphor- und -phosphonsäuren und deren salzen sowie deren verwendung
US6358748B1 (en) * 2000-09-28 2002-03-19 The United States Of America As Represented By The U.S. Department Of Energy Microbend fiber-optic chemical sensor
WO2002040998A2 (de) * 2000-11-17 2002-05-23 Zeptosens Ag Kit und verfahren zur multianalytbestimmung
JP2002221485A (ja) * 2000-11-22 2002-08-09 Minolta Co Ltd マイクロチップ
DE50115872D1 (de) 2000-12-06 2011-06-16 Ecole Polytech Verfahren zur herstellung eines bioanalytischen reagenzes, nachweisverfahren beruhend auf der verwendung des bioanalytischen reagenz, sowie dessen verwendung
DE10108483A1 (de) 2001-02-22 2002-09-05 Bayer Ag Phosphorhaltige Polymere für optischen Signalwandler
US6577780B2 (en) * 2001-03-08 2003-06-10 Veridian Systems Cell designs for optical biosensors
JP2002365211A (ja) * 2001-04-02 2002-12-18 Fuji Photo Film Co Ltd 測定装置
JP2002365210A (ja) * 2001-06-11 2002-12-18 Hitachi Ltd 生体分子検出方法
EP2169383A1 (de) * 2001-06-15 2010-03-31 Bayer Technology Services GmbH Körper für Durchflussküvetten und deren Verwendung
GB0117230D0 (en) * 2001-07-14 2001-09-05 Marconi Applied Technologies Detecting analytes
DE10133844B4 (de) * 2001-07-18 2006-08-17 Micronas Gmbh Verfahren und Vorrichtung zur Detektion von Analyten
US6782013B2 (en) * 2001-07-25 2004-08-24 Jds Uniphase Corporation Waveguide wavelength locker
EP1424549A1 (en) * 2001-08-07 2004-06-02 Mitsubishi Chemical Corporation SURFACE PLASMON RESONANCE SENSOR CHIP, AND SAMPLE ANALYSIS METHOD AND ANALYSIS APPARATUS USING THE SAME
EP1421217A2 (de) * 2001-08-27 2004-05-26 Zeptosens AG Oberfläche zur immobilisierung von nukleinsäuren
US6791677B2 (en) * 2001-08-28 2004-09-14 Tosoh Corporation Information measuring apparatus using a fine channel device
US6767733B1 (en) 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
FI115343B (fi) * 2001-10-22 2005-04-15 Filtronic Lk Oy Sisäinen monikaista-antenni
US6903815B2 (en) * 2001-11-22 2005-06-07 Kabushiki Kaisha Toshiba Optical waveguide sensor, device, system and method for glucose measurement
US7251210B2 (en) 2002-01-31 2007-07-31 Burstein Technologies, Inc. Method for triggering through disc grooves and related optical analysis discs and system
US7179654B2 (en) * 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
EP1348757A1 (de) * 2002-03-27 2003-10-01 Micronas GmbH Vorrichtung und Verfahren zur Detektion von zellulären Vorgängen mittels Lumineszenzmessungen
JP2003308714A (ja) * 2002-04-17 2003-10-31 Fuji Photo Film Co Ltd 導光フィルム
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
US20030232427A1 (en) * 2002-06-18 2003-12-18 Montagu Jean I. Optically active substrates for examination of biological materials
WO2004001392A1 (en) * 2002-06-19 2003-12-31 Biosensor Applications Sweden Ab (Publ) System, device and method for detection of several individual analytes in a solution, and a disposible flow cell for use therein
US7154598B2 (en) * 2002-07-12 2006-12-26 Decision Biomarkers, Inc. Excitation and imaging of fluorescent arrays
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
WO2004023142A1 (de) * 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
ATE520027T1 (de) 2002-09-03 2011-08-15 Bayer Technology Services Gmbh Analytische plattform und nachweisverfahren mit gegebenenfalls nach fraktionierung in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
US7863052B2 (en) * 2005-08-11 2011-01-04 Sru Biosystems, Inc. Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
DE10248209A1 (de) * 2002-10-16 2004-05-06 Kist-Europe Forschungsgesellschaft Mbh Verfahren und Vorrichtung zur Messung einer Vielzahl von parallel durchgeführten Reaktionen
US20040081384A1 (en) * 2002-10-25 2004-04-29 Datesman Aaron M. Multiple-mode planar-waveguide sensor, fabrication materials and techniques
US20070141567A1 (en) * 2002-11-13 2007-06-21 Wulfman David R Waveguide system for detection of fluorescently labeled nucleic acid sequences
AU2003304679A1 (en) * 2002-12-09 2005-06-08 Rensselaer Polytechnic Institute Nanotube-organic photoelectric conversion devices and methods of making same
AU2003297685A1 (en) * 2002-12-10 2004-06-30 Rensselaer Polytechnic Institute Nanotube based non-linear optics and methods of making same
US6861251B2 (en) 2003-02-24 2005-03-01 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
JP2004279196A (ja) * 2003-03-14 2004-10-07 Dainippon Printing Co Ltd バイオマイクロアレイ用基板およびバイオマイクロアレイ
US7162124B1 (en) * 2003-03-14 2007-01-09 Luxtera, Inc. Fiber to chip coupler
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
US20050084909A1 (en) * 2003-08-29 2005-04-21 Kenichi Uchiyama Antigen measuring device and method thereof, an antibody chip package and a pallet
US8501098B1 (en) * 2003-09-18 2013-08-06 The Research Foundation Of State University Of New York Temporally addressable detection array
US20050074784A1 (en) * 2003-10-07 2005-04-07 Tuan Vo-Dinh Integrated biochip with continuous sampling and processing (CSP) system
EP1691666B1 (en) 2003-12-12 2012-05-30 University of Washington Catheterscope 3d guidance and interface system
WO2005064333A1 (ja) 2003-12-25 2005-07-14 National Institute Of Advanced Industrial Science And Technology タンパク質と糖鎖との相互作用を分析する方法
US7773836B2 (en) 2005-12-14 2010-08-10 Luxtera, Inc. Integrated transceiver with lightpipe coupler
KR100590548B1 (ko) * 2004-03-03 2006-06-19 삼성전자주식회사 광검출 장치
JP2007526460A (ja) * 2004-03-03 2007-09-13 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 細胞集団のタンパク質発現プロファイルの作成のための分析用プラットフォームおよび方法
WO2006046745A1 (en) * 2004-10-29 2006-05-04 Canon Kabushiki Kaisha Sensor for analyzing or identifying property of object, sensing apparatus using same, and sensing method
US7901632B2 (en) * 2004-11-16 2011-03-08 Chi Yung Fu Ultrasensitive olfactory system fabrication with doped aerogels
JP2006153497A (ja) * 2004-11-25 2006-06-15 Toshiba Corp グルコースセンシング膜用塗布液の調製方法および光学式グルコースセンサチップの製造方法
US7530948B2 (en) 2005-02-28 2009-05-12 University Of Washington Tethered capsule endoscope for Barrett's Esophagus screening
WO2006114249A1 (de) 2005-04-26 2006-11-02 Bayer Technology Services Gmbh Neue apparatur und verfahren zur beschichtung von trägersubstraten für einen analytnachweis mittels affinitäts-nachweisverfahren
US7738086B2 (en) * 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US20070097364A1 (en) * 2005-05-09 2007-05-03 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
DE102005026839A1 (de) * 2005-06-10 2006-12-21 Universität Tübingen Verfahren und Vorrichtung zur quantitativen Bestimmung von Analyten in flüssigen Proben
JP5331476B2 (ja) * 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド 遺伝子解析および化学解析用の単分子アレイ
US8597576B2 (en) 2005-06-23 2013-12-03 National Institute Of Advanced Industrial Science And Technology Analyzer for glycan or complex carbohydrate
JP4565237B2 (ja) * 2005-06-23 2010-10-20 独立行政法人産業技術総合研究所 糖鎖あるいは複合糖質の解析装置
JP2009501932A (ja) * 2005-07-21 2009-01-22 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 複数スポット配置を使った励起検出装置
US7790406B2 (en) * 2005-08-11 2010-09-07 Sru Biosystems, Inc Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
CN1940529B (zh) * 2005-09-29 2010-09-01 株式会社东芝 光波导型生物化学传感器芯片及其制造方法
US7960104B2 (en) 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
CA2624896C (en) 2005-10-07 2017-11-07 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
EP1941276A1 (de) 2005-10-29 2008-07-09 Bayer Technology Services GmbH Verfahren zur bestimmung eines oder mehrerer analyten in komplex zusammengesetzten proben biologischen ursprungs und dessen verwendung
JP2009516568A (ja) * 2005-11-23 2009-04-23 ユニヴァーシティ オブ ワシントン 中断される走査共振を使用する可変順次フレーミングを用いたビームの走査
US20090303479A1 (en) * 2006-02-06 2009-12-10 Stmicroelectronics S.R.L. Optical Apparatus and Method for the Inspection of Nucleic Acid Probes by Polarized Radiation
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
CA2643700A1 (en) 2006-02-24 2007-11-22 Callida Genomics, Inc. High throughput genome sequencing on dna arrays
SG170028A1 (en) 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
JP2009528128A (ja) 2006-03-03 2009-08-06 ユニヴァーシティ オブ ワシントン 多クラッド光ファイバ走査器
JP4365832B2 (ja) 2006-03-07 2009-11-18 株式会社日立製作所 生化学分析用セル、生化学分析用キット及び生化学分析装置
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
JP2008060445A (ja) * 2006-09-01 2008-03-13 Nec Corp 発光素子
WO2008070352A2 (en) 2006-10-27 2008-06-12 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20090075343A1 (en) 2006-11-09 2009-03-19 Complete Genomics, Inc. Selection of dna adaptor orientation by nicking
WO2008075578A1 (ja) * 2006-12-19 2008-06-26 Omron Corporation 表面プラズモンセンサ
US7943908B2 (en) * 2007-01-22 2011-05-17 University Of Maryland Sensor system with surface-plasmon-polariton (SPP) enhanced selective fluorescence excitation and method
US8840566B2 (en) 2007-04-02 2014-09-23 University Of Washington Catheter with imaging capability acts as guidewire for cannula tools
US7952718B2 (en) 2007-05-03 2011-05-31 University Of Washington High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor
US7768640B2 (en) * 2007-05-07 2010-08-03 The Board Of Trustees Of The University Of Illinois Fluorescence detection enhancement using photonic crystal extraction
EP2165184A1 (en) 2007-06-04 2010-03-24 University Of Maryland Biotechnology Institute Fluorescence microscope in a microwave cavity
CN101688835B (zh) * 2007-06-28 2014-01-29 皇家飞利浦电子股份有限公司 用于光学检查湿润表面的微电子传感器件
DE102007033124B4 (de) 2007-07-16 2012-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur optischen Detektion von Substanzen in einem flüssigen oder gasförmigen Medium
US8298496B2 (en) 2007-07-23 2012-10-30 Flir Systems, Inc. Fluidic configuration for flow injection analysis
DK2215209T3 (en) 2007-10-30 2018-09-03 Complete Genomics Inc DEVICE FOR HIGH-THROUGHPUT SEQUENCE OF NUCLEIC ACIDS
JP2009133836A (ja) * 2007-11-06 2009-06-18 Toshiba Corp 光学式センサ
AU2008323984A1 (en) * 2007-11-07 2009-05-14 Siemens Heathcare Diagnostics Inc. A method and apparatus for increasing the sensitivity of a biosensor used in a planar waveguide
DE102008011013B4 (de) * 2008-02-25 2014-11-13 Mevitec Gmbh Verfahren und Einrichtung zur komplexen Stoffwechselanalyse
AT506177B1 (de) * 2008-03-26 2009-07-15 Univ Graz Tech Optischer sensor
US9562847B2 (en) * 2008-04-04 2017-02-07 Asmag-Holding Gmbh Modular absorption measuring system
EP2110694B1 (en) 2008-04-18 2013-08-14 Sony DADC Austria AG Method for manufacturing an optical waveguide, optical waveguide, and sensor arrangement
WO2009132028A1 (en) * 2008-04-21 2009-10-29 Complete Genomics, Inc. Array structures for nucleic acid detection
DE102008019928A1 (de) 2008-04-21 2009-12-31 Siemens Healthcare Diagnostics Gmbh Polyelektrolyt-Monoschichten mit kovalenten Bindungsstellen für optische Signalwandler
WO2010007526A1 (en) 2008-07-17 2010-01-21 Andreas Pfuetzner Biomarkers for cardiodiabetes
US8329647B2 (en) 2008-07-17 2012-12-11 Ikfe Institut Fur Klinische Forschung Und Entwicklung Gmbh Method of treating a subject according to biomarkers for insulin resistance
CN102176864B (zh) * 2008-08-07 2014-12-31 马萨诸塞大学 分光镜传感器
DE102008052223A1 (de) * 2008-10-17 2010-04-22 Albert-Ludwigs-Universität Freiburg Lumineszenzscanner sowie Verfahren zur Detektion von Lumineszenz in Halbleiterbauteilen
WO2010064147A2 (en) 2008-12-04 2010-06-10 Ikfe Gmbh Biomarkers for atherosclerosis
AU2009325962A1 (en) 2008-12-11 2011-07-28 Ikfe Institut Fur Klinische Forschung Und Entwicklung Gmbh Biomarkers for insulin sensitizer drug response
US20100209350A1 (en) 2008-12-30 2010-08-19 Andreas Pfuetzner Biomarkers for Adipose Tissue Activity
EP2382475A2 (en) 2009-01-07 2011-11-02 IKFE GmbH Biomarkers for appetite regulation
DE102009016712A1 (de) 2009-04-09 2010-10-14 Bayer Technology Services Gmbh Einweg-Mikrofluidik-Testkassette zur Bioassay von Analyten
DE102009025072A1 (de) * 2009-06-16 2010-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Erzeugen eines Bereiches mit erhöhtem Brechungsindex und ein Substrat mit örtlich variablem Brechungsindex
EP2375242A1 (en) 2010-04-06 2011-10-12 FOM Institute for Atomic and Moleculair Physics Integrated plasmonic nanocavity sensing device
WO2012021749A1 (en) 2010-08-11 2012-02-16 Celula, Inc. Genotyping dna
US8305577B2 (en) * 2010-11-04 2012-11-06 Nokia Corporation Method and apparatus for spectrometry
EP2694949A1 (en) 2011-04-05 2014-02-12 Integrated Plasmonics Corporation Integrated plasmonic sensing device and apparatus
RU2476861C2 (ru) * 2011-05-19 2013-02-27 Игорь Иванович Смыслов Лазерноспектрокомпьютерный концентратомер люминесцентов, частиц и их запахов и способ его использования
WO2013079619A1 (en) * 2011-12-01 2013-06-06 Biosurfit, S.A. Photometric device and method
TW201416061A (zh) * 2012-10-19 2014-05-01 Nat Univ Chung Cheng 雙面光柵波導生物感測器
US20150077756A1 (en) * 2013-06-13 2015-03-19 Lumense, Inc. System and method for continuous real-time monitoring of water at contaminated sites
WO2015131056A2 (en) * 2014-02-28 2015-09-03 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US9618693B2 (en) * 2014-06-13 2017-04-11 Infineon Technologies Ag Liquid sensing systems and methods using a ring resonator sensor
US9702813B2 (en) * 2014-07-23 2017-07-11 Infineon Technologies Ag Sensing systems and methods using a coupling structure
MX384725B (es) 2014-08-08 2025-03-14 Quantum Si Inc Dispositivo integrado con fuente de luz externa para el sondeo, detección y análisis de moléculas.
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9851290B2 (en) * 2015-06-22 2017-12-26 Sharp Laboratories Of America, Inc. Particle detector for particulate matter accumulated on a surface
JP6731815B2 (ja) * 2016-09-08 2020-07-29 株式会社日立ハイテク 自動分析装置
US20210190772A1 (en) * 2017-01-23 2021-06-24 University Of Louisville Research Foundation, Inc. Electrically-modulated surface waves and an electrode interface comprising a metallic bilayer
DE102017127671A1 (de) * 2017-11-23 2019-05-23 Osram Opto Semiconductors Gmbh Photonischer Gassensor und Verfahren zur Herstellung eines photonischen Gassensors
EP3492909B1 (en) 2017-12-01 2023-11-01 ams AG Chemical sensing device using fluorescent sensing material
EP3775847B1 (en) * 2018-03-29 2026-04-29 Illumina, Inc. Illumination for fluorescence imaging using objective lens
JP7179549B2 (ja) * 2018-09-19 2022-11-29 旭化成エレクトロニクス株式会社 光導波路、光学式濃度測定装置、および製造方法
EP3990185B1 (en) 2019-06-28 2024-09-11 Illumina Cambridge Limited Flowcells with linear waveguides
US12006535B2 (en) 2019-11-19 2024-06-11 Sarmal, Inc. Methods and devices for detecting SARS-COV-2
JP2023502472A (ja) 2019-11-19 2023-01-24 サーマル，インコーポレイテッド Ｓａｒｓ－ｃｏｖ－２を検出する方法およびデバイス
KR102378269B1 (ko) * 2020-02-17 2022-03-24 가톨릭대학교산학협력단 회전식의 방사형 다중 진단키트
KR102378277B1 (ko) * 2020-02-17 2022-03-24 가톨릭대학교산학협력단 비회전식의 방사형 다중 진단키트
US12498328B2 (en) 2020-05-07 2025-12-16 Hand Held Products, Inc. Apparatuses, systems, and methods for sample testing
US12553885B2 (en) 2020-05-07 2026-02-17 Hand Held Products, Inc. Apparatuses, systems, and methods for sample testing
US11740177B2 (en) 2020-09-18 2023-08-29 Salvus, Llc Interferometric detection and quantification system and methods of use in aquatics
US11994504B2 (en) 2020-09-18 2024-05-28 Salvus, Llc Interferometric detection and quantification system and methods of use in food processing and food supply chain
US12399172B2 (en) 2020-09-18 2025-08-26 Salvus, Llc Interferometric detection and quantification system and methods of use in healthcare
CN117043583A (zh) * 2021-01-29 2023-11-10 奥索临床诊断有限公司 诊断性光子生物传感器方法、装置以及系统
EP4306940A1 (en) * 2022-07-15 2024-01-17 lino Biotech AG Device for use in the detection of binding affinities
US12517292B2 (en) * 2022-08-23 2026-01-06 Photonic Inc. Method providing suppression of excitation field for quantum light emitters using optical interferometers
DE102022213412A1 (de) 2022-12-12 2024-06-13 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung und Verfahren zur dynamischen Fluoreszenzanalyse, insbesondere für die Molekulardiagnostik
WO2024249362A1 (en) * 2023-06-01 2024-12-05 The Regents Of The University Of California Rare antibody phage isolation and discrimination (rapid) biological panning
EP4621387A3 (en) * 2024-03-20 2025-11-12 Hand Held Products, Inc. Method for functionalizing a sample channel in a waveguide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5163118A (en) * 1986-11-10 1992-11-10 The United States Of America As Represented By The Secretary Of The Air Force Lattice mismatched hetrostructure optical waveguide
US5165005A (en) * 1988-01-29 1992-11-17 Fiberchem Inc. Planar and other waveguide refractive index sensors using metal cladding
GB8807486D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Waveguide sensor
US5082629A (en) * 1989-12-29 1992-01-21 The Board Of The University Of Washington Thin-film spectroscopic sensor
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
GB9314991D0 (en) * 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
CN1149335A (zh) * 1994-05-27 1997-05-07 希巴-盖吉股份公司 探测短暂受激发光的方法

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