AU2016277883B2 - PD-1-CD28 fusion proteins and their use in medicine - Google Patents

PD-1-CD28 fusion proteins and their use in medicine Download PDF

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Publication number
AU2016277883B2
AU2016277883B2 AU2016277883A AU2016277883A AU2016277883B2 AU 2016277883 B2 AU2016277883 B2 AU 2016277883B2 AU 2016277883 A AU2016277883 A AU 2016277883A AU 2016277883 A AU2016277883 A AU 2016277883A AU 2016277883 B2 AU2016277883 B2 AU 2016277883B2
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arg
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AU2016277883A1 (en
AU2016277883A8 (en
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Stefan Endres
Sebastian KOBOLD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2016277883A 2015-06-19 2016-06-20 PD-1-CD28 fusion proteins and their use in medicine Active AU2016277883B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15172913.4 2015-06-19
EP15172913 2015-06-19
PCT/EP2016/064195 WO2016203048A1 (en) 2015-06-19 2016-06-20 Pd-1-cd28 fusion proteins and their use in medicine

Publications (3)

Publication Number Publication Date
AU2016277883A1 AU2016277883A1 (en) 2018-01-18
AU2016277883A8 AU2016277883A8 (en) 2018-01-25
AU2016277883B2 true AU2016277883B2 (en) 2020-09-17

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AU2016277883A Active AU2016277883B2 (en) 2015-06-19 2016-06-20 PD-1-CD28 fusion proteins and their use in medicine

Country Status (13)

Country Link
US (2) US11192935B2 (OSRAM)
EP (3) EP4349854A3 (OSRAM)
JP (3) JP7085988B2 (OSRAM)
CN (3) CN115925971A (OSRAM)
AU (1) AU2016277883B2 (OSRAM)
CA (1) CA2989949A1 (OSRAM)
DK (2) DK3909972T5 (OSRAM)
ES (2) ES2976647T3 (OSRAM)
FI (1) FI3909972T3 (OSRAM)
HU (1) HUE054201T2 (OSRAM)
PL (1) PL3310805T3 (OSRAM)
PT (1) PT3310805T (OSRAM)
WO (1) WO2016203048A1 (OSRAM)

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US20180044404A1 (en) 2015-03-05 2018-02-15 Fred Hutchinson Cancer Research Center Immunomodulatory fusion proteins and uses thereof
EP3466967A1 (en) 2015-05-18 2019-04-10 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CN115925971A (zh) * 2015-06-19 2023-04-07 塞巴斯蒂安·科博尔德 Pd-1-cd28融合蛋白及其在医学中的用途
CN108137707A (zh) * 2015-06-29 2018-06-08 约翰霍普金斯大学 免疫检查点嵌合受体疗法
CN105331585A (zh) * 2015-11-13 2016-02-17 科济生物医药（上海）有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
WO2017162797A1 (en) * 2016-03-23 2017-09-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins of pd-1 and 4-1bb
CN107523545A (zh) * 2016-06-20 2017-12-29 上海细胞治疗研究院 一种高效稳定表达抗体的杀伤性细胞及其用途
CA3026858A1 (en) * 2016-06-30 2018-01-04 F. Hoffmann-La Roche Ag Improved adoptive t-cell therapy
AU2017306432A1 (en) 2016-08-02 2019-03-21 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
BR112019007100A2 (pt) 2016-10-07 2019-06-25 Tcr2 Therapeutics Inc composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US20210187022A1 (en) * 2016-12-21 2021-06-24 TCR2 Therapeutics Inc. Engineered t cells for the treatment of cancer
EP4043485A1 (en) * 2017-01-26 2022-08-17 Novartis AG Cd28 compositions and methods for chimeric antigen receptor therapy
AU2018236461B2 (en) 2017-03-17 2025-03-27 Fred Hutchinson Cancer Center Immunomodulatory fusion proteins and uses thereof
WO2019173324A1 (en) * 2018-03-06 2019-09-12 The Trustees Of The University Of Pennsylvania Prostate-specific membrane antigen cars and methods of use thereof
CN108727504B (zh) * 2018-04-16 2021-08-27 泉州向日葵生物科技有限公司 一种ifn与抗pd-l1抗体的融合蛋白及其应用
CN111606999B (zh) * 2019-02-26 2022-09-06 南京惟亚德生物医药有限公司 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用
CN120944827A (zh) * 2019-03-27 2025-11-14 宾夕法尼亚大学董事会 Tn-MUC1嵌合抗原受体(CAR)T细胞疗法
MX2022000769A (es) * 2019-07-19 2022-05-18 Memorial Sloan Kettering Cancer Center Polipéptido de fusión para inmunoterapia.
CN113832114A (zh) * 2020-06-23 2021-12-24 南京大学 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用
CN113832111A (zh) * 2020-06-23 2021-12-24 南京大学 一种类外泌体技术用于制备新型溶瘤病毒的方法
IL305795A (en) * 2021-03-10 2023-11-01 B G Negev Technologies & Applications Ltd At Ben Gurion Univ Reporter cells expressing chimeric proteins for use in determining the presence and or activity of immune barrier molecules
CN115197314B (zh) * 2021-04-11 2025-08-19 中国科学院分子细胞科学卓越创新中心 一种pd1变体及其用途
EP4340862A4 (en) * 2021-05-20 2025-05-21 Achelois Biopharma, Inc. Immune checkpoint multivalent particles compositions and methods of use
WO2023235479A1 (en) * 2022-06-02 2023-12-07 TCR2 Therapeutics Inc. Compositions and methods for treating cancer
CN121057753A (zh) * 2022-11-14 2025-12-02 阿奇洛伊斯生物制药公司 免疫检查点多价颗粒组合物和使用方法
WO2025212859A1 (en) * 2024-04-03 2025-10-09 Solid Biosciences, Inc. Methods and constructs for increasing solid organ transplant survival

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US20140242049A1 (en) * 2011-10-26 2014-08-28 National Cancer Center Mutant ctla4 gene transfected t cell and composition including same for anticancer immunotherapy

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Also Published As

Publication number Publication date
EP3909972B1 (en) 2024-02-14
JP2022084787A (ja) 2022-06-07
EP4349854A2 (en) 2024-04-10
PL3310805T3 (pl) 2021-08-23
ES2976647T3 (es) 2024-08-06
FI3909972T3 (fi) 2024-05-03
HUE054201T2 (hu) 2021-08-30
JP7085988B2 (ja) 2022-06-17
JP2024073636A (ja) 2024-05-29
ES2870174T3 (es) 2021-10-26
CN115927474A (zh) 2023-04-07
PT3310805T (pt) 2021-05-19
DK3909972T5 (da) 2024-08-05
US20220169699A1 (en) 2022-06-02
JP7460675B2 (ja) 2024-04-02
CN108026151A (zh) 2018-05-11
JP2018518990A (ja) 2018-07-19
CN108026151B (zh) 2022-07-15
EP3310805B1 (en) 2021-02-17
EP4349854A3 (en) 2024-07-10
WO2016203048A1 (en) 2016-12-22
DK3310805T3 (da) 2021-05-03
EP3909972A1 (en) 2021-11-17
AU2016277883A1 (en) 2018-01-18
CA2989949A1 (en) 2016-12-22
US11192935B2 (en) 2021-12-07
EP3310805A1 (en) 2018-04-25
CN115925971A (zh) 2023-04-07
US20190010207A1 (en) 2019-01-10
AU2016277883A8 (en) 2018-01-25
DK3909972T3 (da) 2024-04-29

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Free format text: IN VOL 32 , NO 2 , PAGE(S) 263 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME SEBASTIEN KOBOLD; STEFAN ENDRES, APPLICATION NO. 2016277883, UNDER INID (71) CORRECT THE APPLICANT NAME TO SEBASTIAN KOBOLD

FGA Letters patent sealed or granted (standard patent)