US4476116A
(en)
|
1982-12-10 |
1984-10-09 |
Syntex (U.S.A.) Inc. |
Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
ATE171185T1
(en)
|
1985-03-15 |
1998-10-15 |
Antivirals Inc |
POLYNUCLEOTIDE IMMUNOTESTING AGENTS AND METHODS
|
US4866042A
(en)
|
1987-11-18 |
1989-09-12 |
Neuwelt Edward A |
Method for the delivery of genetic material across the blood brain barrier
|
US6294520B1
(en)
|
1989-03-27 |
2001-09-25 |
Albert T. Naito |
Material for passage through the blood-brain barrier
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
JPH0813274B2
(en)
|
1990-08-13 |
1996-02-14 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
Sugar modified oligonucleotides for detecting and modulating gene expression
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
DE69333842T2
(en)
|
1992-07-23 |
2006-04-27 |
Isis Pharmaceuticals, Inc., Carlsbad |
Novel 2'-O-alkyl nucleosides and phosphoramidites, processes for their preparation and their uses
|
WO1994008026A1
(en)
|
1992-09-25 |
1994-04-14 |
Rhone-Poulenc Rorer S.A. |
Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain
|
PT698092E
(en)
*
|
1993-05-11 |
2007-10-29 |
Univ North Carolina |
Antisense oligonucleotides which combat aberrant splicing and methods of using the same
|
EP0736094A1
(en)
|
1993-12-24 |
1996-10-09 |
Medical Research Council |
Polycystic kidney disease 1 gene and uses thereof
|
US5656612A
(en)
|
1994-05-31 |
1997-08-12 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
FR2727867B1
(en)
|
1994-12-13 |
1997-01-31 |
Rhone Poulenc Rorer Sa |
GENE TRANSFER IN MEDULLAR MOTONURONES USING ADENOVIRAL VECTORS
|
US6166197A
(en)
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
DK0882061T3
(en)
|
1996-02-14 |
2004-09-27 |
Isis Pharmaceuticals Inc |
Sugar modified gapped oligonucleotides
|
GB9605808D0
(en)
|
1996-03-20 |
1996-05-22 |
Isis Innovation |
CFTR gene regulator
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
USRE44779E1
(en)
|
1997-03-07 |
2014-02-25 |
Santaris Pharma A/S |
Bicyclonucleoside and oligonucleotide analogues
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
JP3756313B2
(en)
|
1997-03-07 |
2006-03-15 |
武 今西 |
Novel bicyclonucleosides and oligonucleotide analogues
|
DE69832798T2
(en)
|
1997-06-03 |
2006-09-14 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
REGULATORY SEQUENCES FOR THE IN VIVO EXPRESSION OF A HETEROLOGICAL DNA SEQUENCE IN ENDOTHELIAL CELLS AND THEIR USES.
|
US6963589B1
(en)
|
1997-07-03 |
2005-11-08 |
Canon Kabushiki Kaisha |
Information processing apparatus for and method of transmitting and/or receiving broadcast signal
|
US6391452B1
(en)
|
1997-07-18 |
2002-05-21 |
Bayer Corporation |
Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
|
GB9716231D0
(en)
|
1997-07-31 |
1997-10-08 |
Amersham Int Ltd |
Base analogues
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
ES2242291T5
(en)
|
1997-09-12 |
2016-03-11 |
Exiqon A/S |
Bicyclic and tricyclic nucleoside analogs, nucleotides and oligonucleotides
|
US7045610B2
(en)
|
1998-04-03 |
2006-05-16 |
Epoch Biosciences, Inc. |
Modified oligonucleotides for mismatch discrimination
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
US7071324B2
(en)
|
1998-10-13 |
2006-07-04 |
Brown University Research Foundation |
Systems and methods for sequencing by hybridization
|
US20030224514A1
(en)
|
2002-05-31 |
2003-12-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of PPAR-delta expression
|
US6436657B1
(en)
|
1998-12-18 |
2002-08-20 |
E. I. Du Pont De Nemours And Company |
Polynucleotides encoding aminomethyltransferases
|
CZ296576B6
(en)
|
1999-02-12 |
2006-04-12 |
Sankyo Company Limited |
Nucleoside analogue, oligonucleotide analogue, pharmaceutical composition, probe and a primer containing thereof
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
DE60044241D1
(en)
|
1999-03-18 |
2010-06-02 |
Exiqon As |
XYLO-LNA ANALOG
|
DK1163250T3
(en)
|
1999-03-24 |
2006-11-13 |
Exiqon As |
Improved synthesis of [2.2.1] bicyclonucleosides
|
US6734291B2
(en)
|
1999-03-24 |
2004-05-11 |
Exiqon A/S |
Synthesis of [2.2.1]bicyclo nucleosides
|
US6383752B1
(en)
|
1999-03-31 |
2002-05-07 |
Hybridon, Inc. |
Pseudo-cyclic oligonucleobases
|
ATE356824T1
(en)
|
1999-05-04 |
2007-04-15 |
Santaris Pharma As |
L-RIBO-LNA ANALOGUE
|
US6083482A
(en)
|
1999-05-11 |
2000-07-04 |
Icn Pharmaceuticals, Inc. |
Conformationally locked nucleosides and oligonucleotides
|
US6531591B1
(en)
|
1999-07-07 |
2003-03-11 |
Exiqon A/S |
Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
|
JP4151751B2
(en)
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
New bicyclonucleoside analogues
|
US6677445B1
(en)
|
1999-08-27 |
2004-01-13 |
Chiron Corporation |
Chimeric antisense oligonucleotides and cell transfecting formulations thereof
|
US6187586B1
(en)
|
1999-12-29 |
2001-02-13 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of AKT-3 expression
|
US6784291B2
(en)
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
US6809194B1
(en)
|
2000-05-10 |
2004-10-26 |
Chiron Corporation |
Akt3 inhibitors
|
US7553644B2
(en)
|
2000-07-13 |
2009-06-30 |
The Johns Hopkins University School Of Medicine |
Detection and treatment of polycystic kidney disease
|
EP1314734A1
(en)
|
2000-08-29 |
2003-05-28 |
Takeshi Imanishi |
Novel nucleoside analogs and oligonucleotide derivatives containing these analogs
|
ES2300366T3
(en)
|
2000-09-02 |
2008-06-16 |
Grunenthal Gmbh |
OLIGONUCLEOTID ANTISENTIDO AGAINST VR1.
|
US6998484B2
(en)
|
2000-10-04 |
2006-02-14 |
Santaris Pharma A/S |
Synthesis of purine locked nucleic acid analogues
|
JP2002345489A
(en)
|
2000-11-03 |
2002-12-03 |
Astrazeneca Ab |
Chemical substance
|
ATE287413T1
(en)
|
2001-07-12 |
2005-02-15 |
Santaris Pharma As |
METHOD FOR PRODUCING THE LNA PHOSPHORAMIDITE
|
WO2003016492A2
(en)
|
2001-08-16 |
2003-02-27 |
The Regents Of The University Of Michigan |
Adamts13 genes and proteins and variants, and uses thereof
|
CA2459347C
(en)
|
2001-09-04 |
2012-10-09 |
Exiqon A/S |
Locked nucleic acid (lna) compositions and uses thereof
|
US6936589B2
(en)
|
2001-09-28 |
2005-08-30 |
Albert T. Naito |
Parenteral delivery systems
|
WO2003040395A2
(en)
|
2001-11-07 |
2003-05-15 |
Applera Corporation |
Universal nucleotides for nucleic acid analysis
|
EP2354148B1
(en)
|
2002-02-13 |
2013-09-04 |
Takeshi Imanishi |
Nucleoside analogues and oligonucleotide derivative comprising nucleotide analogue thereof
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
AU2003222743B2
(en)
|
2002-05-08 |
2008-12-11 |
Roche Innovation Center Copenhagen A/S |
Synthesis of locked nucleic acid derivatives
|
AU2003247610A1
(en)
|
2002-06-21 |
2004-01-06 |
Ptc Therapeutics, Inc. |
METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
|
US20040023220A1
(en)
|
2002-07-23 |
2004-02-05 |
Lawrence Greenfield |
Integrated method for PCR cleanup and oligonucleotide removal
|
CA2493297A1
(en)
|
2002-08-12 |
2004-02-19 |
Universite De Sherbrooke |
Methods to reprogram splice site selection in pre-messenger rnas
|
WO2004014222A2
(en)
|
2002-08-12 |
2004-02-19 |
The Regents Of The University Of Michigan |
Diagnosis and treatment of tuberous sclerosis
|
WO2004044132A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
ES2607471T3
(en)
|
2002-11-18 |
2017-03-31 |
Roche Innovation Center Copenhagen A/S |
Antisense design
|
US7217807B2
(en)
*
|
2002-11-26 |
2007-05-15 |
Rosetta Genomics Ltd |
Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
|
EP3450559A1
(en)
|
2003-03-07 |
2019-03-06 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
WO2004083432A1
(en)
|
2003-03-21 |
2004-09-30 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
CA2519860C
(en)
|
2003-03-21 |
2018-01-16 |
Santaris Pharma A/S |
Short interfering rna (sirna) analogues
|
EP1620450A4
(en)
|
2003-04-13 |
2011-01-19 |
Enzon Pharmaceuticals Inc |
Polymeric oligonucleotide prodrugs
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
US20070009899A1
(en)
|
2003-10-02 |
2007-01-11 |
Mounts William M |
Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases
|
GB0326578D0
(en)
|
2003-11-14 |
2003-12-17 |
Univ Belfast |
Cancer diagnosis and therapy
|
US20050221354A1
(en)
|
2004-02-18 |
2005-10-06 |
Wyeth |
Nucleic acid arrays for monitoring expression profiles of drug target genes
|
EP1784501B1
(en)
|
2004-05-14 |
2015-11-18 |
Rosetta Genomics Ltd |
VIRAL AND VIRUS ASSOCIATED MicroRNAS AND USES THEREOF
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US20070087376A1
(en)
|
2004-08-30 |
2007-04-19 |
Potashkin Judith A |
Splice variants of pre-mRNA transcripts as biomarkers in idiopathic neurodegenerative diseases
|
CA2588646A1
(en)
|
2004-11-19 |
2006-05-26 |
Acadia Pharmaceuticals Inc. |
Methods to identify ligands of hormone nuclear receptors
|
US8211864B2
(en)
|
2005-01-26 |
2012-07-03 |
Medical College Of Georgia Research Institute |
Compositions and methods for the intracellular disruption of VEGF and VEGFR-2 by intraceptors
|
US20100150839A1
(en)
|
2005-02-04 |
2010-06-17 |
Massachusetts Institute Of Technology |
Compositions and Methods for Modulating Cognitive Function
|
ES2732071T3
(en)
|
2005-04-01 |
2019-11-20 |
Univ Florida |
Biomarkers of liver lesions
|
WO2006119494A2
(en)
*
|
2005-05-04 |
2006-11-09 |
Exagen Diagnostics, Inc. |
Acute myelogenous leukemia biomarkers
|
ES2382104T3
(en)
|
2005-06-17 |
2012-06-05 |
Baxter International Inc. |
Compositions with thrombolytic activity comprising ADAMTS13
|
HUE027486T2
(en)
|
2005-06-23 |
2016-09-28 |
Isis Pharmaceuticals Inc |
Compositions and methods for modulation of SMN2 splicing
|
LT2578685T
(en)
|
2005-08-23 |
2019-06-10 |
The Trustees Of The University Of Pennsylvania |
Rna containing modified nucleosides and methods of use thereof
|
EP1937312B1
(en)
|
2005-08-30 |
2016-06-29 |
Ionis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
WO2007047913A2
(en)
|
2005-10-20 |
2007-04-26 |
Isis Pharmaceuticals, Inc |
Compositions and methods for modulation of lmna expression
|
US20080280848A1
(en)
|
2005-10-28 |
2008-11-13 |
Volker Patzel |
Structures of Active Guide Rna Molecules and Method of Selection
|
WO2007048629A2
(en)
|
2005-10-28 |
2007-05-03 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Modulation of rna silencing efficiency by argonaute proteins
|
EP1954254A4
(en)
|
2005-11-01 |
2010-12-22 |
Harvard College |
Modulating endoplasmic reticulum stress in the treatment of tuberous sclerosis
|
US7785834B2
(en)
|
2005-11-10 |
2010-08-31 |
Ercole Biotech, Inc. |
Soluble TNF receptors and their use in treatment of disease
|
EP1792981A1
(en)
|
2005-12-02 |
2007-06-06 |
Humboldt-Universität zu Berlin |
Microginin producing proteins and nucleic acids encoding a microginin gene cluster as well as methods for creating microginins
|
PL3210633T3
(en)
|
2006-01-26 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Compositions and their uses directed to huntingtin
|
EP1984499B1
(en)
|
2006-01-27 |
2015-05-27 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
PL2314594T3
(en)
|
2006-01-27 |
2014-12-31 |
Isis Pharmaceuticals Inc |
6-modified bicyclic nucleic acid analogs
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
US8007790B2
(en)
|
2006-04-03 |
2011-08-30 |
Stowers Institute For Medical Research |
Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
|
JP2009536222A
(en)
|
2006-05-05 |
2009-10-08 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
Compounds and methods for modulating the expression of PCSK9
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
CA2651453C
(en)
|
2006-05-11 |
2014-10-14 |
Isis Pharmaceuticals, Inc. |
5'-modified bicyclic nucleic acid analogs
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
CN101460624B
(en)
|
2006-06-08 |
2013-06-05 |
阿明诺化学株式会社 |
Sense oligonucleotide capable of controlling the expression of iNOS and composition comprising the same
|
WO2008001778A1
(en)
|
2006-06-27 |
2008-01-03 |
Takeda Pharmaceutical Company Limited |
Genetically modified animal and use thereof
|
CA2658421C
(en)
|
2006-07-24 |
2018-03-20 |
Athena Diagnostics, Inc. |
Pkd mutations and evaluation of same
|
DK2092065T4
(en)
|
2006-10-18 |
2019-10-21 |
Ionis Pharmaceuticals Inc |
The antisense compounds
|
US20090264353A1
(en)
|
2007-10-19 |
2009-10-22 |
Santaris Pharma A/S |
Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease
|
DK2099461T3
(en)
|
2006-11-13 |
2012-07-02 |
Santaris Pharma As |
LNA Nucleoside Phosphoramidates
|
US8293684B2
(en)
|
2006-11-29 |
2012-10-23 |
Exiqon |
Locked nucleic acid reagents for labelling nucleic acids
|
EP2118118B1
(en)
|
2007-01-19 |
2017-09-27 |
Exiqon A/S |
Mediated cellular delivery of lna oligonucleotides
|
EP2114981B1
(en)
|
2007-01-29 |
2013-05-08 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
KR101551985B1
(en)
|
2007-03-09 |
2015-09-09 |
리가가쿠 겐큐쇼 |
Compound having structure derived from mononucleoside or mononucleotide nucleic acid labeling substance and method and kit for detection of nucleic acid
|
AR065648A1
(en)
|
2007-03-09 |
2009-06-24 |
Pioneer Hi Bred Int |
IDENTIFICATION OF AMMONIUM CONVEYORS (AMTS) FOR THE REGULATION OF NITROGEN METABOLISM IN PLANTS
|
WO2008111908A1
(en)
|
2007-03-15 |
2008-09-18 |
Jyoti Chattopadhyaya |
Five- and six-membered conformationally locked 2',4'- carbocyclic ribo-thymidines for the treatment of infections and cancer
|
EP2149605B1
(en)
|
2007-03-22 |
2013-07-03 |
Santaris Pharma A/S |
Short RNA antagonist compounds for the modulation of target mRNA
|
CA2688321A1
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
EP2173760B2
(en)
|
2007-06-08 |
2015-11-04 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
ES2376507T5
(en)
|
2007-07-05 |
2015-08-31 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
WO2009023855A2
(en)
|
2007-08-15 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
CN101896186A
(en)
|
2007-10-26 |
2010-11-24 |
莱顿教学医院 |
The mode and the method for antagonism disorder of muscle
|
WO2009064920A2
(en)
|
2007-11-13 |
2009-05-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
CA3043911A1
(en)
|
2007-12-04 |
2009-07-02 |
Arbutus Biopharma Corporation |
Targeting lipids
|
US8846386B2
(en)
|
2007-12-18 |
2014-09-30 |
University Of Kentucky Research Foundation |
sVEGFR-2 and its role in lymphangiogenesis modulation
|
WO2009084472A1
(en)
|
2007-12-28 |
2009-07-09 |
Public University Corporation Yokohama City University |
Method for detecting intractable epilepsy developed in neonatal period and infancy
|
US20110065774A1
(en)
|
2008-01-31 |
2011-03-17 |
Alnylam Pharmaceuticals |
Chemically modified oligonucleotides and uses thereof
|
WO2009100320A2
(en)
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
CA2717045C
(en)
|
2008-03-13 |
2018-04-10 |
Celera Corporation |
Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
|
WO2009124238A1
(en)
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
WO2009124295A2
(en)
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
EP2119783A1
(en)
*
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
EP2304031A2
(en)
|
2008-06-11 |
2011-04-06 |
Bionucleon S.r.l. |
Inhibition of hrp-3 using modified oligonucleotides
|
EP2151248A1
(en)
|
2008-07-30 |
2010-02-10 |
Johann Bauer |
Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
DK2356129T3
(en)
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituted alpha-L bicyclic nucleosides
|
US20110229891A1
(en)
|
2008-11-07 |
2011-09-22 |
Centre Hospitalier Universitaire Saint-Justine |
Syngap1 dysfunctions and uses thereof in diagnostic and therapeutic applications for mental retardation
|
EP2370581B1
(en)
|
2008-12-04 |
2016-08-03 |
CuRNA, Inc. |
Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
|
US9006194B2
(en)
|
2008-12-19 |
2015-04-14 |
Drexel University |
Compositions and methods for diminishing viral infection and inflammation associated with viral infection
|
US20100166784A1
(en)
*
|
2008-12-30 |
2010-07-01 |
The Washington University |
Method and compositions for modulating th17 cell development
|
US8680254B2
(en)
|
2009-01-14 |
2014-03-25 |
Philadelphia Health & Education Corporation |
Modulation of pre-mRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
|
KR101742334B1
(en)
|
2009-05-08 |
2017-06-01 |
큐알엔에이, 인크. |
Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
|
DK3449926T3
(en)
|
2009-06-17 |
2019-11-11 |
Biogen Ma Inc |
COMPOSITIONS AND PROCEDURES FOR MODULATING SMN2 SPLITING BY AN INDIVIDUAL
|
EP2275545A1
(en)
|
2009-07-16 |
2011-01-19 |
Julius-Maximilians-Universität Würzburg |
Use of microRNA-24 and/or its targets for the treatment and prevention of ischemia and induction of angiogenesis
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
WO2011020118A1
(en)
|
2009-08-14 |
2011-02-17 |
Theramind Research, Llc |
Methods and compositions for treatment of tuberous sclerosis complex
|
JP2013503646A
(en)
|
2009-09-08 |
2013-02-04 |
ラボラトリー コーポレイション オブ アメリカ ホールディングス |
Compositions and methods for diagnosing autism spectrum disorders
|
WO2011032034A2
(en)
|
2009-09-10 |
2011-03-17 |
University Of Idaho |
Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
|
CN102596983B
(en)
|
2009-10-29 |
2016-06-15 |
国立大学法人大阪大学 |
The artificial nucleosides of cross-linking type and nucleotides
|
ES2693459T3
(en)
*
|
2009-11-12 |
2018-12-11 |
The University Of Western Australia |
Antisense molecules and methods for the treatment of pathologies
|
US9334495B2
(en)
|
2009-11-25 |
2016-05-10 |
Elitechgroup B.V. |
Minor groove binder (MGB)-oligonucleotide miRNA antagonists
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011097643A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2550361B1
(en)
|
2010-03-25 |
2017-02-08 |
The J. David Gladstone Institutes |
Compositions and methods for treating neurological disorders
|
WO2011127210A1
(en)
|
2010-04-06 |
2011-10-13 |
Massachusetts Institute Of Technology |
Targeted delivery of nucleic acids
|
US20110269735A1
(en)
|
2010-04-19 |
2011-11-03 |
Celera Corporation |
Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
|
BR112012026471A2
(en)
|
2010-04-19 |
2016-11-29 |
Nlife Therapeutics S L |
conjugate, process for the synthesis thereof, method for imaging a cell expressing a neurotransmitter carrier comprising contacting said cell with the conjugate, process for preparing a gate of formula (ii) and (xiv) and compound
|
WO2011139695A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
US8802642B2
(en)
|
2010-04-28 |
2014-08-12 |
Iowa State University Research Foundation, Inc. |
Spinal muscular atrophy treatment via targeting SMN2 catalytic core
|
US20130184223A1
(en)
|
2010-05-20 |
2013-07-18 |
University Of Rochester |
Methods and compositions related to modulating autophagy
|
WO2011156278A1
(en)
|
2010-06-07 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2582397A4
(en)
|
2010-06-15 |
2014-10-29 |
Isis Pharmaceuticals Inc |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
WO2011163499A2
(en)
|
2010-06-23 |
2011-12-29 |
Opko Curna, Llc |
Treatment of sodium channel, voltage-gated, alpha subunit (scna) related diseases by inhibition of natural antisense transcript to scna
|
EP2630241B1
(en)
|
2010-10-22 |
2018-10-17 |
CuRNA, Inc. |
Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
|
US8853377B2
(en)
|
2010-11-30 |
2014-10-07 |
Shire Human Genetic Therapies, Inc. |
mRNA for use in treatment of human genetic diseases
|
US20130309246A1
(en)
|
2011-02-02 |
2013-11-21 |
The Trustees Of Princeton University |
Jagged1 as a marker and therapeutic target for breast cancer bone metastasis
|
WO2012138487A2
(en)
|
2011-04-07 |
2012-10-11 |
The Board Of Regents Of The University Of Texas System |
Oligonucleotide modulation of splicing
|
US9644035B2
(en)
|
2011-04-08 |
2017-05-09 |
Omeros Corporation |
Methods for treating conditions associated with MASP-2 dependent complement activation
|
CN106912197B
(en)
|
2011-04-28 |
2022-01-25 |
生命技术公司 |
Methods and compositions for multiplex PCR
|
US20140357558A1
(en)
|
2011-06-24 |
2014-12-04 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of spinal muscular atrophy
|
SG10201700554VA
(en)
|
2011-07-19 |
2017-03-30 |
Wave Life Sciences Pte Ltd |
Methods for the synthesis of functionalized nucleic acids
|
US8592156B2
(en)
|
2011-08-08 |
2013-11-26 |
Roche Molecular Systems, Inc. |
Predicting response to anti-CD20 therapy in DLBCL patients
|
US10023861B2
(en)
|
2011-08-29 |
2018-07-17 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
WO2013036403A1
(en)
|
2011-09-06 |
2013-03-14 |
Curna, Inc. |
TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES
|
WO2013043878A2
(en)
|
2011-09-20 |
2013-03-28 |
The George Washington University |
Alternative splicing variants of genes associated with prostate cancer risk and survival
|
BR112014011018A2
(en)
|
2011-11-11 |
2017-05-02 |
Santaris Pharma As |
compounds for smn2 splining modulation
|
US9534222B2
(en)
|
2011-11-15 |
2017-01-03 |
University Of Utah Research Foundation |
Morpholinos, morpholino upregulating, and associated methods
|
EP2785860B1
(en)
|
2011-11-29 |
2015-06-03 |
Life Technologies Corporation |
Methods and compositions for multiplex pcr
|
ES2842938T3
(en)
|
2012-01-11 |
2021-07-15 |
Ionis Pharmaceuticals Inc |
Compositions and Methods for IKBKAP Splice Modulation
|
WO2013120003A1
(en)
|
2012-02-08 |
2013-08-15 |
Isis Pharmaceuticals, Inc. |
Modulation of rna by repeat targeting
|
PE20142364A1
(en)
|
2012-02-10 |
2015-01-10 |
Hoffmann La Roche |
COMPOUNDS TO TREAT SPINAL MUSCULAR ATROPHY
|
US8846885B2
(en)
|
2012-02-17 |
2014-09-30 |
Ajinomoto Co., Inc. |
Oligonucleotide with protected base
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
EP2839006B1
(en)
|
2012-04-20 |
2018-01-03 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
US20140378526A1
(en)
|
2012-05-11 |
2014-12-25 |
City Of Hope |
Design of nucleic acid binding molecules with non-watson crick and non-canonical pairing based on artificial mutation consensus sequences to counter escape mutations
|
WO2013177195A1
(en)
|
2012-05-22 |
2013-11-28 |
Idenix Pharmaceuticals, Inc. |
3',5'-cyclic phosphate prodrugs for hcv infection
|
US9109001B2
(en)
|
2012-05-22 |
2015-08-18 |
Idenix Pharmaceuticals, Inc. |
3′,5′-cyclic phosphoramidate prodrugs for HCV infection
|
EP3536787A1
(en)
|
2012-06-08 |
2019-09-11 |
Translate Bio, Inc. |
Nuclease resistant polynucleotides and uses thereof
|
WO2014012081A2
(en)
|
2012-07-13 |
2014-01-16 |
Ontorii, Inc. |
Chiral control
|
US8729263B2
(en)
|
2012-08-13 |
2014-05-20 |
Novartis Ag |
1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
|
IN2015DN01765A
(en)
|
2012-08-20 |
2015-05-29 |
Univ California |
|
EP2898072A1
(en)
|
2012-09-24 |
2015-07-29 |
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. |
Restoration of the cftr function by splicing modulation
|
WO2014049536A2
(en)
|
2012-09-25 |
2014-04-03 |
Universidade De Lisboa |
Drug targets for cystic fibrosis and other conditions
|
EP2900682A1
(en)
|
2012-09-27 |
2015-08-05 |
IDENIX Pharmaceuticals, Inc. |
Esters and malonates of sate prodrugs
|
UA116639C2
(en)
|
2012-10-09 |
2018-04-25 |
Рег'Юлес Терап'Ютікс Інк. |
Methods for treatment of alport syndrome
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2014066915A2
(en)
|
2012-10-26 |
2014-05-01 |
Smith Larry J |
Methods and compositions to produce ss-rnai activity with enhanced potency
|
WO2014078749A1
(en)
|
2012-11-15 |
2014-05-22 |
The Regents Of The University Of California |
Splice modulating oligonucleotides that inhibit cancer
|
EP2935304A1
(en)
|
2012-12-19 |
2015-10-28 |
IDENIX Pharmaceuticals, Inc. |
4'-fluoro nucleosides for the treatment of hcv
|
CN104004826B
(en)
|
2013-01-07 |
2016-03-02 |
赵晨 |
The gene PRPF4 of sudden change is preparing the application in retinal hereditary disease diagnostic reagent
|
EP2946019A1
(en)
|
2013-01-18 |
2015-11-25 |
Anna Mary Rose |
Therapeutics and diagnostics based on minisatellite repeat element 1 (msr1)
|
WO2014121287A2
(en)
|
2013-02-04 |
2014-08-07 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
EP2957567B1
(en)
|
2013-02-18 |
2019-06-05 |
Shionogi & Co., Ltd. |
Nucleoside and nucleotide, having nitrogen-containing hetercycle structure
|
WO2014137930A1
(en)
|
2013-03-04 |
2014-09-12 |
Idenix Pharmaceuticals, Inc. |
Thiophosphate nucleosides for the treatment of hcv
|
EP2970358B1
(en)
|
2013-03-04 |
2021-06-30 |
Idenix Pharmaceuticals LLC |
3'-deoxy nucleosides for the treatment of hcv
|
WO2014165542A1
(en)
|
2013-04-01 |
2014-10-09 |
Idenix Pharmaceuticals, Inc. |
2',4'-fluoro nucleosides for the treatment of hcv
|
US10590412B2
(en)
|
2013-04-19 |
2020-03-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
RU2686080C2
(en)
|
2013-05-01 |
2019-04-24 |
Ионис Фармасьютикалз, Инк. |
Compositions and methods
|
WO2014198890A1
(en)
|
2013-06-13 |
2014-12-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of erythropoietic protoporphyria
|
WO2014201413A1
(en)
|
2013-06-14 |
2014-12-18 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating non-coding rna
|
WO2014209841A2
(en)
|
2013-06-25 |
2014-12-31 |
F. Hoffmann-La Roche Ag |
Compounds for treating spinal muscular atrophy
|
WO2015023939A1
(en)
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin
|
WO2015023941A1
(en)
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Oligonucleotides targeting euchromatin regions of genes
|
WO2015023938A1
(en)
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Epigenetic regulators of frataxin
|
MX2016002044A
(en)
|
2013-08-16 |
2016-08-17 |
Rana Therapeutics Inc |
Compositions and methods for modulating rna.
|
CA2915764A1
(en)
|
2013-08-19 |
2015-02-26 |
F. Hoffmann-La Roche Ag |
Screening method
|
ES2779302T3
(en)
|
2013-09-04 |
2020-08-14 |
Cold Spring Harbor Laboratory |
Reduction of mRNA degradation with nonsense mediation
|
JP6618910B2
(en)
|
2013-09-05 |
2019-12-11 |
サレプタ セラピューティクス,インコーポレイテッド |
Inclusion of antisense-induced exon 2 in acid α-glucosidase
|
EP3480312A1
(en)
|
2013-09-11 |
2019-05-08 |
Synthena AG |
Nucleic acids and methods for the treatment of pompe disease
|
WO2015190922A1
(en)
|
2014-06-10 |
2015-12-17 |
Erasmus University Medical Center Rotterdam |
Antisense oligonucleotides useful in treatment of pompe disease
|
GB201410693D0
(en)
*
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
GB201411468D0
(en)
|
2014-06-27 |
2014-08-13 |
Univ Edinburgh |
Novel treatment for endometriosis
|
CA2958524A1
(en)
|
2014-08-20 |
2016-02-25 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof
|
CA2963288A1
(en)
|
2014-10-03 |
2016-04-07 |
Cold Spring Harbor Laboratory |
Targeted augmentation of nuclear gene output
|
US20170224758A1
(en)
|
2014-10-17 |
2017-08-10 |
The Broad Institute, Inc. |
Compositions and methods of treating muscular dystrophy
|
JP2017533721A
(en)
|
2014-11-14 |
2017-11-16 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
Compounds and methods for the regulation of proteins
|
GB201421379D0
(en)
|
2014-12-02 |
2015-01-14 |
Isis Innovation Ltd And Medical Res Council |
Molecule
|
CA2974503A1
(en)
|
2015-01-21 |
2016-07-28 |
Phaserx, Inc. |
Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
|
WO2016128343A1
(en)
|
2015-02-09 |
2016-08-18 |
F. Hoffmann-La Roche Ag |
Compounds for the treatment of cancer
|
US9840709B2
(en)
|
2015-02-20 |
2017-12-12 |
Rosalind Franklin University Of Medicine And Science |
Antisense compounds targeting genes associated with cystic fibrosis
|
WO2016138534A2
(en)
|
2015-02-27 |
2016-09-01 |
Sarepta Therapeutics, Inc. |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
BR112017015864A2
(en)
|
2015-04-03 |
2018-07-31 |
Ionis Pharmaceuticals, Inc. |
compounds and methods for modulating tmprss6 expression
|
EP4249472A3
(en)
|
2015-05-30 |
2023-12-13 |
PTC Therapeutics, Inc. |
Methods for modulating rna splicing
|
EP3352872A4
(en)
|
2015-09-24 |
2019-07-10 |
The Trustees of the University of Pennsylvania |
Triptycene derivatives for nucleic acid junction stabilization
|
GB2546719B
(en)
|
2015-10-09 |
2021-07-14 |
Univ Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
US10196639B2
(en)
|
2015-10-09 |
2019-02-05 |
University Of Southampton |
Modulation of gene expression and screening for deregulated protein expression
|
EP3183347A4
(en)
|
2015-10-17 |
2018-04-18 |
Lifesplice Pharma LLC |
Splice modulating oligonucleotides and methods of use thereof
|
EP3390636B1
(en)
|
2015-12-14 |
2021-05-19 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of dravet syndrome
|
WO2017106211A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of polycystic kidney disease
|
JP7049247B2
(en)
|
2015-12-14 |
2022-04-06 |
コールド スプリング ハーバー ラボラトリー |
Compositions and Methods for the Treatment of Kidney Disease
|
WO2017106375A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of tuberous sclerosis complex
|
ES2903394T3
(en)
|
2015-12-14 |
2022-04-01 |
Cold Spring Harbor Laboratory |
Compositions for the treatment of retinitis pigmentosa 13
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
EP4104867A3
(en)
|
2015-12-14 |
2023-03-01 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of central nervous system diseases
|
WO2017106370A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of eye diseases
|
CA3005090A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of liver diseases
|
JP2018538288A
(en)
|
2015-12-14 |
2018-12-27 |
コールド スプリング ハーバー ラボラトリー |
Antisense oligomers for the treatment of Alagille syndrome
|
SG11201909203WA
(en)
|
2017-04-03 |
2019-11-28 |
Encoded Therapeutics Inc |
Tissue selective transgene expression
|
WO2019040923A1
(en)
|
2017-08-25 |
2019-02-28 |
Stoke Therapeutics, Inc. |
Antisense oligomers for treatment of conditions and diseases
|
GB2610100B
(en)
|
2017-10-23 |
2023-08-16 |
Stoke Therapeutics Inc |
Antisense oligomers for treatment of non-sense mediated RNA decay based conditions and diseases
|