AU567953B2 - 2-(7-aroyl-(benzothiophen-5-yl or benzofuran-5-yl))-acetic acid derivatives - Google Patents

2-(7-aroyl-(benzothiophen-5-yl or benzofuran-5-yl))-acetic acid derivatives

Info

Publication number
AU567953B2
AU567953B2 AU30593/84A AU3059384A AU567953B2 AU 567953 B2 AU567953 B2 AU 567953B2 AU 30593/84 A AU30593/84 A AU 30593/84A AU 3059384 A AU3059384 A AU 3059384A AU 567953 B2 AU567953 B2 AU 567953B2
Authority
AU
Australia
Prior art keywords
acid
compound
formula
lower alkyl
benzofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU30593/84A
Other languages
English (en)
Other versions
AU3059384A (en
Inventor
James Patrick Dunn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of AU3059384A publication Critical patent/AU3059384A/en
Application granted granted Critical
Publication of AU567953B2 publication Critical patent/AU567953B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU30593/84A 1983-07-14 1984-07-13 2-(7-aroyl-(benzothiophen-5-yl or benzofuran-5-yl))-acetic acid derivatives Ceased AU567953B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51354583A 1983-07-14 1983-07-14
US513545 1983-07-14

Publications (2)

Publication Number Publication Date
AU3059384A AU3059384A (en) 1985-01-17
AU567953B2 true AU567953B2 (en) 1987-12-10

Family

ID=24043724

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30593/84A Ceased AU567953B2 (en) 1983-07-14 1984-07-13 2-(7-aroyl-(benzothiophen-5-yl or benzofuran-5-yl))-acetic acid derivatives

Country Status (22)

Country Link
EP (1) EP0132130B1 (enExample)
JP (1) JPS6038376A (enExample)
KR (1) KR880002533B1 (enExample)
AR (1) AR240815A1 (enExample)
AT (1) ATE50769T1 (enExample)
AU (1) AU567953B2 (enExample)
CA (1) CA1241008A (enExample)
CS (1) CS252476B2 (enExample)
DE (1) DE3481512D1 (enExample)
DK (1) DK347484A (enExample)
ES (2) ES8604554A1 (enExample)
FI (1) FI842738A7 (enExample)
GR (1) GR79949B (enExample)
HU (1) HU200450B (enExample)
IL (1) IL72409A (enExample)
NO (1) NO842878L (enExample)
NZ (1) NZ208894A (enExample)
PH (1) PH20790A (enExample)
PL (4) PL146523B1 (enExample)
PT (1) PT78905B (enExample)
SU (2) SU1409130A3 (enExample)
ZA (1) ZA845445B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0226670B1 (en) * 1985-12-04 1991-04-10 Imperial Chemical Industries Plc Process for hydroxyaraldehydes
GB8825505D0 (en) 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
US5674891A (en) * 1994-07-27 1997-10-07 The Procter & Gamble Company Dihydrobenzothiophene compounds useful as anti-inflammatory agents
JPH10506615A (ja) * 1994-07-27 1998-06-30 ザ、プロクター、エンド、ギャンブル、カンパニー 抗炎症剤として有用なジヒドロベンゾフラン及び関連化合物
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
ATE216704T1 (de) * 1996-12-26 2002-05-15 Tanabe Seiyaku Co Propiophenonderivate und verfahren zu ihrer herstellung
GB9814801D0 (en) * 1998-07-09 1998-09-09 Univ Strathclyde Integrin dependent cell adhesion inhibitors
AU2002353286A1 (en) 2002-12-10 2004-06-30 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
WO2023210740A1 (ja) * 2022-04-28 2023-11-02 第一三共株式会社 ベンゾチオフェン化合物
CN115403544B (zh) * 2022-09-16 2024-05-31 台州永健医药科技有限公司 一种丹酚酸c的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2469884A (en) * 1983-02-19 1984-08-23 Beecham Group Plc Dihydrobenzo furan (thiophene) and dihydro isobenzofuran derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2077733B1 (enExample) * 1970-02-10 1973-03-16 Roussel Uclaf
DE2909754A1 (de) * 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel
US4237144A (en) * 1979-06-21 1980-12-02 Merck & Co., Inc. 2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans
DE2931672A1 (de) * 1979-08-04 1981-02-26 Basf Ag Substituierte 2,3-dihydrobenzofurylmethylester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2469884A (en) * 1983-02-19 1984-08-23 Beecham Group Plc Dihydrobenzo furan (thiophene) and dihydro isobenzofuran derivatives

Also Published As

Publication number Publication date
ES544539A0 (es) 1986-06-16
ATE50769T1 (de) 1990-03-15
DK347484D0 (da) 1984-07-13
NO842878L (no) 1985-01-15
AR240815A2 (es) 1991-02-28
PL145622B1 (en) 1988-10-31
IL72409A (en) 1988-05-31
PL255164A1 (en) 1986-07-15
ES534324A0 (es) 1986-02-16
AU3059384A (en) 1985-01-17
FI842738A0 (fi) 1984-07-09
PT78905B (en) 1986-07-22
KR850001202A (ko) 1985-03-16
DK347484A (da) 1985-01-15
PL248729A1 (en) 1986-06-17
ES8607960A1 (es) 1986-06-16
FI842738L (fi) 1985-01-15
DE3481512D1 (de) 1990-04-12
PL146833B1 (en) 1989-03-31
HUT36108A (en) 1985-08-28
NZ208894A (en) 1987-01-23
EP0132130A2 (en) 1985-01-23
AR240815A1 (es) 1991-02-28
PL146523B1 (en) 1989-02-28
PL255162A1 (en) 1986-07-15
IL72409A0 (en) 1984-11-30
ES8604554A1 (es) 1986-02-16
PH20790A (en) 1987-04-14
CS252476B2 (en) 1987-09-17
EP0132130A3 (en) 1986-12-10
SU1614762A3 (ru) 1990-12-15
JPS6038376A (ja) 1985-02-27
PT78905A (en) 1984-08-01
CS545984A2 (en) 1987-01-15
ZA845445B (en) 1986-02-26
PL255163A1 (en) 1986-07-15
SU1409130A3 (ru) 1988-07-07
GR79949B (enExample) 1984-10-31
KR880002533B1 (ko) 1988-11-28
FI842738A7 (fi) 1985-01-15
CA1241008A (en) 1988-08-23
EP0132130B1 (en) 1990-03-07
HU200450B (en) 1990-06-28

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