AU2017250769B2 - Transgenic T cell and chimeric antigen receptor T cell compositions and related methods - Google Patents

Transgenic T cell and chimeric antigen receptor T cell compositions and related methods Download PDF

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AU2017250769B2
AU2017250769B2 AU2017250769A AU2017250769A AU2017250769B2 AU 2017250769 B2 AU2017250769 B2 AU 2017250769B2 AU 2017250769 A AU2017250769 A AU 2017250769A AU 2017250769 A AU2017250769 A AU 2017250769A AU 2017250769 B2 AU2017250769 B2 AU 2017250769B2
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promoter
car
cells
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AU2017250769A1 (en
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Justin Gabriel Andre Francois Eyquem
Jorge MANSILLA-SOTO
Michel W. J. Sadelain
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Memorial Sloan Kettering Cancer Center
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AU2017250769A 2016-04-15 2017-04-14 Transgenic T cell and chimeric antigen receptor T cell compositions and related methods Active AU2017250769B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662323623P 2016-04-15 2016-04-15
US62/323,623 2016-04-15
US201662323675P 2016-04-16 2016-04-16
US62/323,675 2016-04-16
US201762461677P 2017-02-21 2017-02-21
US62/461,677 2017-02-21
US201762462243P 2017-02-22 2017-02-22
US62/462,243 2017-02-22
PCT/US2017/027601 WO2017180989A2 (en) 2016-04-15 2017-04-14 Transgenic t cell and chimeric antigen receptor t cell compositions and related methods

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AU2017250769A1 AU2017250769A1 (en) 2018-11-01
AU2017250769B2 true AU2017250769B2 (en) 2022-07-14

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US (2) US11377637B2 (OSRAM)
EP (3) EP4628587A2 (OSRAM)
JP (1) JP7058223B2 (OSRAM)
KR (3) KR20240000616A (OSRAM)
CN (1) CN109790517B (OSRAM)
AU (1) AU2017250769B2 (OSRAM)
BR (1) BR112018071199A2 (OSRAM)
ES (2) ES2933961T3 (OSRAM)
PT (2) PT4180519T (OSRAM)
SG (1) SG11201808831TA (OSRAM)
WO (1) WO2017180989A2 (OSRAM)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114058582A (zh) 2015-01-26 2022-02-18 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
US11643668B2 (en) 2015-06-17 2023-05-09 The Uab Research Foundation CRISPR/Cas9 complex for genomic editing
WO2016205680A1 (en) * 2015-06-17 2016-12-22 The Uab Research Foundation Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
CA3001008A1 (en) 2015-10-05 2017-04-13 Precision Biosciences, Inc. Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene
CN108601821B (zh) * 2015-10-05 2023-09-19 精密生物科学公司 包含经修饰的人T细胞受体α恒定区基因的经遗传修饰的细胞
EP3371301A4 (en) 2015-11-04 2019-06-26 Fate Therapeutics, Inc. METHOD AND COMPOSITIONS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC CELLS
CN115806940A (zh) * 2015-11-04 2023-03-17 菲特治疗公司 多能细胞的基因组工程改造
CA3020330A1 (en) * 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
PT4180519T (pt) 2016-04-15 2025-09-04 Memorial Sloan Kettering Cancer Center Células t transgénicas e composições de células t que expressam um recetor antigénico quimérico e métodos relacionados
AU2017347637B2 (en) * 2016-10-19 2024-02-15 Cellectis Targeted gene insertion for improved immune cells therapy
GB2607227B (en) * 2016-10-27 2023-05-10 Intima Bioscience Inc Viral methods of T cell therapy
CA3058807A1 (en) 2017-04-03 2018-10-11 Neon Therapeutics, Inc. Protein antigens and uses thereof
IL270361B2 (en) 2017-05-01 2025-04-01 Univ Pennsylvania Monoclonal antibodies against alpha-synuclein fibrils
MX2019015188A (es) 2017-06-15 2020-08-03 Univ California Inserciones de adn no virales orientadas.
WO2019005957A1 (en) 2017-06-30 2019-01-03 Precision Biosciences, Inc. GENETICALLY MODIFIED T CELLS COMPRISING A MODIFIED INTRON IN THE ALPHA T CELL RECEPTOR GENE
US20200216515A1 (en) * 2017-07-26 2020-07-09 Cellectis Methods of antigen-dependent chimeric antigen receptor (car) immune cell selection
AU2018355587B2 (en) 2017-10-27 2023-02-02 The Regents Of The University Of California Targeted replacement of endogenous T cell receptors
TW201930340A (zh) 2017-12-18 2019-08-01 美商尼恩醫療公司 新抗原及其用途
KR102828999B1 (ko) * 2018-02-11 2025-07-04 메모리얼 슬로안 케터링 캔서 센터 비-hla 제한된 t 세포 수용체 및 이의 용도
SG11202007513PA (en) * 2018-02-16 2020-09-29 Kite Pharma Inc Modified pluripotent stem cells and methods of making and use
US20200224160A1 (en) * 2018-02-27 2020-07-16 Sorrento Therapeutics, Inc. Process for dna integration using rna-guided endonucleases
AU2019253562B2 (en) * 2018-04-09 2025-11-27 The Trustees Of The University Of Pennsylvania Methods and compositions comprising a viral vector for expression of a transgene and an effector
WO2019200122A1 (en) 2018-04-12 2019-10-17 Precision Biosciences, Inc. Optimized engineered nucleases having specificity for the human t cell receptor alpha constant region gene
WO2019204397A1 (en) * 2018-04-17 2019-10-24 Wake Forest University Health Sciences Methods and compositions for th9 cell mediated cancer treatment
US20210207174A1 (en) * 2018-05-25 2021-07-08 The Regents Of The University Of California Genetic engineering of endogenous proteins
JP2021525530A (ja) 2018-06-01 2021-09-27 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ キメラ抗原受容体細胞治療薬を用いたサイトカイン放出症候群の抑制
TW202015719A (zh) 2018-06-19 2020-05-01 美商尼恩醫療公司 新抗原及其用途
CN110616188B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种通用型car-t细胞及其制备方法和应用
US12359169B2 (en) 2018-06-20 2025-07-15 Shanghai Longyao Biotechnology Inc., Ltd. Universal CAR-T cell and preparation method and use thereof
EP3817763B1 (en) * 2018-07-03 2025-09-03 SOTIO Biotech Inc. Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof
EP3845638A4 (en) * 2018-07-26 2022-05-11 Kyoto University METHOD OF PRODUCTION OF A CELL DELIVERED BY A RECEPTOR GENE OF A FOREIGN ANTIGEN
BR112021001694A2 (pt) 2018-08-14 2021-05-04 Sotio, LLC polipeptídeos do receptor de antígeno quimérico em combinação com moléculas de metabolismo trans que modulam o ciclo de krebs e seus usos terapêuticos
AU2019372673A1 (en) 2018-11-01 2021-05-27 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for T cell engineering
MX2021006968A (es) 2018-12-12 2021-10-13 Kite Pharma Inc Antígeno quimérico y receptores de las células t, y métodos de uso.
PT3898946T (pt) * 2018-12-19 2023-05-09 Inst Curie Células t invariantes associadas a mucosa (mait) que expressam recetores de antigénio quiméricos
EP3917546A4 (en) * 2019-02-01 2023-03-08 KSQ Therapeutics, Inc. GENE REGULATORY COMPOSITIONS AND METHODS FOR IMPROVED IMMUNOTHERAPY
US12419913B2 (en) 2019-02-08 2025-09-23 Dna Twopointo, Inc. Modification of CAR-T cells
AU2020226401A1 (en) * 2019-02-18 2021-10-14 Memorial Sloan-Kettering Cancer Center Combinations of multiple chimeric antigen receptors for immunotherapy
EP3934668A1 (en) 2019-03-06 2022-01-12 Lentigen Technology, Inc. Compositions and methods for treating cancer with self-driving chimeric antigen receptors
BR112021019368A2 (pt) 2019-03-29 2021-12-07 Hoffmann La Roche Método para produzir fcrn biotinilado no terminal c
MX2021012054A (es) * 2019-04-11 2022-01-18 Fate Therapeutics Inc Reconstitución de cd3 en ipsc y células efectoras inmunitarias modificadas.
MX2021013223A (es) 2019-05-01 2022-02-17 Juno Therapeutics Inc Celulas que expresan un receptor quimerico de un locus cd247 modificado, polinucleotidos relacionados y metodos.
EP3969482A1 (en) * 2019-05-16 2022-03-23 University of Washington Lockr-mediated recruitment of car t cells
BR112021025401A2 (pt) * 2019-06-19 2022-02-01 Hoffmann La Roche Métodos para produzir um anticorpo trivalente, ácido desoxirribonucleico, uso de um ácido desoxirribonucleico, célula de mamífero recombinante, composição e método para produzir uma célula de mamífero recombinante
AU2020315796A1 (en) 2019-07-19 2022-02-24 Memorial Hospital For Cancer And Allied Diseases Fusion polypeptide for immunotherapy
AU2020318781A1 (en) 2019-07-23 2022-02-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Immune cells defective for SUV39H1
CN111826353B (zh) * 2019-07-24 2024-03-26 浙江煦顼技术有限公司 调节t细胞功能和反应的方法
WO2021061832A1 (en) * 2019-09-23 2021-04-01 Regents Of The University Of Minnesota Genetically-edited immune cells and methods of therapy
CN114765991A (zh) * 2019-09-25 2022-07-19 小利兰·斯坦福大学董事会 非色素睫状上皮细胞特异性启动子
SG10201909544YA (en) * 2019-10-11 2021-05-28 Nat Univ Singapore Genetically Modified T Cells And Uses Thereof
AR120469A1 (es) * 2019-11-13 2022-02-16 Crispr Therapeutics Ag Proceso de fabricación para hacer células t que expresen receptores de antígeno quiméricos
WO2021095012A1 (en) * 2019-11-13 2021-05-20 Crispr Therapeutics Ag Methods of manufacturing car-t cells
CN113122576A (zh) * 2019-12-31 2021-07-16 博雅辑因（北京）生物科技有限公司 一种通用型truck-t细胞、其制备方法以及用途
EP4084815A1 (en) * 2020-01-02 2022-11-09 Edity Therapeutics Ltd. Delivery compositions and methods
CA3171369A1 (en) * 2020-02-28 2021-09-02 Wisconsin Alumni Research Foundation Nonviral generation of genome edited chimeric antigen receptor t cells
JP2023518295A (ja) * 2020-03-20 2023-04-28 オルナ セラピューティクス インコーポレイテッド 環状ｒｎａ組成物及び方法
GB202006903D0 (en) * 2020-05-11 2020-06-24 Adaptimmune Ltd Modified iPSCs
JP2023532347A (ja) * 2020-06-29 2023-07-27 セル メディカ，インコーポレイテッド キメラ抗原受容体の緊張性シグナル伝達を減少させる方法および組成物
WO2022011065A1 (en) * 2020-07-07 2022-01-13 The Nemours Foundation Tumor-activated alloreactive and xenoreactive t cells and their use in immunotherapy against cancer
CA3190266A1 (en) 2020-07-30 2022-02-03 Institut Curie Immune cells defective for socs1
AU2021320556A1 (en) * 2020-08-07 2023-03-09 Neogene Therapeutics B.V. Methods to enrich genetically engineered T cells
JP2023544337A (ja) * 2020-09-30 2023-10-23 ブイオーアール バイオファーマ インコーポレーテッド キメラ抗原受容体発現系
WO2022118310A1 (en) * 2020-12-01 2022-06-09 Lepton Pharmaceuticals Ltd. Methods for enhancing therapeutic efficacy of isolated cells for cell therapy
TW202237827A (zh) 2020-12-03 2022-10-01 美商世紀治療股份有限公司 經基因工程改造之細胞及其用途
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
EP4019538A1 (en) * 2020-12-22 2022-06-29 Charité - Universitätsmedizin Berlin Reprogramming immune cells by targeted integration of zeta-deficient chimeric antigen receptor transgenes
MX2023010641A (es) 2021-03-11 2024-02-07 Mnemo Therapeutics Peptidos neoantigénicos tumorales y usos de los mismos.
KR20230172630A (ko) 2021-03-11 2023-12-22 므네모 테라퓨틱스 종양 네오 항원성 펩타이드
KR20240006721A (ko) 2021-03-11 2024-01-15 엥스띠뛰 퀴리 막 형질 전환 네오 안티젠 펩타이드
US20240271095A1 (en) * 2021-05-14 2024-08-15 Appia Bio, Inc. Production of engineered t cells from stem cells
EP4413031A1 (en) 2021-10-06 2024-08-14 Miltenyi Biotec B.V. & Co. KG Method for targeted gene insertion into immune cells
EP4416292A2 (en) 2021-10-14 2024-08-21 Arsenal Biosciences, Inc. Immune cells having co-expressed shrnas and logic gate systems
JP2024541859A (ja) * 2021-10-14 2024-11-13 アッピア バイオ，インコーポレイティド 幹細胞の遺伝子改変による複数のｔ細胞受容体を有するｔ細胞
US20250000907A1 (en) * 2021-11-22 2025-01-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Engineered immune cells with reduced sirt6 expression
EP4456910A1 (en) 2021-12-28 2024-11-06 Mnemo Therapeutics Immune cells with inactivated suv39h1 and modified tcr
JP2025504882A (ja) 2022-01-21 2025-02-19 ムネモ・セラピューティクス Ｒｎａによるｓｕｖ３９ｈ１発現の調節
CN115304679B (zh) * 2022-01-21 2024-07-16 郑州大学第一附属医院 一种促进t细胞分化的限制型car及其应用
WO2023178227A2 (en) * 2022-03-17 2023-09-21 University Of Florida Research Foundation, Incorporated Chimeric lactate receptor engineered t cells
WO2023225670A2 (en) * 2022-05-20 2023-11-23 Tome Biosciences, Inc. Ex vivo programmable gene insertion
EP4279085A1 (en) 2022-05-20 2023-11-22 Mnemo Therapeutics Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease
EP4573114A2 (en) 2022-08-19 2025-06-25 Memorial Sloan-Kettering Cancer Center T cell receptors targeting ras mutations and uses thereof
EP4580604A2 (en) * 2022-09-02 2025-07-09 OncoSenX, Inc. Compositions and methods for in vivo expression of chimeric antigen receptors
BE1031219B1 (fr) 2022-12-28 2024-07-29 Quidditas Sa Composition, cellules immunitaires la comprenant et utilisation de ces dernières
WO2025096594A2 (en) * 2023-10-30 2025-05-08 Allogene Therapeutics, Inc. Cells expressing anti-cd19 chimeric antigen receptors and methods of use thereof
WO2025096560A1 (en) * 2023-10-30 2025-05-08 Allogene Therapeutics, Inc. Engineered cells
WO2025163107A1 (en) 2024-02-01 2025-08-07 Institut Gustave Roussy Immune cells defective for znf217 and uses thereof
WO2025213167A1 (en) * 2024-04-05 2025-10-09 Roswell Park Cancer Institute Corporation Complement signaling as a t-cell checkpoint in the tumor microenvironment (tme)

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
DK1409646T3 (da) 2000-12-19 2012-08-06 Altor Bioscience Corp Transgene dyr omfattende et humaniseret immunsystem
IL162111A0 (en) 2001-12-22 2005-11-20 4Antibody Ag Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo
EP1321477B1 (en) 2001-12-22 2004-10-13 4-Antibody AG Method for the generation of genetically modified vertebrate precursor lymphocytes and use thereof for the production of heterologous binding proteins
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
WO2005026718A1 (en) 2003-08-28 2005-03-24 Five Prime Therapeutics, Inc. Stem cell libraries
US20110213288A1 (en) 2007-04-23 2011-09-01 The Board Of Regents, The University Of Texas System Device And Method For Transfecting Cells For Therapeutic Uses
JP5271901B2 (ja) 2007-06-11 2013-08-21 タカラバイオ株式会社 特異的遺伝子発現方法
ES2627552T3 (es) 2008-12-04 2017-07-28 Sigma Aldrich Company Edición de genoma en ratas usando nucleasas con dedos de cinc
JP2013500018A (ja) * 2009-07-24 2013-01-07 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー ゲノム編集のための方法
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
DK2496698T3 (en) 2009-11-03 2019-04-15 Hope City TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION
US8956828B2 (en) * 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
JP6050230B2 (ja) 2010-07-21 2016-12-21 サンガモ バイオサイエンシーズ， インコーポレイテッド Ｈｌａ遺伝子座の修飾のための方法及び組成物
NO2748201T3 (OSRAM) 2011-08-23 2018-05-12
WO2013158309A2 (en) 2012-04-18 2013-10-24 The Board Of Trustees Of The Leland Stanford Junior University Non-disruptive gene targeting
HUE064187T2 (hu) 2012-05-25 2024-02-28 Cellectis Eljárás immunterápiára alkalmas allogén és immunszupresszív-rezisztens T-sejt módosítására
RS59199B1 (sr) 2012-05-25 2019-10-31 Univ California Metode i jedinjenja za rnk-upravljanu ciljanu dnk modifikaciju i za rnk- upravljanu modulaciju transkripta
EP3763810A3 (en) * 2012-10-10 2021-07-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
KR102064230B1 (ko) 2013-02-15 2020-01-13 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 키메라 항원 수용체 및 이의 이용 방법
US9499855B2 (en) 2013-03-14 2016-11-22 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
US9937207B2 (en) 2013-03-21 2018-04-10 Sangamo Therapeutics, Inc. Targeted disruption of T cell receptor genes using talens
CA3185368A1 (en) 2013-04-03 2014-10-09 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted t cells derived from pluripotent stem cells
JP6578271B2 (ja) 2013-04-17 2019-09-18 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ 免疫抑制ＴＧＦ−βシグナルコンバーター
EP3783098A1 (en) 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
ES2883131T3 (es) 2013-05-29 2021-12-07 Cellectis Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
AU2014273490B2 (en) 2013-05-29 2019-05-09 Cellectis Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
WO2015140347A1 (en) 2014-03-21 2015-09-24 Cellectis Engineering mammalian genome using dna-guided argonaute interference systems (dais)
KR20200138445A (ko) 2014-04-24 2020-12-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용
AU2015255675A1 (en) 2014-05-09 2016-12-01 Research Foundation Of The City University Of New York TCR(alpha)-LCR-derived gene regulatory cassettes
US9970001B2 (en) * 2014-06-05 2018-05-15 Sangamo Therapeutics, Inc. Methods and compositions for nuclease design
HUE049776T2 (hu) 2014-06-06 2020-10-28 Regeneron Pharma Módszerek és készítmények egy célzott lókusz módosítására
AU2015317370A1 (en) 2014-09-19 2017-03-23 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors
WO2016081924A1 (en) 2014-11-20 2016-05-26 Duke University Compositions, systems and methods for cell therapy
EP4269601A3 (en) 2015-03-27 2024-01-10 President and Fellows of Harvard College Modified t cells and methods of making and using the same
WO2016166268A1 (en) 2015-04-17 2016-10-20 Cellectis Engineering animal or plant genome using dna-guided argonaute interference systems (dais) from mesophilic prokaryotes
DE212016000094U1 (de) * 2015-05-15 2017-12-18 Oru Kayak, Inc. Zusammenfaltbares Kajak mit großem Cockpit
CN108024544B (zh) * 2015-07-13 2022-04-29 桑格摩生物治疗股份有限公司 用于核酸酶介导的基因组工程化的递送方法及组合物
IL257105B (en) 2015-07-31 2022-09-01 Univ Minnesota Modified cells and methods of therapy
CA3001008A1 (en) 2015-10-05 2017-04-13 Precision Biosciences, Inc. Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene
CN108601821B (zh) 2015-10-05 2023-09-19 精密生物科学公司 包含经修饰的人T细胞受体α恒定区基因的经遗传修饰的细胞
CN115806940A (zh) 2015-11-04 2023-03-17 菲特治疗公司 多能细胞的基因组工程改造
EP3371301A4 (en) 2015-11-04 2019-06-26 Fate Therapeutics, Inc. METHOD AND COMPOSITIONS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC CELLS
EP3377523A4 (en) 2015-11-19 2019-06-19 The Regents of The University of California CONDITIONALLY REPRIMATABLE IMMUNOCELL RECEPTORS AND METHOD FOR USE THEREOF
US20190241910A1 (en) 2016-03-11 2019-08-08 Bluebird Bio, Inc. Genome edited immune effector cells
CU24649B1 (es) 2016-03-19 2023-02-13 Exuma Biotech Corp Retrovirus recombinantes incompetentes de replicación para la transducción de linfocitos y expansión regulada de los mismos
CA3020330A1 (en) 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
PT4180519T (pt) 2016-04-15 2025-09-04 Memorial Sloan Kettering Cancer Center Células t transgénicas e composições de células t que expressam um recetor antigénico quimérico e métodos relacionados

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
H. TORIKAI, A. REIK, P.-Q. LIU, Y. ZHOU, L. ZHANG, S. MAITI, H. HULS, J. C. MILLER, P. KEBRIAEI, B. RABINOVITCH, D. A. LEE, R. E. : "A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR", BLOOD, vol. 119, no. 24, 14 June 2012 (2012-06-14), pages 5697 - 5705, XP055071623, ISSN: 00064971, DOI: 10.1182/blood-2012-01-405365 *

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