AU2018355427A1 - Methods of making chimeric antigen receptor-expressing cells - Google Patents

Methods of making chimeric antigen receptor-expressing cells Download PDF

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Publication number
AU2018355427A1
AU2018355427A1 AU2018355427A AU2018355427A AU2018355427A1 AU 2018355427 A1 AU2018355427 A1 AU 2018355427A1 AU 2018355427 A AU2018355427 A AU 2018355427A AU 2018355427 A AU2018355427 A AU 2018355427A AU 2018355427 A1 AU2018355427 A1 AU 2018355427A1
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Australia
Prior art keywords
molecule
cells
car
stat3
cell
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Abandoned
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AU2018355427A
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Inventor
Joseph A. Fraietta
Carl H. June
Jan J. Melenhorst
Roderick O'CONNOR
Elena ORLANDO
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Novartis AG
University of Pennsylvania Penn
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Novartis AG
University of Pennsylvania Penn
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2501/20—Cytokines; Chemokines
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AU2018355427A 2017-10-25 2018-10-25 Methods of making chimeric antigen receptor-expressing cells Abandoned AU2018355427A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762577099P 2017-10-25 2017-10-25
US62/577,099 2017-10-25
US201862637854P 2018-03-02 2018-03-02
US62/637,854 2018-03-02
PCT/US2018/057545 WO2019084288A1 (en) 2017-10-25 2018-10-25 METHODS FOR DESIGNING CHIMERIC ANTIGENIC RECEPTOR EXPRESSION CELLS

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AU2018355427A1 true AU2018355427A1 (en) 2020-04-30

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AU2018355427A Abandoned AU2018355427A1 (en) 2017-10-25 2018-10-25 Methods of making chimeric antigen receptor-expressing cells

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US (1) US20200370012A1 (enExample)
EP (1) EP3700926A1 (enExample)
JP (1) JP2021500894A (enExample)
KR (1) KR20200069358A (enExample)
CN (1) CN111566124A (enExample)
AU (1) AU2018355427A1 (enExample)
BR (1) BR112020007710A2 (enExample)
CA (1) CA3078270A1 (enExample)
IL (1) IL273956A (enExample)
MX (1) MX2020004229A (enExample)
RU (1) RU2020116579A (enExample)
SG (1) SG11202003177RA (enExample)
WO (1) WO2019084288A1 (enExample)

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