AU2019360937A1 - Expression vectors for large-scale production of rAAV in the baculovirus/Sf9 system - Google Patents

Expression vectors for large-scale production of rAAV in the baculovirus/Sf9 system Download PDF

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Publication number
AU2019360937A1
AU2019360937A1 AU2019360937A AU2019360937A AU2019360937A1 AU 2019360937 A1 AU2019360937 A1 AU 2019360937A1 AU 2019360937 A AU2019360937 A AU 2019360937A AU 2019360937 A AU2019360937 A AU 2019360937A AU 2019360937 A1 AU2019360937 A1 AU 2019360937A1
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Prior art keywords
aav
aavhu
aava
certain embodiments
clv
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Abandoned
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AU2019360937A
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Inventor
Luis Maranga
Jeffrey Morley SLACK
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Voyager Therapeutics Inc
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Voyager Therapeutics Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
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    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14041—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
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    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14144—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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AU2019360937A 2018-10-15 2019-10-15 Expression vectors for large-scale production of rAAV in the baculovirus/Sf9 system Abandoned AU2019360937A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862745703P 2018-10-15 2018-10-15
US62/745,703 2018-10-15
PCT/US2019/056199 WO2020081490A1 (en) 2018-10-15 2019-10-15 EXPRESSION VECTORS FOR LARGE-SCALE PRODUCTION OF rAAV IN THE BACULOVIRUS/Sf9 SYSTEM

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AU2019360937A1 true AU2019360937A1 (en) 2021-05-20

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AU2019360937A Abandoned AU2019360937A1 (en) 2018-10-15 2019-10-15 Expression vectors for large-scale production of rAAV in the baculovirus/Sf9 system

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US (1) US20210395777A1 (https=)
EP (1) EP3867389A1 (https=)
JP (1) JP2022505106A (https=)
CN (1) CN113166781A (https=)
AU (1) AU2019360937A1 (https=)
CA (1) CA3116701A1 (https=)
TW (1) TW202028468A (https=)
WO (1) WO2020081490A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7805169B2 (ja) * 2019-06-26 2026-01-23 ビロベク，インコーポレイテッド バキュロウイルス発現系
BR112023002374A2 (pt) * 2020-08-12 2023-03-21 UCB Biopharma SRL Terapia genética usando construções de ácido nucléico compreendendo sequências promotoras de proteína 2 de ligação de metil cpg (mecp2)
WO2022155364A1 (en) * 2021-01-13 2022-07-21 Dignity Health Modulation of chitinase protein expression
WO2022187473A2 (en) * 2021-03-03 2022-09-09 Voyager Therapeutics, Inc. Controlled expression of viral proteins
WO2022269466A1 (en) * 2021-06-22 2022-12-29 Pfizer Inc. Production of adeno-associated virus vector in insect cells
CN114058646B (zh) * 2021-11-10 2023-11-03 武汉科前生物股份有限公司 一种表达PCV2d cap蛋白的载体及方法
CN115960961A (zh) * 2022-12-21 2023-04-14 武汉华美生物工程有限公司 一种昆虫细胞表达载体、表达系统及其应用
KR20250129743A (ko) 2022-12-29 2025-08-29 보이저 테라퓨틱스, 인크. Mapt를 조절하기 위한 조성물 및 방법

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