AU2015300766B2 - Integrated device for temporal binning of received photons - Google Patents

Integrated device for temporal binning of received photons Download PDF

Info

Publication number
AU2015300766B2
AU2015300766B2 AU2015300766A AU2015300766A AU2015300766B2 AU 2015300766 B2 AU2015300766 B2 AU 2015300766B2 AU 2015300766 A AU2015300766 A AU 2015300766A AU 2015300766 A AU2015300766 A AU 2015300766A AU 2015300766 B2 AU2015300766 B2 AU 2015300766B2
Authority
AU
Australia
Prior art keywords
charge carrier
charge
region
time
carriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015300766A
Other languages
English (en)
Other versions
AU2015300766A1 (en
Inventor
David Boisvert
Keith G. Fife
Jonathan M. Rothberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quantum Si Inc
Original Assignee
Quantum Si Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Si Inc filed Critical Quantum Si Inc
Publication of AU2015300766A1 publication Critical patent/AU2015300766A1/en
Application granted granted Critical
Publication of AU2015300766B2 publication Critical patent/AU2015300766B2/en
Priority to AU2021202729A priority Critical patent/AU2021202729B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/80—Constructional details of image sensors
    • H10F39/802—Geometry or disposition of elements in pixels, e.g. address-lines or gate electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
    • G01S7/483—Details of pulse systems
    • G01S7/486—Receivers
    • G01S7/4865—Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70—SSIS architectures; Circuits associated therewith
    • H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70—SSIS architectures; Circuits associated therewith
    • H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • H04N25/771—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising storage means other than floating diffusion
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/70—SSIS architectures; Circuits associated therewith
    • H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
    • H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
    • H04N25/772—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising A/D, V/T, V/F, I/T or I/F converters
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/011—Manufacture or treatment of image sensors covered by group H10F39/12
    • H10F39/026—Wafer-level processing
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10F—INORGANIC SEMICONDUCTOR DEVICES SENSITIVE TO INFRARED RADIATION, LIGHT, ELECTROMAGNETIC RADIATION OF SHORTER WAVELENGTH OR CORPUSCULAR RADIATION
    • H10F39/00—Integrated devices, or assemblies of multiple devices, comprising at least one element covered by group H10F30/00, e.g. radiation detectors comprising photodiode arrays
    • H10F39/10—Integrated devices
    • H10F39/12—Image sensors
    • H10F39/15—Charge-coupled device [CCD] image sensors
    • H10F39/151—Geometry or disposition of pixel elements, address lines or gate electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/069—Supply of sources
    • G01N2201/0696—Pulsed
    • G01N2201/0697—Pulsed lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S17/00—Systems using the reflection or reradiation of electromagnetic waves other than radio waves, e.g. lidar systems
    • G01S17/88—Lidar systems specially adapted for specific applications
    • G01S17/89—Lidar systems specially adapted for specific applications for mapping or imaging
    • G01S17/894—Three-dimensional [3D] imaging with simultaneous measurement of time-of-flight at a two-dimensional [2D] array of receiver pixels, e.g. time-of-flight cameras or flash lidar
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
    • G01S7/483—Details of pulse systems
    • G01S7/486—Receivers
    • G01S7/4861—Circuits for detection, sampling, integration or read-out
    • G01S7/4863—Detector arrays, e.g. charge-transfer gates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Signal Processing (AREA)
  • Multimedia (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Remote Sensing (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Light Receiving Elements (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Communication System (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
AU2015300766A 2014-08-08 2015-08-07 Integrated device for temporal binning of received photons Ceased AU2015300766B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021202729A AU2021202729B2 (en) 2014-08-08 2021-04-30 Integrated device for temporal binning of received photons

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462035377P 2014-08-08 2014-08-08
US62/035,377 2014-08-08
US201562164506P 2015-05-20 2015-05-20
US62/164,506 2015-05-20
PCT/US2015/044360 WO2016022998A2 (en) 2014-08-08 2015-08-07 Integrated device for temporal binning of received photons

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021202729A Division AU2021202729B2 (en) 2014-08-08 2021-04-30 Integrated device for temporal binning of received photons

Publications (2)

Publication Number Publication Date
AU2015300766A1 AU2015300766A1 (en) 2017-03-16
AU2015300766B2 true AU2015300766B2 (en) 2021-02-04

Family

ID=54064569

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015300766A Ceased AU2015300766B2 (en) 2014-08-08 2015-08-07 Integrated device for temporal binning of received photons
AU2021202729A Ceased AU2021202729B2 (en) 2014-08-08 2021-04-30 Integrated device for temporal binning of received photons

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021202729A Ceased AU2021202729B2 (en) 2014-08-08 2021-04-30 Integrated device for temporal binning of received photons

Country Status (10)

Country Link
US (8) US9759658B2 (https=)
EP (2) EP3471402B1 (https=)
JP (2) JP6707520B2 (https=)
KR (3) KR102585730B1 (https=)
CN (2) CN107112333B (https=)
AU (2) AU2015300766B2 (https=)
BR (1) BR112017002485B1 (https=)
CA (1) CA2957540A1 (https=)
MX (2) MX2021007934A (https=)
WO (1) WO2016022998A2 (https=)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105917003A (zh) 2013-11-17 2016-08-31 宽腾矽公司 用于生物和化学试样的快速分析的有源像素集成装置
KR102585730B1 (ko) 2014-08-08 2023-10-10 퀀텀-에스아이 인코포레이티드 수신된 광자들의 시간 비닝을 위한 집적 디바이스
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
CN106796175B (zh) 2014-08-08 2021-01-05 宽腾矽公司 用于探测、检测和分析分子的光学系统和检测芯片
MX384725B (es) 2014-08-08 2025-03-14 Quantum Si Inc Dispositivo integrado con fuente de luz externa para el sondeo, detección y análisis de moléculas.
KR101725099B1 (ko) * 2014-12-05 2017-04-26 삼성전자주식회사 컴퓨터 단층 촬영장치 및 그 제어방법
AU2015203591A1 (en) * 2015-06-26 2017-01-19 Canon Kabushiki Kaisha System and method for object matching
JP2017098809A (ja) * 2015-11-26 2017-06-01 キヤノン株式会社 光電変換装置、および、撮像システム
JP2019512090A (ja) * 2016-02-17 2019-05-09 テッセラクト ヘルス インコーポレイテッドＴｅｓｓｅｒａｃｔ Ｈｅａｌｔｈ，Ｉｎｃ． 寿命イメージングおよび検出用途のためのセンサおよびデバイス
MX2018014856A (es) * 2016-06-01 2019-03-07 Quantum Si Inc Llamador de pulso y llamador de base.
US10341571B2 (en) * 2016-06-08 2019-07-02 Invisage Technologies, Inc. Image sensors with electronic shutter
JP6908819B2 (ja) * 2016-09-29 2021-07-28 ミツミ電機株式会社 近接センサ
EP3305170B1 (en) * 2016-10-04 2020-12-02 ams AG Fluorescence lifetime sensor module and method of determining a fluorescence lifetime using a sensor module
JP6808463B2 (ja) * 2016-11-30 2021-01-06 キヤノン株式会社 光電変換装置および光電変換システム
CN116466494A (zh) 2016-12-16 2023-07-21 宽腾矽公司 紧密的光束整形及操纵总成
TW201837184A (zh) 2016-12-19 2018-10-16 美商寬騰矽公司 分子載入樣品孔以供分析
KR102560427B1 (ko) * 2016-12-22 2023-07-28 퀀텀-에스아이 인코포레이티드 직접 비닝 픽셀을 갖는 집적 광검출기
GB201622429D0 (en) 2016-12-30 2017-02-15 Univ Court Of The Univ Of Edinburgh The Photon sensor apparatus
JP7356909B2 (ja) 2017-05-05 2023-10-05 クアンタム－エスアイ インコーポレイテッド 生物学的反応における表面反応性と防汚特性が改変された基板
BR112020000799A2 (pt) * 2017-07-24 2020-07-14 Quantum-Si Incorporated estruturas fotônicas de rejeição óptica
WO2019023174A1 (en) 2017-07-24 2019-01-31 Quantum-Si Incorporated MASSIVELY PARALLEL BIO-OPTOELECTRONIC INSTRUMENT HAND-HELD
CN111566261B (zh) 2017-08-18 2025-03-25 诺迪勒思附属公司 选择结合试剂的方法
US10817780B2 (en) 2017-10-29 2020-10-27 Christopher J. Rourk Electron transport gate circuits and methods of manufacture, operation and use
WO2019084537A1 (en) * 2017-10-29 2019-05-02 Rourk Christopher J ELECTRON TRANSPORT DOOR CIRCUITS AND METHODS OF MANUFACTURE, OPERATION AND USE
EP3813356B1 (en) 2017-10-30 2025-02-05 Sony Semiconductor Solutions Corporation Solid-state imaging device
KR20200115590A (ko) * 2018-01-26 2020-10-07 퀀텀-에스아이 인코포레이티드 서열화 디바이스들을 위한 머신 학습 가능형 펄스 및 염기 호출
US11808700B2 (en) * 2018-06-15 2023-11-07 Quantum-Si Incorporated Data acquisition control for advanced analytic instruments having pulsed optical sources
WO2019246328A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
EP3824553B1 (en) 2018-07-16 2025-01-01 Gigajot Technology, Inc. High-sensitivity depth sensor with non-avalanche photodetector and method for operating the same
CN108760641B (zh) * 2018-08-17 2023-05-16 龙岩学院 基于单光子探测的熔焊过程监测装置及监测方法
CA3109816A1 (en) * 2018-08-29 2020-03-05 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors
JP2020072317A (ja) * 2018-10-30 2020-05-07 ソニーセミコンダクタソリューションズ株式会社 センサ及び制御方法
BR112021008098A2 (pt) 2018-11-15 2021-08-10 Quantum-Si Incorporated métodos e composições para o sequenciamento de proteínas
EP3884048A4 (en) 2018-11-20 2022-08-17 Nautilus Biotechnology, Inc. DESIGN AND SELECTION OF AFFINITY REAGENTS
US11607119B2 (en) * 2018-12-17 2023-03-21 Qatar University Fluorescence lifetime spectroscopy based capsule endoscopy
DE102018222118A1 (de) * 2018-12-18 2020-06-18 Robert Bosch Gmbh CCD-Photodetektor und zugehöriges Verfahren zum Betrieb
JP2020118569A (ja) 2019-01-24 2020-08-06 ソニーセミコンダクタソリューションズ株式会社 受光装置および測距装置
EP3937780A4 (en) * 2019-03-14 2022-12-07 InSilixa, Inc. METHODS AND SYSTEMS FOR TIMED FLUORESCENCE-BASED DETECTION
CA3135206A1 (en) 2019-04-29 2020-11-05 Pierre Indermuhle Methods and systems for integrated on-chip single-molecule detection
US11423306B2 (en) * 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
EP3973272A1 (en) * 2019-06-28 2022-03-30 Quantum-Si Incorporated Optical and electrical secondary path rejection
CN114174858B (zh) * 2019-07-12 2025-08-12 索尼半导体解决方案公司 半导体装置
EP4017339A1 (en) * 2019-08-20 2022-06-29 Intuitive Surgical Operations, Inc. Systems and a method for directing an imaging device to detect fluorescence and for determining a lifetime of the fluorescence
KR20220079943A (ko) 2019-10-11 2022-06-14 퀀텀-에스아이 인코포레이티드 증기 상에서의 표면 개질
CN110579460B (zh) * 2019-10-14 2023-04-18 深圳大学 一种寻址扫描快速荧光寿命显微成像系统及方法
AU2020372908A1 (en) 2019-10-29 2022-06-02 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices
CA3159371A1 (en) * 2019-10-31 2021-05-06 Quantum-Si Incorporated Pixel with enhanced drain
KR20220137027A (ko) 2020-01-14 2022-10-11 퀀텀-에스아이 인코포레이티드 진폭 변조 레이저
TW202145595A (zh) 2020-01-14 2021-12-01 美商寬騰矽公司 用於壽命及光譜特性分析之感應器
JP7763763B2 (ja) * 2020-01-14 2025-11-04 クアンタム－エスアイ インコーポレイテッド 寿命特性評価のための集積センサ
US12422354B2 (en) 2020-01-28 2025-09-23 Daylight Solutions, Inc. Fluid analyzer with removable test cell for detection and quantitation of compounds in liquids
TW202147591A (zh) * 2020-03-02 2021-12-16 美商寬騰矽公司 用於多維信號分析之整合感應器
EP4133524A2 (en) 2020-04-08 2023-02-15 Quantum-si Incorporated Integrated sensor with reduced skew
WO2021236983A2 (en) 2020-05-20 2021-11-25 Quantum-Si Incorporated Methods and compositions for protein sequencing
US11532150B1 (en) * 2020-06-02 2022-12-20 Honeywell Federal Manufacturing & Technologies, Llc Method for determining a histogram of variable sample rate waveforms
AU2021288692A1 (en) 2020-06-11 2023-02-02 Nautilus Subsidiary, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
US20220065785A1 (en) * 2020-07-23 2022-03-03 Quantum-Si Incorporated System and method for detecting change points
WO2022087240A2 (en) 2020-10-22 2022-04-28 Quantum-Si Incorporated Integrated circuit with sequentially-coupled charge storage and associated techniques
EP4217716A4 (en) * 2020-10-27 2024-11-27 Quantum-si Incorporated CALIBRATION OF SINGLE MOLECULE DETECTION SYSTEM
US12297496B2 (en) 2020-12-11 2025-05-13 Quantum-Si Incorporated Integrated circuit with improved charge transfer efficiency and associated techniques
JP2023554368A (ja) 2020-12-15 2023-12-27 クアンタム－エスアイ インコーポレイテッド 単一分子速度論による分子バーコード分析
EP4281775B1 (en) 2021-01-21 2026-04-29 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
IL307484A (en) 2021-04-08 2023-12-01 Quantum Si Inc Integrated circuit having mirrored pixel configuration
CN113268142B (zh) * 2021-06-09 2024-04-02 江苏集萃脑机融合智能技术研究所有限公司 基于直接测量飞行时间技术的脑机接口系统、脑机接口穿戴设备及其控制方法
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
CA3227592A1 (en) 2021-09-22 2023-03-30 Gregory KAPP Methods and systems for determining polypeptide interactions
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
WO2023137051A2 (en) 2022-01-12 2023-07-20 Quantum-Si Incorporated Integrated sensor
US12092578B2 (en) 2022-03-29 2024-09-17 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
EP4544077A1 (en) 2022-06-21 2025-04-30 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
WO2024019988A1 (en) * 2022-07-18 2024-01-25 Cellsbin, Inc. Devices for biological analysis
WO2024039853A1 (en) * 2022-08-19 2024-02-22 Quantum-Si Incorporated Backside illuminated structures with parallel charge transfer
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
CN115588678B (zh) * 2022-11-02 2026-02-27 华中科技大学 一种电荷耦合器件以及电荷耦合器件的制备方法
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
CN120418452A (zh) * 2022-12-30 2025-08-01 深圳华大智造科技股份有限公司 基因数据的编码和解码方法、装置及基因检测系统
EP4689173A1 (en) 2023-03-24 2026-02-11 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
US20240394902A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
DE102023127992A1 (de) * 2023-10-13 2025-04-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Anregung und Messung von Fluoreszenzlebensdauern mittels optischer 3D Vermessung
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
WO2025137166A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
US20250298016A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040169842A1 (en) * 2002-03-27 2004-09-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse
EP2182523A1 (en) * 2008-10-31 2010-05-05 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line

Family Cites Families (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890500A (en) 1974-02-11 1975-06-17 Gen Electric Apparatus for sensing radiation and providing electrical readout
US5198543A (en) 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
US5355165A (en) * 1992-08-06 1994-10-11 Princeton Scientific Instruments, Inc. Very high frame rate CCD imager
AU673245B2 (en) 1993-02-01 1996-10-31 Seq, Ltd. Methods and apparatus for DNA sequencing
US5471515A (en) 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
US6456326B2 (en) 1994-01-28 2002-09-24 California Institute Of Technology Single chip camera device having double sampling operation
CN1149335A (zh) 1994-05-27 1997-05-07 希巴-盖吉股份公司 探测短暂受激发光的方法
US5912155A (en) 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5990506A (en) 1996-03-20 1999-11-23 California Institute Of Technology Active pixel sensors with substantially planarized color filtering elements
WO1998022799A2 (de) 1996-11-18 1998-05-28 Novartis Ag Messvorrichtung und deren verwendung
CN1251609A (zh) 1997-02-12 2000-04-26 尤金·Y·查恩 分析聚合物的方法和产品
IT1290553B1 (it) 1997-02-27 1998-12-10 Ist Nazionale Fisica Nucleare Rivelatore dell'energia e della posizione di incidenza di radiazioni elettromagnetiche o di particelle ionizzanti a deriva controllata
US6265193B1 (en) 1997-03-12 2001-07-24 Pe Corporation (Ny) DNA polymerases having improved labeled nucleotide incorporation properties
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6825921B1 (en) * 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
EP0921196A1 (en) 1997-12-02 1999-06-09 Roche Diagnostics GmbH Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
WO1999049082A2 (en) 1998-03-23 1999-09-30 Invitrogen Corporation Modified nucleotides and methods useful for nucleic acid sequencing
JP3813818B2 (ja) 1998-05-01 2006-08-23 アリゾナ ボード オブ リージェンツ オリゴヌクレオチドおよびｄｎａ分子のヌクレオチド配列の決定方法
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6280939B1 (en) 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
JP4326050B2 (ja) * 1998-09-22 2009-09-02 ハイスペック合資会社 高速撮像素子
WO2000036151A1 (en) 1998-12-14 2000-06-22 Li-Cor, Inc. A heterogeneous assay for pyrophosphate detection
US6445491B2 (en) 1999-01-29 2002-09-03 Irma America, Inc. Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification
AU3174600A (en) 1999-03-10 2000-09-28 Asm Scientific, Inc. A method for direct nucleic acid sequencing
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
EP1681357A3 (en) 1999-05-19 2006-07-26 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6137117A (en) 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
CN2433618Y (zh) * 1999-10-29 2001-06-06 中国科学院上海原子核研究所 基因芯片检测装置
US6399335B1 (en) 1999-11-16 2002-06-04 Advanced Research And Technology Institute, Inc. γ-phosphoester nucleoside triphosphates
JP4433347B2 (ja) * 2000-01-17 2010-03-17 富士フイルム株式会社 蛍光撮像装置
US20020090650A1 (en) 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US7175811B2 (en) 2000-04-28 2007-02-13 Edgelight Biosciences Micro-array evanescent wave fluorescence detection device
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
JP2004516810A (ja) 2000-06-07 2004-06-10 リ−コール インコーポレーティッド 電荷スイッチヌクレオチド
US6975898B2 (en) 2000-06-19 2005-12-13 University Of Washington Medical imaging, diagnosis, and therapy using a scanning single optical fiber system
US7158224B2 (en) 2000-06-25 2007-01-02 Affymetrix, Inc. Optically active substrates
FR2813121A1 (fr) 2000-08-21 2002-02-22 Claude Weisbuch Dispositif perfectionne de support d'elements chromophores
US7153672B1 (en) 2000-08-30 2006-12-26 University Of Rochester Method of performing reverse transcription reaction using reverse transcriptase encoded by non-LTR retrotransposable element
US20020031836A1 (en) 2000-09-11 2002-03-14 Feldstein Mark J. Fluidics system
EP1207387A1 (en) 2000-11-20 2002-05-22 Institut Curie Multi-photon imaging installation.
JP4270742B2 (ja) 2000-11-30 2009-06-03 Ｎｅｃエレクトロニクス株式会社 固体撮像装置
AU2002258997A1 (en) 2001-04-24 2002-11-05 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymerases
US7668697B2 (en) 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US7727722B2 (en) 2001-08-29 2010-06-01 General Electric Company Ligation amplification
US7256019B2 (en) 2001-08-29 2007-08-14 Ge Healthcare Bio-Sciences Corp. Terminal phosphate blocked nucleoside polyphosphates
US7223541B2 (en) 2001-08-29 2007-05-29 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides and methods of use
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
JP4318296B2 (ja) 2001-08-29 2009-08-19 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 標識ヌクレオシドポリホスフェート
US7052839B2 (en) 2001-08-29 2006-05-30 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides and methods of use
EP1436385A4 (en) 2001-09-14 2005-12-14 Invitrogen Corp DNA POLYMERASES AND MUTANTS CORRESPONDING
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB2382648B (en) 2001-12-11 2003-11-12 Amersham Pharm Biotech Uk Ltd System and method for time correlated multi-photon counting measurements
CN1138862C (zh) * 2002-01-28 2004-02-18 国前 一种核酸分析用收集装置及其应用方法
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US8238993B2 (en) 2002-04-04 2012-08-07 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime
US20040144927A1 (en) * 2003-01-28 2004-07-29 Auner Gregory W. Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20040106163A1 (en) 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
WO2004047353A2 (en) 2002-11-19 2004-06-03 Safetzone Technologies Corporation Guest communication system and method
US7393640B2 (en) 2003-02-05 2008-07-01 Ge Healthcare Bio-Sciences Corp. Terminal-phosphate-labeled nucleotides with new linkers
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
FR2857158B1 (fr) 2003-07-01 2006-04-28 St Microelectronics Sa Procede de commande d'un photocopieur de type mos
US7078670B2 (en) * 2003-09-15 2006-07-18 Imagerlabs, Inc. Low noise charge gain circuit and CCD using same
WO2005073407A1 (en) 2003-10-07 2005-08-11 Ut-Battelle, Llc Advanced integrated circuit biochip
WO2005043137A1 (de) 2003-10-18 2005-05-12 Bayer Healthcare Ag Direkte beobachtung molekularer veränderungen in biologischen testsystemen mittels messungen der fluoreszenz-lebensdauer
DE10348949A1 (de) * 2003-10-18 2005-05-19 Bayer Healthcare Ag Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005069737A2 (en) 2004-01-27 2005-08-04 Ramot At Tel Aviv University Ltd. Method and system for detecting analytes
WO2005080605A2 (en) 2004-02-19 2005-09-01 Helicos Biosciences Corporation Methods and kits for analyzing polynucleotide sequences
EP1583150A1 (en) 2004-03-31 2005-10-05 CSEM Centre Suisse d'Electronique et de Microtechnique SA Image sensor with large-area, high-sensitivity and high-speed pixels
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
US20060019265A1 (en) 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
EP1622200A1 (en) 2004-07-26 2006-02-01 CSEM Centre Suisse d'Electronique et de Microtechnique SA Solid-state photodetector pixel and photodetecting method
US7315019B2 (en) 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7345764B2 (en) 2005-02-07 2008-03-18 Vladimir Bulovic Apparatus and method for a slim format spectrometer
US20060223067A1 (en) 2005-03-31 2006-10-05 Paolo Vatta Mutant DNA polymerases and methods of use
US7365299B2 (en) 2005-05-09 2008-04-29 Sensors Unlimited, Inc. Method and apparatus for providing flexible photodetector binning
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
WO2007002890A2 (en) 2005-06-28 2007-01-04 Agencourt Personal Genomics Corporation Methods of producing and sequencing modified polynucleotides
EP1920072A2 (en) 2005-07-01 2008-05-14 Dako Denmark A/S In situ hybridization detection method
US7426322B2 (en) 2005-07-20 2008-09-16 Searete Llc. Plasmon photocatalysis
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US7501631B2 (en) 2005-10-07 2009-03-10 Schick Technologies, Inc. Shielding an imaging array from X-ray noise
EP1960550B1 (en) 2005-12-12 2010-09-15 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Probe for nucleic acid sequencing and methods of use
US8921086B2 (en) 2005-12-22 2014-12-30 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
CA2633476C (en) 2005-12-22 2015-04-21 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
JP5110535B2 (ja) 2006-03-31 2012-12-26 国立大学法人静岡大学 半導体測距素子及び固体撮像装置
DE102006030541B4 (de) 2006-06-23 2010-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optische Anordnung
EP3936857B1 (en) 2006-09-01 2023-06-21 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
JP4710017B2 (ja) 2006-10-20 2011-06-29 国立大学法人静岡大学 Ｃｍｏｓイメージセンサ
US8343746B2 (en) 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
FR2908888B1 (fr) 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
WO2008069141A1 (ja) 2006-11-30 2008-06-12 National University Corporation Shizuoka University 半導体測距素子及び固体撮像装置
JP5270835B2 (ja) 2006-12-29 2013-08-21 パナソニック株式会社 光検出素子、空間情報の検出装置
US8174696B2 (en) 2007-03-22 2012-05-08 Universite De Strasbourg Device for sorting and concentrating electromagnetic energy and apparatus comprising at least one such device
EP2134871B1 (en) 2007-03-30 2012-03-07 Pacific Biosciences of California, Inc. Systems and methods for enhancing fluorescent signals
US7873085B2 (en) 2007-10-23 2011-01-18 Andrei Babushkin Method and device for controlling optical output of laser diode
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
WO2009091847A2 (en) 2008-01-14 2009-07-23 Life Technologies Corporation Compositions, methods and systems for single molecule sequencing
AU2009212165A1 (en) 2008-02-07 2009-08-13 Pacific Biosciences Of California, Inc. CIS reactive oxygen quenchers integrated into linkers
WO2009102470A2 (en) 2008-02-12 2009-08-20 Pacific Biosciences Of California, Inc. Compositions and methods for use in analytical reactions
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
AU2009223702B2 (en) 2008-03-13 2013-08-22 Pacific Biosciences Of California, Inc. Labeled reactants and their uses
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
WO2009120374A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
MX2010010600A (es) 2008-03-28 2011-03-30 Pacific Biosciences California Inc Composiciones y metodos para secuenciacion de acidos nucleicos.
WO2009145818A1 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc Single molecule loading methods and compositions
US9127259B2 (en) 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
WO2009145820A2 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8420366B2 (en) 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
EP2274446B1 (en) 2008-03-31 2015-09-09 Pacific Biosciences of California, Inc. Two slow-step polymerase enzyme systems and methods
US10670559B2 (en) * 2008-07-11 2020-06-02 Cornell University Nanofluidic channels with integrated charge sensors and methods based thereon
JP5283216B2 (ja) * 2008-07-31 2013-09-04 国立大学法人静岡大学 高速電荷転送フォトダイオード、ロックインピクセル及び固体撮像装置
WO2010025331A1 (en) * 2008-08-28 2010-03-04 Mesa Imaging Ag Demodulation pixel with daisy chain charge storage sites and method of operation therefor
US20100148221A1 (en) 2008-11-13 2010-06-17 Zena Technologies, Inc. Vertical photogate (vpg) pixel structure with nanowires
AU2009288696A1 (en) 2008-09-05 2010-03-11 Pacific Biosciences Of California, Inc. Sequencing by cognate sampling
CA2737505C (en) 2008-09-16 2017-08-29 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8921046B2 (en) 2008-09-19 2014-12-30 Pacific Biosciences Of California, Inc. Nucleic acid sequence analysis
US8481264B2 (en) 2008-09-19 2013-07-09 Pacific Biosciences Of California, Inc. Immobilized nucleic acid complexes for sequence analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
WO2010036287A1 (en) 2008-09-24 2010-04-01 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8383369B2 (en) 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
AU2009300369B2 (en) 2008-09-30 2014-08-14 Pacific Biosciences Of California, Inc. Ultra-high multiplex analytical systems and methods
US8367813B2 (en) 2008-11-17 2013-02-05 Pacific Biosciences Of California, Inc. Phospholink nucleotides for sequencing applications
WO2010073136A2 (en) 2008-12-22 2010-07-01 Koninklijke Philips Electronics N.V. High dynamic range light sensor
JP5688756B2 (ja) * 2008-12-25 2015-03-25 国立大学法人静岡大学 半導体素子及び固体撮像装置
US20120100530A1 (en) 2009-01-30 2012-04-26 Oxford Nanopore Technologies Limited Enzyme mutant
BRPI0924456A2 (pt) 2009-03-12 2016-02-16 Rsp Systems As sonda óptica para medir sinais de luz, e, método para coletar sinais ópticos de uma amostra.
US20100261185A1 (en) 2009-03-27 2010-10-14 Life Technologies Corporation Labeled enzyme compositions, methods and systems
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP5415805B2 (ja) 2009-03-31 2014-02-12 オリンパスメディカルシステムズ株式会社 診断支援装置
BRPI1006740A2 (pt) * 2009-04-15 2017-07-11 Koninklijke Philips Electronics Nv Dispositivo para detecção de fluorescência com tempo controlado para aplicações de sequenciamento de dna e estrutura de dados
JP4798254B2 (ja) 2009-05-13 2011-10-19 株式会社デンソー 受光デバイス及びその制御方法
WO2010148252A1 (en) 2009-06-17 2010-12-23 Jody Vykoukal Method and apparatus for quantitative microimaging
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
DE102009037596B4 (de) 2009-08-14 2014-07-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pixelstruktur, System und Verfahren zur optischen Abstandsmessung sowie Steuerschaltung für die Pixelstruktur
US9698196B2 (en) * 2009-08-14 2017-07-04 Heptagon Micro Optics Pte. Ltd. Demodulation pixel incorporating majority carrier current, buried channel and high-low junction
WO2011040971A2 (en) 2009-09-30 2011-04-07 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
JP5648922B2 (ja) 2009-10-05 2015-01-07 国立大学法人静岡大学 半導体素子及び固体撮像装置
US8278728B2 (en) 2009-10-17 2012-10-02 Florida Institute Of Technology Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels
US9579402B2 (en) 2009-12-04 2017-02-28 Biotium, Inc. Heterocycle-substituted xanthene dyes
JP6017107B2 (ja) 2009-12-28 2016-10-26 ソニー株式会社 イメージセンサ及びその製造方法、並びにセンサデバイス
WO2011090745A1 (en) 2009-12-29 2011-07-28 Life Technologies Corporation Single molecule detection and sequencing using fluorescence lifetime imaging
EP2362207A1 (de) 2010-01-28 2011-08-31 F. Hoffmann-La Roche AG Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung
US20130072768A1 (en) 2010-02-19 2013-03-21 Barry Colin Crane Intravascular glucose sensor
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
CN102985803A (zh) 2010-02-19 2013-03-20 加利福尼亚太平洋生物科学股份有限公司 集成的分析系统和方法
US20130005047A1 (en) 2010-03-25 2013-01-03 Mocon, Inc. Luminescence lifetime based analyte sensing instruments and calibration technique
WO2011150431A1 (en) 2010-05-28 2011-12-01 The Regents Of The University Of Colorado, A Body Corporate Multi-photon tissue imaging
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
JP2012132741A (ja) 2010-12-21 2012-07-12 Fujifilm Corp 時間分解蛍光測定装置、及び方法
JP2012134827A (ja) 2010-12-22 2012-07-12 Toshiba Corp 放射線画像検出器
US8946845B1 (en) 2011-02-02 2015-02-03 Aptina Imaging Corporation Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors
CN103404124A (zh) 2011-03-01 2013-11-20 松下电器产业株式会社 固体摄像装置
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
WO2013040058A1 (en) 2011-09-12 2013-03-21 Jian Guo Imaging fluorescence or luminescence lifetime
US20130090537A1 (en) 2011-10-07 2013-04-11 2M Engineering Limited Blood glucose sensor
CA2856163C (en) 2011-10-28 2019-05-07 Illumina, Inc. Microarray fabrication system and method
WO2013066959A1 (en) 2011-10-31 2013-05-10 The Trustees Of Columbia University In The City Of New York Systems and methods for imaging using single photon avalanche diodes
US8804021B2 (en) 2011-11-03 2014-08-12 Omnivision Technologies, Inc. Method, apparatus and system for providing improved full well capacity in an image sensor pixel
US9606060B2 (en) * 2012-01-13 2017-03-28 California Institute Of Technology Filterless time-domain detection of one or more fluorophores
US8906660B2 (en) 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
EP3222627B1 (en) 2012-02-15 2019-08-07 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
DE102012206089B4 (de) 2012-03-15 2017-02-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren
US20130256822A1 (en) 2012-03-28 2013-10-03 Omnivision Technologies, Inc. Method and device with enhanced ion doping
CN102914525B (zh) 2012-04-10 2016-06-01 广东工业大学 基于光学加法外差调制的新型荧光寿命显微成像装置及方法
WO2013171197A1 (en) 2012-05-15 2013-11-21 Ait Austrian Institute Of Technology Gmbh Compact plasmon-enhanced fluorescence biosensor
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
EP3699577B1 (en) * 2012-08-20 2023-11-08 Illumina, Inc. System for fluorescence lifetime based sequencing
WO2014068951A1 (ja) 2012-10-30 2014-05-08 パナソニック株式会社 試料保持担体およびそれを用いた蛍光検出装置
NL2011568A (en) 2012-10-31 2014-05-06 Asml Netherlands Bv Sensor and lithographic apparatus.
US9223084B2 (en) 2012-12-18 2015-12-29 Pacific Biosciences Of California, Inc. Illumination of optical analytical devices
GB201302664D0 (en) 2013-02-15 2013-04-03 Cmosis Nv A pixel structure
WO2014134501A2 (en) 2013-02-28 2014-09-04 Olive Medical Corporation Videostroboscopy of vocal chords with cmos sensors
US9741754B2 (en) 2013-03-06 2017-08-22 Apple Inc. Charge transfer circuit with storage nodes in image sensors
KR102007277B1 (ko) 2013-03-11 2019-08-05 삼성전자주식회사 3차원 이미지 센서의 거리 픽셀 및 이를 포함하는 3차원 이미지 센서
WO2015006345A2 (en) 2013-07-09 2015-01-15 Nd Industries, Inc. Multi-row magnetic dial for the conveyance of workpieces and related method
US20150042954A1 (en) 2013-08-08 2015-02-12 University Of Rochester System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics
CN105917003A (zh) 2013-11-17 2016-08-31 宽腾矽公司 用于生物和化学试样的快速分析的有源像素集成装置
EP3078191B1 (en) 2013-12-04 2020-04-29 Rambus Inc. High dynamic-range image sensor
CN103728446B (zh) * 2013-12-11 2016-02-24 天津大学 光子计数型多通道时间分辨荧光免疫分析系统及计数方法
US9736388B2 (en) 2013-12-13 2017-08-15 Bio-Rad Laboratories, Inc. Non-destructive read operations with dynamically growing images
JP6612240B2 (ja) 2014-01-31 2019-11-27 ザ ジェネラル ホスピタル コーポレイション 光ルミネセンス検出のための装置及び方法
US9765395B2 (en) 2014-04-28 2017-09-19 Nanomedical Diagnostics, Inc. System and method for DNA sequencing and blood chemistry analysis
KR20150134543A (ko) 2014-05-22 2015-12-02 삼성전자주식회사 소자 제조용 기판 및 반도체 소자
EP3957232B1 (en) 2014-07-24 2025-12-31 University Health Network DATA COLLECTION AND ANALYSIS FOR DIAGNOSTIC PURPOSES
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
MX384725B (es) 2014-08-08 2025-03-14 Quantum Si Inc Dispositivo integrado con fuente de luz externa para el sondeo, detección y análisis de moléculas.
CN106796175B (zh) 2014-08-08 2021-01-05 宽腾矽公司 用于探测、检测和分析分子的光学系统和检测芯片
KR102585730B1 (ko) 2014-08-08 2023-10-10 퀀텀-에스아이 인코포레이티드 수신된 광자들의 시간 비닝을 위한 집적 디바이스
JP2018505565A (ja) 2014-12-19 2018-02-22 ジーレイ スイッツァーランド エスアー モノリシックｃｍｏｓ集積ピクセル検出器ならびに様々な用途を含む粒子検出および撮像のためのシステムおよび方法
US9871065B2 (en) 2014-12-22 2018-01-16 Google Inc. RGBZ pixel unit cell with first and second Z transfer gates
US9666748B2 (en) 2015-01-14 2017-05-30 International Business Machines Corporation Integrated on chip detector and zero waveguide module structure for use in DNA sequencing
JP6302146B1 (ja) 2015-02-09 2018-03-28 エスプロス フォトニックス アーゲー Ｔｏｆ距離センサ
EP3271762B1 (en) 2015-03-16 2023-01-04 Pacific Biosciences of California, Inc. Analytical system comprising integrated devices and systems for free-space optical coupling
TWI569008B (zh) 2015-04-27 2017-02-01 財團法人工業技術研究院 尿素濃度檢測元件以及尿素濃度檢測方法
CA2986237A1 (en) 2015-05-20 2016-11-24 Quantum-Si Incorporated Method of determining the sequence of a nucleic acid using time resolved luminescence
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10976257B2 (en) 2015-06-08 2021-04-13 The Regents Of The University Of Michigan Pixel circuit and method for optical sensing
CN105300949B (zh) 2015-11-26 2019-06-11 浙江大学 一种荧光寿命测量方法及装置
JP2019512090A (ja) 2016-02-17 2019-05-09 テッセラクト ヘルス インコーポレイテッドＴｅｓｓｅｒａｃｔ Ｈｅａｌｔｈ，Ｉｎｃ． 寿命イメージングおよび検出用途のためのセンサおよびデバイス
MX2018014856A (es) 2016-06-01 2019-03-07 Quantum Si Inc Llamador de pulso y llamador de base.
US10249656B2 (en) 2016-06-07 2019-04-02 Semiconductor Components Industries, Llc Charge packet signal processing using pinned photodiode devices
EP4250361A3 (en) 2016-12-13 2024-04-17 STMicroelectronics (Research & Development) Limited A charge storage cell and method of manufacturing a charge storage cell
KR102560427B1 (ko) 2016-12-22 2023-07-28 퀀텀-에스아이 인코포레이티드 직접 비닝 픽셀을 갖는 집적 광검출기
WO2019246328A1 (en) 2018-06-22 2019-12-26 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
CA3109816A1 (en) 2018-08-29 2020-03-05 Quantum-Si Incorporated System and methods for detecting lifetime using photon counting photodetectors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040169842A1 (en) * 2002-03-27 2004-09-02 Sarnoff Corporation Method and apparatus for generating charge from a light pulse
EP2182523A1 (en) * 2008-10-31 2010-05-05 CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement Charge sampling device and method based on a MOS-transmission line

Also Published As

Publication number Publication date
KR102585730B1 (ko) 2023-10-10
JP2017531356A (ja) 2017-10-19
KR20220047677A (ko) 2022-04-18
WO2016022998A2 (en) 2016-02-11
CA2957540A1 (en) 2016-02-11
US9945779B2 (en) 2018-04-17
EP3471402B1 (en) 2023-05-31
JP6707520B2 (ja) 2020-06-10
BR112017002485A2 (pt) 2017-12-05
EP3194935A2 (en) 2017-07-26
KR20220139454A (ko) 2022-10-14
US9606058B2 (en) 2017-03-28
JP6935541B2 (ja) 2021-09-15
US9696258B2 (en) 2017-07-04
US11209363B2 (en) 2021-12-28
JP2020162127A (ja) 2020-10-01
EP3471402A1 (en) 2019-04-17
MX2021007934A (es) 2023-01-17
US20180259456A1 (en) 2018-09-13
US20160380025A1 (en) 2016-12-29
US20160133668A1 (en) 2016-05-12
EP3194935B1 (en) 2018-10-31
US20160377543A1 (en) 2016-12-29
BR112017002485B1 (pt) 2020-12-01
US12203854B2 (en) 2025-01-21
KR102384909B1 (ko) 2022-04-11
AU2021202729A1 (en) 2021-05-27
MX2017001806A (es) 2018-01-30
CN107112333B (zh) 2020-07-10
KR102452571B1 (ko) 2022-10-07
KR20170042663A (ko) 2017-04-19
AU2021202729B2 (en) 2023-06-29
CN111710687A (zh) 2020-09-25
WO2016022998A3 (en) 2016-04-14
CN111710687B (zh) 2023-11-14
US9759658B2 (en) 2017-09-12
US20210025823A1 (en) 2021-01-28
AU2015300766A1 (en) 2017-03-16
CN107112333A (zh) 2017-08-29
US10775305B2 (en) 2020-09-15
US20170322153A1 (en) 2017-11-09
US20230408411A1 (en) 2023-12-21
MX384613B (es) 2025-03-14
US20220155229A1 (en) 2022-05-19
US11719636B2 (en) 2023-08-08

Similar Documents

Publication Publication Date Title
AU2021202729B2 (en) Integrated device for temporal binning of received photons
US12111261B2 (en) Integrated photodetector with direct binning pixel
HK40007164B (en) Integrated device for temporal binning of received photons
HK40007164A (en) Integrated device for temporal binning of received photons
HK1241966B (en) Integrated device for temporal binning of received photons
HK1241966A1 (en) Integrated device for temporal binning of received photons

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired