AU538410B2 - Tetrazolyl alkoxy carbostyril derivatives - Google Patents
Tetrazolyl alkoxy carbostyril derivativesInfo
- Publication number
- AU538410B2 AU538410B2 AU50397/79A AU5039779A AU538410B2 AU 538410 B2 AU538410 B2 AU 538410B2 AU 50397/79 A AU50397/79 A AU 50397/79A AU 5039779 A AU5039779 A AU 5039779A AU 538410 B2 AU538410 B2 AU 538410B2
- Authority
- AU
- Australia
- Prior art keywords
- carbostyril derivatives
- tetrazolyl
- alkoxy
- tetrazolyl alkoxy
- carbostyril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Tetrazolyl alkoxy carbostyril derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10786978 | 1978-09-01 | ||
JP10786978A JPS5535019A (en) | 1978-09-01 | 1978-09-01 | Carbostyryl derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5039779A AU5039779A (en) | 1980-03-06 |
AU538410B2 true AU538410B2 (en) | 1984-08-16 |
Family
ID=14470137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU50397/79A Expired AU538410B2 (en) | 1978-09-01 | 1979-08-29 | Tetrazolyl alkoxy carbostyril derivatives |
Country Status (23)
Country | Link |
---|---|
US (1) | US4277479A (forum.php) |
JP (1) | JPS5535019A (forum.php) |
AR (1) | AR229342A1 (forum.php) |
AT (1) | AT364363B (forum.php) |
AU (1) | AU538410B2 (forum.php) |
BE (1) | BE878548A (forum.php) |
CA (1) | CA1139761A (forum.php) |
CH (1) | CH641799A5 (forum.php) |
DE (1) | DE2934747A1 (forum.php) |
DK (1) | DK158788C (forum.php) |
ES (1) | ES483792A1 (forum.php) |
FI (1) | FI68398C (forum.php) |
FR (1) | FR2434809A1 (forum.php) |
GB (1) | GB2033893B (forum.php) |
IT (1) | IT1119929B (forum.php) |
MX (1) | MX6749E (forum.php) |
NL (1) | NL183888C (forum.php) |
NO (1) | NO153177C (forum.php) |
PH (1) | PH18452A (forum.php) |
PT (1) | PT70136A (forum.php) |
SE (1) | SE432252B (forum.php) |
SU (1) | SU1064868A3 (forum.php) |
ZA (1) | ZA794627B (forum.php) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57156469A (en) * | 1981-03-19 | 1982-09-27 | Otsuka Pharmaceut Co Ltd | Preparation of tetrazole derivative |
JPS57183761A (en) * | 1981-04-30 | 1982-11-12 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5859980A (ja) * | 1981-10-05 | 1983-04-09 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
JPS5877880A (ja) * | 1981-11-05 | 1983-05-11 | Otsuka Pharmaceut Co Ltd | テトラゾ−ル誘導体 |
DE3225169A1 (de) * | 1982-07-06 | 1984-01-12 | Basf Ag, 6700 Ludwigshafen | Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen |
US4803162A (en) * | 1984-05-15 | 1989-02-07 | Fluorodiagnostic Limited Partners | Composition, article and process for detecting a microorganism |
CA1292234C (en) * | 1984-05-29 | 1991-11-19 | Simon Fraser Campbell | Heterocyclic-substituted quinolone inotropic agents |
GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
KR940000785B1 (ko) * | 1986-04-02 | 1994-01-31 | 오오쓰까세이야꾸 가부시끼가이샤 | 카르보스티릴 유도체 및 그의 염의 제조 방법 |
JPH0681752B2 (ja) * | 1986-04-02 | 1994-10-19 | 大塚製薬株式会社 | カルボスチリル誘導体 |
JPH0681727B2 (ja) * | 1986-04-02 | 1994-10-19 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
DK167187A (da) * | 1986-04-02 | 1987-10-03 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse |
JP2753622B2 (ja) | 1988-05-02 | 1998-05-20 | 大塚製薬株式会社 | カルボスチリル誘導体 |
US5064837A (en) * | 1989-11-13 | 1991-11-12 | Schering Corporation | 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions |
JPH07100648B1 (forum.php) * | 1990-01-08 | 1995-11-01 | ||
TW201305B (forum.php) * | 1991-04-03 | 1993-03-01 | Otsuka Pharma Co Ltd | |
CA2093633A1 (en) * | 1991-08-23 | 1993-02-24 | Seiji Sato | Carbostyril derivative and platelets aggregation inhibitory agent |
JPH0776521A (ja) * | 1993-09-07 | 1995-03-20 | Otsuka Pharmaceut Co Ltd | 気道炎症抑制剤 |
US6187790B1 (en) | 1999-03-04 | 2001-02-13 | Neal R. Cutler | Use of cilostazol for treatment of sexual dysfunction |
US20030045547A1 (en) * | 2001-05-02 | 2003-03-06 | Shinji Aki | Process for producing carbostyril derivatives |
JP4060523B2 (ja) * | 1999-11-24 | 2008-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体の製造法 |
IL151838A0 (en) | 2000-03-20 | 2003-04-10 | Teva Pharma | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n- (4-methoxyphenyl)-3-chloropropionamide |
US6825214B2 (en) | 2000-08-14 | 2004-11-30 | Teva Pharmaceutical Industries, Ltd. | Substantially pure cilostazol and processes for making same |
US6515128B2 (en) | 2000-03-20 | 2003-02-04 | Teva Pharmaceutical Industries Ltd. | Processes for preparing cilostazol |
JP3845059B2 (ja) * | 2000-08-14 | 2006-11-15 | テバ ファーマシューティカル インダストリーズ リミティド | シロスタゾールの製造方法 |
US6451813B1 (en) | 2001-01-26 | 2002-09-17 | R. T. Alamo Ventures I, Llc | Treatment of gastroparesis in certain patient groups |
US6458804B1 (en) * | 2001-01-26 | 2002-10-01 | R.T. Alamo Venturesi, Llc | Methods for the treatment of central nervous system disorders in certain patient groups |
US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
US20050101631A1 (en) * | 2002-08-01 | 2005-05-12 | Otsuka Pharmaceuticals Company | Process for producing carbostyril derivatives |
JP2003063965A (ja) * | 2001-06-13 | 2003-03-05 | Otsuka Pharmaceut Factory Inc | 注射用シロスタゾール水性製剤 |
US6388080B1 (en) | 2001-06-29 | 2002-05-14 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6573382B2 (en) * | 2001-06-29 | 2003-06-03 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6660864B2 (en) * | 2001-06-29 | 2003-12-09 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6531603B1 (en) * | 2001-06-29 | 2003-03-11 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6596871B2 (en) * | 2001-06-29 | 2003-07-22 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
WO2003002121A1 (en) * | 2001-06-29 | 2003-01-09 | Aaipharma, Inc. | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone |
US6657061B2 (en) * | 2001-06-29 | 2003-12-02 | Grayson Walker Stowell | Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
AU2002322456A1 (en) * | 2001-06-29 | 2003-03-03 | Aaipharma, Inc. | Polymorphic forms of 6-(4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy)-3, 4-dihydro-2(1h)-quinolinone |
SI1489080T1 (sl) * | 2002-09-10 | 2011-05-31 | Otsuka Pharma Co Ltd | Postopek za pridobivanje cilostazola |
US6743806B2 (en) * | 2002-10-23 | 2004-06-01 | Otsuka Pharmaceutical Company, Limited | Active oxygen scavenger |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
TWI323660B (en) | 2003-02-25 | 2010-04-21 | Otsuka Pharma Co Ltd | Pten inhibitor or maxi-k channels opener |
ITMI20031670A1 (it) * | 2003-08-26 | 2005-02-27 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Processo per la preparazione di cilostazolo e di suoi intermedi. |
US7524960B2 (en) * | 2004-03-16 | 2009-04-28 | Chemagis Ltd. | Highly pure cilostazol and an improved process for obtaining same |
US20050255155A1 (en) * | 2004-05-11 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Modified release cilostazol compositions |
EP1802304A1 (en) * | 2004-09-17 | 2007-07-04 | Ranbaxy Laboratories Limited | Cilostazol-containing pharmaceutical composition based on particles of less than 50 micrometers |
CN100462360C (zh) * | 2005-08-15 | 2009-02-18 | 上海立科药物化学有限公司 | N-环己基-5-(4-氯丁基)-1h-四氮唑的合成方法 |
WO2007032557A1 (en) | 2005-09-15 | 2007-03-22 | Otsuka Pharmaceutical Co., Ltd. | Combination drug containing probucol and a tetrazolylalkoxy-dihydrocarbostyril derivative with superoxide supressant effects |
US20070105898A1 (en) * | 2005-11-09 | 2007-05-10 | Apotex Pharmachem Inc. | Process for the production of cilostazol |
AR065588A1 (es) | 2007-03-09 | 2009-06-17 | Otsuka Pharma Co Ltd | Un medicamento para tratar enfermedad pulmonar obstructiva cronica |
TW200848041A (en) | 2007-03-30 | 2008-12-16 | Otsuka Pharma Co Ltd | A medicament for treating schizophrenia comprising cilostazol |
US8349817B2 (en) | 2007-04-25 | 2013-01-08 | Concert Pharmaceuticals, Inc. | Analogues of cilostazol |
EP2527336A1 (en) | 2007-04-25 | 2012-11-28 | Concert Pharmaceuticals Inc. | Deuterated analogues of cilostazol |
CA2687289C (en) | 2007-05-22 | 2015-09-15 | Otsuka Pharmaceutical Co., Ltd. | A medicament comprising a carbostyril derivative and donepezil for treating alzheimer's disease |
CN103601792B (zh) | 2007-06-04 | 2016-06-29 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
EP2194048A1 (en) | 2008-12-02 | 2010-06-09 | Dirk Sartor | Nitrate esters for the treatment of vascular and metabolic diseases |
US8779146B2 (en) | 2010-04-28 | 2014-07-15 | Nuformix Limited | Cilostazol cocrystals and compositions |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2681236B1 (en) | 2011-03-01 | 2018-01-03 | Synergy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
RS65632B1 (sr) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Ltd | Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe |
KR20220147691A (ko) | 2013-08-09 | 2022-11-03 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
CN114340631A (zh) | 2019-05-21 | 2022-04-12 | 阿德利克斯股份有限公司 | 用于降低患者的血清磷酸盐的组合 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2470084A (en) * | 1945-09-25 | 1949-05-17 | Bilhuber Inc E | Substituted alpha-halogen alkyl tetrazoles and process for obtaining the same |
US2470085A (en) * | 1947-03-07 | 1949-05-17 | Bilhuber Inc E | Substituted amino alkyl tetrazoles |
AR207554A1 (es) * | 1972-12-02 | 1976-10-15 | Otsuka Pharma Co Ltd | Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2) |
JPS5310986B2 (forum.php) * | 1974-02-05 | 1978-04-18 | ||
JPS5310989B2 (forum.php) * | 1974-04-25 | 1978-04-18 | ||
US4070470A (en) * | 1974-06-24 | 1978-01-24 | Otsuka Pharmaceutical Co., Ltd. | Platelet aggregation inhibiting carbostyrils, their compositions and method of use |
FI58329C (fi) * | 1974-11-08 | 1981-01-12 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat |
US4129565A (en) * | 1975-07-11 | 1978-12-12 | Nisshin Flour Milling Co., Ltd. | Isocarbostyril derivatives |
US4210753A (en) * | 1976-03-17 | 1980-07-01 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds |
JPS52116482A (en) * | 1976-03-24 | 1977-09-29 | Otsuka Pharmaceut Co Ltd | Carbostyril derivatives and its preparation |
JPS5430183A (en) * | 1977-08-10 | 1979-03-06 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril derivative |
-
1978
- 1978-09-01 JP JP10786978A patent/JPS5535019A/ja active Granted
-
1979
- 1979-08-22 CA CA000334272A patent/CA1139761A/en not_active Expired
- 1979-08-28 DE DE19792934747 patent/DE2934747A1/de active Granted
- 1979-08-29 PH PH22976A patent/PH18452A/en unknown
- 1979-08-29 AU AU50397/79A patent/AU538410B2/en not_active Expired
- 1979-08-29 US US06/070,710 patent/US4277479A/en not_active Expired - Lifetime
- 1979-08-29 AR AR277883A patent/AR229342A1/es active
- 1979-08-30 NL NLAANVRAGE7906523,A patent/NL183888C/xx not_active IP Right Cessation
- 1979-08-30 DK DK363179A patent/DK158788C/da active
- 1979-08-30 SU SU792804457A patent/SU1064868A3/ru active
- 1979-08-30 FI FI792699A patent/FI68398C/fi not_active IP Right Cessation
- 1979-08-31 SE SE7907236A patent/SE432252B/sv not_active IP Right Cessation
- 1979-08-31 ZA ZA00794627A patent/ZA794627B/xx unknown
- 1979-08-31 ES ES483792A patent/ES483792A1/es not_active Expired
- 1979-08-31 CH CH792079A patent/CH641799A5/de not_active IP Right Cessation
- 1979-08-31 BE BE0/196976A patent/BE878548A/xx not_active IP Right Cessation
- 1979-08-31 MX MX798357U patent/MX6749E/es unknown
- 1979-08-31 IT IT68748/79A patent/IT1119929B/it active
- 1979-08-31 PT PT70136A patent/PT70136A/pt unknown
- 1979-08-31 NO NO792829A patent/NO153177C/no unknown
- 1979-08-31 FR FR7921869A patent/FR2434809A1/fr active Granted
- 1979-09-03 AT AT0584579A patent/AT364363B/de not_active IP Right Cessation
- 1979-09-03 GB GB7930520A patent/GB2033893B/en not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |