AU2015275870B2 - Reducing intron retention - Google Patents

Reducing intron retention Download PDF

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AU2015275870B2
AU2015275870B2 AU2015275870A AU2015275870A AU2015275870B2 AU 2015275870 B2 AU2015275870 B2 AU 2015275870B2 AU 2015275870 A AU2015275870 A AU 2015275870A AU 2015275870 A AU2015275870 A AU 2015275870A AU 2015275870 B2 AU2015275870 B2 AU 2015275870B2
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seq
acid polymer
polynucleic acid
sequence
protein
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AU2015275870A1 (en
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Jana KRALOVICOVA
Igor Vorechovsky
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University of Southampton
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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AU2015275870A 2014-06-16 2015-06-16 Reducing intron retention Active AU2015275870B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021290279A AU2021290279A1 (en) 2014-06-16 2021-12-22 Reducing intron retention

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1410693.4 2014-06-16
GBGB1410693.4A GB201410693D0 (en) 2014-06-16 2014-06-16 Splicing modulation
PCT/GB2015/051756 WO2015193651A1 (en) 2014-06-16 2015-06-16 Reducing intron retention

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AU2021290279A Division AU2021290279A1 (en) 2014-06-16 2021-12-22 Reducing intron retention

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AU2015275870A1 AU2015275870A1 (en) 2017-02-02
AU2015275870B2 true AU2015275870B2 (en) 2021-10-14

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AU2021290279A Pending AU2021290279A1 (en) 2014-06-16 2021-12-22 Reducing intron retention

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US (6) US9745577B2 (enExample)
EP (2) EP3155124B1 (enExample)
JP (3) JP7043169B2 (enExample)
KR (1) KR102638276B1 (enExample)
CN (1) CN107073137A (enExample)
AU (2) AU2015275870B2 (enExample)
CA (1) CA2951208A1 (enExample)
ES (1) ES2907033T3 (enExample)
GB (1) GB201410693D0 (enExample)
IL (2) IL295051B2 (enExample)
SG (2) SG10202112949PA (enExample)
WO (1) WO2015193651A1 (enExample)

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