AU2015256232B2 - A non-caloric sweetener - Google Patents

A non-caloric sweetener Download PDF

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Publication number
AU2015256232B2
AU2015256232B2 AU2015256232A AU2015256232A AU2015256232B2 AU 2015256232 B2 AU2015256232 B2 AU 2015256232B2 AU 2015256232 A AU2015256232 A AU 2015256232A AU 2015256232 A AU2015256232 A AU 2015256232A AU 2015256232 B2 AU2015256232 B2 AU 2015256232B2
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AU
Australia
Prior art keywords
rebaudioside
product
ppm
udp
sucrose
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AU2015256232A
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AU2015256232A1 (en
Inventor
Venkata Sai Prakash Chaturvedula
Guohong MAO
Oliver YU
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Conagen Inc
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Conagen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1062—Sucrose synthase (2.4.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01013—Sucrose synthase (2.4.1.13)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
AU2015256232A 2014-05-05 2015-05-05 A non-caloric sweetener Active AU2015256232B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/269,435 US9522929B2 (en) 2014-05-05 2014-05-05 Non-caloric sweetener
US14/269,435 2014-05-05
PCT/US2015/029163 WO2015171555A1 (en) 2014-05-05 2015-05-05 A non-caloric sweetener

Publications (2)

Publication Number Publication Date
AU2015256232A1 AU2015256232A1 (en) 2016-11-24
AU2015256232B2 true AU2015256232B2 (en) 2019-09-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015256232A Active AU2015256232B2 (en) 2014-05-05 2015-05-05 A non-caloric sweetener

Country Status (16)

Country Link
US (9) US9522929B2 (cg-RX-API-DMAC7.html)
EP (3) EP4023660A1 (cg-RX-API-DMAC7.html)
JP (1) JP6641357B2 (cg-RX-API-DMAC7.html)
KR (1) KR102378988B1 (cg-RX-API-DMAC7.html)
CN (1) CN106536536B (cg-RX-API-DMAC7.html)
AR (1) AR100277A1 (cg-RX-API-DMAC7.html)
AU (1) AU2015256232B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016025147B1 (cg-RX-API-DMAC7.html)
CA (1) CA2982075A1 (cg-RX-API-DMAC7.html)
DK (1) DK3140314T3 (cg-RX-API-DMAC7.html)
ES (1) ES2750373T3 (cg-RX-API-DMAC7.html)
HU (1) HUE045937T2 (cg-RX-API-DMAC7.html)
MX (1) MX367883B (cg-RX-API-DMAC7.html)
NZ (1) NZ725866A (cg-RX-API-DMAC7.html)
WO (1) WO2015171555A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201607592B (cg-RX-API-DMAC7.html)

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WO2016049315A1 (en) 2014-09-26 2016-03-31 Purecircle Usa Inc. Stevia composition, production method and uses
US9752174B2 (en) 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
US9522929B2 (en) 2014-05-05 2016-12-20 Conagen Inc. Non-caloric sweetener
BR112017005656A2 (pt) 2014-09-19 2018-07-31 Purecircle Sdn Bhd glicosídeos de esteviol de alta pureza
DK3201351T3 (da) 2014-10-03 2021-02-22 Conagen Inc Kaloriefrie sødestoffer og fremgangsmåder til syntetisering
US10711024B2 (en) 2014-12-17 2020-07-14 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
WO2016156616A1 (en) 2015-04-03 2016-10-06 Dsm Ip Assets B.V. Steviol glycosides
BR112017022019A2 (pt) 2015-04-14 2018-07-31 Conagen Inc. produção de adoçantes não calóricos por meio da utilização de catalisadores de células inteiras modificadas
US10494397B2 (en) * 2016-07-15 2019-12-03 Pepsico, Inc. Rebaudioside analogs
BR112019007504B1 (pt) 2016-10-14 2023-05-09 Conagen Inc Método de preparação de uma composição de glicosídeo de esteviol
MX2019004630A (es) * 2016-10-21 2019-07-15 Pepsico Inc Metodo para preparar rebaudiosido j usando el metodo enzimatico.
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CN110914445B (zh) 2017-02-03 2024-08-27 泰莱解决方案美国有限责任公司 工程化糖基转移酶和甜菊醇糖苷葡糖基化方法
AU2017402700A1 (en) * 2017-03-06 2019-10-17 Conagen Inc. Biosynthetic production of steviol glycoside rebaudioside D4 from rebaudioside E
AU2018294258A1 (en) 2017-06-30 2020-02-06 Conagen Inc. Hydrolysis of steviol glycosides by beta-glucosidase
CN109423486B (zh) * 2017-08-29 2022-02-25 中国科学院分子植物科学卓越创新中心 新型udp-糖基转移酶及其应用
CN107446874B (zh) * 2017-09-25 2020-07-28 四川盈嘉合生科技有限公司 重组大肠杆菌及其在合成莱鲍迪苷d中的用途
CN111868252B (zh) 2018-03-12 2025-06-03 科纳根公司 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产
WO2019100676A1 (zh) * 2018-05-25 2019-05-31 邦泰生物工程(深圳)有限公司 一种酶改质甜菊糖的制备方法和制备用酶及应用
JP7584401B2 (ja) 2018-07-30 2024-11-15 テイト アンド ライル ソリューションズ ユー・エス・エー エル・エル・シー 操作されたグリコシルトランスフェラーゼおよびステビオールグリコシドのグルコシル化方法
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WO2020097922A1 (zh) * 2018-11-16 2020-05-22 邦泰生物工程(深圳)有限公司 一种udp-葡萄糖基转移酶突变体、其应用及其制备莱鲍迪苷d的方法
CN113474464B (zh) * 2018-12-12 2025-06-10 科纳根公司 变体甜菊醇糖苷的生物合成生产
CN109750072B (zh) * 2019-01-31 2022-04-19 南京工业大学 一种酶法制备莱鲍迪苷e的方法
WO2020205685A1 (en) * 2019-03-29 2020-10-08 Conagen Inc. Biosynthetic production of udp-rhamnose
CN110878288B (zh) * 2019-12-09 2020-12-29 安徽农业大学 多肽、核酸及其在合成橙花叔醇糖苷上的应用
CN111378630A (zh) * 2020-04-09 2020-07-07 北京农学院 一种融合蛋白及其高效表达方法与应用
CN114045273B (zh) * 2021-11-15 2022-07-22 四川大学 糖基转移酶OsUGT91C1突变体及其应用
JP2025500510A (ja) * 2021-12-24 2025-01-09 サムヤン コーポレイション 糖転移酵素変異体、およびこれを利用したステビオール配糖体の製造方法
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US20160208303A1 (en) 2016-07-21
BR112016025147A2 (pt) 2017-12-12
EP3140314A4 (en) 2017-10-18
KR20160147994A (ko) 2016-12-23
EP3140314A1 (en) 2017-03-15
US9765104B2 (en) 2017-09-19
US10597418B2 (en) 2020-03-24
EP4023660A1 (en) 2022-07-06
US9522929B2 (en) 2016-12-20
HUE045937T2 (hu) 2020-01-28
NZ725866A (en) 2022-11-25
US20180051049A1 (en) 2018-02-22
CA2982075A1 (en) 2015-11-12
US10941174B2 (en) 2021-03-09
AU2015256232A1 (en) 2016-11-24
EP3418288A1 (en) 2018-12-26
US20150315623A1 (en) 2015-11-05
DK3140314T3 (da) 2019-10-21
US9527880B2 (en) 2016-12-27
US20160208225A1 (en) 2016-07-21
US10654881B2 (en) 2020-05-19
CN106536536A8 (zh) 2017-07-07
WO2015171555A1 (en) 2015-11-12
JP2017519812A (ja) 2017-07-20
BR112016025147B1 (pt) 2021-11-03
US20180009835A1 (en) 2018-01-11
US9988414B2 (en) 2018-06-05
KR102378988B1 (ko) 2022-03-28
EP3140314B1 (en) 2019-07-31
US20200361978A1 (en) 2020-11-19
ES2750373T3 (es) 2020-03-25
US20180037600A1 (en) 2018-02-08
CN106536536A (zh) 2017-03-22
CN106536536B (zh) 2019-12-06
ZA201607592B (en) 2019-02-27
AR100277A1 (es) 2016-09-21
US20180244709A1 (en) 2018-08-30
US10138263B2 (en) 2018-11-27
JP6641357B2 (ja) 2020-02-05
US10450339B2 (en) 2019-10-22
MX2016014506A (es) 2017-02-23
EP3418288B1 (en) 2022-01-19
MX367883B (es) 2019-09-10
US20160207954A1 (en) 2016-07-21

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