AU2015318556C1 - Cytotoxic and anti-mitotic compounds, and methods of using the same - Google Patents

Cytotoxic and anti-mitotic compounds, and methods of using the same Download PDF

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Publication number
AU2015318556C1
AU2015318556C1 AU2015318556A AU2015318556A AU2015318556C1 AU 2015318556 C1 AU2015318556 C1 AU 2015318556C1 AU 2015318556 A AU2015318556 A AU 2015318556A AU 2015318556 A AU2015318556 A AU 2015318556A AU 2015318556 C1 AU2015318556 C1 AU 2015318556C1
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amino
alkyl
methyl
methoxy
aryl
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AU2015318556A1 (en
AU2015318556B2 (en
Inventor
Stuart Daniel Barnscher
Elyse Marie Josee Bourque
Graham Albert Edwin GARNETT
Tom Han Hsiao HSIEH
Alexander Laurence MANDEL
James R. RICH
Geoffrey C. Winters
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Zymeworks BC Inc
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Zymeworks BC Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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AU2015318556A 2014-09-17 2015-09-17 Cytotoxic and anti-mitotic compounds, and methods of using the same Active AU2015318556C1 (en)

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US201462051883P 2014-09-17 2014-09-17
US62/051,883 2014-09-17
PCT/CA2015/050910 WO2016041082A1 (en) 2014-09-17 2015-09-17 Cytotoxic and anti-mitotic compounds, and methods of using the same

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US20200207865A2 (en) 2020-07-02
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US20170247408A1 (en) 2017-08-31
KR102609034B1 (ko) 2023-12-01
RU2017110069A (ru) 2018-10-17
BR112017005126A2 (pt) 2018-08-07
MX2017003476A (es) 2017-08-02
CN113416229A (zh) 2021-09-21
US20180208667A1 (en) 2018-07-26
ES2905569T3 (es) 2022-04-11
AU2015318556B2 (en) 2020-06-18
DK3194421T3 (da) 2022-02-14
HUE057768T2 (hu) 2022-06-28
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RS62860B1 (sr) 2022-02-28
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IL287645A (en) 2021-12-01
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