AU509073B2 - Novel tetracyclic derivatives - Google Patents

Novel tetracyclic derivatives

Info

Publication number
AU509073B2
AU509073B2 AU25331/77A AU2533177A AU509073B2 AU 509073 B2 AU509073 B2 AU 509073B2 AU 25331/77 A AU25331/77 A AU 25331/77A AU 2533177 A AU2533177 A AU 2533177A AU 509073 B2 AU509073 B2 AU 509073B2
Authority
AU
Australia
Prior art keywords
novel tetracyclic
tetracyclic derivatives
derivatives
novel
tetracyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU25331/77A
Other languages
English (en)
Other versions
AU2533177A (en
Inventor
Willem Jacob Van Der Burg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of AU2533177A publication Critical patent/AU2533177A/en
Application granted granted Critical
Publication of AU509073B2 publication Critical patent/AU509073B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AU25331/77A 1976-05-24 1977-05-20 Novel tetracyclic derivatives Expired AU509073B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.
NL76.05526 1976-05-24

Publications (2)

Publication Number Publication Date
AU2533177A AU2533177A (en) 1978-11-23
AU509073B2 true AU509073B2 (en) 1980-04-17

Family

ID=19826245

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25331/77A Expired AU509073B2 (en) 1976-05-24 1977-05-20 Novel tetracyclic derivatives

Country Status (18)

Country Link
US (1) US4145434A (OSRAM)
JP (2) JPS532465A (OSRAM)
AU (1) AU509073B2 (OSRAM)
BE (1) BE854915A (OSRAM)
CA (1) CA1122976A (OSRAM)
CH (2) CH633536A5 (OSRAM)
DE (2) DE2760372C2 (OSRAM)
DK (1) DK157868C (OSRAM)
ES (3) ES459024A1 (OSRAM)
FI (1) FI65238C (OSRAM)
FR (1) FR2352800A1 (OSRAM)
GB (1) GB1567862A (OSRAM)
HU (1) HU173795B (OSRAM)
IE (1) IE45419B1 (OSRAM)
LU (1) LU77387A1 (OSRAM)
NL (1) NL7605526A (OSRAM)
SE (1) SE436202B (OSRAM)
ZA (1) ZA772752B (OSRAM)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007450A1 (de) * 1978-07-07 1980-02-06 Ciba-Geigy Ag Azatetracyclische Carbonitrile, ihre Herstellung, pharmazeutische Präparate, die diese enthalten und deren Verwendung
DE3069086D1 (de) * 1979-12-10 1984-10-04 Ciba Geigy Ag Azatetracyclic carbonitriles
FR2504140A1 (fr) * 1981-04-16 1982-10-22 Centre Nat Rech Scient Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant
NZ204242A (en) * 1982-05-18 1986-08-08 Hoffmann La Roche 8-halo-6-phenyl-2,3-dihydro-1h,4h-pyrrolo(3,4-d)(2)benzazepine-(1-or 3-ones or 1,3-diones)
JPS62101941U (OSRAM) * 1985-12-16 1987-06-29
IE62754B1 (en) * 1988-08-26 1995-02-22 Akzo Nv Tetracyclic antidepressants
EP0569096A1 (en) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Depot preparation
PT690863E (pt) * 1993-04-06 2003-07-31 Abbott Lab Compostos tetraciclicos como agonistas da dopamina
RU2139051C1 (ru) * 1994-03-02 1999-10-10 Акцо Нобель Н.В. Сублингвальная или трансбуккальная фармацевтическая композиция
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
NZ329953A (en) * 1996-04-12 1999-06-29 Janssen Pharmaceutica Nv Substituted tetracyclic n-oxide tetrahydrofuran derivatives, salts and stereoisomeric forms thereof for the treatment of cns cardiovascular or gastrointestinal disorders
JP2001526702A (ja) * 1997-05-26 2001-12-18 アクゾ・ノベル・エヌ・ベー 芳香族スルホン酸の塩類
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
RU2005135454A (ru) * 2003-05-16 2006-06-27 Пфайзер Продактс Инк. (Us) Терапевтические комбинации атипичных нейролептиков с модуляторами гамк и/или противосудорожными препаратами
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030959A2 (OSRAM) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
JP2007522200A (ja) * 2004-02-13 2007-08-09 ファイザー・プロダクツ・インク 非定型抗精神病薬とコルチコトロピン放出因子拮抗薬の治療的組合せ
CA2565996A1 (en) * 2004-05-11 2005-11-17 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
KR20070084123A (ko) * 2004-10-15 2007-08-24 엔.브이.오가논 양극성 장애 및 관련 증상의 치료
PL1710241T3 (pl) * 2005-04-07 2010-04-30 Msd Oss Bv Związki pośrednie do wytwarzania trans-5-chloro-2-metylo-2,3,3a,12b-tetrahydro-1H-dibenz-[2,3:6,7]oksepino[4,5-c]pirolu
US7872147B2 (en) 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
SI1710245T1 (sl) * 2005-04-07 2007-12-31 Organon Nv Kristalna oblika asenapin maleata
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
WO2007046554A1 (ja) * 2005-10-21 2007-04-26 Sumitomo Chemical Company, Limited ジベンゾオキセピノピロール化合物の製造方法、その中間体及び該中間体の製造方法
US7750167B2 (en) * 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
TW200817414A (en) * 2006-07-05 2008-04-16 Organon Nv Process for the preparation of asenapine and intermediate products used in said process
WO2008040816A1 (en) * 2006-10-06 2008-04-10 N.V. Organon Amorphous asenapine and processes for preparing same
US7875729B2 (en) * 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
EP2170399A1 (en) * 2007-06-05 2010-04-07 Synthon B.V. Intranasal administration of asenapine and pharmaceutical compositions therefor
JP5245428B2 (ja) * 2007-07-06 2013-07-24 住友化学株式会社 トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体
ATE527266T1 (de) * 2008-01-04 2011-10-15 Organon Nv Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte
CA2716080C (en) 2008-02-20 2016-12-13 Targia Pharmaceuticals Cns pharmaceutical compositions and methods of use
JP2011526881A (ja) * 2008-06-25 2011-10-20 ファイザー・インク ジアリール化合物およびそれらの使用
RU2012102247A (ru) 2009-06-24 2013-07-27 Мсд Осс Б.В. Инъекционные композиции, содержащие асенапин и способ лечения с их применением
TW201118102A (en) 2009-07-29 2011-06-01 Organon Nv Hydroxyasenapine compounds, derivatives thereof and pharmaceutical compositions comprising same
AU2011268335A1 (en) 2010-06-18 2013-01-10 Dr. Reddy's Laboratories Ltd. Asenapine maleate
KR101810717B1 (ko) 2010-07-29 2017-12-19 라보라토리오스 레스비, 에스.엘. 아세나핀을 제조하는 신규한 방법
MX346185B (es) 2010-11-15 2017-03-10 Agenebio Inc Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.
WO2012066565A2 (en) 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
EP2468751B1 (en) 2010-12-24 2016-03-16 Medichem, S.A. Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
ITMI20110734A1 (it) 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
EP2524921A1 (en) * 2011-05-17 2012-11-21 Sandoz AG Novel Crystalline Salts of Asenapine
EP2524919A1 (en) * 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
US9505771B2 (en) 2011-05-18 2016-11-29 Laboratories Lesvi S.L. Stable micronised monoclin form of asenapine maleate and its synthesis
WO2012156676A1 (en) 2011-05-18 2012-11-22 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
WO2013024492A2 (en) 2011-07-01 2013-02-21 Megafine Pharma (P) Ltd. A process for the preparation of asenapine and novel salts thereof
WO2013011461A1 (en) 2011-07-20 2013-01-24 Ranbaxy Laboratories Limited Process for the preparation of asenapine maleate
WO2013035109A1 (en) 2011-09-08 2013-03-14 Mylan Laboratories Ltd Improved process for the preparation of asenapine maleate
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
EP2572703A1 (en) 2011-09-21 2013-03-27 Hexal AG Compressed oral dosage form for asenapine maleate
EP2785718A1 (en) 2011-11-28 2014-10-08 Ranbaxy Laboratories Limited Process for the preparation of asenapine intermediate
CN103254201B (zh) * 2012-02-21 2016-04-13 四川科伦药物研究有限公司 一种阿塞那平的制备方法
WO2013190481A1 (en) * 2012-06-21 2013-12-27 Alembic Pharmaceuticals Limited Process for preparing asenapine and salts of intermediates thereof
ITMI20121810A1 (it) 2012-10-24 2014-04-25 Chemo Iberica Sa Poliformi di maleato di asenapina e processo per la loro preparazione
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014127786A1 (en) 2013-02-22 2014-08-28 Zentiva, K.S. Orally disintegrating pharmaceutical composition comprising asenapine
CN103113379A (zh) * 2013-03-12 2013-05-22 盛世泰科生物医药技术(苏州)有限公司 阿塞那平马来酸盐的合成工艺
CN103351393B (zh) * 2013-07-03 2016-04-06 华裕(无锡)制药有限公司 用于制备阿森那平之还原剂及阿森那平之制备方法
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN103772401A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 11-氯-2,3,3a,12b-四氢-2-甲基-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯-1-酮的一种新精制方法
CN103772400A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 反式-5-氯-2,3,3a,12b-四氢-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯的制备方法
CA2987081C (en) 2015-06-11 2022-08-30 Alrise Biosystems Gmbh Process for the preparation of drug loaded microparticles
EP3310785B1 (en) 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
ES3001152T3 (es) 2016-12-20 2025-03-04 Lts Lohmann Therapie Systeme Ag Sistema terapéutico transdérmico que contiene asenapina y polisiloxano o poliisobutileno
AU2017384526B2 (en) 2016-12-20 2023-11-02 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
WO2019002204A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER
CA3104478A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3810099A1 (en) 2018-06-20 2021-04-28 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
WO2019243452A1 (en) 2018-06-20 2019-12-26 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
CN110183457A (zh) * 2019-06-27 2019-08-30 浙江天顺药业有限公司 一种阿塞那平及其制备方法
CN110606852B (zh) 2019-08-13 2021-02-05 浙江奥翔药业股份有限公司 制备阿塞那平的方法
US11679407B2 (en) * 2020-06-26 2023-06-20 Intel Corporation Liquid metal thermal interface material application
WO2023006954A1 (en) 2021-07-30 2023-02-02 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Asenapine for use in cancer
EP4572852A1 (en) 2022-08-19 2025-06-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7510774A (en) * 1974-11-07 1975-02-13 Ciba-Geigy Ag New azepine derivatives and process forthe production thereof
AU7755875A (en) * 1974-01-31 1976-07-29 Akzo N.V. Novel tetracylic piperidino derivatives
AU7840075A (en) * 1974-02-22 1976-08-26 Ciba-Geigy Ag Thiepino- and oxepino - pyrrole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507232A (de) * 1968-11-27 1971-05-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Thiepin- und Oxepinderivaten

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7755875A (en) * 1974-01-31 1976-07-29 Akzo N.V. Novel tetracylic piperidino derivatives
AU7840075A (en) * 1974-02-22 1976-08-26 Ciba-Geigy Ag Thiepino- and oxepino - pyrrole derivatives
AU7510774A (en) * 1974-11-07 1975-02-13 Ciba-Geigy Ag New azepine derivatives and process forthe production thereof

Also Published As

Publication number Publication date
DK227477A (da) 1977-11-25
CH633536A5 (de) 1982-12-15
DK157868B (da) 1990-02-26
JPS6134426B2 (OSRAM) 1986-08-07
ES470408A1 (es) 1979-01-01
ZA772752B (en) 1978-04-26
BE854915A (fr) 1977-11-23
DE2760372C2 (OSRAM) 1991-05-29
FI65238B (fi) 1983-12-30
US4145434A (en) 1979-03-20
JPS6238348B2 (OSRAM) 1987-08-17
LU77387A1 (OSRAM) 1977-08-29
CA1122976A (en) 1982-05-04
AU2533177A (en) 1978-11-23
DE2723209A1 (de) 1977-12-15
FR2352800A1 (fr) 1977-12-23
ES470407A1 (es) 1979-01-01
CH637382A5 (de) 1983-07-29
GB1567862A (en) 1980-05-21
SE7705957L (sv) 1977-11-25
IE45419B1 (en) 1982-08-25
FR2352800B1 (OSRAM) 1980-02-01
NL7605526A (nl) 1977-11-28
HU173795B (hu) 1979-08-28
ES459024A1 (es) 1978-11-01
DK157868C (da) 1990-07-30
JPS532465A (en) 1978-01-11
JPS61178965A (ja) 1986-08-11
FI771635A7 (OSRAM) 1977-11-25
SE436202B (sv) 1984-11-19
IE45419L (en) 1977-11-24
FI65238C (fi) 1984-04-10

Similar Documents

Publication Publication Date Title
AU509073B2 (en) Novel tetracyclic derivatives
AU519064B2 (en) 4-n-acylfortimicin b derivatives
AU509754B2 (en) Benazepine derivatives
AU517585B2 (en) Phenoxybenzyloxycarbonyl derivatives
AU507258B2 (en) Fluoroacacylresorcin derivatives
AU517829B2 (en) Morphanthridine derivatives
AU504526B2 (en) Pipeazine derivatives
AU502122B2 (en) 5-0-acylated-imidazole-4-carboxamide derivatives
AU515192B2 (en) Quinoxaline-din-oxide derivatives
AU512647B2 (en) Solpenamide derivatives
AU513821B2 (en) Ergoline derivatives
AU511572B2 (en) Tetracyclic compounds
AU514803B2 (en) 4-phenylpipridine derivatives
AU513069B2 (en) 17-spirosiltine derivatives
AU507708B2 (en) Hydrazino-pyridazine derivatives
AU506714B2 (en) Bis benzopyram derivatives
AU505150B2 (en) Triazolobenzazepine derivatives
AU519085B2 (en) 1-carba-2-penem derivatives
AU511948B2 (en) Nortropine-carbazate derivatives
AU503490B2 (en) Aminoalkyl-dibenzocyclohepton-5-one derivatives
AU1858676A (en) Aminoalkyl-dibenzocyclohepton-5-one derivatives
AU540464B2 (en) Morphanthridine derivatives
AU515135B2 (en) Ribofuranosyl-imidazole derivatives
AU512688B2 (en) Thienyl-and T-aminophenyl-pyrrolidine derivatives
AU508555B2 (en) 6-carboxy-flavone derivatives