AU2022312698A1 - Multispecific binding agents against cd40 and cd137 in combination therapy for cancer - Google Patents

Multispecific binding agents against cd40 and cd137 in combination therapy for cancer Download PDF

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Publication number
AU2022312698A1
AU2022312698A1 AU2022312698A AU2022312698A AU2022312698A1 AU 2022312698 A1 AU2022312698 A1 AU 2022312698A1 AU 2022312698 A AU2022312698 A AU 2022312698A AU 2022312698 A AU2022312698 A AU 2022312698A AU 2022312698 A1 AU2022312698 A1 AU 2022312698A1
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AU
Australia
Prior art keywords
binding agent
heavy chain
binding
region
cancer
Prior art date
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Pending
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AU2022312698A
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English (en)
Inventor
Homer Adams, Iii
Gaurav Bajaj
Karsten Beckmann
Jordan BLUM
Esther Cornelia Wilhelmina Breij
Bart-Jan DE KREUK
Sina FELLERMEIER-KOPF
Mark Fereshteh
Yali FU
Patricia GARRIDO CASTRO
Friederike GIESEKE
Lars GUELEN
Richard HIBBERT
Brandon Higgs
Ivan KUZMANOV
Aran Frank Labrijn
Alexander Muik
Joost Neijssen
Michelle NIEWOOD
Claudia PAULMANN
Ugur Sahin
Janine Schuurman
Vanessa SPIRES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biontech SE
Genmab AS
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Biontech SE
Genmab AS
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Publication date
Application filed by Biontech SE, Genmab AS filed Critical Biontech SE
Publication of AU2022312698A1 publication Critical patent/AU2022312698A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
AU2022312698A 2021-07-13 2022-07-13 Multispecific binding agents against cd40 and cd137 in combination therapy for cancer Pending AU2022312698A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163221340P 2021-07-13 2021-07-13
US63/221,340 2021-07-13
US202263364594P 2022-05-12 2022-05-12
US63/364,594 2022-05-12
PCT/EP2022/069639 WO2023285552A1 (en) 2021-07-13 2022-07-13 Multispecific binding agents against cd40 and cd137 in combination therapy for cancer

Publications (1)

Publication Number Publication Date
AU2022312698A1 true AU2022312698A1 (en) 2024-01-25

Family

ID=82898866

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022312698A Pending AU2022312698A1 (en) 2021-07-13 2022-07-13 Multispecific binding agents against cd40 and cd137 in combination therapy for cancer

Country Status (9)

Country Link
US (1) US20240327544A1 (https=)
EP (1) EP4370552A1 (https=)
JP (1) JP2024525758A (https=)
KR (1) KR20240046323A9 (https=)
AU (1) AU2022312698A1 (https=)
CA (1) CA3225254A1 (https=)
IL (1) IL309831A (https=)
MX (1) MX2024000674A (https=)
WO (1) WO2023285552A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202000198QA (en) 2017-08-04 2020-02-27 Genmab As Binding agents binding to pd-l1 and cd137 and use thereof
WO2023218051A1 (en) * 2022-05-12 2023-11-16 Genmab A/S Binding agents capable of binding to cd27 in combination therapy
KR20250071228A (ko) * 2022-09-20 2025-05-21 커러스 바이오로직스 피티와이 엘티디 고갈된 면역 세포를 구제하는 방법
CN120302979A (zh) * 2022-12-01 2025-07-11 生物技术公司 针对CD40和CD137的多特异性抗体与抗PD1 Ab和化学治疗的组合治疗

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ SAHIN, UGUR; MUIK, ALEXANDER; FELLERMEIER-KOPF, SINA; FU, YALI; ADAMS, HOMER, III; BAJAJ, GAURAV; HIGGS, BRANDON; FERESHTEH, MARK; SPIRES, VANESSA; BLUM, JORDAN; GARRIDO CASTRO, PATRICIA; NIEWOOD, MICHELLE; GIESEKE, FRIEDERIKE; BECKMANN, KARSTEN; PAULMANN, CLAUDIA; KUZMANOV, IVAN; BREIJ, ESTHER CORNELIA WILHELMINA; GUELEN, LARS; NEIJSSEN, JOOST; DE KREUK, BART-JAN; HIBBERT, RICHARD; SCHUURMAN, JANINE AND LABRIJN, ARAN FRANK