AU2016350219B2 - Innovative preparation and crystallization of iosimenol - Google Patents

Innovative preparation and crystallization of iosimenol Download PDF

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Publication number
AU2016350219B2
AU2016350219B2 AU2016350219A AU2016350219A AU2016350219B2 AU 2016350219 B2 AU2016350219 B2 AU 2016350219B2 AU 2016350219 A AU2016350219 A AU 2016350219A AU 2016350219 A AU2016350219 A AU 2016350219A AU 2016350219 B2 AU2016350219 B2 AU 2016350219B2
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AU
Australia
Prior art keywords
iosimenol
crystal
group
crystallization
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016350219A
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English (en)
Other versions
AU2016350219A1 (en
Inventor
Ivan Hlavacek
Jiri Malinak
Yoshito Masuda
Jiri Prokop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of AU2016350219A1 publication Critical patent/AU2016350219A1/en
Application granted granted Critical
Publication of AU2016350219B2 publication Critical patent/AU2016350219B2/en
Priority to AU2021205101A priority Critical patent/AU2021205101B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D2009/0086—Processes or apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00139—Controlling the temperature using electromagnetic heating
    • B01J2219/00141—Microwaves
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
AU2016350219A 2015-11-04 2016-11-02 Innovative preparation and crystallization of iosimenol Ceased AU2016350219B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021205101A AU2021205101B2 (en) 2015-11-04 2021-07-16 Innovative preparation and crystallization of iosimenol

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250720P 2015-11-04 2015-11-04
US62/250,720 2015-11-04
PCT/JP2016/004798 WO2017077710A1 (en) 2015-11-04 2016-11-02 Innovative preparation and crystallization of iosimenol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021205101A Division AU2021205101B2 (en) 2015-11-04 2021-07-16 Innovative preparation and crystallization of iosimenol

Publications (2)

Publication Number Publication Date
AU2016350219A1 AU2016350219A1 (en) 2018-05-17
AU2016350219B2 true AU2016350219B2 (en) 2021-04-29

Family

ID=57354423

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016350219A Ceased AU2016350219B2 (en) 2015-11-04 2016-11-02 Innovative preparation and crystallization of iosimenol
AU2021205101A Expired - Fee Related AU2021205101B2 (en) 2015-11-04 2021-07-16 Innovative preparation and crystallization of iosimenol

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021205101A Expired - Fee Related AU2021205101B2 (en) 2015-11-04 2021-07-16 Innovative preparation and crystallization of iosimenol

Country Status (23)

Country Link
US (1) US10544089B2 (enExample)
EP (1) EP3371147B1 (enExample)
JP (1) JP6778746B2 (enExample)
KR (1) KR20180077198A (enExample)
CN (1) CN108368031B (enExample)
AU (2) AU2016350219B2 (enExample)
CA (1) CA3002502A1 (enExample)
CY (1) CY1124164T1 (enExample)
DK (1) DK3371147T3 (enExample)
ES (1) ES2873828T3 (enExample)
HR (1) HRP20210820T1 (enExample)
HU (1) HUE054876T2 (enExample)
LT (1) LT3371147T (enExample)
MY (1) MY186399A (enExample)
NZ (1) NZ742104A (enExample)
PH (1) PH12018500872A1 (enExample)
PL (1) PL3371147T3 (enExample)
PT (1) PT3371147T (enExample)
SA (1) SA518391413B1 (enExample)
SG (1) SG11201803241YA (enExample)
SI (1) SI3371147T1 (enExample)
TW (1) TWI724049B (enExample)
WO (1) WO2017077710A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
CN111777525B (zh) * 2019-04-04 2021-08-27 成都西岭源药业有限公司 一种碘克沙醇的精制方法
KR102179649B1 (ko) * 2019-10-11 2020-11-18 (주)에이에스텍 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법
CN115931935A (zh) * 2022-12-28 2023-04-07 深圳晶泰科技有限公司 一种提高微晶电子衍射数据质量的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
WO2009091758A1 (en) * 2008-01-14 2009-07-23 Mallinckrodt Inc. Process for the preparation of iosimenol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
WO2009091758A1 (en) * 2008-01-14 2009-07-23 Mallinckrodt Inc. Process for the preparation of iosimenol

Also Published As

Publication number Publication date
KR20180077198A (ko) 2018-07-06
NZ742104A (en) 2023-01-27
HK1257821A1 (en) 2019-11-01
EP3371147B1 (en) 2021-04-07
AU2021205101A1 (en) 2021-08-19
PL3371147T3 (pl) 2021-10-25
SG11201803241YA (en) 2018-05-30
TW201722906A (zh) 2017-07-01
DK3371147T3 (da) 2021-05-25
ES2873828T3 (es) 2021-11-04
JP6778746B2 (ja) 2020-11-04
US10544089B2 (en) 2020-01-28
HRP20210820T1 (hr) 2021-06-25
CN108368031B (zh) 2022-05-03
MY186399A (en) 2021-07-22
PT3371147T (pt) 2021-05-24
WO2017077710A1 (en) 2017-05-11
SA518391413B1 (ar) 2022-03-06
AU2021205101B2 (en) 2022-11-24
CN108368031A (zh) 2018-08-03
EP3371147A1 (en) 2018-09-12
PH12018500872A1 (en) 2018-11-05
LT3371147T (lt) 2021-08-10
TWI724049B (zh) 2021-04-11
US20190177266A1 (en) 2019-06-13
HUE054876T2 (hu) 2021-10-28
CY1124164T1 (el) 2022-05-27
AU2016350219A1 (en) 2018-05-17
CA3002502A1 (en) 2017-05-11
JP2018536654A (ja) 2018-12-13
SI3371147T1 (sl) 2021-08-31

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