AU2016319785C1 - Acetamide thienotriazolodiazepines and uses thereof - Google Patents

Acetamide thienotriazolodiazepines and uses thereof Download PDF

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Publication number
AU2016319785C1
AU2016319785C1 AU2016319785A AU2016319785A AU2016319785C1 AU 2016319785 C1 AU2016319785 C1 AU 2016319785C1 AU 2016319785 A AU2016319785 A AU 2016319785A AU 2016319785 A AU2016319785 A AU 2016319785A AU 2016319785 C1 AU2016319785 C1 AU 2016319785C1
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Prior art keywords
optionally substituted
certain embodiments
alkyl
unsubstituted
compound
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AU2016319785B2 (en
AU2016319785A8 (en
AU2016319785A1 (en
Inventor
James E. Bradner
Jun Qi
Minoru Tanaka
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of AU2016319785A8 publication Critical patent/AU2016319785A8/en
Publication of AU2016319785B2 publication Critical patent/AU2016319785B2/en
Priority to AU2020294169A priority Critical patent/AU2020294169B2/en
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Publication of AU2016319785C1 publication Critical patent/AU2016319785C1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • AIDS & HIV (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2016319785A 2015-09-11 2016-09-09 Acetamide thienotriazolodiazepines and uses thereof Ceased AU2016319785C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020294169A AU2020294169B2 (en) 2015-09-11 2020-12-21 Acetamide thienotriazolodiazepines and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562217544P 2015-09-11 2015-09-11
US62/217,544 2015-09-11
PCT/US2016/051017 WO2017044792A1 (en) 2015-09-11 2016-09-09 Acetamide thienotriazoldiazepines and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020294169A Division AU2020294169B2 (en) 2015-09-11 2020-12-21 Acetamide thienotriazolodiazepines and uses thereof

Publications (4)

Publication Number Publication Date
AU2016319785A1 AU2016319785A1 (en) 2018-03-22
AU2016319785A8 AU2016319785A8 (en) 2019-07-25
AU2016319785B2 AU2016319785B2 (en) 2020-09-24
AU2016319785C1 true AU2016319785C1 (en) 2021-04-01

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AU2016319785A Ceased AU2016319785C1 (en) 2015-09-11 2016-09-09 Acetamide thienotriazolodiazepines and uses thereof
AU2020294169A Expired - Fee Related AU2020294169B2 (en) 2015-09-11 2020-12-21 Acetamide thienotriazolodiazepines and uses thereof

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Country Status (21)

Country Link
US (2) US10881668B2 (cg-RX-API-DMAC7.html)
EP (1) EP3347020A4 (cg-RX-API-DMAC7.html)
JP (1) JP2018526424A (cg-RX-API-DMAC7.html)
KR (1) KR20180051576A (cg-RX-API-DMAC7.html)
CN (1) CN108472299A (cg-RX-API-DMAC7.html)
AU (2) AU2016319785C1 (cg-RX-API-DMAC7.html)
BR (1) BR112018004617A2 (cg-RX-API-DMAC7.html)
CA (1) CA2996977A1 (cg-RX-API-DMAC7.html)
CL (1) CL2018000622A1 (cg-RX-API-DMAC7.html)
CO (1) CO2018002568A2 (cg-RX-API-DMAC7.html)
CR (1) CR20180199A (cg-RX-API-DMAC7.html)
HK (1) HK1256419A1 (cg-RX-API-DMAC7.html)
IL (1) IL257593A (cg-RX-API-DMAC7.html)
MX (1) MX2018003030A (cg-RX-API-DMAC7.html)
PE (1) PE20181086A1 (cg-RX-API-DMAC7.html)
PH (1) PH12018550026A1 (cg-RX-API-DMAC7.html)
RU (1) RU2018112953A (cg-RX-API-DMAC7.html)
SG (1) SG10202007099TA (cg-RX-API-DMAC7.html)
UA (1) UA123946C2 (cg-RX-API-DMAC7.html)
WO (1) WO2017044792A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201801549B (cg-RX-API-DMAC7.html)

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JP2017526741A (ja) 2014-08-08 2017-09-14 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体およびその使用
CA2986441A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
HK1256417A1 (zh) 2015-09-11 2019-09-20 达纳-法伯癌症研究所股份有限公司 氰基噻吩並三唑並二氮雜環庚三烯及其用途
BR112018004617A2 (pt) 2015-09-11 2018-09-25 Dana Farber Cancer Inst Inc acetamida tienotriazoldiazepinas e usos das mesmas
SG11201803210YA (en) 2015-11-25 2018-05-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
CN107629057B (zh) * 2016-07-19 2020-03-27 上海勋和医药科技有限公司 Bet蛋白抑制剂及其应用
AU2018334788B2 (en) 2017-09-22 2022-11-24 CSPC Zhongqi Pharmaceutical Technology(Shijiazhuang) Co., Ltd. Thienodiazepine derivatives and application thereof
EP3936507A4 (en) * 2019-03-07 2022-11-23 Medshine Discovery Inc. Compounds having both effects of bet bromodomain protein inhibition and pd-l1 gene regulation
WO2021175432A1 (en) 2020-03-04 2021-09-10 Boehringer Ingelheim International Gmbh Method for administration of an anti cancer agent
CN112444582B (zh) * 2021-02-01 2021-06-04 宁波大学 基于液滴萃取的质谱分析方法
CN113816970B (zh) * 2021-09-18 2022-08-09 济宁医学院附属医院 一种选择性铜离子螯合剂、其制备方法及其在肺纤维化中的应用

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