AU2012299191B2 - Microorganisms and methods for producing 1,3-butanediol and related alcohols - Google Patents

Microorganisms and methods for producing 1,3-butanediol and related alcohols Download PDF

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Publication number
AU2012299191B2
AU2012299191B2 AU2012299191A AU2012299191A AU2012299191B2 AU 2012299191 B2 AU2012299191 B2 AU 2012299191B2 AU 2012299191 A AU2012299191 A AU 2012299191A AU 2012299191 A AU2012299191 A AU 2012299191A AU 2012299191 B2 AU2012299191 B2 AU 2012299191B2
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Prior art keywords
coa
butanediol
pathway
butadiene
reductase
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Ceased
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AU2012299191A
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AU2012299191A1 (en
Inventor
Anthony P. Burgard
Mark J. Burk
Robin E. Osterhout
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Genomatica Inc
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Genomatica Inc
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Priority to AU2013202930A priority Critical patent/AU2013202930B2/en
Priority to AU2013202925A priority patent/AU2013202925B2/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2012299191A 2011-08-19 2012-08-17 Microorganisms and methods for producing 1,3-butanediol and related alcohols Ceased AU2012299191B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2013202930A AU2013202930B2 (en) 2011-08-19 2013-04-08 Microorganisms and methods for producing 1,3-butanediol and related alcohols
AU2013202925A AU2013202925B2 (en) 2011-08-19 2013-04-08 Microorganisms and methods for producing 1,3-butanediol and related alcohols

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161525659P 2011-08-19 2011-08-19
US61/525,659 2011-08-19
US201161530885P 2011-09-02 2011-09-02
US61/530,885 2011-09-02
US201161535264P 2011-09-15 2011-09-15
US61/535,264 2011-09-15
US201261645509P 2012-05-10 2012-05-10
US61/645,509 2012-05-10
PCT/US2012/051347 WO2013028519A1 (en) 2011-08-19 2012-08-17 Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2013202930A Division AU2013202930B2 (en) 2011-08-19 2013-04-08 Microorganisms and methods for producing 1,3-butanediol and related alcohols
AU2013202925A Division AU2013202925B2 (en) 2011-08-19 2013-04-08 Microorganisms and methods for producing 1,3-butanediol and related alcohols

Publications (2)

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AU2012299191A1 AU2012299191A1 (en) 2013-05-02
AU2012299191B2 true AU2012299191B2 (en) 2016-03-03

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US (3) US20130109064A1 (https=)
EP (2) EP2744906B1 (https=)
JP (2) JP6272757B2 (https=)
KR (2) KR102043381B1 (https=)
CN (1) CN103890185A (https=)
AU (1) AU2012299191B2 (https=)
BR (1) BR112014003708A2 (https=)
CA (1) CA2845681A1 (https=)
CO (1) CO7020858A2 (https=)
IN (1) IN2014CN01258A (https=)
MX (1) MX348612B (https=)
PH (1) PH12014500391A1 (https=)
SG (2) SG11201400113XA (https=)
WO (1) WO2013028519A1 (https=)

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