CN108368031B - 碘美醇的创新性制备和晶体 - Google Patents

碘美醇的创新性制备和晶体 Download PDF

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Publication number
CN108368031B
CN108368031B CN201680066838.8A CN201680066838A CN108368031B CN 108368031 B CN108368031 B CN 108368031B CN 201680066838 A CN201680066838 A CN 201680066838A CN 108368031 B CN108368031 B CN 108368031B
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China
Prior art keywords
iomesol
crystallization
iomenol
mixture
group
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Expired - Fee Related
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CN201680066838.8A
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English (en)
Chinese (zh)
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CN108368031A (zh
Inventor
伊日·毛利纳克
伊万·赫拉瓦切克
伊日·普罗科普
增田由人
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Publication of CN108368031A publication Critical patent/CN108368031A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D2009/0086—Processes or apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00139—Controlling the temperature using electromagnetic heating
    • B01J2219/00141—Microwaves
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
CN201680066838.8A 2015-11-04 2016-11-02 碘美醇的创新性制备和晶体 Expired - Fee Related CN108368031B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250720P 2015-11-04 2015-11-04
US62/250,720 2015-11-04
PCT/JP2016/004798 WO2017077710A1 (en) 2015-11-04 2016-11-02 Innovative preparation and crystallization of iosimenol

Publications (2)

Publication Number Publication Date
CN108368031A CN108368031A (zh) 2018-08-03
CN108368031B true CN108368031B (zh) 2022-05-03

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CN201680066838.8A Expired - Fee Related CN108368031B (zh) 2015-11-04 2016-11-02 碘美醇的创新性制备和晶体

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US (1) US10544089B2 (enExample)
EP (1) EP3371147B1 (enExample)
JP (1) JP6778746B2 (enExample)
KR (1) KR20180077198A (enExample)
CN (1) CN108368031B (enExample)
AU (2) AU2016350219B2 (enExample)
CA (1) CA3002502A1 (enExample)
CY (1) CY1124164T1 (enExample)
DK (1) DK3371147T3 (enExample)
ES (1) ES2873828T3 (enExample)
HR (1) HRP20210820T1 (enExample)
HU (1) HUE054876T2 (enExample)
LT (1) LT3371147T (enExample)
MY (1) MY186399A (enExample)
NZ (1) NZ742104A (enExample)
PH (1) PH12018500872A1 (enExample)
PL (1) PL3371147T3 (enExample)
PT (1) PT3371147T (enExample)
SA (1) SA518391413B1 (enExample)
SG (1) SG11201803241YA (enExample)
SI (1) SI3371147T1 (enExample)
TW (1) TWI724049B (enExample)
WO (1) WO2017077710A1 (enExample)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
CN111777525B (zh) * 2019-04-04 2021-08-27 成都西岭源药业有限公司 一种碘克沙醇的精制方法
KR102179649B1 (ko) * 2019-10-11 2020-11-18 (주)에이에스텍 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법
CN115931935A (zh) * 2022-12-28 2023-04-07 深圳晶泰科技有限公司 一种提高微晶电子衍射数据质量的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US20100280270A1 (en) * 2008-01-14 2010-11-04 Bailey Allan R Process for the Prepartion of Iosimenol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US20100280270A1 (en) * 2008-01-14 2010-11-04 Bailey Allan R Process for the Prepartion of Iosimenol

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KR20180077198A (ko) 2018-07-06
NZ742104A (en) 2023-01-27
HK1257821A1 (en) 2019-11-01
EP3371147B1 (en) 2021-04-07
AU2021205101A1 (en) 2021-08-19
PL3371147T3 (pl) 2021-10-25
SG11201803241YA (en) 2018-05-30
TW201722906A (zh) 2017-07-01
DK3371147T3 (da) 2021-05-25
ES2873828T3 (es) 2021-11-04
JP6778746B2 (ja) 2020-11-04
US10544089B2 (en) 2020-01-28
HRP20210820T1 (hr) 2021-06-25
MY186399A (en) 2021-07-22
PT3371147T (pt) 2021-05-24
AU2016350219B2 (en) 2021-04-29
WO2017077710A1 (en) 2017-05-11
SA518391413B1 (ar) 2022-03-06
AU2021205101B2 (en) 2022-11-24
CN108368031A (zh) 2018-08-03
EP3371147A1 (en) 2018-09-12
PH12018500872A1 (en) 2018-11-05
LT3371147T (lt) 2021-08-10
TWI724049B (zh) 2021-04-11
US20190177266A1 (en) 2019-06-13
HUE054876T2 (hu) 2021-10-28
CY1124164T1 (el) 2022-05-27
AU2016350219A1 (en) 2018-05-17
CA3002502A1 (en) 2017-05-11
JP2018536654A (ja) 2018-12-13
SI3371147T1 (sl) 2021-08-31

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