AU2013214783B2 - CDK8/CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer - Google Patents

CDK8/CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer Download PDF

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Publication number
AU2013214783B2
AU2013214783B2 AU2013214783A AU2013214783A AU2013214783B2 AU 2013214783 B2 AU2013214783 B2 AU 2013214783B2 AU 2013214783 A AU2013214783 A AU 2013214783A AU 2013214783 A AU2013214783 A AU 2013214783A AU 2013214783 B2 AU2013214783 B2 AU 2013214783B2
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patient
cdk8
cancer
small molecule
molecule compound
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AU2013214783A1 (en
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Donald C. Porter
Igor B. Robinson
Mark P. Wentland
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Senex Biotechnology Inc
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Senex Biotechnology Inc
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4739—Cyclin; Prad 1
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    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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AU2013214783A 2012-02-02 2013-02-01 CDK8/CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer Ceased AU2013214783B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261594023P 2012-02-02 2012-02-02
US61/594,023 2012-02-02
US201261673419P 2012-07-19 2012-07-19
US61/673,419 2012-07-19
PCT/US2013/024515 WO2013116786A1 (en) 2012-02-02 2013-02-01 Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer

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AU2013214783A1 AU2013214783A1 (en) 2014-08-28
AU2013214783B2 true AU2013214783B2 (en) 2017-07-06

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US (2) US9321737B2 (https=)
EP (2) EP2809324B1 (https=)
JP (1) JP6193268B2 (https=)
KR (1) KR20150023223A (https=)
CN (1) CN104363913B (https=)
AU (1) AU2013214783B2 (https=)
BR (1) BR112014019052A8 (https=)
CL (1) CL2014002062A1 (https=)
CO (1) CO7151516A2 (https=)
EA (2) EA028595B1 (https=)
GE (2) GEP20186818B (https=)
MY (1) MY165446A (https=)
PH (1) PH12014501862A1 (https=)
SG (1) SG11201404596UA (https=)
UA (1) UA117342C2 (https=)
WO (1) WO2013116786A1 (https=)

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