CN108368031B - 碘美醇的创新性制备和晶体 - Google Patents

碘美醇的创新性制备和晶体 Download PDF

Info

Publication number
CN108368031B
CN108368031B CN201680066838.8A CN201680066838A CN108368031B CN 108368031 B CN108368031 B CN 108368031B CN 201680066838 A CN201680066838 A CN 201680066838A CN 108368031 B CN108368031 B CN 108368031B
Authority
CN
China
Prior art keywords
iomesol
crystallization
iomenol
mixture
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201680066838.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN108368031A (zh
Inventor
伊日·毛利纳克
伊万·赫拉瓦切克
伊日·普罗科普
增田由人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of CN108368031A publication Critical patent/CN108368031A/zh
Application granted granted Critical
Publication of CN108368031B publication Critical patent/CN108368031B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D2009/0086—Processes or apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00139—Controlling the temperature using electromagnetic heating
    • B01J2219/00141—Microwaves
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
CN201680066838.8A 2015-11-04 2016-11-02 碘美醇的创新性制备和晶体 Expired - Fee Related CN108368031B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250720P 2015-11-04 2015-11-04
US62/250,720 2015-11-04
PCT/JP2016/004798 WO2017077710A1 (en) 2015-11-04 2016-11-02 Innovative preparation and crystallization of iosimenol

Publications (2)

Publication Number Publication Date
CN108368031A CN108368031A (zh) 2018-08-03
CN108368031B true CN108368031B (zh) 2022-05-03

Family

ID=57354423

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680066838.8A Expired - Fee Related CN108368031B (zh) 2015-11-04 2016-11-02 碘美醇的创新性制备和晶体

Country Status (23)

Country Link
US (1) US10544089B2 (enExample)
EP (1) EP3371147B1 (enExample)
JP (1) JP6778746B2 (enExample)
KR (1) KR20180077198A (enExample)
CN (1) CN108368031B (enExample)
AU (2) AU2016350219B2 (enExample)
CA (1) CA3002502A1 (enExample)
CY (1) CY1124164T1 (enExample)
DK (1) DK3371147T3 (enExample)
ES (1) ES2873828T3 (enExample)
HR (1) HRP20210820T1 (enExample)
HU (1) HUE054876T2 (enExample)
LT (1) LT3371147T (enExample)
MY (1) MY186399A (enExample)
NZ (1) NZ742104A (enExample)
PH (1) PH12018500872A1 (enExample)
PL (1) PL3371147T3 (enExample)
PT (1) PT3371147T (enExample)
SA (1) SA518391413B1 (enExample)
SG (1) SG11201803241YA (enExample)
SI (1) SI3371147T1 (enExample)
TW (1) TWI724049B (enExample)
WO (1) WO2017077710A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
CN111777525B (zh) * 2019-04-04 2021-08-27 成都西岭源药业有限公司 一种碘克沙醇的精制方法
KR102179649B1 (ko) * 2019-10-11 2020-11-18 (주)에이에스텍 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법
CN115931935A (zh) * 2022-12-28 2023-04-07 深圳晶泰科技有限公司 一种提高微晶电子衍射数据质量的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US20100280270A1 (en) * 2008-01-14 2010-11-04 Bailey Allan R Process for the Prepartion of Iosimenol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US20100280270A1 (en) * 2008-01-14 2010-11-04 Bailey Allan R Process for the Prepartion of Iosimenol

Also Published As

Publication number Publication date
LT3371147T (lt) 2021-08-10
PT3371147T (pt) 2021-05-24
SG11201803241YA (en) 2018-05-30
HK1257821A1 (en) 2019-11-01
SA518391413B1 (ar) 2022-03-06
PH12018500872A1 (en) 2018-11-05
CN108368031A (zh) 2018-08-03
KR20180077198A (ko) 2018-07-06
ES2873828T3 (es) 2021-11-04
AU2016350219B2 (en) 2021-04-29
PL3371147T3 (pl) 2021-10-25
US20190177266A1 (en) 2019-06-13
US10544089B2 (en) 2020-01-28
HUE054876T2 (hu) 2021-10-28
TWI724049B (zh) 2021-04-11
CY1124164T1 (el) 2022-05-27
AU2021205101B2 (en) 2022-11-24
AU2021205101A1 (en) 2021-08-19
EP3371147B1 (en) 2021-04-07
HRP20210820T1 (hr) 2021-06-25
JP2018536654A (ja) 2018-12-13
CA3002502A1 (en) 2017-05-11
JP6778746B2 (ja) 2020-11-04
EP3371147A1 (en) 2018-09-12
NZ742104A (en) 2023-01-27
WO2017077710A1 (en) 2017-05-11
TW201722906A (zh) 2017-07-01
DK3371147T3 (da) 2021-05-25
MY186399A (en) 2021-07-22
AU2016350219A1 (en) 2018-05-17
SI3371147T1 (sl) 2021-08-31

Similar Documents

Publication Publication Date Title
AU2021205101B2 (en) Innovative preparation and crystallization of iosimenol
CA2998434C (en) L-ornithine phenyl acetate and methods of making thereof
US10689352B2 (en) Solid state forms of trisodium valsartan: sacubitril
KR101888215B1 (ko) L-오르니틴 페닐아세테이트의 제조 방법
SG174517A1 (en) Useful pharmaceutical salts of 7-[(3r, 4r)-3-hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
AU2019202311A1 (en) L-ornithine phenyl acetate and methods of making thereof
KR20120032538A (ko) 핀골리모드 염의 제조 방법
CN114096519B (zh) 亚稳态晶变体及其制备方法(i)
CN110267956A (zh) 用于制备阿维巴坦钠结晶形式c的方法
EP3094637B1 (en) Solid forms of tenofovir
TW202409034A (zh) 度洛巴坦（Ｄｕｒｌｏｂａｃｔａｍ）結晶型
HK1257821B (en) Innovative preparation and crystallization of iosimenol
CN115925569B (zh) 一种无水l-苯丙氨酸晶型的制备方法
US10590153B2 (en) Process for producing crystalline DTPMP
WO2011085130A1 (en) Solid state forms of fosamprenavir calcium salt and process for preparation thereof
HK1230621A1 (en) Solid forms of tenofovir
HK1230621B (en) Solid forms of tenofovir

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20220503

CF01 Termination of patent right due to non-payment of annual fee