AU2018323053A1 - Cyclic di-nucleotides as stimulator of interferon genes modulators - Google Patents
Cyclic di-nucleotides as stimulator of interferon genes modulators Download PDFInfo
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- AU2018323053A1 AU2018323053A1 AU2018323053A AU2018323053A AU2018323053A1 AU 2018323053 A1 AU2018323053 A1 AU 2018323053A1 AU 2018323053 A AU2018323053 A AU 2018323053A AU 2018323053 A AU2018323053 A AU 2018323053A AU 2018323053 A1 AU2018323053 A1 AU 2018323053A1
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Classifications
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C07D—HETEROCYCLIC COMPOUNDS
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A61P19/00—Drugs for skeletal disorders
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201762552148P | 2017-08-30 | 2017-08-30 | |
| US62/552,148 | 2017-08-30 | ||
| US201862660565P | 2018-04-20 | 2018-04-20 | |
| US62/660,565 | 2018-04-20 | ||
| PCT/IB2018/056658 WO2019043634A2 (en) | 2017-08-30 | 2018-08-30 | CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS |
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| AU2018323053A1 true AU2018323053A1 (en) | 2020-03-19 |
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| AU2018323053A Abandoned AU2018323053A1 (en) | 2017-08-30 | 2018-08-30 | Cyclic di-nucleotides as stimulator of interferon genes modulators |
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| AU (1) | AU2018323053A1 (https=) |
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| SG (1) | SG11202001847WA (https=) |
| TW (1) | TWI808092B (https=) |
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| WO2018156625A1 (en) | 2017-02-21 | 2018-08-30 | Board Of Regents,The University Of Texas System | Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling |
| MX2020002303A (es) | 2017-08-30 | 2020-09-10 | Beijing Xuanyi Pharmasciences Co Ltd | Dinucleotidos ciclicos como moduladores del estimulador de genes de interferon. |
| KR20200098511A (ko) | 2017-11-10 | 2020-08-20 | 다케다 야쿠힌 고교 가부시키가이샤 | Sting 조절제 화합물, 및 제조 및 사용 방법 |
| ES2980374T3 (es) * | 2018-03-08 | 2024-10-01 | Bristol Myers Squibb Co | Dinucleótidos cíclicos como agentes anticancerosos |
| BR112020024605A2 (pt) | 2018-06-01 | 2021-04-06 | Eisai R&D Management Co., Ltd. | Métodos para o tratamento de câncer de bexiga |
| CN112867727B (zh) * | 2018-10-12 | 2024-05-17 | 上海济煜医药科技有限公司 | 环二核苷酸类化合物及其应用 |
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| CA2927009C (en) | 2013-10-21 | 2019-04-23 | Drexel University | Use of sting agonists to treat chronic hepatitis b virus infection |
| WO2015074145A1 (en) | 2013-11-22 | 2015-05-28 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
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| EA035817B1 (ru) * | 2015-03-10 | 2020-08-14 | Адуро Байотек, Инк. | Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона" |
| KR102222186B1 (ko) | 2015-08-13 | 2021-03-03 | 머크 샤프 앤드 돔 코포레이션 | Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 |
| JP2018534295A (ja) | 2015-10-28 | 2018-11-22 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達を活性化するための組成物および方法 |
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| KR102789862B1 (ko) | 2016-01-11 | 2025-04-03 | 인네이트 튜머 이뮤니티, 인코포레이티드 | Sting 활성과 연관된 상태 예컨대 암의 치료를 위한 시클릭 디뉴클레오티드 |
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2018
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- 2018-08-30 WO PCT/IB2018/056658 patent/WO2019043634A2/en not_active Ceased
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- 2018-08-30 SG SG11202001847WA patent/SG11202001847WA/en unknown
- 2018-08-30 JP JP2020533876A patent/JP7311514B2/ja active Active
- 2018-08-30 BR BR112020004047-9A patent/BR112020004047A2/pt not_active IP Right Cessation
- 2018-08-30 EP EP18850228.0A patent/EP3692048A4/en active Pending
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- 2018-08-30 RU RU2020112502A patent/RU2020112502A/ru unknown
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| US11773132B2 (en) | 2023-10-03 |
| WO2019043634A2 (en) | 2019-03-07 |
| CN111263767A (zh) | 2020-06-09 |
| BR112020004047A2 (pt) | 2020-09-01 |
| IL272928A (en) | 2020-04-30 |
| WO2019043634A3 (en) | 2019-04-11 |
| SG11202001847WA (en) | 2020-03-30 |
| JP7311514B2 (ja) | 2023-07-19 |
| CA3073919A1 (en) | 2019-03-07 |
| JP2020532585A (ja) | 2020-11-12 |
| TW201919650A (zh) | 2019-06-01 |
| TWI808092B (zh) | 2023-07-11 |
| KR102782200B1 (ko) | 2025-03-17 |
| RU2020112502A (ru) | 2021-10-01 |
| US20200331957A1 (en) | 2020-10-22 |
| CN111263767B (zh) | 2023-07-18 |
| KR20200058411A (ko) | 2020-05-27 |
| MX2020002303A (es) | 2020-09-10 |
| EP3692048A2 (en) | 2020-08-12 |
| RU2020112502A3 (https=) | 2021-10-08 |
| EP3692048A4 (en) | 2021-10-20 |
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