AU2014298629B2 - Methods of preparing nicotinamide riboside and derivatives thereof - Google Patents

Methods of preparing nicotinamide riboside and derivatives thereof Download PDF

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Publication number
AU2014298629B2
AU2014298629B2 AU2014298629A AU2014298629A AU2014298629B2 AU 2014298629 B2 AU2014298629 B2 AU 2014298629B2 AU 2014298629 A AU2014298629 A AU 2014298629A AU 2014298629 A AU2014298629 A AU 2014298629A AU 2014298629 B2 AU2014298629 B2 AU 2014298629B2
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substituted
unsubstituted
formula
optionally
compound
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AU2014298629A1 (en
Inventor
Kerri CROSSEY
Mark Doherty
Marie MIGAUD
Philip REDPATH
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Queens University of Belfast
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Queens University of Belfast
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Priority to AU2018211238A priority Critical patent/AU2018211238A1/en
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Priority to AU2020201254A priority patent/AU2020201254B2/en
Priority to AU2022203196A priority patent/AU2022203196B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2014298629A 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof Active AU2014298629B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2018211238A AU2018211238A1 (en) 2013-07-29 2018-08-01 Methods of preparing nicotinamide riboside and derivatives thereof
AU2020201254A AU2020201254B2 (en) 2013-07-29 2020-02-21 Methods of preparing nicotinamide riboside and derivatives thereof
AU2022203196A AU2022203196B2 (en) 2013-07-29 2022-05-12 Method of preparing nicotinamide riboside and derivatives thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1313465.5 2013-07-29
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
PCT/EP2014/065971 WO2015014722A1 (en) 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018211238A Division AU2018211238A1 (en) 2013-07-29 2018-08-01 Methods of preparing nicotinamide riboside and derivatives thereof

Publications (2)

Publication Number Publication Date
AU2014298629A1 AU2014298629A1 (en) 2016-02-11
AU2014298629B2 true AU2014298629B2 (en) 2018-08-16

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
AU2014298629A Active AU2014298629B2 (en) 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof
AU2018211238A Abandoned AU2018211238A1 (en) 2013-07-29 2018-08-01 Methods of preparing nicotinamide riboside and derivatives thereof
AU2020201254A Active AU2020201254B2 (en) 2013-07-29 2020-02-21 Methods of preparing nicotinamide riboside and derivatives thereof
AU2022203196A Active AU2022203196B2 (en) 2013-07-29 2022-05-12 Method of preparing nicotinamide riboside and derivatives thereof

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2018211238A Abandoned AU2018211238A1 (en) 2013-07-29 2018-08-01 Methods of preparing nicotinamide riboside and derivatives thereof
AU2020201254A Active AU2020201254B2 (en) 2013-07-29 2020-02-21 Methods of preparing nicotinamide riboside and derivatives thereof
AU2022203196A Active AU2022203196B2 (en) 2013-07-29 2022-05-12 Method of preparing nicotinamide riboside and derivatives thereof

Country Status (14)

Country Link
US (6) US10000519B2 (cg-RX-API-DMAC7.html)
EP (2) EP3321274A1 (cg-RX-API-DMAC7.html)
JP (1) JP6208352B2 (cg-RX-API-DMAC7.html)
KR (2) KR102414886B1 (cg-RX-API-DMAC7.html)
CN (2) CN108707174A (cg-RX-API-DMAC7.html)
AU (4) AU2014298629B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016001774B1 (cg-RX-API-DMAC7.html)
CA (2) CA3192957A1 (cg-RX-API-DMAC7.html)
ES (1) ES2652654T3 (cg-RX-API-DMAC7.html)
GB (1) GB201313465D0 (cg-RX-API-DMAC7.html)
HK (1) HK1255037A1 (cg-RX-API-DMAC7.html)
MX (1) MX349969B (cg-RX-API-DMAC7.html)
WO (1) WO2015014722A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201802315B (cg-RX-API-DMAC7.html)

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WO2017011788A1 (en) 2015-07-15 2017-01-19 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
EP3331894B1 (en) 2015-08-05 2021-02-17 Metro International Biotech, LLC Nicotinamide mononucleotide derivatives and their uses
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US10611790B2 (en) * 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
US11248018B2 (en) 2016-02-23 2022-02-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent
EP3429354A4 (en) 2016-03-16 2020-03-25 Chromadex Inc. CONJUGATES OF VITAMIN B AND AMINO ACIDS OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYLE RIBOSIDES DERIVATIVES THEREOF, AND PROCESSES FOR THEIR PREPARATION
AU2017254657A1 (en) 2016-04-20 2018-11-15 ChromaDex Inc. Use of Nicotinic acid Riboside or Nicotinamide Ribosite derivatives, and reduced derivatives thereof, as nad+increasing precursors
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
NZ803738A (en) 2016-11-11 2024-05-31 Chromadex Inc Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
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WO2019122084A1 (en) 2017-12-22 2019-06-27 Stemtek Therapeutics, S.L. Process for the preparation of nicotinamide riboside chloride derivatives
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CN110283221A (zh) * 2018-03-19 2019-09-27 药源药物化学（上海）有限公司 杂环化合物的制备和纯化方法
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
CA3141304A1 (en) * 2018-05-22 2019-11-28 Jumpstart Fertility Pty Ltd Amino acid salts of nicotinic acid ribosides as anti-aging agents
US20210267251A1 (en) * 2018-06-21 2021-09-02 Societe Des Produits Nestle S.A. Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
EP3897666A2 (en) 2018-12-17 2021-10-27 Mitopower LLC Nicotinyl riboside compounds and their uses
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CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
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Also Published As

Publication number Publication date
WO2015014722A1 (en) 2015-02-05
AU2020201254A1 (en) 2020-03-12
US20240101588A1 (en) 2024-03-28
JP2016530248A (ja) 2016-09-29
AU2022203196A1 (en) 2022-06-02
BR112016001774B1 (pt) 2021-06-22
EP3321274A1 (en) 2018-05-16
JP6208352B2 (ja) 2017-10-04
ZA201802315B (en) 2023-02-22
KR102303966B1 (ko) 2021-09-24
ES2652654T3 (es) 2018-02-05
US20180186824A1 (en) 2018-07-05
AU2014298629A1 (en) 2016-02-11
EP3027635A1 (en) 2016-06-08
HK1218918A1 (en) 2017-03-17
CN105636973B (zh) 2018-06-01
CA2918955C (en) 2023-05-09
US20240239831A1 (en) 2024-07-18
KR20210038718A (ko) 2021-04-07
EP3027635B1 (en) 2017-09-20
US10815262B2 (en) 2020-10-27
US12252506B2 (en) 2025-03-18
AU2020201254B2 (en) 2022-05-26
MX2016001211A (es) 2016-10-28
KR102414886B1 (ko) 2022-07-01
CN105636973A (zh) 2016-06-01
US20220259250A1 (en) 2022-08-18
US11981698B2 (en) 2024-05-14
AU2022203196B2 (en) 2023-11-23
BR112016001774A2 (pt) 2017-08-01
CA3192957A1 (en) 2015-02-05
US10000519B2 (en) 2018-06-19
US20160168184A1 (en) 2016-06-16
US20200291055A1 (en) 2020-09-17
CA2918955A1 (en) 2015-02-05
AU2018211238A1 (en) 2018-08-16
US11584770B2 (en) 2023-02-21
HK1255037A1 (en) 2019-08-02
BR112016001774A8 (pt) 2020-01-21
NZ716277A (en) 2021-03-26
CN108707174A (zh) 2018-10-26
MX349969B (es) 2017-08-23
GB201313465D0 (en) 2013-09-11
KR20160043974A (ko) 2016-04-22

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