JP7085988B2 - Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用 - Google Patents

Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用 Download PDF

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JP7085988B2
JP7085988B2 JP2018517487A JP2018517487A JP7085988B2 JP 7085988 B2 JP7085988 B2 JP 7085988B2 JP 2018517487 A JP2018517487 A JP 2018517487A JP 2018517487 A JP2018517487 A JP 2018517487A JP 7085988 B2 JP7085988 B2 JP 7085988B2
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cells
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fusion protein
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JP2018518990A5 (OSRAM
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セバスチャン コボルド
ステファン エンドレス
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2018517487A 2015-06-19 2016-06-20 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用 Active JP7085988B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022044885A JP7460675B2 (ja) 2015-06-19 2022-03-22 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用
JP2024044396A JP2024073636A (ja) 2015-06-19 2024-03-21 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15172913.4 2015-06-19
EP15172913 2015-06-19
PCT/EP2016/064195 WO2016203048A1 (en) 2015-06-19 2016-06-20 Pd-1-cd28 fusion proteins and their use in medicine

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JP2022044885A Division JP7460675B2 (ja) 2015-06-19 2022-03-22 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用

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JP2018518990A JP2018518990A (ja) 2018-07-19
JP2018518990A5 JP2018518990A5 (OSRAM) 2019-06-06
JP7085988B2 true JP7085988B2 (ja) 2022-06-17

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JP2018517487A Active JP7085988B2 (ja) 2015-06-19 2016-06-20 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用
JP2022044885A Active JP7460675B2 (ja) 2015-06-19 2022-03-22 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用
JP2024044396A Pending JP2024073636A (ja) 2015-06-19 2024-03-21 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用

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JP2024044396A Pending JP2024073636A (ja) 2015-06-19 2024-03-21 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用

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US (2) US11192935B2 (OSRAM)
EP (3) EP4349854A3 (OSRAM)
JP (3) JP7085988B2 (OSRAM)
CN (3) CN115925971A (OSRAM)
AU (1) AU2016277883B2 (OSRAM)
CA (1) CA2989949A1 (OSRAM)
DK (2) DK3909972T5 (OSRAM)
ES (2) ES2870174T3 (OSRAM)
FI (1) FI3909972T3 (OSRAM)
HU (1) HUE054201T2 (OSRAM)
PL (1) PL3310805T3 (OSRAM)
PT (1) PT3310805T (OSRAM)
WO (1) WO2016203048A1 (OSRAM)

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CA2989949A1 (en) * 2015-06-19 2016-12-22 Sebastian KOBOLD Pd-1-cd28 fusion proteins and their use in medicine
KR20180038447A (ko) * 2015-06-29 2018-04-16 더 존스 홉킨스 유니버시티 면역 체크포인트 키메라 수용체 치료법
CN105331585A (zh) * 2015-11-13 2016-02-17 科济生物医药（上海）有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
EP4286522A3 (en) * 2016-03-23 2024-02-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins of pd-1 and 4-1bb
CN107523545A (zh) * 2016-06-20 2017-12-29 上海细胞治疗研究院 一种高效稳定表达抗体的杀伤性细胞及其用途
KR20190025855A (ko) * 2016-06-30 2019-03-12 에프. 호프만-라 로슈 아게 개선된 입양 t-세포 요법
JP7109789B2 (ja) 2016-08-02 2022-08-01 ティーシーアール２ セラピューティクス インク． 融合タンパク質を使用したｔｃｒの再プログラム化のための組成物及び方法
CA3036745A1 (en) 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
AU2017382902A1 (en) * 2016-12-21 2019-07-18 TCR2 Therapeutics Inc. Engineered T cells for the treatment of cancer
US11535662B2 (en) * 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
WO2018170475A1 (en) 2017-03-17 2018-09-20 Fred Hutchinson Cancer Research Center Immunomodulatory fusion proteins and uses thereof
EP3762410A4 (en) * 2018-03-06 2022-04-06 The Trustees of the University of Pennsylvania CHEMICAL PROSTATE MEMBRANE SPECIFIC ANTIGEN SPECIFIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF
CN108727504B (zh) * 2018-04-16 2021-08-27 泉州向日葵生物科技有限公司 一种ifn与抗pd-l1抗体的融合蛋白及其应用
CN111606999B (zh) * 2019-02-26 2022-09-06 南京惟亚德生物医药有限公司 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用
JP7654557B2 (ja) * 2019-03-27 2025-04-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法
CN115298208A (zh) * 2019-07-19 2022-11-04 纪念斯隆-凯特琳癌症中心 免疫治疗用融合多肽
CN113832111A (zh) * 2020-06-23 2021-12-24 南京大学 一种类外泌体技术用于制备新型溶瘤病毒的方法
CN113832114A (zh) * 2020-06-23 2021-12-24 南京大学 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用
EP4305174A4 (en) * 2021-03-10 2025-04-30 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University REPORTER CELLS EXPRESSING CHIMERIC POLYPEPTIDES TO DETERMINE THE PRESENCE AND/OR ACTIVITY OF IMMUNE CHECKPOINT MOLECULES
CN115197314B (zh) * 2021-04-11 2025-08-19 中国科学院分子细胞科学卓越创新中心 一种pd1变体及其用途
US20240252613A1 (en) * 2021-05-20 2024-08-01 Achelois Biopharma, Inc. Immune checkpoint multivalent particles compositions and methods of use
WO2023235479A1 (en) * 2022-06-02 2023-12-07 TCR2 Therapeutics Inc. Compositions and methods for treating cancer
WO2024107577A2 (en) * 2022-11-14 2024-05-23 Achelois Biopharma, Inc. Immune checkpoint multivalent particles compositions and methods of use
WO2025212859A1 (en) * 2024-04-03 2025-10-09 Solid Biosciences, Inc. Methods and constructs for increasing solid organ transplant survival

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JP2014532642A (ja) 2011-10-26 2014-12-08 ナショナル キャンサー センター 変異ｃｔｌａ４遺伝子移入ｔ細胞及びこれを含む抗がん免疫治療用組成物

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JP2014532642A (ja) 2011-10-26 2014-12-08 ナショナル キャンサー センター 変異ｃｔｌａ４遺伝子移入ｔ細胞及びこれを含む抗がん免疫治療用組成物

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ES2976647T3 (es) 2024-08-06
EP3310805A1 (en) 2018-04-25
AU2016277883A8 (en) 2018-01-25
EP3310805B1 (en) 2021-02-17
EP4349854A2 (en) 2024-04-10
DK3310805T3 (da) 2021-05-03
JP2024073636A (ja) 2024-05-29
CN115925971A (zh) 2023-04-07
US20190010207A1 (en) 2019-01-10
PL3310805T3 (pl) 2021-08-23
WO2016203048A1 (en) 2016-12-22
EP3909972B1 (en) 2024-02-14
JP2018518990A (ja) 2018-07-19
EP4349854A3 (en) 2024-07-10
DK3909972T3 (da) 2024-04-29
JP7460675B2 (ja) 2024-04-02
EP3909972A1 (en) 2021-11-17
FI3909972T3 (fi) 2024-05-03
HUE054201T2 (hu) 2021-08-30
AU2016277883A1 (en) 2018-01-18
US11192935B2 (en) 2021-12-07
CN108026151A (zh) 2018-05-11
CN108026151B (zh) 2022-07-15
US20220169699A1 (en) 2022-06-02
CA2989949A1 (en) 2016-12-22
DK3909972T5 (da) 2024-08-05
CN115927474A (zh) 2023-04-07
PT3310805T (pt) 2021-05-19
AU2016277883B2 (en) 2020-09-17
JP2022084787A (ja) 2022-06-07
ES2870174T3 (es) 2021-10-26

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