PL3310805T3 - Białka fuzyjne pd-1-cd28 i ich zastosowanie w medycynie - Google Patents
Białka fuzyjne pd-1-cd28 i ich zastosowanie w medycynieInfo
- Publication number
- PL3310805T3 PL3310805T3 PL16736802T PL16736802T PL3310805T3 PL 3310805 T3 PL3310805 T3 PL 3310805T3 PL 16736802 T PL16736802 T PL 16736802T PL 16736802 T PL16736802 T PL 16736802T PL 3310805 T3 PL3310805 T3 PL 3310805T3
- Authority
- PL
- Poland
- Prior art keywords
- medicine
- fusion proteins
- fusion
- proteins
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15172913 | 2015-06-19 | ||
| PCT/EP2016/064195 WO2016203048A1 (en) | 2015-06-19 | 2016-06-20 | Pd-1-cd28 fusion proteins and their use in medicine |
| EP16736802.6A EP3310805B1 (en) | 2015-06-19 | 2016-06-20 | Pd-1-cd28 fusion proteins and their use in medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3310805T3 true PL3310805T3 (pl) | 2021-08-23 |
Family
ID=53476720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16736802T PL3310805T3 (pl) | 2015-06-19 | 2016-06-20 | Białka fuzyjne pd-1-cd28 i ich zastosowanie w medycynie |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11192935B2 (OSRAM) |
| EP (3) | EP4349854A3 (OSRAM) |
| JP (3) | JP7085988B2 (OSRAM) |
| CN (3) | CN115925971A (OSRAM) |
| AU (1) | AU2016277883B2 (OSRAM) |
| CA (1) | CA2989949A1 (OSRAM) |
| DK (2) | DK3909972T5 (OSRAM) |
| ES (2) | ES2976647T3 (OSRAM) |
| FI (1) | FI3909972T3 (OSRAM) |
| HU (1) | HUE054201T2 (OSRAM) |
| PL (1) | PL3310805T3 (OSRAM) |
| PT (1) | PT3310805T (OSRAM) |
| WO (1) | WO2016203048A1 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180044404A1 (en) | 2015-03-05 | 2018-02-15 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| EP3466967A1 (en) | 2015-05-18 | 2019-04-10 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN115925971A (zh) * | 2015-06-19 | 2023-04-07 | 塞巴斯蒂安·科博尔德 | Pd-1-cd28融合蛋白及其在医学中的用途 |
| CN108137707A (zh) * | 2015-06-29 | 2018-06-08 | 约翰霍普金斯大学 | 免疫检查点嵌合受体疗法 |
| CN105331585A (zh) * | 2015-11-13 | 2016-02-17 | 科济生物医药（上海）有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
| WO2017162797A1 (en) * | 2016-03-23 | 2017-09-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| CN107523545A (zh) * | 2016-06-20 | 2017-12-29 | 上海细胞治疗研究院 | 一种高效稳定表达抗体的杀伤性细胞及其用途 |
| CA3026858A1 (en) * | 2016-06-30 | 2018-01-04 | F. Hoffmann-La Roche Ag | Improved adoptive t-cell therapy |
| AU2017306432A1 (en) | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| BR112019007100A2 (pt) | 2016-10-07 | 2019-06-25 | Tcr2 Therapeutics Inc | composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| US20210187022A1 (en) * | 2016-12-21 | 2021-06-24 | TCR2 Therapeutics Inc. | Engineered t cells for the treatment of cancer |
| EP4043485A1 (en) * | 2017-01-26 | 2022-08-17 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
| AU2018236461B2 (en) | 2017-03-17 | 2025-03-27 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
| WO2019173324A1 (en) * | 2018-03-06 | 2019-09-12 | The Trustees Of The University Of Pennsylvania | Prostate-specific membrane antigen cars and methods of use thereof |
| CN108727504B (zh) * | 2018-04-16 | 2021-08-27 | 泉州向日葵生物科技有限公司 | 一种ifn与抗pd-l1抗体的融合蛋白及其应用 |
| CN111606999B (zh) * | 2019-02-26 | 2022-09-06 | 南京惟亚德生物医药有限公司 | 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用 |
| CN120944827A (zh) * | 2019-03-27 | 2025-11-14 | 宾夕法尼亚大学董事会 | Tn-MUC1嵌合抗原受体(CAR)T细胞疗法 |
| MX2022000769A (es) * | 2019-07-19 | 2022-05-18 | Memorial Sloan Kettering Cancer Center | Polipéptido de fusión para inmunoterapia. |
| CN113832114A (zh) * | 2020-06-23 | 2021-12-24 | 南京大学 | 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用 |
| CN113832111A (zh) * | 2020-06-23 | 2021-12-24 | 南京大学 | 一种类外泌体技术用于制备新型溶瘤病毒的方法 |
| IL305795A (en) * | 2021-03-10 | 2023-11-01 | B G Negev Technologies & Applications Ltd At Ben Gurion Univ | Reporter cells expressing chimeric proteins for use in determining the presence and or activity of immune barrier molecules |
| CN115197314B (zh) * | 2021-04-11 | 2025-08-19 | 中国科学院分子细胞科学卓越创新中心 | 一种pd1变体及其用途 |
| EP4340862A4 (en) * | 2021-05-20 | 2025-05-21 | Achelois Biopharma, Inc. | Immune checkpoint multivalent particles compositions and methods of use |
| WO2023235479A1 (en) * | 2022-06-02 | 2023-12-07 | TCR2 Therapeutics Inc. | Compositions and methods for treating cancer |
| CN121057753A (zh) * | 2022-11-14 | 2025-12-02 | 阿奇洛伊斯生物制药公司 | 免疫检查点多价颗粒组合物和使用方法 |
| WO2025212859A1 (en) * | 2024-04-03 | 2025-10-09 | Solid Biosciences, Inc. | Methods and constructs for increasing solid organ transplant survival |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19822115B4 (de) | 1998-05-08 | 2004-04-08 | Heinrich-Pette-Institut | Retrovirale Gentransfervektoren |
| KR101130597B1 (ko) | 2005-09-13 | 2012-04-02 | 다카라 바이오 가부시키가이샤 | Ｔ 세포 리셉터 및 그 리셉터를 코드하는 핵산 |
| WO2010012829A1 (en) | 2008-07-31 | 2010-02-04 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Her2/neu specific t cell receptors |
| ZA200807283B (en) | 2008-08-22 | 2009-10-28 | Mechlift Invest Pty Ltd | Data unit for a bin lifting device |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| ES2872077T3 (es) | 2011-04-08 | 2021-11-02 | Us Health | Receptor de antígenos quiméricos anti-variante III del receptor de factor de crecimiento epidérmico y uso de los mismos para el tratamiento de cáncer |
| ES2888651T3 (es) * | 2011-07-29 | 2022-01-05 | Univ Pennsylvania | Receptores de conmutación coestimulantes |
| US9868774B2 (en) | 2011-10-20 | 2018-01-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-CD22 chimeric antigen receptors |
| WO2013062365A2 (ko) * | 2011-10-26 | 2013-05-02 | 국립암센터 | 변이 ｃｔｌａ4 유전자 이입 ｔ 세포 및 이를 포함하는 항암 면역치료용 조성물 |
| JP6074435B2 (ja) | 2011-10-26 | 2017-02-01 | ナショナル キャンサー センター | 変異ｃｔｌａ４遺伝子移入ｔ細胞及びこれを含む抗がん免疫治療用組成物 |
| CA3116051C (en) | 2012-03-23 | 2023-09-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin chimeric antigen receptors |
| MX394639B (es) | 2012-04-11 | 2025-03-24 | Us Health | Receptores del antigeno quimerico que seleccionan el antigeno para la maduracion de las celulas b |
| GB201206559D0 (en) | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| JP6285553B2 (ja) | 2013-08-26 | 2018-02-28 | インノバイオファーム リミテッド | 抗ｃｄ３０キメラ抗原受容体およびその使用 |
| KR20180041087A (ko) | 2014-12-02 | 2018-04-23 | 프로스펙트 차터케어 알더블유엠씨, 엘엘씨 디/비/에이 로저 윌리암스 메디컬 센터 | 암을 치료하기 위한 방법 및 조성물 |
| CN115925971A (zh) | 2015-06-19 | 2023-04-07 | 塞巴斯蒂安·科博尔德 | Pd-1-cd28融合蛋白及其在医学中的用途 |
| CA3071661A1 (en) | 2017-09-06 | 2019-03-14 | Fred Hutchinson Cancer Research Center | Strep-tag specific chimeric receptors and uses thereof |
| CN110951718B (zh) * | 2019-12-02 | 2022-09-30 | 吉林凯莱英医药化学有限公司 | 共固定化酶、其制备方法及其应用 |
-
2016
- 2016-06-20 CN CN202210854297.2A patent/CN115925971A/zh active Pending
- 2016-06-20 ES ES21155542T patent/ES2976647T3/es active Active
- 2016-06-20 JP JP2018517487A patent/JP7085988B2/ja active Active
- 2016-06-20 FI FIEP21155542.0T patent/FI3909972T3/fi active
- 2016-06-20 EP EP24156660.3A patent/EP4349854A3/en active Pending
- 2016-06-20 ES ES16736802T patent/ES2870174T3/es active Active
- 2016-06-20 US US15/737,877 patent/US11192935B2/en active Active
- 2016-06-20 DK DK21155542.0T patent/DK3909972T5/da active
- 2016-06-20 CN CN202210834160.0A patent/CN115927474A/zh active Pending
- 2016-06-20 HU HUE16736802A patent/HUE054201T2/hu unknown
- 2016-06-20 WO PCT/EP2016/064195 patent/WO2016203048A1/en not_active Ceased
- 2016-06-20 PT PT167368026T patent/PT3310805T/pt unknown
- 2016-06-20 CA CA2989949A patent/CA2989949A1/en active Pending
- 2016-06-20 EP EP21155542.0A patent/EP3909972B1/en active Active
- 2016-06-20 PL PL16736802T patent/PL3310805T3/pl unknown
- 2016-06-20 CN CN201680048221.3A patent/CN108026151B/zh active Active
- 2016-06-20 EP EP16736802.6A patent/EP3310805B1/en active Active
- 2016-06-20 DK DK16736802.6T patent/DK3310805T3/da active
- 2016-06-20 AU AU2016277883A patent/AU2016277883B2/en active Active
-
2021
- 2021-10-29 US US17/515,250 patent/US20220169699A1/en active Pending
-
2022
- 2022-03-22 JP JP2022044885A patent/JP7460675B2/ja active Active
-
2024
- 2024-03-21 JP JP2024044396A patent/JP2024073636A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3909972B1 (en) | 2024-02-14 |
| JP2022084787A (ja) | 2022-06-07 |
| EP4349854A2 (en) | 2024-04-10 |
| ES2976647T3 (es) | 2024-08-06 |
| FI3909972T3 (fi) | 2024-05-03 |
| HUE054201T2 (hu) | 2021-08-30 |
| JP7085988B2 (ja) | 2022-06-17 |
| JP2024073636A (ja) | 2024-05-29 |
| ES2870174T3 (es) | 2021-10-26 |
| CN115927474A (zh) | 2023-04-07 |
| PT3310805T (pt) | 2021-05-19 |
| DK3909972T5 (da) | 2024-08-05 |
| US20220169699A1 (en) | 2022-06-02 |
| JP7460675B2 (ja) | 2024-04-02 |
| CN108026151A (zh) | 2018-05-11 |
| JP2018518990A (ja) | 2018-07-19 |
| CN108026151B (zh) | 2022-07-15 |
| EP3310805B1 (en) | 2021-02-17 |
| EP4349854A3 (en) | 2024-07-10 |
| AU2016277883B2 (en) | 2020-09-17 |
| WO2016203048A1 (en) | 2016-12-22 |
| DK3310805T3 (da) | 2021-05-03 |
| EP3909972A1 (en) | 2021-11-17 |
| AU2016277883A1 (en) | 2018-01-18 |
| CA2989949A1 (en) | 2016-12-22 |
| US11192935B2 (en) | 2021-12-07 |
| EP3310805A1 (en) | 2018-04-25 |
| CN115925971A (zh) | 2023-04-07 |
| US20190010207A1 (en) | 2019-01-10 |
| AU2016277883A8 (en) | 2018-01-25 |
| DK3909972T3 (da) | 2024-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3310805T3 (pl) | Białka fuzyjne pd-1-cd28 i ich zastosowanie w medycynie | |
| HUS2500022I1 (hu) | Terápiás ellenanyagok és alkalmazásaik | |
| IL256687B (en) | Isolated tau-binding antibody and its use in treatment and diagnosis | |
| IL258712A (en) | A system for creating a spray and a capsule for use in a system for creating a spray | |
| ZA201801640B (en) | Gitrl fusion proteins and uses thereof | |
| SG10201913807QA (en) | Multivalent and multispecific gitr-binding fusion proteins | |
| SG10201912405TA (en) | Multivalent and multispecific 41bb-binding fusion proteins | |
| ZA201603262B (en) | Interleukin-2 fusion proteins and uses thereof | |
| SG11201707182WA (en) | Immunomodulatory fusion proteins and uses thereof | |
| GB201509062D0 (en) | OX40L fusion proteins and uses thereof | |
| HUE051661T2 (hu) | Készítmények és gyógyászati felhasználások a TCR újraprogramozására fúziós fehérjék felhasználásával | |
| EP3147298A4 (en) | Pd-l1 fusion protein and use thereof | |
| SI3565828T1 (sl) | SIRP1 alfa-41BBL fuzijski protein in postopki za njegovo uporabo | |
| ZA201800238B (en) | Multivalent and multispecific dr5-binding fusion proteins | |
| GB2570063B (en) | Fusion protein and applications thereof | |
| SI3290441T1 (sl) | RGMA-vezavni protein in njegova uporaba | |
| IL251799A0 (en) | Serpin-fused polypeptides and methods of using them | |
| EP3235831A4 (en) | Artificial multi-antigen fusion protein and preparation and use thereof | |
| EP3237452A4 (en) | Fusion proteins and methods thereof | |
| DK3158058T3 (da) | Fusionsproteiner og bruger deraf | |
| EP3029071A4 (en) | Saxatilin-fc fusion protein and use thereof | |
| ZA201608886B (en) | Human cytolytic fusion proteins | |
| TH1601000600A (th) | โปรตีนการเชื่อมหลอมที่ใช้ในการรักษา |